RGD Reference Report - Interleukin-5 expression in the lung epithelium of transgenic mice leads to pulmonary changes pathognomonic of asthma. - Rat Genome Database

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Interleukin-5 expression in the lung epithelium of transgenic mice leads to pulmonary changes pathognomonic of asthma.

Authors: Lee, JJ  McGarry, MP  Farmer, SC  Denzler, KL  Larson, KA  Carrigan, PE  Brenneise, IE  Horton, MA  Haczku, A  Gelfand, EW  Leikauf, GD  Lee, NA 
Citation: Lee JJ, etal., J Exp Med. 1997 Jun 16;185(12):2143-56.
RGD ID: 4890963
Pubmed: PMID:9182686   (View Abstract at PubMed)
PMCID: PMC2196351   (View Article at PubMed Central)

We have generated transgenic mice that constitutively express murine interleukin (IL)-5 in the lung epithelium. Airway expression of this cytokine resulted in a dramatic accumulation of peribronchial eosinophils and striking pathologic changes including the expansion of bronchus-associated lymphoid tissue (BALT), goblet cell hyperplasia, epithelial hypertrophy, and focal collagen deposition. These changes were also accompanied by eosinophil infiltration of the airway lumen. In addition, transgenic animals displayed airway hyperresponsiveness to methacholine in the absence of aerosolized antigen challenge. These findings demonstrate that lung-specific IL-5 expression can induce pathologic changes characteristic of asthma and may provide useful models to evaluate the efficacy of potential respiratory disease therapies or pharmaceuticals.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
asthma  ISOIl5 (Mus musculus)4890963; 4890963 RGD 
asthma  IMP 4890963 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Il5  (interleukin 5)

Genes (Mus musculus)
Il5  (interleukin 5)

Genes (Homo sapiens)
IL5  (interleukin 5)


Additional Information