GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Htr2c | multiple interactions | EXP | | 6480464 | CTD | [Fluoxetine results in increased abundance of Serotonin] which results in decreased expression of HTR2C mRNA; Fluoxetine binds to and results in decreased activity of HTR2C protein; Fluoxetine inhibits the reaction [Serotonin binds to and results in increased activity of HTR2C protein] | PMID:21554931 PMID:9050900 | Htr2c | affects binding | ISO | HTR2C (Homo sapiens) | 6480464 | CTD | Fluoxetine binds to HTR2C protein | PMID:18083778 | Htr2c | increases expression | ISO | Htr2c (Mus musculus) | 6480464 | CTD | Fluoxetine results in increased expression of HTR2C mRNA; Fluoxetine results in increased expression of HTR2C mRNA alternative form | PMID:15659601 PMID:21083617 | Htr2c | multiple interactions | ISO | Htr2c (Mus musculus) | 6480464 | CTD | [[Fluoxetine binds to and results in increased activity of HTR2C protein] which results in increased phosphorylation of and results in increased activity of EGFR protein] which results in increased phosphorylation of and results in increased activity of MAPK1 protein; [[Fluoxetine binds to and results in increased activity of HTR2C protein] which results in increased phosphorylation of and results in increased activity of EGFR protein] which results in increased phosphorylation of and results in increased activity of MAPK3 protein; [Fluoxetine binds to and results in increased activity of HTR2C protein] which results in increased phosphorylation of and results in increased activity of EGFR protein; Fluoxetine binds to and results in increased activity of HTR2C protein | PMID:19662385 | |
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