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ONTOLOGY REPORT - ANNOTATIONS

Term:regulation of DNA damage response, signal transduction by p53 class mediator
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Accession:GO:0043516 term browser browse the term
Definition:Any process that modulates the frequency, rate or extent of the cascade of processes induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, in response to the detection of DNA damage.
Synonyms:exact_synonym: regulation of p53 induced by DNA damage response


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regulation of DNA damage response, signal transduction by p53 class mediator term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AABR07010705.1 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 Ensembl chr 2:142,289,467...142,290,623 JBrowse link
G AABR07033047.1 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 Ensembl chr11:3,479,411...3,480,543 JBrowse link
G Kmt5a lysine methyltransferase 5A involved_in ISO
IBA		 (PMID:17707234)
GO_REF:0000033		 RGD
GO_Central		 PMID:17707234 GO_REF:0000033 NCBI chr12:32,139,353...32,167,777
Ensembl chr12:32,139,178...32,162,711 		JBrowse link
G Kmt5al2 lysine methyltransferase 5A like 2 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr  X:92,178,344...92,180,517
Ensembl chr  X:92,178,016...92,179,731 		JBrowse link
G Npm1 nucleophosmin 1 acts_upstream_of_or_within ISO MGI:98834 (PMID:16199867) RGD PMID:16199867 NCBI chr10:17,741,512...17,751,626
Ensembl chr10:17,739,941...17,751,645 		JBrowse link
G Smyd2 SET and MYND domain containing 2 involved_in ISO
ISS		 (PMID:17108971)
GO_REF:0000024		 RGD
UniProt		 PMID:17108971 GO_REF:0000024 NCBI chr13:101,425,270...101,466,576
Ensembl chr13:101,425,273...101,466,576 		JBrowse link
G Sox4 SRY-box transcription factor 4 involved_in ISO (PMID:19234109) RGD PMID:19234109 NCBI chr17:35,667,809...35,672,515
Ensembl chr17:35,667,537...35,673,665 		JBrowse link
G Tp53 tumor protein p53 involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
MGI:1890508 (PMID:21522133)		 Ensembl
RGD		 PMID:21522133 GO_REF:0000107 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
G Zmpste24 zinc metallopeptidase STE24 acts_upstream_of_or_within ISO MGI:2180033|MGI:98834 (PMID:16079796), (PMID:21522133) RGD PMID:16079796 PMID:21522133 NCBI chr 5:134,627,218...134,660,360
Ensembl chr 5:134,627,229...134,660,110 		JBrowse link
negative regulation of DNA damage response, signal transduction by p53 class mediator term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd44 CD44 molecule involved_in ISO
IEA		 (PMID:17045821)
(MGI:3690285|PMID:17045821)
GO_REF:0000107		 RGD
Ensembl		 PMID:17045821 GO_REF:0000107 MGI:3690285 NCBI chr 3:89,155,850...89,244,615
Ensembl chr 3:89,157,058...89,244,620 		JBrowse link
G Cd74 CD74 molecule involved_in ISS
ISO
IEA
IBA		 GO_REF:0000024
(PMID:17045821)
(MGI:3690285|PMID:17045821)
GO_REF:0000107
GO_REF:0000033		 BHF-UCL
RGD
Ensembl
GO_Central		 PMID:17045821 GO_REF:0000024 GO_REF:0000033 GO_REF:0000107 MGI:3690285 NCBI chr18:54,256,757...54,266,003
Ensembl chr18:54,256,778...54,266,003 		JBrowse link
G Dyrk1a dual specificity tyrosine phosphorylation regulated kinase 1A involved_in ISO
IEA		 (MGI:5318016|PMID:20736167)
GO_REF:0000107		 RGD
Ensembl		 PMID:20736167 GO_REF:0000107 MGI:5318016 NCBI chr11:33,890,706...34,009,420
Ensembl chr11:33,890,490...34,009,420 		JBrowse link
G Dyrk3 dual specificity tyrosine phosphorylation regulated kinase 3 involved_in IEA
ISO		 GO_REF:0000107
(MGI:4838949|PMID:20167603)		 Ensembl
RGD		 PMID:20167603 GO_REF:0000107 MGI:4838949 NCBI chr13:42,594,120...42,604,898
Ensembl chr13:42,594,121...42,604,778 		JBrowse link
G Kdm1a lysine demethylase 1A involved_in ISO (PMID:17805299) RGD PMID:17805299 NCBI chr 5:148,782,976...148,838,319
Ensembl chr 5:148,782,976...148,838,319 		JBrowse link
G Marchf7 membrane associated ring-CH-type finger 7 involved_in ISO
IEA
ISS		 (PMID:29295817)
GO_REF:0000107
GO_REF:0000024		 RGD
Ensembl
UniProt		 PMID:29295817 GO_REF:0000024 GO_REF:0000107 NCBI chr 3:44,680,229...44,720,172
Ensembl chr 3:44,681,632...44,720,168 		JBrowse link
G Mdm2 MDM2 proto-oncogene involved_in ISO (PMID:10360174), (PMID:9529249) RGD PMID:9529249 PMID:10360174 NCBI chr 7:53,290,660...53,315,205
Ensembl chr 7:53,290,664...53,314,915 		JBrowse link
G Mif macrophage migration inhibitory factor involved_in ISO (PMID:17045821)
(MGI:3690285|PMID:17045821)		 RGD PMID:17045821 MGI:3690285 NCBI chr20:12,790,919...12,791,784
Ensembl chr20:12,790,902...12,799,504 		JBrowse link
G Psmd10 proteasome 26S subunit, non-ATPase 10 involved_in ISS
ISO
IEA		 GO_REF:0000024
(PMID:16023600)
GO_REF:0000107		 UniProt
RGD
Ensembl		 PMID:16023600 GO_REF:0000024 GO_REF:0000107 NCBI chr  X:104,656,809...104,665,122
Ensembl chr  X:104,656,812...104,665,097 		JBrowse link
G Pttg1ip PTTG1 interacting protein acts_upstream_of_or_within ISO (PMID:24506068) RGD PMID:24506068 NCBI chr20:11,030,013...11,047,742
Ensembl chr20:11,030,015...11,047,316 		JBrowse link
G Sirt1 sirtuin 1 involved_in ISO (PMID:11672523) RGD PMID:11672523 NCBI chr20:25,307,225...25,329,273
Ensembl chr20:25,306,917...25,329,260 		JBrowse link
G Snai1 snail family transcriptional repressor 1 involved_in ISO (PMID:15314165) RGD PMID:15314165 NCBI chr 3:156,248,479...156,252,969
Ensembl chr 3:156,248,485...156,252,969 		JBrowse link
G Snai2 snail family transcriptional repressor 2 involved_in ISO (PMID:15314165) RGD PMID:15314165 NCBI chr11:86,182,788...86,186,203
Ensembl chr11:86,181,909...86,186,200 		JBrowse link
G Twist1 twist family bHLH transcription factor 1 involved_in ISO (PMID:17690110) RGD PMID:17690110 NCBI chr 6:50,674,910...50,676,904
Ensembl chr 6:50,674,678...50,677,653 		JBrowse link
negative regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pcbp4 poly(rC) binding protein 4 acts_upstream_of_or_within ISO (PMID:20817677) RGD PMID:20817677 NCBI chr 8:107,092,688...107,103,276
Ensembl chr 8:107,093,013...107,103,276 		JBrowse link
positive regulation of DNA damage response, signal transduction by p53 class mediator term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ankrd1 ankyrin repeat domain 1 involved_in ISO
IEA		 (PMID:20599664)
GO_REF:0000107		 RGD
Ensembl		 PMID:20599664 GO_REF:0000107 NCBI chr 1:233,815,851...233,834,891
Ensembl chr 1:233,815,851...233,834,919 		JBrowse link
G Atm ATM serine/threonine kinase involved_in ISO (PMID:9733515) RGD PMID:9733515 NCBI chr 8:53,828,741...53,932,773
Ensembl chr 8:53,831,093...53,932,437 		JBrowse link
G Atr ATR serine/threonine kinase involved_in ISO (PMID:9925639) RGD PMID:9925639 NCBI chr 8:96,426,704...96,524,152
Ensembl chr 8:96,426,724...96,524,136 		JBrowse link
G Cdkn2a cyclin-dependent kinase inhibitor 2A involved_in ISO (PMID:9529249) RGD PMID:9529249 NCBI chr 5:103,984,949...103,992,143
Ensembl chr 5:103,984,949...104,003,149 		JBrowse link
G Ddx5 DEAD-box helicase 5 involved_in ISO (PMID:15660129) RGD PMID:15660129 NCBI chr10:91,723,508...91,732,210
Ensembl chr10:91,723,508...91,732,283 		JBrowse link
G Eef1e1 eukaryotic translation elongation factor 1 epsilon 1 acts_upstream_of_or_within ISO MGI:3574590 (PMID:15680327) RGD PMID:15680327 NCBI chr17:26,148,652...26,159,358
Ensembl chr17:26,148,633...26,215,720 		JBrowse link
G Hic1 HIC ZBTB transcriptional repressor 1 involved_in ISO (MGI:5297787|PMID:16269335) RGD PMID:16269335 MGI:5297787 NCBI chr10:60,014,520...60,019,475
Ensembl chr10:60,011,528...60,019,475 		JBrowse link
G Pla2r1 phospholipase A2 receptor 1 involved_in ISS
ISO		 GO_REF:0000024
(PMID:19197340)		 UniProt
RGD		 PMID:19197340 GO_REF:0000024 NCBI chr 3:44,883,943...45,013,793
Ensembl chr 3:44,883,943...45,013,660 		JBrowse link
G Pmaip1 phorbol-12-myristate-13-acetate-induced protein 1 involved_in ISO
IEA		 (PMID:15102863)
GO_REF:0000107
(MGI:2679929|PMID:14500851)		 RGD
Ensembl		 PMID:14500851 PMID:15102863 GO_REF:0000107 MGI:2679929 NCBI chr18:59,986,020...59,992,434
Ensembl chr18:59,986,017...59,992,429 		JBrowse link
G Spred1 sprouty-related, EVH1 domain containing 1 involved_in ISO (MGI:5318016|PMID:20736167) RGD PMID:20736167 MGI:5318016 NCBI chr 3:103,983,120...104,050,321
Ensembl chr 3:103,983,072...104,049,718 		JBrowse link
G Spred2 sprouty-related, EVH1 domain containing 2 involved_in ISO (MGI:5318016|PMID:20736167) RGD PMID:20736167 MGI:5318016 NCBI chr14:94,149,210...94,250,787
Ensembl chr14:94,148,837...94,249,162 		JBrowse link
positive regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ing4 inhibitor of growth family, member 4 involved_in ISO (PMID:15251430) RGD PMID:15251430 NCBI chr 4:157,841,882...157,850,519
Ensembl chr 4:157,841,951...157,850,265 		JBrowse link
G Rpl26 ribosomal protein L26 involved_in ISO (PMID:16213212) RGD PMID:16213212 NCBI chr10:53,610,836...53,613,966
Ensembl chr10:53,610,421...53,613,966 		JBrowse link
G Zfp385a zinc finger protein 385A involved_in ISO (PMID:17719541) RGD PMID:17719541 NCBI chr 7:134,448,914...134,475,548
Ensembl chr 7:134,448,921...134,475,548 		JBrowse link
G Znhit1 zinc finger, HIT-type containing 1 involved_in ISO (PMID:17700068) RGD PMID:17700068 NCBI chr12:19,686,606...19,692,880
Ensembl chr12:19,686,148...19,692,880 		JBrowse link
regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cops3 COP9 signalosome subunit 3 involved_in ISO (PMID:15861129) RGD PMID:15861129 NCBI chr10:44,618,115...44,652,807
Ensembl chr10:44,618,115...44,641,597 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19692
    regulation of biological process 12906
      regulation of cellular process 12363
        regulation of cellular response to stress 510
          regulation of DNA damage response, signal transduction by p53 class mediator 40
            negative regulation of DNA damage response, signal transduction by p53 class mediator + 15
            positive regulation of DNA damage response, signal transduction by p53 class mediator + 15
            regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator + 6
Path 2
Term Annotations click to browse term
  biological_process 19692
    biological regulation 13309
      regulation of biological process 12906
        signaling 7594
          signal transduction 7019
            intracellular signal transduction 2743
              signal transduction in response to DNA damage 188
                DNA damage response, signal transduction by p53 class mediator 73
                  regulation of DNA damage response, signal transduction by p53 class mediator 40
                    negative regulation of DNA damage response, signal transduction by p53 class mediator + 15
                    positive regulation of DNA damage response, signal transduction by p53 class mediator + 15
                    regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator + 6
paths to the root