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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2848
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Htr2c
Name: 5-hydroxytryptamine receptor 2C
Acc ID: CHEBI:7735
Term: olanzapine
Definition: A benzodiazepine that is 10H-thieno[2,3-b][1,5]benzodiazepine substituted by a methyl group at position 2 and a 4-methylpiperazin-1-yl group at position 4.
Chemical ID: MESH:C076029
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Htr2caffects bindingISOHtr2c (Mus musculus)6480464CTDolanzapine binds to HTR2C proteinPMID:24389121
Htr2caffects bindingISOHTR2C (Homo sapiens)6480464CTDolanzapine binds to HTR2C proteinPMID:16983399
Htr2caffects response to substanceISOHTR2C (Homo sapiens)6480464CTDHTR2C gene polymorphism affects the susceptibility to Olanzapine; HTR2C gene SNP affects the susceptibility to Olanzapine; HTR2C protein affects the susceptibility to OlanzapinePMID:15666332 PMID:19142110 PMID:19434072
Htr2cincreases response to substanceISOHTR2C (Homo sapiens)6480464CTDHTR2C gene polymorphism results in increased susceptibility to olanzapinePMID:19434072
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