RGD Reference Report - Altered RNA editing of serotonin 2C receptor in a rat model of depression. - Rat Genome Database

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Altered RNA editing of serotonin 2C receptor in a rat model of depression.

Authors: Iwamoto, K  Nakatani, N  Bundo, M  Yoshikawa, T  Kato, T 
Citation: Iwamoto K, etal., Neurosci Res. 2005 Sep;53(1):69-76.
RGD ID: 1624993
Pubmed: PMID:16005997   (View Abstract at PubMed)
DOI: DOI:10.1016/j.neures.2005.06.001   (Journal Full-text)

Altered RNA editing of serotonin 2C receptor (HTR2C) has been suggested to be involved in the pathophysiology of major depression. Here we examined RNA editing status of HTR2C in the learned helplessness (LH) rats, one of well-established animal models of depression. LH rats showed the significantly increased RNA editing of site E, and tendency for increased RNA editing of other editing sites. Treatment with fluoxetine, a selective serotonin reuptake inhibitor, or imipramine, a tricyclic antidepressant, affected the RNA editing status of the LH rats. Although, these antidepressants differentially altered RNA editing status, they commonly reduced RNA editing efficiency of site E. We further revealed that altered RNA editing in the LH rats and by antidepressants was not explained by altered expression of RNA editing enzymes or their substrates (adenosine deaminases that act on RNA, HTR2C, and spliced form of HTR2C). These results suggest that alteration of RNA editing of HTR2C may play a role in the pathophysiology of depression and action of antidepressants.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
major depressive disorder treatmentISOHtr2c (Rattus norvegicus)1624993; 1624993mRNA:increased editingRGD 
major depressive disorder treatmentIDA 1624993mRNA:increased editingRGD 

Objects Annotated

Genes (Rattus norvegicus)
Htr2c  (5-hydroxytryptamine receptor 2C)

Genes (Mus musculus)
Htr2c  (5-hydroxytryptamine (serotonin) receptor 2C)

Genes (Homo sapiens)
HTR2C  (5-hydroxytryptamine receptor 2C)


Additional Information