GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Htr2c | decreases expression | EXP | | 6480464 | CTD | Cocaine results in decreased expression of HTR2C mRNA | PMID:16076954 | Htr2c | increases response to substance | ISO | Htr2c (Mus musculus) | 6480464 | CTD | HTR2C mutant form results in increased susceptibility to Cocaine | PMID:12427861 | Htr2c | multiple interactions | ISO | Htr2c (Mus musculus) | 6480464 | CTD | [1-(3-chlorophenyl)piperazine binds to and results in increased activity of HTR2C protein] which results in increased susceptibility to Cocaine; [6-chloro-2-(1-piperazinyl)pyrazine binds to and results in increased activity of HTR2C protein] which results in increased susceptibility to Cocaine; HTR2C protein affects the reaction [Cocaine results in increased abundance of Dopamine] | PMID:10541732 PMID:12427861 | |
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