Imported Disease Annotations - ClinVarTerm | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | genetic disease | | ISO | ARRB2 (Homo sapiens) | 8554872 | ClinVar Annotator: match by term: Inborn genetic diseases | ClinVar | | | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Imported Disease Annotations - CTD
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References
References - curated
| # | Reference Title | Reference Citation |
| 1. | {beta}-Arrestin-2 Mediates Anti-apoptotic Signaling through Regulation of BAD Phosphorylation. | Ahn S, etal., J Biol Chem. 2009 Mar 27;284(13):8855-65. Epub 2009 Jan 26. |
| 2. | Beta-arrestin2, a novel member of the arrestin/beta-arrestin gene family. | Attramadal H, etal., J Biol Chem 1992 Sep 5;267(25):17882-90. |
| 3. | β-arrestin 2 stimulates degradation of HIF-1α and modulates tumor progression of glioblastoma. | Bae WY, etal., Cell Death Differ. 2021 Nov;28(11):3092-3104. doi: 10.1038/s41418-021-00802-2. Epub 2021 May 18. |
| 4. | Beta-arrestins: multifunctional cellular mediators. | Barki-Harrington L and Rockman HA, Physiology (Bethesda). 2008 Feb;23:17-22. |
| 5. | The physiology, signaling, and pharmacology of dopamine receptors. | Beaulieu JM and Gainetdinov RR, Pharmacol Rev. 2011 Mar;63(1):182-217. doi: 10.1124/pr.110.002642. Epub 2011 Feb 8. |
| 6. | An Akt/beta-arrestin 2/PP2A signaling complex mediates dopaminergic neurotransmission and behavior. | Beaulieu JM, etal., Cell. 2005 Jul 29;122(2):261-73. |
| 7. | A beta-arrestin 2 signaling complex mediates lithium action on behavior. | Beaulieu JM, etal., Cell. 2008 Jan 11;132(1):125-36. doi: 10.1016/j.cell.2007.11.041. |
| 8. | Differences in the C-terminus contribute to variations in trafficking between rat and human 5-HT(2A) receptor isoforms: identification of a primate-specific tripeptide ASK motif that confers GRK-2 and beta arrestin-2 interactions. | Bhattacharya A, etal., J Neurochem. 2010 Feb;112(3):723-32. Epub 2009 Nov 16. |
| 9. | Modulation of voluntary ethanol consumption by beta-arrestin 2. | Björk K, etal., FASEB J. 2008 Jul;22(7):2552-60. doi: 10.1096/fj.07-102442. Epub 2008 Mar 26. |
| 10. | beta-arrestin 2 oligomerization controls the Mdm2-dependent inhibition of p53. | Boularan C, etal., Proc Natl Acad Sci U S A. 2007 Nov 13;104(46):18061-6. Epub 2007 Nov 5. |
| 11. | Dopamine promotes striatal neuronal apoptotic death via ERK signaling cascades. | Chen J, etal., Eur J Neurosci. 2009 Jan;29(2):287-306. |
| 12. | Reactive oxygen species are involved in regulating hypocontractility of mesenteric artery to norepinephrine in cirrhotic rats with portal hypertension. | Chen W, etal., Int J Biol Sci. 2014 Mar 15;10(4):386-95. doi: 10.7150/ijbs.8081. eCollection 2014. |
| 13. | Cone arrestin identified by targeting expression of a functional family. | Craft CM, etal., J Biol Chem 1994 Feb 11;269(6):4613-9. |
| 14. | Gender related alterations of beta-adrenoceptor mechanisms in heart failure due to arteriovenous fistula. | Dent MR, etal., J Cell Physiol. 2011 Oct 20. doi: 10.1002/jcp.23058. |
| 15. | GRK mythology: G-protein receptor kinases in cardiovascular disease. | Dorn GW 2nd J Mol Med (Berl). 2009 May;87(5):455-63. Epub 2009 Feb 20. |
| 16. | Differential regulation of beta-arrestin 1 and beta-arrestin 2 gene expression in rat brain by morphine. | Fan XL, etal., Neuroscience. 2003;117(2):383-9. doi: 10.1016/s0306-4522(02)00930-2. |
| 17. | Decreased immunodensities of micro-opioid receptors, receptor kinases GRK 2/6 and beta-arrestin-2 in postmortem brains of opiate addicts. | Ferrer-Alcón M, etal., Brain Res Mol Brain Res. 2004 Feb 5;121(1-2):114-22. doi: 10.1016/j.molbrainres.2003.11.009. |
| 18. | c-Src regulates clathrin adapter protein 2 interaction with beta-arrestin and the angiotensin II type 1 receptor during clathrin- mediated internalization. | Fessart D, etal., Mol Endocrinol. 2005 Feb;19(2):491-503. Epub 2004 Oct 21. |
| 19. | Defective lymphocyte chemotaxis in beta-arrestin2- and GRK6-deficient mice. | Fong AM, etal., Proc Natl Acad Sci U S A 2002 May 28;99(11):7478-83. |
| 20. | Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. | Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27. |
| 21. | Rat ISS GO annotations from GOA human gene data--August 2006 | GOA data from the GO Consortium |
| 22. | Arrestin2 and arrestin3 are differentially expressed in the rat brain during postnatal development. | Gurevich EV, etal., Neuroscience. 2002;109(3):421-36. |
| 23. | Morphine promotes rapid, arrestin-dependent endocytosis of mu-opioid receptors in striatal neurons. | Haberstock-Debic H, etal., J Neurosci. 2005 Aug 24;25(34):7847-57. |
| 24. | Corticotropin releasing factor (CRF) receptor signaling in the central nervous system: new molecular targets. | Hauger RL, etal., CNS Neurol Disord Drug Targets. 2006 Aug;5(4):453-79. |
| 25. | Vascular hyporesponsiveness to angiotensin II in rats with CCl(4)-induced liver cirrhosis. | Hennenberg M, etal., Eur J Clin Invest. 2009 Oct;39(10):906-13. Epub 2009 Jun 12. |
| 26. | Vascular dysfunction in human and rat cirrhosis: role of receptor-desensitizing and calcium-sensitizing proteins. | Hennenberg M, etal., Hepatology. 2007 Feb;45(2):495-506. |
| 27. | Partial purification of a bone-resorbing factor elaborated from human allogeneic cultures. | Horton JE, etal., Cell Immunol 1979 Mar 1;43(1):1-10. |
| 28. | β-Arrestin 2 (ARRB2) Polymorphism is Associated With Adverse Consequences of Chronic Heroin Use. | Karavidha KK, etal., Am J Addict. 2021 Jul;30(4):351-357. doi: 10.1111/ajad.13150. Epub 2021 Mar 30. |
| 29. | Chrysin abrogates early hepatocarcinogenesis and induces apoptosis in N-nitrosodiethylamine-induced preneoplastic nodules in rats. | Khan MS, etal., Toxicol Appl Pharmacol. 2011 Feb 15;251(1):85-94. Epub 2010 Dec 15. |
| 30. | Differential regulation of endosomal GPCR/ß-arrestin complexes and trafficking by MAPK. | Khoury E, etal., J Biol Chem. 2014 Aug 22;289(34):23302-17. doi: 10.1074/jbc.M114.568147. Epub 2014 Jul 11. |
| 31. | Independent beta-arrestin2 and Gq/protein kinase Czeta pathways for ERK stimulated by angiotensin type 1A receptors in vascular smooth muscle cells converge on transactivation of the epidermal growth factor receptor. | Kim J, etal., J Biol Chem. 2009 May 1;284(18):11953-62. Epub 2009 Mar 2. |
| 32. | PAF enhances MMP-2 production in rat aortic VSMCs via a beta-arrestin2-dependent ERK signaling pathway. | Kim YH, etal., J Lipid Res. 2013 Oct;54(10):2678-86. doi: 10.1194/jlr.M037176. Epub 2013 Aug 2. |
| 33. | Loss of intracellular dystrophin: a potential mechanism for myocardial reperfusion injury. | Kyoi S, etal., Circ J. 2003 Aug;67(8):725-7. |
| 34. | Effects of Chinese Fructus Mume formula and its separated prescription extract on insulin resistance in type 2 diabetic rats. | Li JB, etal., J Huazhong Univ Sci Technolog Med Sci. 2013 Dec;33(6):877-85. doi: 10.1007/s11596-013-1215-7. Epub 2013 Dec 13. |
| 35. | Improvement of morphine-mediated analgesia by inhibition of β-arrestin2 expression in mice periaqueductal gray matter. | Li Y, etal., Int J Mol Sci. 2009 Mar;10(3):954-63. doi: 10.3390/ijms10030954. Epub 2009 Mar 5. |
| 36. | Impact of SNP-SNP interaction among ABCB1, ARRB2, DRD1 and OPRD1 on methadone dosage requirement in Han Chinese patients. | Luo R, etal., Pharmacogenomics. 2017 Dec;18(18):1659-1670. doi: 10.2217/pgs-2017-0072. Epub 2017 Nov 27. |
| 37. | Preferential Interaction between the dopamine D2 receptor and Arrestin2 in neostriatal neurons. | Macey TA, etal., Mol Pharmacol. 2004 Dec;66(6):1635-42. Epub 2004 Sep 10. |
| 38. | G protein-coupled receptor kinase 2 and beta-arrestins are recruited to FSH receptor in stimulated rat primary Sertoli cells. | Marion S, etal., J Endocrinol. 2006 Aug;190(2):341-50. |
| 39. | Beta-arrestin 2: a receptor-regulated MAPK scaffold for the activation of JNK3. | McDonald PH, etal., Science. 2000 Nov 24;290(5496):1574-7. |
| 40. | Kappa opioids promote the proliferation of astrocytes via Gbetagamma and beta-arrestin 2-dependent MAPK-mediated pathways. | McLennan GP, etal., J Neurochem. 2008 Dec;107(6):1753-65. doi: 10.1111/j.1471-4159.2008.05745.x. Epub 2008 Nov 10. |
| 41. | Disrupted circadian expression of β-arrestin 2 affects reward-related µ-opioid receptor function in alcohol dependence. | Meinhardt MW, etal., J Neurochem. 2022 Feb;160(4):454-468. doi: 10.1111/jnc.15559. Epub 2022 Jan 4. |
| 42. | Rat ISS GO annotations from MGI mouse gene data--August 2006 | MGD data from the GO Consortium |
| 43. | Targeting of beta-arrestin2 to the centrosome and primary cilium: role in cell proliferation control. | Molla-Herman A, etal., PLoS One. 2008;3(11):e3728. Epub 2008 Nov 14. |
| 44. | G protein-coupled receptor kinase 2 and arrestin2 regulate arterial smooth muscle P2Y-purinoceptor signalling. | Morris GE, etal., Cardiovasc Res. 2011 Jan 1;89(1):193-203. Epub 2010 Aug 12. |
| 45. | G protein-coupled receptor kinase 6/beta-arrestin 2 system in a rat model of dopamine supersensitivity psychosis. | Oda Y, etal., J Psychopharmacol. 2015 Dec;29(12):1308-13. doi: 10.1177/0269881115593903. Epub 2015 Jul 14. |
| 46. | β-Arrestin2 influences the response to methadone in opioid-dependent patients. | Oneda B, etal., Pharmacogenomics J. 2011 Aug;11(4):258-66. doi: 10.1038/tpj.2010.37. Epub 2010 Jun 1. |
| 47. | Targeting of cyclic AMP degradation to beta 2-adrenergic receptors by beta-arrestins. | Perry SJ, etal., Science 2002 Oct 25;298(5594):834-6. |
| 48. | Beta-arrestin- and G protein receptor kinase-mediated calcium-sensing receptor desensitization. | Pi M, etal., Mol Endocrinol. 2005 Apr;19(4):1078-87. Epub 2005 Jan 6. |
| 49. | KEGG Annotation Import Pipeline | Pipeline to import KEGG annotations from KEGG into RGD |
| 50. | PID Annotation Import Pipeline | Pipeline to import Pathway Interaction Database annotations from NCI into RGD |
| 51. | ¿-arrestin 1 (ARRDC1) and ß-arrestins cooperate to mediate Notch degradation in mammals. | Puca L, etal., J Cell Sci. 2013 Oct 1;126(Pt 19):4457-68. doi: 10.1242/jcs.130500. Epub 2013 Jul 25. |
| 52. | GOA pipeline | RGD automated data pipeline |
| 53. | ClinVar Automated Import and Annotation Pipeline | RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations |
| 54. | Data Import for Chemical-Gene Interactions | RGD automated import pipeline for gene-chemical interactions |
| 55. | Licochalcone B Ameliorates Liver Cancer via Targeting of Apoptotic Genes, DNA Repair Systems, and Cell Cycle Control. | Sadek K, etal., Iran J Pharm Res. 2020 Fall;19(4):372-386. doi: 10.22037/ijpr.2020.1101292. |
| 56. | Angiotensin II-stimulated signaling through G proteins and beta-arrestin. | Shenoy SK and Lefkowitz RJ, Sci STKE. 2005 Nov 22;2005(311):cm14. |
| 57. | Arresting a transient receptor potential (TRP) channel: beta-arrestin 1 mediates ubiquitination and functional down-regulation of TRPV4. | Shukla AK, etal., J Biol Chem. 2010 Sep 24;285(39):30115-25. Epub 2010 Jul 22. |
| 58. | Different internalization properties of the alpha1a- and alpha1b-adrenergic receptor subtypes: the potential role of receptor interaction with beta-arrestins and AP50. | Stanasila L, etal., Mol Pharmacol. 2008 Sep;74(3):562-73. Epub 2008 Jun 3. |
| 59. | Beta-arrestins 1 and 2 are associated with nicotine dependence in European American smokers. | Sun D, etal., Mol Psychiatry. 2008 Apr;13(4):398-406. doi: 10.1038/sj.mp.4002036. Epub 2007 Jun 19. |
| 60. | Arrb2 causes hepatic lipid metabolism disorder via AMPK pathway based on metabolomics in alcoholic fatty liver. | Sun YY, etal. |
| 61. | Heterodimerization of V1a and V2 vasopressin receptors determines the interaction with beta-arrestin and their trafficking patterns. | Terrillon S, etal., Proc Natl Acad Sci U S A. 2004 Feb 10;101(6):1548-53. doi: 10.1073/pnas.0305322101. Epub 2004 Feb 2. |
| 62. | Biased agonism of the calcium-sensing receptor. | Thomsen AR, etal., Cell Calcium. 2012 Feb;51(2):107-16. doi: 10.1016/j.ceca.2011.11.009. Epub 2011 Dec 20. |
| 63. | {Beta}-blocker drugs mediate calcium signaling in native central nervous system neurons by {beta}-arrestin-biased agonism. | Tzingounis AV, etal., Proc Natl Acad Sci U S A. 2010 Dec 7;107(49):21028-33. Epub 2010 Nov 15. |
| 64. | Molecular basis of parathyroid hormone receptor signaling and trafficking: a family B GPCR paradigm. | Vilardaga JP, etal., Cell Mol Life Sci. 2011 Jan;68(1):1-13. doi: 10.1007/s00018-010-0465-9. Epub 2010 Aug 12. |
| 65. | β-arrestin2 functions as a key regulator in the sympathetic-triggered immunodepression after stroke. | Wang H, etal., J Neuroinflammation. 2018 Apr 10;15(1):102. doi: 10.1186/s12974-018-1142-4. |
| 66. | A G protein-coupled receptor kinase induces Xenopus oocyte maturation. | Wang J and Liu XJ, J Biol Chem 2003 May 2;278(18):15809-14. Epub 2003 Feb 24. |
| 67. | The expression change of beta-arrestins in fibroblast-like synoviocytes from rats with collagen-induced arthritis and the effect of total glucosides of paeony. | Wang QT, etal., J Ethnopharmacol. 2011 Jan 27;133(2):511-6. Epub 2010 Oct 19. |
| 68. | Overactivation of cannabinoid receptor type 1 in rostral ventrolateral medulla promotes cardiovascular responses in spontaneously hypertensive rats. | Wang T, etal., J Hypertens. 2017 Mar;35(3):538-545. doi: 10.1097/HJH.0000000000001179. |
| 69. | Beta-arrestin1 and 2 differently modulate metabotropic glutamate receptor 7 signaling in rat developmental sevoflurane-induced neuronal apoptosis. | Wang WY, etal., Neuroscience. 2016 Jan 28;313:199-212. doi: 10.1016/j.neuroscience.2015.11.038. Epub 2015 Nov 24. |
| 70. | ß-Arrestin-biased AT1R stimulation promotes extracellular matrix synthesis in renal fibrosis. | Wang Y, etal., Am J Physiol Renal Physiol. 2017 Jul 1;313(1):F1-F8. doi: 10.1152/ajprenal.00588.2016. Epub 2017 Mar 8. |
| 71. | ß-arrestin 2 mediates cardiac ischemia-reperfusion injury via inhibiting GPCR-independent cell survival signalling. | Wang Y, etal., Cardiovasc Res. 2017 Nov 1;113(13):1615-1626. doi: 10.1093/cvr/cvx147. |
| 72. | Antinociceptive potentiation and attenuation of tolerance by intrathecal {beta}-arrestin 2 small interfering RNA in rats. | Yang CH, etal., Br J Anaesth. 2011 Nov;107(5):774-81. Epub 2011 Sep 17. |
| 73. | The contribution of rare and common variants in 30 genes to risk nicotine dependence. | Yang J, etal., Mol Psychiatry. 2015 Nov;20(11):1467-78. doi: 10.1038/mp.2014.156. Epub 2014 Dec 2. |
| 74. | Reduced expression of arrestin beta 2 by graft monocytes during acute rejection of rat kidneys. | Zakrzewicz A, etal., Immunobiology. 2011 Jul;216(7):854-61. doi: 10.1016/j.imbio.2010.11.005. Epub 2010 Dec 3. |
| 75. | Role of ssarrestins in bradykinin B2 receptor-mediated signalling. | Zimmerman B, etal., Cell Signal. 2011 Apr;23(4):648-59. doi: 10.1016/j.cellsig.2010.11.016. Epub 2010 Dec 8. |
| 76. | Beta-arrestin-dependent regulation of the cofilin pathway downstream of protease-activated receptor-2. | Zoudilova M, etal., J Biol Chem. 2007 Jul 13;282(28):20634-46. Epub 2007 May 11. |
Additional References at PubMed
| PMID:9767391 | PMID:10617462 | PMID:10644702 | PMID:11130073 | PMID:11171997 | PMID:12477932 | PMID:12582207 | PMID:12958028 | PMID:12958365 | PMID:14769794 | PMID:15125834 | PMID:15218143 |
| PMID:15489334 | PMID:15501822 | PMID:15611106 | PMID:15635042 | PMID:15878855 | PMID:16325578 | PMID:16368719 | PMID:16378096 | PMID:16820410 | PMID:16903783 | PMID:17456469 | PMID:17513300 |
| PMID:17666399 | PMID:18604210 | PMID:19188335 | PMID:19429870 | PMID:19531493 | PMID:19996297 | PMID:22457824 | PMID:22888001 | PMID:23139825 | PMID:23192415 | PMID:23341447 | PMID:23360390 |
| PMID:23382074 | PMID:23576578 | PMID:23816471 | PMID:23873795 | PMID:23884833 | PMID:24974728 | PMID:25081544 | PMID:25081814 | PMID:25542150 | PMID:25972452 | PMID:26157145 | PMID:26398586 |
| PMID:26531813 | PMID:26545496 | PMID:26839314 | PMID:27007854 | PMID:27431999 | PMID:27523794 | PMID:27922111 | PMID:28339772 | PMID:28391016 | PMID:28888936 | PMID:29510185 | PMID:29515120 |
| PMID:29563057 | PMID:31269046 | PMID:31612867 | PMID:31948726 | PMID:32471349 | PMID:32579945 | PMID:33025031 |
Genomics
Comparative Map Data
| Arrb2 (Rattus norvegicus - Norway rat) |
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| ARRB2 (Homo sapiens - human) |
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| Arrb2 (Mus musculus - house mouse) |
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| Arrb2 (Chinchilla lanigera - long-tailed chinchilla) |
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| ARRB2 (Pan paniscus - bonobo/pygmy chimpanzee) |
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| ARRB2 (Canis lupus familiaris - dog) |
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| Arrb2 (Ictidomys tridecemlineatus - thirteen-lined ground squirrel) |
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| ARRB2 (Sus scrofa - pig) |
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| ARRB2 (Chlorocebus sabaeus - green monkey) |
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| Arrb2 (Heterocephalus glaber - naked mole-rat) |
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Variants
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Variants in Arrb2
20 total Variants 
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