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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2848
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Htr2c
Name: 5-hydroxytryptamine receptor 2C
Acc ID: CHEBI:5118
Term: fluoxetine
Definition: A racemate comprising equimolar amounts of (R)- and (S)-fluoxetine. A selective serotonin reuptake inhibitor (SSRI), it is used (generally as the hydrochloride salt) for the treatment of depression (and the depressive phase of bipolar disorder), bullimia nervosa, and obsessive-compulsive disorder.
Chemical ID: MESH:D005473
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Htr2cmultiple interactionsEXP 6480464CTD[Fluoxetine results in increased abundance of Serotonin] which results in decreased expression of HTR2C mRNA; Fluoxetine binds to and results in decreased activity of HTR2C protein; Fluoxetine inhibits the reaction [Serotonin binds to and results in increased activity of HTR2C protein]PMID:21554931 PMID:9050900
Htr2caffects bindingISOHTR2C (Homo sapiens)6480464CTDFluoxetine binds to HTR2C proteinPMID:18083778
Htr2cincreases expressionISOHtr2c (Mus musculus)6480464CTDFluoxetine results in increased expression of HTR2C mRNA; Fluoxetine results in increased expression of HTR2C mRNA alternative formPMID:15659601 PMID:21083617
Htr2cmultiple interactionsISOHtr2c (Mus musculus)6480464CTD[[Fluoxetine binds to and results in increased activity of HTR2C protein] which results in increased phosphorylation of and results in increased activity of EGFR protein] which results in increased phosphorylation of and results in increased activity of MAPK1 protein; [[Fluoxetine binds to and results in increased activity of HTR2C protein] which results in increased phosphorylation of and results in increased activity of EGFR protein] which results in increased phosphorylation of and results in increased activity of MAPK3 protein; [Fluoxetine binds to and results in increased activity of HTR2C protein] which results in increased phosphorylation of and results in increased activity of EGFR protein; Fluoxetine binds to and results in increased activity of HTR2C proteinPMID:19662385
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