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Pathways
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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml).
Term:Retinoic acid-inducible gene (RIG) I-like receptor signaling pathway
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Accession:PW:0000816 term browser browse the term
Definition:This family of pattern recognition receptors are cytoplasmic proteins that recognize exogenous cytoplasmic DNA. The signaling cascades they set in motion lead to the expression of inflammatory mediators.
Synonyms:related_synonym: RIG-I signaling pathway;   RLR signaling pathway


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Retinoic acid-inducible gene (RIG) I-like receptor signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atg12 autophagy related 12 IEA KEGG rno:04622 NCBI chr18:39,452,247...39,462,424
Ensembl chr18:39,452,191...39,462,418 		JBrowse link
G Atg5 autophagy related 5 IEA KEGG rno:04622 NCBI chr20:47,798,217...47,889,216
Ensembl chr20:47,798,290...47,889,209 		JBrowse link
G Azi2 5-azacytidine induced 2 IEA KEGG rno:04622 NCBI chr 8:117,773,248...117,797,844
Ensembl chr 8:117,773,279...117,797,847 		JBrowse link
G Casp8 caspase 8 IEA KEGG rno:04622 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542 		JBrowse link
G Chuk component of inhibitor of nuclear factor kappa B kinase complex IEA KEGG rno:04622 NCBI chr 1:242,959,539...242,995,066
Ensembl chr 1:242,959,760...242,995,065 		JBrowse link
G Cxcl10 C-X-C motif chemokine ligand 10 IEA KEGG rno:04622 NCBI chr14:15,704,772...15,706,969
Ensembl chr14:15,704,758...15,706,975 		JBrowse link
G Cyld CYLD lysine 63 deubiquitinase IEA KEGG rno:04622 NCBI chr19:18,310,632...18,373,696
Ensembl chr19:18,314,019...18,373,658 		JBrowse link
G Ddx3 DEAD-box helicase 3 IEA KEGG rno:04622 NCBI chr13:98,520,538...98,523,707
Ensembl chr13:98,520,201...98,524,176 		JBrowse link
G Ddx3x DEAD-box helicase 3, X-linked IEA KEGG rno:04622 NCBI chr  X:9,479,532...9,493,169
Ensembl chr  X:9,479,532...9,493,168 		JBrowse link
G Ddx3y DEAD box helicase 3, Y-linked IEA KEGG rno:04622 NCBI chr  Y:1,115,095...1,135,754
Ensembl chr  Y:1,116,309...1,135,706 		JBrowse link
G Dhx58 DEXH-box helicase 58 IEA KEGG rno:04622 NCBI chr10:85,620,352...85,631,776
Ensembl chr10:85,620,357...85,631,525 		JBrowse link
G Fadd Fas associated via death domain IEA KEGG rno:04622 NCBI chr 1:199,743,200...199,745,746
Ensembl chr 1:199,739,994...199,745,653 		JBrowse link
G Ifih1 interferon induced with helicase C domain 1 IEA KEGG rno:04622 NCBI chr 3:47,228,980...47,275,403
Ensembl chr 3:47,227,364...47,275,456 		JBrowse link
G Ifna1 interferon, alpha 1 IEA KEGG rno:04622 NCBI chr 5:103,097,356...103,097,925
Ensembl chr 5:103,097,356...103,097,925 		JBrowse link
G Ifna2 interferon alpha 2 IEA KEGG rno:04622 NCBI chr 5:103,258,617...103,259,195 JBrowse link
G Ifna4 interferon, alpha 4 IEA KEGG rno:04622 NCBI chr 5:103,069,174...103,070,120
Ensembl chr 5:103,069,483...103,070,052 		JBrowse link
G Ifna4l1 interferon, alpha 4 like 1 IEA KEGG rno:04622 NCBI chr 5:103,524,733...103,525,302
Ensembl chr 5:103,524,733...103,525,302 		JBrowse link
G Ifna5 interferon, alpha 5 IEA KEGG rno:04622 NCBI chr 5:103,187,852...103,188,430 JBrowse link
G Ifnb1 interferon beta 1 IEA KEGG rno:04622 NCBI chr 5:103,020,758...103,021,595
Ensembl chr 5:103,020,969...103,021,523 		JBrowse link
G Ifnk interferon kappa IEA KEGG rno:04622 NCBI chr 5:49,732,073...49,734,281
Ensembl chr 5:49,732,073...49,734,281 		JBrowse link
G Ikbkb inhibitor of nuclear factor kappa B kinase subunit beta IEA KEGG rno:04622 NCBI chr16:69,319,487...69,373,251
Ensembl chr16:69,319,554...69,373,250 		JBrowse link
G Ikbke inhibitor of nuclear factor kappa B kinase subunit epsilon IEA KEGG rno:04622 NCBI chr13:42,712,154...42,738,470
Ensembl chr13:42,712,159...42,737,143 		JBrowse link
G Ikbkg inhibitor of nuclear factor kappa B kinase regulatory subunit gamma IEA KEGG rno:04622 NCBI chr  X:152,216,485...152,241,476
Ensembl chr  X:152,216,596...152,239,499 		JBrowse link
G Il12a interleukin 12A IEA KEGG rno:04622 NCBI chr 2:152,965,769...152,973,035
Ensembl chr 2:152,965,769...152,972,734 		JBrowse link
G Il12b interleukin 12B IEA KEGG rno:04622 NCBI chr10:28,888,832...28,903,802
Ensembl chr10:28,893,008...28,902,903 		JBrowse link
G Irf3 interferon regulatory factor 3 IEA KEGG rno:04622 NCBI chr 1:95,479,966...95,484,926
Ensembl chr 1:95,479,821...95,484,935 		JBrowse link
G Irf7 interferon regulatory factor 7 IEA KEGG rno:04622 NCBI chr 1:196,367,380...196,370,943
Ensembl chr 1:196,367,361...196,370,832 		JBrowse link
G Isg15 ISG15 ubiquitin-like modifier IEA KEGG rno:04622 NCBI chr 5:166,784,148...166,785,435
Ensembl chr 5:166,784,148...166,785,435 		JBrowse link
G Map3k1 mitogen-activated protein kinase kinase kinase 1 IEA KEGG rno:04622 NCBI chr 2:43,348,572...43,414,706
Ensembl chr 2:43,350,098...43,414,463 		JBrowse link
G Map3k7 mitogen activated protein kinase kinase kinase 7 IEA KEGG rno:04622 NCBI chr 5:46,356,973...46,415,597
Ensembl chr 5:46,357,931...46,415,597 		JBrowse link
G Mapk10 mitogen activated protein kinase 10 IEA KEGG rno:04622 NCBI chr14:6,497,662...6,790,109
Ensembl chr14:6,497,707...6,786,201 		JBrowse link
G Mapk11 mitogen-activated protein kinase 11 IEA KEGG rno:04622 NCBI chr 7:120,218,471...120,225,488
Ensembl chr 7:120,218,478...120,225,395 		JBrowse link
G Mapk12 mitogen-activated protein kinase 12 IEA KEGG rno:04622 NCBI chr 7:120,206,005...120,216,711
Ensembl chr 7:120,206,271...120,216,664 		JBrowse link
G Mapk13 mitogen activated protein kinase 13 IEA KEGG rno:04622 NCBI chr20:6,835,277...6,845,500
Ensembl chr20:6,835,320...6,844,222 		JBrowse link
G Mapk14 mitogen activated protein kinase 14 IEA KEGG rno:04622 NCBI chr20:6,749,646...6,810,590
Ensembl chr20:6,749,670...6,810,589 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 IEA KEGG rno:04622 NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981 		JBrowse link
G Mapk9 mitogen-activated protein kinase 9 IEA KEGG rno:04622 NCBI chr10:34,169,661...34,211,138
Ensembl chr10:34,169,675...34,210,178 		JBrowse link
G Mavs mitochondrial antiviral signaling protein IEA KEGG rno:04622 NCBI chr 3:118,451,650...118,466,094
Ensembl chr 3:118,451,743...118,466,094 		JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 IEA KEGG rno:04622 NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404 		JBrowse link
G Nfkbia NFKB inhibitor alpha IEA KEGG rno:04622 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941 		JBrowse link
G Nfkbib NFKB inhibitor beta IEA KEGG rno:04622 NCBI chr 1:84,046,292...84,053,862
Ensembl chr 1:84,046,295...84,053,862 		JBrowse link
G Nlrx1 NLR family member X1 IEA KEGG rno:04622 NCBI chr 8:44,588,476...44,606,678
Ensembl chr 8:44,590,048...44,606,484 		JBrowse link
G Otud5 OTU deubiquitinase 5 IEA KEGG rno:04622 NCBI chr  X:14,626,173...14,659,331
Ensembl chr  X:14,626,164...14,659,573 		JBrowse link
G Pin1 peptidylprolyl cis/trans isomerase, NIMA-interacting 1 IEA KEGG rno:04622 NCBI chr 8:19,189,408...19,200,785
Ensembl chr 8:19,189,373...19,200,785 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit IEA KEGG rno:04622 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Rig1 RNA sensor RIG-1 IEA KEGG rno:04622 NCBI chr 5:55,321,351...55,369,947
Ensembl chr 5:55,321,235...55,370,819 		JBrowse link
G Ripk1 receptor interacting serine/threonine kinase 1 IEA KEGG rno:04622 NCBI chr17:30,839,639...30,871,824
Ensembl chr17:30,839,650...30,871,824 		JBrowse link
G Rnf125 ring finger protein 125 IEA KEGG rno:04622 NCBI chr18:12,254,066...12,275,719
Ensembl chr18:12,253,852...12,275,983 		JBrowse link
G Tank TRAF family member-associated NFKB activator IEA KEGG rno:04622 NCBI chr 3:46,114,230...46,190,270
Ensembl chr 3:46,114,274...46,190,264 		JBrowse link
G Tbk1 TANK-binding kinase 1 IEA KEGG rno:04622 NCBI chr 7:57,077,830...57,110,868
Ensembl chr 7:57,077,830...57,110,892 		JBrowse link
G Tbkbp1 TBK1 binding protein 1 IEA KEGG rno:04622 NCBI chr10:82,120,558...82,135,749
Ensembl chr10:82,120,564...82,134,352 		JBrowse link
G Tkfc triokinase and FMN cyclase IEA KEGG rno:04622 NCBI chr 1:207,238,230...207,253,035
Ensembl chr 1:207,236,557...207,252,737 		JBrowse link
G Tnf tumor necrosis factor IEA KEGG rno:04622 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tradd TNFRSF1A-associated via death domain IEA KEGG rno:04622 NCBI chr19:33,136,148...33,142,714
Ensembl chr19:33,136,138...33,142,638 		JBrowse link
G Traf2 Tnf receptor-associated factor 2 IEA KEGG rno:04622 NCBI chr 3:8,341,950...8,366,609
Ensembl chr 3:8,341,951...8,366,538 		JBrowse link
G Traf3 Tnf receptor-associated factor 3 IEA KEGG rno:04622 NCBI chr 6:130,199,696...130,307,168
Ensembl chr 6:130,206,484...130,305,481 		JBrowse link
G Traf6 TNF receptor associated factor 6 IEA KEGG rno:04622 NCBI chr 3:87,963,517...87,988,316
Ensembl chr 3:87,963,514...87,983,507 		JBrowse link
G Trim25 tripartite motif-containing 25 IEA KEGG rno:04622 NCBI chr10:73,812,818...73,831,271
Ensembl chr10:73,812,818...73,831,257 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 6091
    signaling pathway 2634
      signaling pathway pertinent to immunity 793
        signaling pathway in the innate immune response 146
          pattern recognition receptor mediated signaling pathway 145
            Retinoic acid-inducible gene (RIG) I-like receptor signaling pathway 58
Path 2
Term Annotations click to browse term
  pathway 6091
    regulatory pathway 3867
      immune response pathway 539
        innate immune response pathway 296
          inflammatory response pathway 228
            pattern recognition receptor mediated signaling pathway 145
              Retinoic acid-inducible gene (RIG) I-like receptor signaling pathway 58
paths to the root