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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2848
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Htr2c
Name: 5-hydroxytryptamine receptor 2C
Acc ID: CHEBI:8871
Term: risperidone
Definition: A member of the class of pyridopyrimidines that is 2-methyl-6,7,8,9-tetrahydropyrido[1,2-a]pyrimidin-4-one carrying an additional 2-[4-(6-fluoro-1,2-benzoxazol-3-yl)piperidin-1-yl]ethyl group at position 2.
Chemical ID: MESH:D018967
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Htr2caffects response to substanceISOHTR2C (Homo sapiens)6480464CTDHTR2C gene polymorphism affects the susceptibility to Risperidone; HTR2C protein affects the susceptibility to RisperidonePMID:19142101
Htr2cincreases response to substanceISOHTR2C (Homo sapiens)6480464CTDHTR2C protein results in increased susceptibility to RisperidonePMID:19997080
Htr2cmultiple interactionsISOHTR2C (Homo sapiens)6480464CTDHTR2C gene polymorphism affects the reaction [Risperidone results in increased expression of PRL protein]PMID:19997080
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