RGD Reference Report - Possible involvement of spinal noradrenergic mechanisms in the antiallodynic effect of intrathecally administered 5-HT(2C) receptor agonists in the rats with peripheral nerve injury. - Rat Genome Database

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Possible involvement of spinal noradrenergic mechanisms in the antiallodynic effect of intrathecally administered 5-HT(2C) receptor agonists in the rats with peripheral nerve injury.

Authors: Obata, H  Ito, N  Sasaki, M  Saito, S  Goto, F 
Citation: Obata H, etal., Eur J Pharmacol. 2007 Mar 30;.
RGD ID: 1624996
Pubmed: PMID:17451674   (View Abstract at PubMed)
DOI: DOI:10.1016/j.ejphar.2007.03.029   (Journal Full-text)

Intrathecal administration of serotonin type 2C (5-HT(2C)) receptor agonists produces an antiallodynic effect in a rat model of neuropathic pain. In the present study, we characterized this effect pharmacologically. Allodynia was produced by tight ligation of the fifth (L5) and sixth (L6) lumbar spinal nerves on the left side, and was measured by applying von Frey filaments to the left hindpaw. 6-chloro-2-(1-piperazinyl)-pyrazine (MK212; 100 mug) and 1-(m-chlorophenyl)-piperazine (mCPP; 300 mug) were used as 5-HT(2C) receptor agonists. Intrathecal administration of these agonists resulted in an antiallodynic effect. Intrathecal administration of atropine (30 mug), a muscarinic receptor antagonist, and yohimbine (30 mug), an alpha(2)-adrenoceptor antagonist, reversed the effects of 5-HT(2C) receptor agonists. Intrathecal pretreatment with 6-hydroxydopamine, an adrenergic neurotoxin, inhibited the antiallodynic effect of MK212. These results suggest that spinal noradrenergic mechanisms are involved in the antiallodynic effects of intrathecally administered 5-HT(2C) receptor agonists. Previously, we demonstrated that intrathecal administration of 5-HT(2A) receptor agonists also produced antiallodynic effects, and the effects were not reversed by yohimbine. Taken together, these findings suggest that 5-HT(2A) and 5-HT(2C) receptors in the dorsal horn of the spinal cord might be involved in alleviating neuropathic pain by different mechanisms.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Pain  ISOHtr2c (Rattus norvegicus)1624996; 1624996 RGD 
Pain  IDA 1624996 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Htr2c  (5-hydroxytryptamine receptor 2C)

Genes (Mus musculus)
Htr2c  (5-hydroxytryptamine (serotonin) receptor 2C)

Genes (Homo sapiens)
HTR2C  (5-hydroxytryptamine receptor 2C)


Additional Information