RGD Reference Report - Increased 5-HT2C receptor binding in the brain stem and cerebral cortex during liver regeneration and hepatic neoplasia in rats. - Rat Genome Database

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Increased 5-HT2C receptor binding in the brain stem and cerebral cortex during liver regeneration and hepatic neoplasia in rats.

Authors: Pyroja, S  Joseph, B  Paulose, CS 
Citation: Pyroja S, etal., J Neurol Sci. 2007 Mar 15;254(1-2):3-8. Epub 2007 Jan 26.
RGD ID: 1624998
Pubmed: PMID:17258772   (View Abstract at PubMed)
DOI: DOI:10.1016/j.jns.2006.12.003   (Journal Full-text)

In the present study, serotonin 2C (5-HT(2C)) receptor binding parameters in the brainstem and cerebral cortex were investigated during liver generation after partial hepatectomy (PH) and N-nitrosodiethylamine (NDEA) induced hepatic neoplasia in male Wistar rats. The serotonin content increased significantly (p<0.01) in the cerebral cortex after PH and in NDEA induced hepatic neoplasia. Brain stem serotonin content increased significantly (p<0.05) after PH and (p<0.001) in NDEA induced hepatic neoplasia. The number and affinity of the 5-HT(2C) receptors in the crude synaptic membrane preparations of the brain stem showed a significant (p<0.001) increase after PH and in NDEA induced hepatic neoplasia. The number and affinity of 5-HT(2C) receptors increased significantly (p<0.001) in NDEA induced hepatic neoplasia in the crude synaptic membrane preparations of the cerebral cortex. There was a significant (p<0.01) increase in plasma norepinephrine in PH and (p<0.001) in NDEA induced hepatic neoplasia, indicating sympathetic stimulation. Thus, our results suggest that during active hepatocyte proliferation 5-HT(2C) receptor in the brain stem and cerebral cortex are up-regulated which in turn induce hepatocyte proliferation mediated through sympathetic stimulation.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Experimental Liver Neoplasms  ISOHtr2c (Rattus norvegicus)1624998; 1624998protein:increased expression:brainstem and cerebral cortexRGD 
Experimental Liver Neoplasms  IEP 1624998protein:increased expression:brainstem and cerebral cortexRGD 

Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
animal organ regeneration  IEP 1624998 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Htr2c  (5-hydroxytryptamine receptor 2C)

Genes (Mus musculus)
Htr2c  (5-hydroxytryptamine (serotonin) receptor 2C)

Genes (Homo sapiens)
HTR2C  (5-hydroxytryptamine receptor 2C)


Additional Information