Htr2c (5-hydroxytryptamine receptor 2C) - Rat Genome Database

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Gene: Htr2c (5-hydroxytryptamine receptor 2C) Rattus norvegicus
Analyze
Symbol: Htr2c
Name: 5-hydroxytryptamine receptor 2C
RGD ID: 2848
Description: Enables G protein-coupled serotonin receptor activity. Involved in several processes, including G protein-coupled receptor signaling pathway; behavioral response to nicotine; and positive regulation of amine transport. Located in external side of plasma membrane. Used to study anxiety disorder; major depressive disorder; and substance-related disorder (multiple). Biomarker of withdrawal disorder. Human ortholog(s) of this gene implicated in bipolar disorder; obesity; and schizophrenia. Orthologous to human HTR2C (5-hydroxytryptamine receptor 2C); PARTICIPATES IN calcium/calcium-mediated signaling pathway; INTERACTS WITH (+)-pilocarpine; 1-bromopropane; 17beta-estradiol.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: 5-HT-1C; 5-HT1C; 5-HT2C; 5-HTR2C; 5-hydroxytryptamine (serotonin) receptor 2C; 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled; 5-hydroxytryptamine receptor 1C; 5HT-1C; serotonin 1c receptor; serotonin receptor 2C
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X115,453,190 - 115,682,325 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 EnsemblX115,452,842 - 115,682,324 (+)EnsemblGRCr8
mRatBN7.2X110,640,777 - 110,870,288 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX110,641,153 - 110,870,287 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_UtxX112,734,293 - 112,956,059 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X116,233,146 - 116,454,918 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X113,792,877 - 114,014,236 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X118,084,520 - 118,318,040 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX118,084,890 - 118,318,039 (+)Ensemblrn6Rnor6.0
Rnor_5.0X118,226,113 - 118,460,830 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4X31,012,921 - 31,244,127 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
CeleraX109,958,913 - 110,179,824 (+)NCBICelera
RGSC_v3.1X31,069,048 - 31,185,684 (-)NCBI
Cytogenetic MapXq34NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-pilocarpine  (EXP)
1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene  (ISO)
1,2-dichloroethane  (ISO)
1-(3-chlorophenyl)piperazine  (ISO)
1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile  (ISO)
1-bromopropane  (EXP)
17beta-estradiol  (EXP)
17beta-estradiol 3-benzoate  (EXP)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP)
2,4,4'-trichlorobiphenyl  (ISO)
2-(4-iodo-2,5-dimethoxyphenyl)-1-methylethylamine  (ISO)
2-chloro-6-(1-piperazinyl)pyrazine  (EXP,ISO)
3,4-methylenedioxymethamphetamine  (EXP,ISO)
6-propyl-2-thiouracil  (EXP)
aflatoxin B1  (ISO)
agomelatine  (ISO)
all-trans-retinoic acid  (ISO)
amitriptyline  (ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
aripiprazole  (ISO)
arsenite(3-)  (ISO)
atrazine  (EXP)
Bardoxolone methyl  (ISO)
benzo[a]pyrene  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP)
Butylbenzyl phthalate  (ISO)
calcitriol  (ISO)
carbamazepine  (EXP)
chlorpyrifos  (EXP)
citalopram  (ISO)
clomipramine  (EXP,ISO)
clozapine  (EXP,ISO)
cocaine  (EXP,ISO)
Cuprizon  (EXP)
cyclosporin A  (ISO)
diazinon  (EXP)
dibutyl phthalate  (EXP,ISO)
dieldrin  (EXP)
dioxygen  (ISO)
dopamine  (ISO)
dorsomorphin  (ISO)
entinostat  (ISO)
ethanol  (ISO)
fenfluramine  (ISO)
fenvalerate  (EXP)
fluoxetine  (EXP,ISO)
fluphenazine  (ISO)
folic acid  (ISO)
genistein  (EXP)
haloperidol  (EXP)
imidacloprid  (EXP)
lead diacetate  (EXP)
lipopolysaccharide  (EXP,ISO)
loxapine  (EXP)
maneb  (ISO)
mesulergine  (EXP,ISO)
methamphetamine  (EXP,ISO)
methimazole  (EXP)
methoxychlor  (EXP)
mianserin  (ISO)
mirtazapine  (ISO)
nefazodone  (ISO)
nitrates  (EXP)
Norfluoxetine  (ISO)
nortriptyline  (ISO)
okadaic acid  (ISO)
olanzapine  (ISO)
paraquat  (EXP,ISO)
paroxetine  (ISO)
PCB138  (ISO)
phenylmercury acetate  (ISO)
potassium dichromate  (ISO)
risperidone  (ISO)
sarpogrelate  (ISO)
SB 206553  (EXP,ISO)
SB 243213  (ISO)
SB 431542  (ISO)
scopolamine  (EXP)
serotonin  (EXP,ISO)
sertraline  (EXP)
silicon dioxide  (EXP)
streptozocin  (ISO)
testosterone  (EXP,ISO)
thimerosal  (ISO)
titanium dioxide  (ISO)
trazodone  (ISO)
trichostatin A  (ISO)
valproic acid  (ISO)
vorinostat  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
animal organ regeneration  (IEP)
behavioral fear response  (ISO,ISS)
behavioral response to nicotine  (IMP)
chemical synaptic transmission  (IBA)
feeding behavior  (IEA,IMP,ISO)
G protein-coupled receptor signaling pathway  (IEA)
G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger  (IBA,TAS)
G protein-coupled serotonin receptor signaling pathway  (IEA,ISO)
intracellular calcium ion homeostasis  (ISO)
locomotory behavior  (IEA)
negative regulation of dopamine metabolic process  (IMP)
phospholipase C-activating G protein-coupled receptor signaling pathway  (ISO,ISS)
phospholipase C-activating serotonin receptor signaling pathway  (IBA,IDA,ISO)
phospholipase D-activating G protein-coupled receptor signaling pathway  (IMP)
positive regulation of acetylcholine secretion, neurotransmission  (IMP)
positive regulation of calcium-mediated signaling  (ISO)
positive regulation of ERK1 and ERK2 cascade  (ISO)
positive regulation of fat cell differentiation  (ISO)
positive regulation of gamma-aminobutyric acid secretion  (IMP)
positive regulation of phosphatidylinositol biosynthetic process  (ISO)
positive regulation of vasoconstriction  (IMP)
regulation of appetite  (ISO,ISS)
regulation of corticotropin-releasing hormone secretion  (ISO,ISS)
regulation of nervous system process  (ISO,ISS)
release of sequestered calcium ion into cytosol  (IBA,ISO)
response to xenobiotic stimulus  (IMP)
sensitization  (IMP)
serotonin receptor signaling pathway  (IBA)
signal transduction  (IEA)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Differential effects of 5-methyl-1-[[2-[(2-methyl-3-pyridyl)oxyl]-5-pyridyl]carbamoyl]-6-trifluoro methylindone (SB 243213) on 5-hydroxytryptamine(2C) receptor-mediated responses. Berg KA, etal., J Pharmacol Exp Ther. 2006 Oct;319(1):260-8. Epub 2006 Jun 28.
2. In vivo evidence that 5-HT(2C) receptors inhibit 5-HT neuronal activity via a GABAergic mechanism. Boothman L, etal., Br J Pharmacol. 2006 Dec;149(7):861-9. Epub 2006 Oct 16.
3. Regulation of serotonin-2C receptor G-protein coupling by RNA editing. Burns CM, etal., Nature 1997 May 15;387(6630):303-8.
4. Vasoconstrictor responses to 5-hydroxytryptamine in the autoperfused hindquarters of spontaneously hypertensive rats. Calama E, etal., Pharmacology. 2004 Jun;71(2):66-72.
5. Identification, molecular cloning, and distribution of a short variant of the 5-hydroxytryptamine2C receptor produced by alternative splicing. Canton H, etal., Mol Pharmacol 1996 Oct;50(4):799-807.
6. Synergism between a serotonin 5-HT2A receptor (5-HT2AR) antagonist and 5-HT2CR agonist suggests new pharmacotherapeutics for cocaine addiction. Cunningham KA, etal., ACS Chem Neurosci. 2013 Jan 16;4(1):110-21. doi: 10.1021/cn300072u. Epub 2012 Aug 11.
7. WAY-163909 [(7bR, 10aR)-1,2,3,4,8,9,10,10a-octahydro-7bH-cyclopenta-[1,4]diazepino[6,7,1h i]indole], a novel 5-hydroxytryptamine 2C receptor-selective agonist with anorectic activity. Dunlop J, etal., J Pharmacol Exp Ther. 2005 May;313(2):862-9. Epub 2005 Feb 10.
8. Effects of the 5-HT2C receptor agonist Ro60-0175 and the 5-HT2A receptor antagonist M100907 on nicotine self-administration and reinstatement. Fletcher PJ, etal., Neuropharmacology. 2012 Jun;62(7):2288-98. doi: 10.1016/j.neuropharm.2012.01.023. Epub 2012 Feb 8.
9. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
10. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
11. Allelic association analysis of the 5-HT2C receptor gene in bipolar affective disorder. Gutierrez B, etal., Neurosci Lett 1996 Jul 5;212(1):65-7.
12. Anxiolytic activity of a novel potent serotonin 5-HT2C receptor antagonist FR260010: a comparison with diazepam and buspirone. Harada K, etal., Eur J Pharmacol. 2006 Dec 28;553(1-3):171-84. Epub 2006 Sep 28.
13. Altered RNA editing of serotonin 2C receptor in a rat model of depression. Iwamoto K, etal., Neurosci Res. 2005 Sep;53(1):69-76.
14. Disruption of PTEN coupling with 5-HT2C receptors suppresses behavioral responses induced by drugs of abuse. Ji SP, etal., Nat Med. 2006 Mar;12(3):324-9. Epub 2006 Feb 12.
15. Molecular characterization of a functional cDNA encoding the serotonin 1c receptor. Julius D, etal., Science 1988 Jul 29;241(4865):558-64.
16. The serotonin-2 receptor modulator, (-)-trans-PAT, decreases voluntary ethanol consumption in rats. Kasper J, etal., Eur J Pharmacol. 2013 Oct 15;718(1-3):98-104. doi: 10.1016/j.ejphar.2013.09.008. Epub 2013 Sep 13.
17. DOI, an agonist of 5-HT2A/2C serotonin receptor, alters the expression of cyclooxygenase-2 in the rat parietal cortex. Mackowiak M, etal., J Physiol Pharmacol 2002 Sep;53(3):395-407.
18. The membrane IgM-associated proteins MB-1 and Ig-beta are sufficient to promote surface expression of a partially functional B-cell antigen receptor in a nonlymphoid cell line. Matsuuchi L, etal., Proc Natl Acad Sci U S A. 1992 Apr 15;89(8):3404-8.
19. Phospholipase D activation by endogenous 5-hydroxytryptamine 2C receptors is mediated by Galpha13 and pertussis toxin-insensitive Gbetagamma subunits. McGrew L, etal., Mol Pharmacol. 2002 Dec;62(6):1339-43.
20. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
21. Differential effects of 5-HT2C receptor ligands on place conditioning and locomotor activity in rats. Mosher T, etal., Eur J Pharmacol. 2005 May 16;515(1-3):107-16.
22. The association between HTR2C polymorphisms and obesity in psychiatric patients using antipsychotics: a cross-sectional study. Mulder H, etal., Pharmacogenomics J. 2006 Oct 3;.
23. Activation of 5-HT2 receptors enhances the release of acetylcholine in the prefrontal cortex and hippocampus of the rat. Nair SG and Gudelsky GA, Synapse. 2004 Sep 15;53(4):202-7.
24. Region-dependent regulation of mesoaccumbens dopamine neurons in vivo by the constitutive activity of central serotonin2C receptors. Navailles S, etal., J Neurochem. 2006 Nov;99(4):1311-9. Epub 2006 Oct 2.
25. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
26. Possible involvement of spinal noradrenergic mechanisms in the antiallodynic effect of intrathecally administered 5-HT(2C) receptor agonists in the rats with peripheral nerve injury. Obata H, etal., Eur J Pharmacol. 2007 Mar 30;.
27. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
28. A 5-HT2C receptor promoter polymorphism (HTR2C - 759C/T) is associated with obesity in women, and with resistance to weight loss in heterozygotes. Pooley EC, etal., Am J Med Genet B Neuropsychiatr Genet. 2004 Apr 1;126(1):124-7.
29. Increased 5-HT2C receptor binding in the brain stem and cerebral cortex during liver regeneration and hepatic neoplasia in rats. Pyroja S, etal., J Neurol Sci. 2007 Mar 15;254(1-2):3-8. Epub 2007 Jan 26.
30. The serotonin(2C) receptor agonist Ro-60-0175 attenuates effects of nicotine in the five-choice serial reaction time task and in drug discrimination. Quarta D, etal., Psychopharmacology (Berl). 2007 May 1;.
31. GOA pipeline RGD automated data pipeline
32. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
33. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
34. Reconstitution of B cell antigen receptor-induced signaling events in a nonlymphoid cell line by expressing the Syk protein-tyrosine kinase. Richards JD, etal., J Biol Chem. 1996 Mar 15;271(11):6458-66.
35. Association between clozapine response and allelic variation in the 5-HT2C receptor gene. Sodhi MS, etal., Neuroreport 1995 Dec 29;7(1):169-72.
36. Mutagenesis analysis of the serotonin 5-HT2C receptor and a Caenorhabditis elegans 5-HT2 homologue: conserved residues of helix 4 and helix 7 contribute to agonist-dependent activation of 5-HT2 receptors. Xie J, etal., J Neurochem 2005 Jan;92(2):375-87.
37. Discovering the mechanisms underlying serotonin (5-HT)2A and 5-HT2C receptor regulation following nicotine withdrawal in rats. Zaniewska M, etal., J Neurochem. 2015 Aug;134(4):704-16. doi: 10.1111/jnc.13192. Epub 2015 Jun 26.
38. Blockade of nucleus accumbens 5-HT2A and 5-HT2C receptors prevents the expression of cocaine-induced behavioral and neurochemical sensitization in rats. Zayara AE, etal., Psychopharmacology (Berl). 2011 Feb;213(2-3):321-35. doi: 10.1007/s00213-010-1996-3. Epub 2010 Sep 3.
Additional References at PubMed
PMID:7582481   PMID:7700379   PMID:8889548   PMID:12429884   PMID:12682077   PMID:12795815   PMID:12970106   PMID:14499940   PMID:14535948   PMID:14689478   PMID:15193431   PMID:15518545  
PMID:15652696   PMID:15668911   PMID:15831837   PMID:16010984   PMID:16195233   PMID:16343451   PMID:17161544   PMID:17203017   PMID:17288998   PMID:17360519   PMID:17429406   PMID:17451451  
PMID:17467185   PMID:17588622   PMID:17596444   PMID:17617403   PMID:18046307   PMID:18067955   PMID:18363829   PMID:18400210   PMID:18439428   PMID:18442977   PMID:18445227   PMID:18582863  
PMID:18599541   PMID:18604238   PMID:18691333   PMID:18703043   PMID:18977370   PMID:19029064   PMID:19057895   PMID:19133244   PMID:19280877   PMID:19368306   PMID:19494808   PMID:19629447  
PMID:19702657   PMID:19782661   PMID:20447448   PMID:20624416   PMID:20719859   PMID:20850460   PMID:20948451   PMID:20980537   PMID:21048120   PMID:21391883   PMID:21556842   PMID:21687728  
PMID:21835345   PMID:21958863   PMID:22291020   PMID:22512261   PMID:23049953   PMID:23123772   PMID:23201361   PMID:23337537   PMID:23632436   PMID:23864045   PMID:23939424   PMID:24269295  
PMID:24531181   PMID:24618688   PMID:24935789   PMID:25134499   PMID:25141845   PMID:25609374   PMID:25727097   PMID:25770211   PMID:25818050   PMID:26120876   PMID:26371055   PMID:26769798  
PMID:26926963   PMID:27252352   PMID:28011743   PMID:28258217   PMID:29555337   PMID:30447306   PMID:30645940   PMID:31706992   PMID:31883927   PMID:33837045   PMID:34762147  


Genomics

Comparative Map Data
Htr2c
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X115,453,190 - 115,682,325 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 EnsemblX115,452,842 - 115,682,324 (+)EnsemblGRCr8
mRatBN7.2X110,640,777 - 110,870,288 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX110,641,153 - 110,870,287 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_UtxX112,734,293 - 112,956,059 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X116,233,146 - 116,454,918 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X113,792,877 - 114,014,236 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X118,084,520 - 118,318,040 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX118,084,890 - 118,318,039 (+)Ensemblrn6Rnor6.0
Rnor_5.0X118,226,113 - 118,460,830 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4X31,012,921 - 31,244,127 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
CeleraX109,958,913 - 110,179,824 (+)NCBICelera
RGSC_v3.1X31,069,048 - 31,185,684 (-)NCBI
Cytogenetic MapXq34NCBI
HTR2C
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X114,584,086 - 114,910,061 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblX114,584,078 - 114,910,061 (+)Ensemblhg38GRCh38
GRCh37X113,818,559 - 114,144,624 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36X113,724,807 - 114,050,880 (+)NCBIBuild 36Build 36hg18NCBI36
Build 34X113,641,530 - 113,967,604NCBI
CeleraX114,253,715 - 114,579,778 (+)NCBICelera
Cytogenetic MapXq23NCBI
HuRefX103,403,272 - 103,731,741 (+)NCBIHuRef
CHM1_1X113,729,484 - 114,055,500 (+)NCBICHM1_1
T2T-CHM13v2.0X112,992,593 - 113,318,748 (+)NCBIT2T-CHM13v2.0
Htr2c
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X145,745,509 - 145,980,273 (+)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX145,745,509 - 145,980,273 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38X146,962,464 - 147,197,277 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX146,962,513 - 147,197,277 (+)Ensemblmm10GRCm38
MGSCv37X143,397,056 - 143,631,820 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36X142,208,881 - 142,443,644 (+)NCBIMGSCv36mm8
CeleraX130,902,904 - 131,136,225 (+)NCBICelera
Cytogenetic MapXF2NCBI
cM MapX68.46NCBI
Htr2c
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955490910,415 - 1,126,373 (-)Ensembl
ChiLan1.0NW_004955490912,615 - 1,126,347 (-)NCBIChiLan1.0ChiLan1.0
HTR2C
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2X114,026,594 - 114,352,146 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1X114,030,203 - 114,355,755 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0X103,673,172 - 103,999,133 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1X114,169,823 - 114,503,179 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX114,199,485 - 114,503,201 (+)EnsemblpanPan2panpan1.1
HTR2C
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X87,342,800 - 87,641,224 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX87,342,792 - 87,638,579 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_TashaX73,595,073 - 73,759,737 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0X89,055,367 - 89,357,473 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 EnsemblX89,055,355 - 89,357,011 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1X86,633,342 - 86,797,977 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X88,307,583 - 88,472,268 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X88,140,047 - 88,305,373 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Htr2c
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X86,426,392 - 86,655,882 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364991,004,732 - 1,109,377 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049364991,002,083 - 1,109,446 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HTR2C
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX94,053,456 - 94,313,355 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1X94,053,415 - 94,313,352 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X108,811,549 - 108,871,722 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Sscrofa10.2X108,566,657 - 108,733,261 (+)NCBISscrofa10.2Sscrofa10.2susScr3
HTR2C
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X102,190,355 - 102,499,928 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 EnsemblX102,325,731 - 102,497,278 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366606527,537,759 - 27,837,340 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Htr2c
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046249401,040,911 - 1,157,057 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046249401,040,744 - 1,299,266 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Htr2c
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1X98,050,130 - 98,051,315 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Htr2c
1025 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:555
Count of miRNA genes:281
Interacting mature miRNAs:353
Transcripts:ENSRNOT00000065293
Prediction methods:Miranda, Pita
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1598872Memor14Memory QTL 144.5exploratory behavior trait (VT:0010471)difference between duration of physical contact or close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)X97528096142528096Rat
738025Stresp3Stress response QTL 34.610.0066stress-related behavior trait (VT:0010451)defensive burying - approachX105359969157758123Rat
61430Cia18Collagen induced arthritis QTL 183.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)X80434318125434318Rat
738029Stresp2Stress response QTL 23.40.0004stress-related behavior trait (VT:0010451)defensive burying - approachX92979612117740458Rat
61431Cia19Collagen induced arthritis QTL 194.4joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)X105468858125434318Rat
738035Stresp1Stress response QTL 14.960.000011stress-related behavior trait (VT:0010451)defensive burying - copingX45182909117740458Rat
2302047Pia34Pristane induced arthritis QTL 345.80.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)1996916163141916163Rat

Markers in Region
DXRat66  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8X115,451,514 - 115,451,662 (+)Marker Load Pipeline
mRatBN7.2X110,639,479 - 110,639,627 (+)MAPPERmRatBN7.2
Rnor_6.0X36,769,460 - 36,769,609NCBIRnor6.0
Rnor_6.0X118,083,215 - 118,083,362NCBIRnor6.0
Rnor_5.0X118,224,438 - 118,224,585UniSTSRnor5.0
RGSC_v3.4X31,245,654 - 31,245,802RGDRGSC3.4
RGSC_v3.4X31,245,655 - 31,245,802UniSTSRGSC3.4
CeleraX109,957,262 - 109,957,405UniSTS
RGSC_v3.1X31,299,123 - 31,299,271RGD
SHRSP x BN MapX31.99RGD
SHRSP x BN MapX31.99UniSTS
Cytogenetic MapXq34-q35.1UniSTS
RH94622  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X110,867,633 - 110,867,746 (+)MAPPERmRatBN7.2
Rnor_6.0X118,315,386 - 118,315,498NCBIRnor6.0
Rnor_5.0X118,458,176 - 118,458,288UniSTSRnor5.0
RGSC_v3.4X31,015,463 - 31,015,575UniSTSRGSC3.4
CeleraX110,177,170 - 110,177,282UniSTS
Cytogenetic MapXq34-q35.1UniSTS
BF399131  
Rat AssemblyChrPosition (strand)SourceJBrowse
CeleraX109,963,331 - 109,963,482UniSTS
Cytogenetic MapXq34-q35.1UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
7 4 17 145 34 39 15 12 15 6 91 43 131 22 52 24 15 15

Sequence


Ensembl Acc Id: ENSRNOT00000065293   ⟹   ENSRNOP00000060345
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 EnsemblX115,452,842 - 115,682,324 (+)Ensembl
mRatBN7.2 EnsemblX110,641,153 - 110,870,287 (+)Ensembl
Rnor_6.0 EnsemblX118,084,890 - 118,318,039 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000090922   ⟹   ENSRNOP00000070471
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 EnsemblX115,452,842 - 115,666,166 (+)Ensembl
mRatBN7.2 EnsemblX110,641,153 - 110,854,129 (+)Ensembl
Rnor_6.0 EnsemblX118,197,217 - 118,315,381 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000120058   ⟹   ENSRNOP00000088450
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 EnsemblX115,566,280 - 115,682,324 (+)Ensembl
mRatBN7.2 EnsemblX110,754,240 - 110,870,287 (+)Ensembl
RefSeq Acc Id: NM_012765   ⟹   NP_036897
RefSeq Status: REVIEWED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X115,453,190 - 115,682,325 (+)NCBI
mRatBN7.2X110,641,153 - 110,870,288 (+)NCBI
Rnor_6.0X118,084,890 - 118,318,040 (+)NCBI
Rnor_5.0X118,226,113 - 118,460,830 (+)NCBI
RGSC_v3.4X31,012,921 - 31,244,127 (-)RGD
CeleraX109,958,913 - 110,179,824 (+)RGD
Sequence:
RefSeq Acc Id: XM_039099497   ⟹   XP_038955425
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X115,453,266 - 115,682,325 (+)NCBI
mRatBN7.2X110,640,777 - 110,870,288 (+)NCBI
RefSeq Acc Id: XM_063279820   ⟹   XP_063135890
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X115,567,167 - 115,682,325 (+)NCBI
RefSeq Acc Id: NP_036897   ⟸   NM_012765
- Peptide Label: precursor
- UniProtKB: P08909 (UniProtKB/Swiss-Prot),   F1LPS1 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000060345   ⟸   ENSRNOT00000065293
Ensembl Acc Id: ENSRNOP00000070471   ⟸   ENSRNOT00000090922
RefSeq Acc Id: XP_038955425   ⟸   XM_039099497
- Peptide Label: isoform X2
- UniProtKB: A0A0G2JY06 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000088450   ⟸   ENSRNOT00000120058
RefSeq Acc Id: XP_063135890   ⟸   XM_063279820
- Peptide Label: isoform X1
- UniProtKB: Q62842 (UniProtKB/TrEMBL),   A6KGA9 (UniProtKB/TrEMBL)
Protein Domains
G-protein coupled receptors family 1 profile

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P08909-F1-model_v2 AlphaFold P08909 1-460 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13701971
Promoter ID:EPDNEW_R12494
Type:initiation region
Name:Htr2c_1
Description:5-hydroxytryptamine receptor 2C
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0X118,084,952 - 118,085,012EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2848 AgrOrtholog
BioCyc Gene G2FUF-1459 BioCyc
Ensembl Genes ENSRNOG00000030877 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000065293 ENTREZGENE
  ENSRNOT00000065293.3 UniProtKB/Swiss-Prot
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/Swiss-Prot
InterPro 5HT2C_rcpt UniProtKB/Swiss-Prot
  5HT_rcpt UniProtKB/Swiss-Prot
  GPCR_Rhodpsn UniProtKB/Swiss-Prot
  GPCR_Rhodpsn_7TM UniProtKB/Swiss-Prot
KEGG Report rno:25187 UniProtKB/Swiss-Prot
NCBI Gene 25187 ENTREZGENE
PANTHER 5-HYDROXYTRYPTAMINE RECEPTOR UniProtKB/Swiss-Prot
  PTHR24247:SF32 UniProtKB/Swiss-Prot
Pfam 7tm_1 UniProtKB/Swiss-Prot
PharmGKB HTR2C RGD
PhenoGen Htr2c PhenoGen
PRINTS 5HT2CRECEPTR UniProtKB/Swiss-Prot
  5HTRECEPTOR UniProtKB/Swiss-Prot
  GPCRRHODOPSN UniProtKB/Swiss-Prot
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/Swiss-Prot
  G_PROTEIN_RECEP_F1_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000030877 RatGTEx
SMART 7TM_GPCR_Srsx UniProtKB/Swiss-Prot
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/Swiss-Prot
UniProt 5HT2C_RAT UniProtKB/Swiss-Prot
  A0A0G2JY06 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6A845_RAT UniProtKB/TrEMBL
  A6KGA9 ENTREZGENE, UniProtKB/TrEMBL
  F1LPS1 ENTREZGENE, UniProtKB/TrEMBL
  P08909 ENTREZGENE
  Q62842 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-11 Htr2c  5-hydroxytryptamine receptor 2C  Htr2c  5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2012-07-17 Htr2c  5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled  Htr2c  5-hydroxytryptamine (serotonin) receptor 2C  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Htr2c  5-hydroxytryptamine (serotonin) receptor 2C      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in choroid plexus, striatum, hippocampus, hypothalamus, olfactory tubercles, and spinal cord 729200
gene_pathway activates the cyclooxygenase metabolic pathway in the parietal cortex 729238