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ONTOLOGY REPORT - ANNOTATIONS

Term:negative regulation of alpha-beta T cell activation
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Accession:GO:0046636 term browser browse the term
Definition:Any process that stops, prevents, or reduces the frequency, rate or extent of alpha-beta T cell activation.
Synonyms:exact_synonym: down regulation of alpha-beta T cell activation;   downregulation of alpha-beta T cell activation;   negative regulation of alpha-beta T lymphocyte activation
 narrow_synonym: inhibition of alpha-beta T cell activation


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negative regulation of alpha-beta T cell activation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adora2a adenosine A2a receptor acts_upstream_of_or_within ISO (PMID:10069416) RGD PMID:10069416 NCBI chr20:13,315,848...13,333,386
Ensembl chr20:13,315,853...13,333,386 		JBrowse link
G Vsir V-set immunoregulatory receptor involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr20:28,281,582...28,307,262
Ensembl chr20:28,281,596...28,303,878 		JBrowse link
negative regulation of alpha-beta T cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gli3 GLI family zinc finger 3 involved_in ISO (MGI:4355451|PMID:19667090) RGD PMID:19667090 MGI:4355451 NCBI chr17:49,438,567...49,709,712
Ensembl chr17:49,438,567...49,709,712 		JBrowse link
G Ihh Indian hedgehog signaling molecule involved_in ISO (MGI:3836494|PMID:19109233) RGD PMID:19109233 MGI:3836494 NCBI chr 9:76,504,315...76,510,532
Ensembl chr 9:76,504,315...76,510,532 		JBrowse link
G Shh sonic hedgehog signaling molecule involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
(PMID:10981962)		 Ensembl
RGD		 PMID:10981962 GO_REF:0000107 NCBI chr 4:6,954,017...6,963,170
Ensembl chr 4:6,954,017...6,963,170 		JBrowse link
negative regulation of alpha-beta T cell proliferation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Btla B and T lymphocyte associated acts_upstream_of_or_within ISO MGI:3027713 (PMID:15568026) RGD PMID:15568026 NCBI chr11:55,563,683...55,588,187
Ensembl chr11:55,564,899...55,587,181 		JBrowse link
G Clec4g C-type lectin domain family 4, member G acts_upstream_of_or_within ISO MGI:5510586 (PMID:23487419) RGD PMID:23487419 NCBI chr12:1,780,370...1,785,027
Ensembl chr12:1,780,371...1,784,985 		JBrowse link
G Foxp3 forkhead box P3 acts_upstream_of_or_within ISO MGI:1857034 (PMID:16945588) RGD PMID:16945588 NCBI chr  X:14,908,494...14,924,994
Ensembl chr  X:14,908,494...14,923,838 		JBrowse link
G Tnfrsf14 TNF receptor superfamily member 14 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 5:165,486,069...165,494,421
Ensembl chr 5:165,484,262...165,493,703 		JBrowse link
negative regulation of CD4-positive, alpha-beta T cell activation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Tarm1 T cell-interacting, activating receptor on myeloid cells 1 involved_in ISO (PMID:26311901) RGD PMID:26311901 NCBI chr 1:65,666,742...65,682,402
Ensembl chr 1:65,671,902...65,679,626 		JBrowse link
G Twsg1 twisted gastrulation BMP signaling modulator 1 involved_in ISO (PMID:17164348) RGD PMID:17164348 NCBI chr 9:105,533,116...105,567,460
Ensembl chr 9:105,533,136...105,567,479 		JBrowse link
negative regulation of CD4-positive, alpha-beta T cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cbfb core-binding factor subunit beta involved_in ISO (MGI:3772948|PMID:18258917) RGD PMID:18258917 MGI:3772948 NCBI chr19:33,049,162...33,092,752
Ensembl chr19:33,049,172...33,092,751 		JBrowse link
G Hmgb1 high mobility group box 1 involved_in ISO (PMID:22473704) RGD PMID:22473704 NCBI chr12:5,972,950...5,979,658
Ensembl chr12:5,901,586...5,978,565
Ensembl chr16:5,901,586...5,978,565 		JBrowse link
G Runx1 RUNX family transcription factor 1 involved_in ISS
ISO		 GO_REF:0000024
(MGI:3772948|PMID:18258917)		 UniProt
RGD		 PMID:18258917 GO_REF:0000024 MGI:3772948 NCBI chr11:31,839,880...32,074,427
Ensembl chr11:31,843,764...32,074,542 		JBrowse link
G Runx3 RUNX family transcription factor 3 involved_in ISO (MGI:3772948|PMID:18258917) RGD PMID:18258917 MGI:3772948 NCBI chr 5:147,360,587...147,419,161
Ensembl chr 5:147,360,994...147,419,156 		JBrowse link
negative regulation of CD4-positive, alpha-beta T cell proliferation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Arg2 arginase 2 involved_in IEA
ISO		 GO_REF:0000107
(MGI:5908533|PMID:25009204)		 Ensembl
RGD		 PMID:25009204 GO_REF:0000107 MGI:5908533 NCBI chr 6:97,936,002...97,961,379
Ensembl chr 6:97,936,002...97,961,378 		JBrowse link
G Cblb Cbl proto-oncogene B involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
MGI:2180572 (PMID:14973438)		 Ensembl
RGD		 PMID:14973438 GO_REF:0000107 NCBI chr11:48,589,878...48,756,940
Ensembl chr11:48,592,703...48,756,839 		JBrowse link
G Cd274 CD274 molecule involved_in ISO (PMID:24691993) RGD PMID:24691993 NCBI chr 1:227,116,674...227,137,379
Ensembl chr 1:227,116,649...227,134,450 		JBrowse link
G Cd44 CD44 molecule involved_in ISO (MGI:5688819|PMID:25065622) RGD PMID:25065622 MGI:5688819 NCBI chr 3:89,155,850...89,244,615
Ensembl chr 3:89,157,058...89,244,620 		JBrowse link
G Foxp3 forkhead box P3 acts_upstream_of_or_within ISO (PMID:17028180) RGD PMID:17028180 NCBI chr  X:14,908,494...14,924,994
Ensembl chr  X:14,908,494...14,923,838 		JBrowse link
G Itch itchy E3 ubiquitin protein ligase acts_upstream_of_or_within ISO MGI:1856404 (PMID:14973438) RGD PMID:14973438 NCBI chr 3:143,642,348...143,733,745
Ensembl chr 3:143,645,637...143,733,543 		JBrowse link
G Lgals5 galectin 5 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr10:63,853,949...63,857,198
Ensembl chr10:63,853,935...63,857,153 		JBrowse link
G Lgals9 galectin 9 involved_in ISO
IBA		 (PMID:20209097)
GO_REF:0000033
(MGI:5688819|PMID:25065622)		 RGD
GO_Central		 PMID:20209097 PMID:25065622 GO_REF:0000033 MGI:5688819 NCBI chr10:63,907,018...63,930,224
Ensembl chr10:63,907,018...63,930,045 		JBrowse link
G Ndfip1 Nedd4 family interacting protein 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
MGI:3695433 (PMID:17137798)		 Ensembl
RGD		 PMID:17137798 GO_REF:0000107 NCBI chr18:30,265,808...30,316,068
Ensembl chr18:30,250,613...30,322,311 		JBrowse link
G Tarm1 T cell-interacting, activating receptor on myeloid cells 1 involved_in ISO (MGI:5908526|PMID:26311901) RGD PMID:26311901 MGI:5908526 NCBI chr 1:65,666,742...65,682,402
Ensembl chr 1:65,671,902...65,679,626 		JBrowse link
G Tnfrsf14 TNF receptor superfamily member 14 acts_upstream_of_or_within ISO (PMID:15568026) RGD PMID:15568026 NCBI chr 5:165,486,069...165,494,421
Ensembl chr 5:165,484,262...165,493,703 		JBrowse link
G Twsg1 twisted gastrulation BMP signaling modulator 1 involved_in ISO (PMID:17164348) RGD PMID:17164348 NCBI chr 9:105,533,116...105,567,460
Ensembl chr 9:105,533,136...105,567,479 		JBrowse link
G Vsir V-set immunoregulatory receptor involved_in
acts_upstream_of_or_within		 ISO (PMID:24691993)
(PMID:21383057)		 RGD PMID:21383057 PMID:24691993 NCBI chr20:28,281,582...28,307,262
Ensembl chr20:28,281,596...28,303,878 		JBrowse link
G Xcl1 X-C motif chemokine ligand 1 involved_in ISO (PMID:10887101) RGD PMID:10887101 NCBI chr13:77,248,687...77,252,343
Ensembl chr13:77,248,717...77,252,329 		JBrowse link
negative regulation of CD8-positive, alpha-beta T cell activation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd274 CD274 molecule involved_in ISO (PMID:28813410), (PMID:28813417) RGD PMID:28813410 PMID:28813417 NCBI chr 1:227,116,674...227,137,379
Ensembl chr 1:227,116,649...227,134,450 		JBrowse link
G Dapl1 death associated protein-like 1 involved_in ISO (MGI:7414447|PMID:35773432) RGD PMID:35773432 MGI:7414447 NCBI chr 3:43,960,993...43,980,940
Ensembl chr 3:43,960,810...43,980,940 		JBrowse link
G Hfe homeostatic iron regulator involved_in ISO UniProtKB:P04439 (PMID:24643698) RGD PMID:24643698 NCBI chr17:41,413,451...41,421,502
Ensembl chr17:41,413,451...41,421,502 		JBrowse link
negative regulation of CD8-positive, alpha-beta T cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Slc4a2 solute carrier family 4 member 2 involved_in ISS
ISO		 GO_REF:0000024
(MGI:6840447|PMID:24515893)		 UniProt
RGD		 PMID:24515893 GO_REF:0000024 MGI:6840447 NCBI chr 4:10,736,419...10,754,407
Ensembl chr 4:10,736,425...10,752,965 		JBrowse link
G Socs1 suppressor of cytokine signaling 1 involved_in IEA
ISO
ISS		 GO_REF:0000107
(MGI:6140589|PMID:24880459)
GO_REF:0000024		 Ensembl
RGD
UniProt		 PMID:24880459 GO_REF:0000024 GO_REF:0000107 MGI:6140589 NCBI chr10:4,882,651...4,884,342
Ensembl chr10:4,882,560...4,884,383 		JBrowse link
G Zbtb7b zinc finger and BTB domain containing 7B involved_in ISO (MGI:5446998|PMID:22730529), (MGI:6140589|PMID:24880459) RGD PMID:22730529 PMID:24880459 MGI:5446998 MGI:6140589 NCBI chr 2:174,795,831...174,811,980
Ensembl chr 2:174,797,453...174,814,236 		JBrowse link
negative regulation of CD8-positive, alpha-beta T cell proliferation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Slc4a2 solute carrier family 4 member 2 involved_in ISS
ISO		 GO_REF:0000024
(MGI:6840447|PMID:24515893)		 UniProt
RGD		 PMID:24515893 GO_REF:0000024 MGI:6840447 NCBI chr 4:10,736,419...10,754,407
Ensembl chr 4:10,736,425...10,752,965 		JBrowse link
G Vsir V-set immunoregulatory receptor involved_in ISO (PMID:24691993) RGD PMID:24691993 NCBI chr20:28,281,582...28,307,262
Ensembl chr20:28,281,596...28,303,878 		JBrowse link
negative regulation of NK T cell activation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd300a Cd300a molecule involved_in ISO (PMID:10540326) RGD PMID:10540326 NCBI chr10:99,929,801...99,942,674
Ensembl chr10:99,929,801...99,942,674 		JBrowse link
negative regulation of NK T cell proliferation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Zbtb7b zinc finger and BTB domain containing 7B involved_in ISO (MGI:5449456|PMID:23105140) RGD PMID:23105140 MGI:5449456 NCBI chr 2:174,795,831...174,811,980
Ensembl chr 2:174,797,453...174,814,236 		JBrowse link
negative regulation of T-helper 1 cell activation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Xcl1 X-C motif chemokine ligand 1 involved_in ISO (PMID:10887101) RGD PMID:10887101 NCBI chr13:77,248,687...77,252,343
Ensembl chr13:77,248,717...77,252,329 		JBrowse link
negative regulation of T-helper 1 cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ascl2 achaete-scute family bHLH transcription factor 2 involved_in ISO (MGI:5565031|PMID:24463518) RGD PMID:24463518 MGI:5565031 NCBI chr 1:198,148,999...198,151,406
Ensembl chr 1:198,148,999...198,151,406 		JBrowse link
G Il4r interleukin 4 receptor acts_upstream_of_or_within ISO MGI:96109 (PMID:16424184) RGD PMID:16424184 NCBI chr 1:180,115,061...180,139,981
Ensembl chr 1:180,115,120...180,139,980 		JBrowse link
G Jak3 Janus kinase 3 involved_in ISS
ISO		 GO_REF:0000024
(MGI:3719947|PMID:16020505)		 BHF-UCL
RGD		 PMID:16020505 GO_REF:0000024 MGI:3719947 NCBI chr16:18,386,330...18,398,542
Ensembl chr16:18,386,405...18,398,536 		JBrowse link
G Tnfsf4 TNF superfamily member 4 involved_in ISO (MGI:4942267|PMID:9670042) RGD PMID:9670042 MGI:4942267 NCBI chr13:73,723,329...73,746,809
Ensembl chr13:73,723,329...73,746,788 		JBrowse link
negative regulation of T-helper 17 cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ascl2 achaete-scute family bHLH transcription factor 2 involved_in ISO (MGI:5565031|PMID:24463518) RGD PMID:24463518 MGI:5565031 NCBI chr 1:198,148,999...198,151,406
Ensembl chr 1:198,148,999...198,151,406 		JBrowse link
G Foxp3 forkhead box P3 involved_in ISO (PMID:23169781) RGD PMID:23169781 NCBI chr  X:14,908,494...14,924,994
Ensembl chr  X:14,908,494...14,923,838 		JBrowse link
G Il2 interleukin 2 involved_in ISO RNAcentral:URS000039ED8D_10090 (MGI:5634593|PMID:25642768) RGD PMID:25642768 MGI:5634593 NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566 		JBrowse link
G Il4 interleukin 4 acts_upstream_of_or_within ISO (PMID:18792410) RGD PMID:18792410 NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750 		JBrowse link
G Pf4 platelet factor 4 IDA RGD PMID:24986443 RGD:329901907 NCBI chr14:17,298,304...17,299,220
Ensembl chr14:17,298,308...17,299,365 		JBrowse link
G Rc3h1 ring finger and CCCH-type domains 1 involved_in ISO (MGI:6142401|PMID:25282160) RGD PMID:25282160 MGI:6142401 NCBI chr13:73,174,075...73,245,762
Ensembl chr13:73,173,946...73,238,839 		JBrowse link
G Rc3h2 ring finger and CCCH-type domains 2 involved_in ISO (MGI:6142401|PMID:25282160) RGD PMID:25282160 MGI:6142401 NCBI chr 3:21,121,531...21,186,711
Ensembl chr 3:21,110,679...21,179,933 		JBrowse link
G Smad7 SMAD family member 7 involved_in IEA
ISO		 GO_REF:0000107
(MGI:5634593|PMID:25642768)		 Ensembl
RGD		 PMID:25642768 GO_REF:0000107 MGI:5634593 NCBI chr18:68,988,429...69,016,774
Ensembl chr18:68,988,429...69,016,765 		JBrowse link
G Tbx21 T-box transcription factor 21 involved_in ISO (MGI:4868293|PMID:21151104) RGD PMID:21151104 MGI:4868293 NCBI chr10:82,082,322...82,098,831
Ensembl chr10:82,082,322...82,098,831 		JBrowse link
G Zbtb7b zinc finger and BTB domain containing 7B acts_upstream_of_or_within ISO MGI:3530739 (PMID:23034280) RGD PMID:23034280 NCBI chr 2:174,795,831...174,811,980
Ensembl chr 2:174,797,453...174,814,236 		JBrowse link
G Zc3h12a zinc finger CCCH type containing 12A involved_in ISS
ISO		 GO_REF:0000024
(MGI:6142401|PMID:25282160)		 UniProt
RGD		 PMID:25282160 GO_REF:0000024 MGI:6142401 NCBI chr 5:137,376,562...137,385,351
Ensembl chr 5:137,376,564...137,385,351 		JBrowse link
negative regulation of T-helper 17 cell lineage commitment term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Loxl3 lysyl oxidase-like 3 involved_in ISO (MGI:5825383|PMID:28065600)
(PMID:28065600)		 RGD PMID:28065600 MGI:5825383 NCBI chr 4:115,540,640...115,556,958
Ensembl chr 4:115,540,685...115,557,466 		JBrowse link
G Tbx21 T-box transcription factor 21 involved_in ISO (MGI:4868293|PMID:21151104) RGD PMID:21151104 MGI:4868293 NCBI chr10:82,082,322...82,098,831
Ensembl chr10:82,082,322...82,098,831 		JBrowse link
G Tnfsf18 TNF superfamily member 18 involved_in ISO (MGI:5551556|PMID:24107315) RGD PMID:24107315 MGI:5551556 NCBI chr13:73,833,478...73,907,249
Ensembl chr13:73,831,252...73,843,169 		JBrowse link
negative regulation of T-helper 2 cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Anxa1 annexin A1 involved_in ISS
IEA
ISO		 GO_REF:0000024
GO_REF:0000107
(PMID:17008549)		 UniProt
Ensembl
RGD		 PMID:17008549 GO_REF:0000024 GO_REF:0000107 NCBI chr 1:217,861,175...217,877,205
Ensembl chr 1:217,861,175...217,877,343 		JBrowse link
G Ascl2 achaete-scute family bHLH transcription factor 2 involved_in ISO (MGI:5565031|PMID:24463518) RGD PMID:24463518 MGI:5565031 NCBI chr 1:198,148,999...198,151,406
Ensembl chr 1:198,148,999...198,151,406 		JBrowse link
G Bcl6 BCL6, transcription repressor acts_upstream_of_or_within ISO MGI:96559 (PMID:12594267) RGD PMID:12594267 NCBI chr11:76,854,090...76,877,389
Ensembl chr11:76,854,090...76,877,389 		JBrowse link
G Hlx H2.0-like homeobox acts_upstream_of_or_within ISO MGI:105367|MGI:2182089 (PMID:16424184) RGD PMID:16424184 NCBI chr13:96,280,335...96,285,750
Ensembl chr13:96,280,339...96,285,750 		JBrowse link
G Socs5 suppressor of cytokine signaling 5 involved_in ISO (MGI:3687909|PMID:12242343) RGD PMID:12242343 MGI:3687909 NCBI chr 6:7,481,039...7,512,644
Ensembl chr 6:7,481,095...7,514,834 		JBrowse link
G Zfp35 zinc finger protein 35 involved_in IEA GO_REF:0000107 Ensembl GO_REF:0000107 NCBI chr18:15,268,852...15,284,334
Ensembl chr18:15,268,814...15,285,088 		JBrowse link
negative regulation of T-helper cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Rc3h1 ring finger and CCCH-type domains 1 acts_upstream_of_or_within ISO MGI:3581675 (PMID:15917799) RGD PMID:15917799 NCBI chr13:73,174,075...73,245,762
Ensembl chr13:73,173,946...73,238,839 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19694
    immune system process 2822
      leukocyte activation 1032
        lymphocyte activation 837
          T cell activation 591
            alpha-beta T cell activation 200
              negative regulation of alpha-beta T cell activation 49
                negative regulation of CD4-positive, alpha-beta T cell activation + 38
                negative regulation of CD8-positive, alpha-beta T cell activation + 7
                negative regulation of NK T cell activation + 2
                negative regulation of alpha-beta T cell differentiation + 30
                negative regulation of alpha-beta T cell proliferation + 18
Path 2
Term Annotations click to browse term
  biological_process 19694
    biological regulation 13309
      regulation of biological process 12906
        regulation of cellular process 12363
          regulation of cell activation 650
            regulation of leukocyte activation 594
              regulation of lymphocyte activation 514
                regulation of T cell activation 378
                  regulation of alpha-beta T cell activation 126
                    negative regulation of alpha-beta T cell activation 49
                      negative regulation of CD4-positive, alpha-beta T cell activation + 38
                      negative regulation of CD8-positive, alpha-beta T cell activation + 7
                      negative regulation of NK T cell activation + 2
                      negative regulation of alpha-beta T cell differentiation + 30
                      negative regulation of alpha-beta T cell proliferation + 18
paths to the root