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Gene Ontology Annotations
Gene Ontology AnnotationsBiological Process Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | cell-cell signaling | | ISO | RGD:1350360 | 1624291 | PMID:7602097 | RGD | PMID:7602097 | cellular response to interleukin-4 | | ISO | RGD:733993 | 1624291 | MGI:MGI:85739|PMID:9013979 | RGD | MGI:MGI:85739 PMID:9013979 | cellular response to interleukin-4 | | IEA | Ensembl:ENSMUSP00000027860 | 1600115 | GO_REF:0000019 | ENSEMBL | GO_REF:0000019 | cellular response to transforming growth factor beta stimulus | | ISO | RGD:733993 | 1624291 | MGI:MGI:85739|PMID:9013979 | RGD | MGI:MGI:85739 PMID:9013979 | cellular response to transforming growth factor beta stimulus | | IEA | Ensembl:ENSMUSP00000027860 | 1600115 | GO_REF:0000019 | ENSEMBL | GO_REF:0000019 | chemotaxis | | ISO | RGD:733993 | 1624291 | MGI:MGI:1344950|PMID:10518929 | RGD | MGI:MGI:1344950 PMID:10518929 | chemotaxis | | IEA | UniProtKB-KW:KW-0145 | 1600115 | GO_REF:0000037 | UniProtKB | GO_REF:0000037 | immune response | | IEA | InterPro:IPR001811|InterPro:IPR008105 | 1600115 | GO_REF:0000002 | InterPro | GO_REF:0000002 | mature natural killer cell chemotaxis | | ISO | RGD:733993 | 1624291 | MGI:MGI:85636|PMID:9029087 | RGD | MGI:MGI:85636 PMID:9029087 | mature natural killer cell chemotaxis | | IEA | Ensembl:ENSMUSP00000027860 | 1600115 | GO_REF:0000019 | ENSEMBL | GO_REF:0000019 | mature natural killer cell chemotaxis | | ISO | RGD:1350360 | 1624291 | PMID:9029087 | RGD | PMID:9029087 | negative regulation of CD4-positive, alpha-beta T cell proliferation | | ISO | RGD:1350360 | 1624291 | PMID:10887101 | RGD | PMID:10887101 | negative regulation of interferon-gamma production | | ISO | RGD:1350360 | 1624291 | PMID:10887101 | RGD | PMID:10887101 | negative regulation of interleukin-2 production | | ISO | RGD:1350360 | 1624291 | PMID:10887101 | RGD | PMID:10887101 | negative regulation of sequence-specific DNA binding transcription factor activity | | ISO | RGD:1350360 | 1624291 | PMID:10887101 | RGD | PMID:10887101 | negative regulation of T cell cytokine production | | ISO | RGD:1350360 | 1624291 | PMID:10887101 | RGD | PMID:10887101 | negative regulation of T-helper 1 cell activation | | ISO | RGD:1350360 | 1624291 | PMID:10887101 | RGD | PMID:10887101 | negative regulation of transcription, DNA-dependent | | ISO | RGD:1350360 | 1624291 | PMID:10887101 | RGD | PMID:10887101 | positive regulation of B cell chemotaxis | | ISO | RGD:733993 | 1624291 | MGI:MGI:5009193|PMID:11181058 | RGD | MGI:MGI:5009193 PMID:11181058 | positive regulation of B cell chemotaxis | | IEA | Ensembl:ENSMUSP00000027860 | 1600115 | GO_REF:0000019 | ENSEMBL | GO_REF:0000019 | positive regulation of CD4-positive, alpha-beta T cell proliferation | | ISO | RGD:733993 | 1624291 | MGI:MGI:5009207|PMID:9973465 | RGD | MGI:MGI:5009207 PMID:9973465 | positive regulation of CD4-positive, alpha-beta T cell proliferation | | IEA | Ensembl:ENSMUSP00000027860 | 1600115 | GO_REF:0000019 | ENSEMBL | GO_REF:0000019 | positive regulation of CD8-positive, alpha-beta T cell proliferation | | ISO | RGD:1350360 | 1624291 | PMID:10887101 | RGD | PMID:10887101 | positive regulation of granzyme A production | | ISO | RGD:1350360 | 1624291 | PMID:18832695 | RGD | PMID:18832695 | positive regulation of granzyme B production | | ISO | RGD:1350360 | 1624291 | PMID:18832695 | RGD | PMID:18832695 | positive regulation of immunoglobulin production in mucosal tissue | | ISO | RGD:733993 | 1624291 | MGI:MGI:5009207|PMID:9973465 | RGD | MGI:MGI:5009207 PMID:9973465 | positive regulation of immunoglobulin production in mucosal tissue | | IEA | Ensembl:ENSMUSP00000027860 | 1600115 | GO_REF:0000019 | ENSEMBL | GO_REF:0000019 | positive regulation of interleukin-10 production | | ISO | RGD:1350360 | 1624291 | PMID:18832695 | RGD | PMID:18832695 | positive regulation of leukocyte chemotaxis | | ISO | RGD:733993 | 1624291 | MGI:MGI:77040|PMID:7973732 | RGD | MGI:MGI:77040 PMID:7973732 | positive regulation of natural killer cell chemotaxis | | ISO | RGD:733993 | 1624291 | MGI:MGI:85636|PMID:9029087 | RGD | MGI:MGI:85636 PMID:9029087 | positive regulation of natural killer cell chemotaxis | | ISO | RGD:1350360 | 1624291 | PMID:9029087 | RGD | PMID:9029087 | positive regulation of neutrophil chemotaxis | | ISO | RGD:733993 | 1624291 | MGI:MGI:5009193|PMID:11181058 | RGD | MGI:MGI:5009193 PMID:11181058 | positive regulation of neutrophil chemotaxis | | IEA | Ensembl:ENSMUSP00000027860 | 1600115 | GO_REF:0000019 | ENSEMBL | GO_REF:0000019 | positive regulation of release of sequestered calcium ion into cytosol | | ISO | RGD:1350360 | 1624291 | PMID:7602097 | RGD | PMID:7602097 | positive regulation of T cell chemotaxis | | ISO | RGD:733993 | 1624291 | MGI:MGI:5009212|PMID:8757601 | RGD | MGI:MGI:5009212 PMID:8757601 | positive regulation of T cell chemotaxis | | IEA | Ensembl:ENSMUSP00000027860 | 1600115 | GO_REF:0000019 | ENSEMBL | GO_REF:0000019 | positive regulation of T cell chemotaxis | | ISO | RGD:1350360 | 1624291 | PMID:7602097 | RGD | PMID:7602097 | positive regulation of T cell chemotaxis | | ISO | RGD:733993 | 1624291 | MGI:MGI:85636|PMID:9029087 | RGD | MGI:MGI:85636 PMID:9029087 | positive regulation of T cell cytokine production | | ISO | RGD:733993 | 1624291 | MGI:MGI:85636|PMID:9029087 | RGD | MGI:MGI:85636 PMID:9029087 | positive regulation of T cell mediated cytotoxicity | | ISO | RGD:1350360 | 1624291 | PMID:18832695 | RGD | PMID:18832695 | positive regulation of T-helper 1 cell cytokine production | | ISO | RGD:733993 | 1624291 | MGI:MGI:5009207|PMID:9973465 | RGD | MGI:MGI:5009207 PMID:9973465 | positive regulation of T-helper 1 cell cytokine production | | IEA | Ensembl:ENSMUSP00000027860 | 1600115 | GO_REF:0000019 | ENSEMBL | GO_REF:0000019 | positive regulation of T-helper 2 cell cytokine production | | ISO | RGD:733993 | 1624291 | MGI:MGI:5009207|PMID:9973465 | RGD | MGI:MGI:5009207 PMID:9973465 | positive regulation of T-helper 2 cell cytokine production | | IEA | Ensembl:ENSMUSP00000027860 | 1600115 | GO_REF:0000019 | ENSEMBL | GO_REF:0000019 | positive regulation of thymocyte migration | | ISO | RGD:733993 | 1624291 | MGI:MGI:77040|PMID:7973732 | RGD | MGI:MGI:77040 PMID:7973732 | positive regulation of thymocyte migration | | IEA | Ensembl:ENSMUSP00000027860 | 1600115 | GO_REF:0000019 | ENSEMBL | GO_REF:0000019 | positive regulation of transforming growth factor beta production | | ISO | RGD:1350360 | 1624291 | PMID:18832695 | RGD | PMID:18832695 | regulation of inflammatory response | | ISO | RGD:1350360 | 1624291 | PMID:18832695 | RGD | PMID:18832695 | release of sequestered calcium ion into cytosol | | ISO | RGD:733993 | 1624291 | MGI:MGI:1344950|PMID:10518929 | RGD | MGI:MGI:1344950 PMID:10518929 | release of sequestered calcium ion into cytosol | | IEA | Ensembl:ENSMUSP00000027860 | 1600115 | GO_REF:0000019 | ENSEMBL | GO_REF:0000019 | release of sequestered calcium ion into cytosol | | ISO | RGD:733993 | 1624291 | MGI:MGI:77040|PMID:7973732 | RGD | MGI:MGI:77040 PMID:7973732 | response to virus | | ISO | RGD:1350360 | 1624291 | PMID:14734774 | RGD | PMID:14734774 | | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Molecular Pathway Annotations| External Database Links | |
| KEGG Pathway | Chemokine signaling pathway |
| Cytokine-cytokine receptor interaction | |
Gene-Chemical Interaction Annotations
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Gene Ontology Annotations
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Molecular Pathway Annotations
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| External Database Links | |
| KEGG Pathway | Chemokine signaling pathway |
| Cytokine-cytokine receptor interaction | |
References - curated| 1. |
Kelner GS, etal., Science 1994 Nov 25;266(5189):1395-9. |
| 2. |
MGD data from the GO Consortium |
| 3. |
Natori Y, etal., Clin Exp Immunol 1998 Aug;113(2):265-8. |
| 4. |
NCBI rat LocusLink and RefSeq merged data July 26, 2002 |
| 5. |
Pipeline to import KEGG annotations from KEGG into RGD Pathway Ontology |
| 6. |
RGD automated data pipeline |
| 7. |
RGD automated import pipeline for gene-chemical interactions |
RGD Disease Portals| Xcl1 has been annotated in the following RGD Disease Portals. |
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Comparative Map Data| Xcl1 (Rattus norvegicus) |
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| XCL1 (Homo sapiens) |
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| Xcl1 (Mus musculus) |
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Position Markers| AI236158 |
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QTLs in Region (RGSC Genome Assembly v3.4)| The following QTLs overlap with this region. | ![]() | Full Report | ![]() | CSV | ![]() | TAB | ![]() | Printer | ![]() | Gviewer |
Nucleotide Sequences| Nucleotide RefSeqs | NM_134361 | (Get FASTA) | Search GEO for Microarray Profiles |
| GenBank Nucleotide | AABR06075930 | (Get FASTA) | Search GEO for Microarray Profiles |
| AAHX01076449 | (Get FASTA) | Search GEO for Microarray Profiles | |
| CH473958 | (Get FASTA) | Search GEO for Microarray Profiles | |
| U23377 | (Get FASTA) | Search GEO for Microarray Profiles |
| RefSeq Acc Id: | NM_134361 | ||||||||||||||||||||
| RefSeq Status: | PROVISIONAL | ||||||||||||||||||||
| Type: | CODING | ||||||||||||||||||||
| Protein Acc Id: | NP_599188 | ||||||||||||||||||||
| Peptide Label: | precursor | ||||||||||||||||||||
| Position: |
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Protein Sequences| Protein RefSeqs | NP_599188 | (Get FASTA) |
| GenBank Protein | AAA69478 | (Get FASTA) |
| EDM09342 | (Get FASTA) | |
| P51672 | (Get FASTA) |
Strain Sequence Variants
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External Database Links| Database | Acc Id | Source(s) |
| Ensembl Genes | ENSRNOG00000002964 | ENTREZGENE, UniProtKB/TrEMBL |
| Ensembl Protein | ENSRNOP00000003976 | ENTREZGENE, UniProtKB/TrEMBL |
| Ensembl Transcript | ENSRNOT00000003976 | ENTREZGENE, UniProtKB/TrEMBL |
| Entrez Gene | 171371 | ENTREZGENE |
| Germonline | ENSRNOG00000002964 | UniProtKB/Swiss-Prot |
| HomoloGene Group ID | 2250 | ENTREZGENE |
| InterPro | Chemokine_IL8 | UniProtKB/Swiss-Prot |
| Lymphotactin | UniProtKB/Swiss-Prot | |
| IPI | IPI00204352 | UniProtKB/Swiss-Prot |
| KEGG Report | rno:171371 | ENTREZGENE, UniProtKB/Swiss-Prot |
| Pfam | IL8 | UniProtKB/Swiss-Prot |
| PRINTS | LYMPHOTACTIN | UniProtKB/Swiss-Prot |
| SMART | SCY | UniProtKB/Swiss-Prot |
| Superfamily-SCOP | Chemokine_IL8 | UniProtKB/Swiss-Prot |
| UniGene | Rn.90962 | ENTREZGENE |
| UniProt | G3V6D4_RAT | UniProtKB/TrEMBL |
| XCL1_RAT | UniProtKB/Swiss-Prot |
Nomenclature History| Date | Current Symbol | Current Name | Previous Symbol | Previous Name | Description | Reference | Status |
|---|---|---|---|---|---|---|---|
| 2006-03-30 | Xcl1 | chemokine (C motif) ligand 1 | small inducible cytokine subfamily C, member 1 (lymphotactin) | Name updated | 10779 | APPROVED | |
| 2004-09-10 | Xcl1 | small inducible cytokine subfamily C, member 1 (lymphotactin) | Scyc1 | Symbol and Name updated | 10779 | APPROVED | |
| 2002-08-07 | Scyc1 | small inducible cytokine subfamily C, member 1 (lymphotactin) | Symbol and Name status set to provisional | 1724 | PROVISIONAL |
| More on Xcl1 | |
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Entrez Gene |
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Ensembl Gene |
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NCBI Map Viewer |
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Vista |
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Vista + UCSC |
| RGD Object Information | |
| RGD ID: | 620452 |
| Created: | 2002-08-06 |
| Species: | Rattus norvegicus |
| Last Modified: | 2013-04-16 |
| Status: | ACTIVE |
© Bioinformatics Program, HMGC at the Medical College of Wisconsin
RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.




