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ONTOLOGY REPORT - ANNOTATIONS

Term:excitatory extracellular ligand-gated monoatomic ion channel activity
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Accession:GO:0005231 term browser browse the term
Definition:Enables the transmembrane transfer of an ion by a channel that opens when a specific extracellular ligand has been bound by the channel complex or one of its constituent parts, where channel opening contributes to an increase in membrane potential.
Synonyms:xref: reactome:R-HSA-399711 "Activation of Ca impermeable AMPA receptors";   reactome:R-HSA-399712 "Activation of Ca permeable AMPA receptors";   reactome:R-HSA-420980 "Activation of Ca permeable AMPA receptors";   reactome:R-HSA-432164 "Ca2+ influx into the post-synaptic cell";   reactome:R-HSA-438037 "Membrane depolarization upon activation of Ca impermeable AMPA receptors"


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excitatory extracellular ligand-gated monoatomic ion channel activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Chrna1 cholinergic receptor nicotinic alpha 1 subunit enables IBA GO_Central GO_REF:0000033 NCBI chr 2:73,393,625...73,410,682
Ensembl chr 2:73,393,559...73,410,682 		JBrowse link
G Chrne cholinergic receptor, nicotinic, epsilon polypeptide enables IBA GO_Central GO_REF:0000033 NCBI chr11:70,505,709...70,510,074
Ensembl chr11:70,505,709...70,510,042 		JBrowse link
G Glra1 glycine receptor, alpha 1 subunit enables IBA GO_Central GO_REF:0000033 NCBI chr11:55,405,065...55,499,024
Ensembl chr11:55,405,064...55,499,024 		JBrowse link
G Glra2 glycine receptor, alpha 2 subunit enables IBA GO_Central GO_REF:0000033 NCBI chr  X:163,912,013...164,110,863
Ensembl chr  X:163,912,013...164,110,389 		JBrowse link
G Glra3 glycine receptor, alpha 3 subunit enables IBA GO_Central GO_REF:0000033 NCBI chr 8:56,393,454...56,583,111
Ensembl chr 8:56,393,495...56,583,105 		JBrowse link
G Glra4 glycine receptor, alpha 4 subunit enables IBA GO_Central GO_REF:0000033 NCBI chr  X:135,655,107...135,680,935
Ensembl chr  X:135,658,423...135,680,890 		JBrowse link
G Glrb glycine receptor, beta subunit enables IBA GO_Central GO_REF:0000033 NCBI chr 3:80,750,905...80,820,994
Ensembl chr 3:80,750,906...80,820,967 		JBrowse link
G Htr3a 5-hydroxytryptamine (serotonin) receptor 3A enables IBA GO_Central GO_REF:0000033 NCBI chr 9:48,810,513...48,822,451
Ensembl chr 9:48,810,513...48,822,399 		JBrowse link
G Htr3b 5-hydroxytryptamine (serotonin) receptor 3B enables IBA GO_Central GO_REF:0000033 NCBI chr 9:48,846,308...48,876,290
Ensembl chr 9:48,846,308...48,876,290 		JBrowse link
G Trpv1 transient receptor potential cation channel, subfamily V, member 1 enables ISO MGI GO_REF:0000096 MGI:4417868 NCBI chr11:73,124,975...73,152,148
Ensembl chr11:73,125,118...73,152,068 		JBrowse link
acetylcholine-gated monoatomic cation-selective channel activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Chrna1 cholinergic receptor nicotinic alpha 1 subunit enables
contributes_to		 ISO
IGI		 (PMID:2383398) MGI
RGD		 PMID:1702709 PMID:2383398 PMID:22461452 GO_REF:0000008 GO_REF:0000096 MGI:4417868 RGD:68734 RGD:8549758 NCBI chr 2:73,393,625...73,410,682
Ensembl chr 2:73,393,559...73,410,682 		JBrowse link
G Chrna10 cholinergic receptor, nicotinic, alpha polypeptide 10 enables IBA
IMP		 (PMID:18077337) GO_Central
MGI		 PMID:18077337 GO_REF:0000033 NCBI chr 7:101,760,469...101,766,564
Ensembl chr 7:101,760,473...101,766,035 		JBrowse link
G Chrna2 cholinergic receptor nicotinic alpha 2 subunit enables ISO
IBA		 MGI
RGD
GO_Central		 PMID:2832952 GO_REF:0000033 GO_REF:0000096 GO_REF:0000119 MGI:4417868 MGI:4834177 RGD:728252 NCBI chr14:66,370,685...66,390,397
Ensembl chr14:66,372,488...66,390,397 		JBrowse link
G Chrna3 cholinergic receptor, nicotinic, alpha polypeptide 3 enables ISO
IMP
IBA		 (PMID:11923417) MGI
RGD
GO_Central		 PMID:11297818 PMID:11923417 GO_REF:0000033 GO_REF:0000096 GO_REF:0000119 MGI:4417868 MGI:4834177 RGD:1643016 NCBI chr 9:54,917,401...54,933,846
Ensembl chr 9:54,917,395...54,933,846 		JBrowse link
G Chrna4 cholinergic receptor, nicotinic, alpha polypeptide 4 enables ISO
IMP
IGI
IBA
TAS		 (PMID:12130686)
(PMID:15569257), (PMID:15741168)
(PMID:15528443)
(PMID:10964949)
(PMID:11222635)		 MGI
RGD
GO_Central		 PMID:10964949 PMID:11222635 PMID:11259617 PMID:12130686 PMID:12202488 More... GO_REF:0000033 GO_REF:0000096 GO_REF:0000119 MGI:4417868 MGI:4834177 RGD:727641 RGD:8549520 NCBI chr 2:180,664,104...180,685,339
Ensembl chr 2:180,660,173...180,685,339 		JBrowse link
G Chrna5 cholinergic receptor, nicotinic, alpha polypeptide 5 enables ISO
IBA		 MGI
RGD
GO_Central		 PMID:11297818 PMID:12814364 GO_REF:0000033 GO_REF:0000096 MGI:4417868 RGD:1298760 RGD:1643016 NCBI chr 9:54,888,112...54,918,704
Ensembl chr 9:54,888,164...54,915,063 		JBrowse link
G Chrna6 cholinergic receptor, nicotinic, alpha polypeptide 6 enables IMP
IBA		 (PMID:11850448) MGI
GO_Central		 PMID:11850448 GO_REF:0000033 NCBI chr 8:27,893,240...27,903,972
Ensembl chr 8:27,893,240...27,903,972 		JBrowse link
G Chrna7 cholinergic receptor, nicotinic, alpha polypeptide 7 enables ISO
IMP
IBA
IDA		 (PMID:9037516)
(PMID:11834293), (PMID:9364063)
(PMID:9495872)		 MGI
RGD
GO_Central		 PMID:9037516 PMID:9364063 PMID:9495872 PMID:11259617 PMID:11297818 More... GO_REF:0000008 GO_REF:0000033 GO_REF:0000096 MGI:4417868 RGD:1600971 RGD:1643016 RGD:727702 RGD:8549520 NCBI chr 7:62,748,440...62,862,274
Ensembl chr 7:62,748,440...62,862,317 		JBrowse link
G Chrna9 cholinergic receptor, nicotinic, alpha polypeptide 9 enables ISO
IMP
IBA		 (PMID:18077337) MGI
RGD
GO_Central		 PMID:7954834 PMID:18077337 GO_REF:0000033 GO_REF:0000096 GO_REF:0000119 MGI:4417868 MGI:4834177 RGD:728400 NCBI chr 5:66,092,317...66,134,823
Ensembl chr 5:66,092,264...66,134,669 		JBrowse link
G Chrnb1 cholinergic receptor nicotinic beta 1 subunit enables
contributes_to		 ISO
IGI
IBA		 (PMID:2383398)
(PMID:8798466)		 MGI
RGD
GO_Central		 PMID:1702709 PMID:2383398 PMID:8798466 PMID:22461452 GO_REF:0000033 GO_REF:0000096 MGI:4417868 RGD:68734 RGD:8549758 NCBI chr11:69,674,862...69,686,742
Ensembl chr11:69,674,862...69,686,769 		JBrowse link
G Chrnb2 cholinergic receptor nicotinic beta 2 subunit enables ISO
IGI
IBA
IMP
IDA		 (PMID:15569257), (PMID:15741168)
(PMID:11222635)
(PMID:17470777), (PMID:9614223)		 MGI
RGD
GO_Central		 PMID:9614223 PMID:11222635 PMID:11259617 PMID:11956333 PMID:15569257 More... GO_REF:0000033 GO_REF:0000096 GO_REF:0000119 MGI:4417868 MGI:4834177 RGD:727635 RGD:8549520 NCBI chr 3:89,660,755...89,671,939
Ensembl chr 3:89,653,502...89,671,939 		JBrowse link
G Chrnb3 cholinergic receptor, nicotinic, beta polypeptide 3 enables IBA GO_Central GO_REF:0000033 NCBI chr 8:27,858,688...27,889,758
Ensembl chr 8:27,858,739...27,889,758 		JBrowse link
G Chrnb4 cholinergic receptor, nicotinic, beta polypeptide 4 enables ISO
IBA		 MGI
GO_Central		 GO_REF:0000033 GO_REF:0000119 MGI:4834177 NCBI chr 9:54,935,438...54,956,236
Ensembl chr 9:54,935,438...54,956,063 		JBrowse link
G Chrnd cholinergic receptor, nicotinic, delta polypeptide enables
contributes_to		 ISO
IGI
IBA		 (PMID:2383398)
(PMID:8798466)		 MGI
RGD
GO_Central		 PMID:1702709 PMID:2383398 PMID:8798466 PMID:22461452 GO_REF:0000033 GO_REF:0000096 MGI:4417868 RGD:68734 RGD:8549758 NCBI chr 1:87,118,319...87,127,792
Ensembl chr 1:87,118,329...87,127,792 		JBrowse link
G Chrne cholinergic receptor, nicotinic, epsilon polypeptide enables
contributes_to		 ISO
IGI		 (PMID:2383398) MGI
RGD		 PMID:2383398 PMID:22461452 GO_REF:0000096 MGI:4417868 RGD:8549758 NCBI chr11:70,505,709...70,510,074
Ensembl chr11:70,505,709...70,510,042 		JBrowse link
G Chrng cholinergic receptor, nicotinic, gamma polypeptide enables ISO
IBA
IGI		 (PMID:8798466)
(PMID:2383398)		 MGI
RGD
GO_Central		 PMID:1702709 PMID:2383398 PMID:8798466 PMID:22461452 GO_REF:0000033 GO_REF:0000096 MGI:4417868 RGD:68734 RGD:8549758 NCBI chr 1:87,133,533...87,139,365
Ensembl chr 1:87,132,379...87,140,416 		JBrowse link
extracellularly ATP-gated monoatomic cation channel activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G P2rx1 purinergic receptor P2X, ligand-gated ion channel, 1 enables ISO
IBA		 MGI
GO_Central
RGD		 PMID:16934235 GO_REF:0000033 GO_REF:0000096 GO_REF:0000119 MGI:4417868 MGI:4834177 RGD:1642659 NCBI chr11:72,889,882...72,906,026
Ensembl chr11:72,889,929...72,906,026 		JBrowse link
G P2rx2 purinergic receptor P2X, ligand-gated ion channel, 2 enables ISO
IGI
IMP
IBA
IDA		 (PMID:15081800)
(PMID:12917379)		 MGI
GO_Central
RGD		 PMID:12917379 PMID:15081800 PMID:15317863 PMID:16190872 PMID:16857707 More... GO_REF:0000033 GO_REF:0000096 GO_REF:0000119 MGI:4417868 MGI:4834177 RGD:1642653 RGD:1642659 RGD:1642661 RGD:1642665 RGD:1642666 NCBI chr 5:110,487,678...110,491,186
Ensembl chr 5:110,487,678...110,491,078 		JBrowse link
G P2rx3 purinergic receptor P2X, ligand-gated ion channel, 3 enables ISO
IGI
TAS
IBA		 (PMID:15081800)
(PMID:9300827)		 MGI
GO_Central
RGD		 PMID:9300827 PMID:12581826 PMID:15081800 PMID:16934235 GO_REF:0000033 GO_REF:0000096 GO_REF:0000119 MGI:4417868 MGI:4834177 RGD:1642659 RGD:1642675 NCBI chr 2:84,826,893...84,867,446
Ensembl chr 2:84,828,927...84,867,806 		JBrowse link
G P2rx4 purinergic receptor P2X, ligand-gated ion channel 4 enables ISO
TAS
IBA
IMP		 (PMID:9931497)
(PMID:15081800)
PMID:12819199		 MGI
GO_Central
RGD		 PMID:9931497 PMID:12819199 PMID:15081800 PMID:16934235 GO_REF:0000033 GO_REF:0000096 GO_REF:0000119 MGI:4417868 MGI:4834177 RGD:1642659 RGD:1642695 NCBI chr 5:122,845,581...122,867,802
Ensembl chr 5:122,845,607...122,867,801 		JBrowse link
G P2rx5 purinergic receptor P2X, ligand-gated ion channel, 5 enables ISO
IBA
IDA		 (PMID:11404011) MGI
GO_Central
RGD		 PMID:11404011 PMID:12135987 GO_REF:0000033 GO_REF:0000096 MGI:4417868 RGD:729229 NCBI chr11:73,029,164...73,063,509
Ensembl chr11:73,051,247...73,063,511 		JBrowse link
G P2rx6 purinergic receptor P2X, ligand-gated ion channel, 6 enables ISO
TAS
IBA		 (PMID:9852680) MGI
GO_Central
RGD		 PMID:8786426 PMID:9852680 GO_REF:0000033 GO_REF:0000096 MGI:4417868 RGD:729425 NCBI chr16:17,379,749...17,389,879
Ensembl chr16:17,379,749...17,395,664 		JBrowse link
G P2rx7 purinergic receptor P2X, ligand-gated ion channel, 7 enables ISO
IMP
IBA		 (PMID:12677010)
(PMID:15713258)		 RGD
MGI
GO_Central		 PMID:12677010 PMID:15713258 PMID:17394459 GO_REF:0000033 GO_REF:0000096 GO_REF:0000119 MGI:4417868 MGI:4834177 RGD:1642698 NCBI chr 5:122,781,990...122,830,399
Ensembl chr 5:122,781,974...122,829,495 		JBrowse link
extracellularly glutamate-gated chloride channel activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Slc17a7 solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 7 enables IDA (PMID:19169251) MGI PMID:19169251 NCBI chr 7:44,813,345...44,825,563
Ensembl chr 7:44,813,373...44,825,566 		JBrowse link
G Slc1a7 solute carrier family 1 (glutamate transporter), member 7 enables IDA (MGI:7294459|PMID:32233906), (MGI:7310191|PMID:16973698) UniProt PMID:16973698 PMID:32233906 MGI:7294459 MGI:7310191 NCBI chr 4:107,825,603...107,870,726
Ensembl chr 4:107,825,529...107,870,729 		JBrowse link
extracellularly glutamate-gated ion channel activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gria2 glutamate receptor, ionotropic, AMPA2 (alpha 2) enables IDA (PMID:14687553) MGI PMID:14687553 NCBI chr 3:80,588,757...80,711,534
Ensembl chr 3:80,588,757...80,710,142 		JBrowse link
G Grik1 glutamate receptor, ionotropic, kainate 1 enables ISO MGI
RGD		 PMID:1977421 GO_REF:0000096 MGI:4417868 RGD:61622 NCBI chr16:87,692,789...88,087,751
Ensembl chr16:87,692,788...88,087,153 		JBrowse link
G Grik2 glutamate receptor, ionotropic, kainate 2 (beta 2) enables ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr10:48,969,776...49,666,523
Ensembl chr10:48,970,929...49,664,862 		JBrowse link
G Grin2a glutamate receptor, ionotropic, NMDA2A (epsilon 1) contributes_to ISO MGI GO_REF:0000096 MGI:4417868 NCBI chr16:9,385,765...9,813,744
Ensembl chr16:9,385,762...9,813,424 		JBrowse link
G Grin2b glutamate receptor, ionotropic, NMDA2B (epsilon 2) enables ISO MGI
RGD		 PMID:1350383 GO_REF:0000096 MGI:4417868 RGD:727540 NCBI chr 6:135,690,219...136,150,658
Ensembl chr 6:135,690,231...136,150,509 		JBrowse link
extracellularly glycine-gated chloride channel activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Chrm5 cholinergic receptor, muscarinic 5 enables TAS (PMID:11756520) MGI PMID:11756520 NCBI chr 2:112,306,055...112,365,487
Ensembl chr 2:112,309,516...112,311,114 		JBrowse link
G Glra1 glycine receptor, alpha 1 subunit enables
contributes_to		 ISO
IMP
IDA		 (PMID:16672662)
(PMID:8062927)
(MGI:5707576|PMID:24801766)		 MGI
RGD
UniProt		 PMID:8062927 PMID:12223345 PMID:16672662 PMID:24801766 GO_REF:0000008 GO_REF:0000096 MGI:4417868 MGI:5707576 RGD:625689 NCBI chr11:55,405,065...55,499,024
Ensembl chr11:55,405,064...55,499,024 		JBrowse link
G Glra2 glycine receptor, alpha 2 subunit enables ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr  X:163,912,013...164,110,863
Ensembl chr  X:163,912,013...164,110,389 		JBrowse link
G Glra3 glycine receptor, alpha 3 subunit enables ISO MGI
RGD		 PMID:2176214 GO_REF:0000096 GO_REF:0000119 MGI:4417868 MGI:4834177 RGD:728440 NCBI chr 8:56,393,454...56,583,111
Ensembl chr 8:56,393,495...56,583,105 		JBrowse link
G Glra4 glycine receptor, alpha 4 subunit enables IDA (MGI:5751681|PMID:10762330) UniProt PMID:10762330 MGI:5751681 NCBI chr  X:135,655,107...135,680,935
Ensembl chr  X:135,658,423...135,680,890 		JBrowse link
G Glrb glycine receptor, beta subunit contributes_to
enables		 ISS
IMP
ISO		 (MGI:78784|PMID:8717357)
(PMID:12809985), (PMID:16672662)		 UniProt
MGI		 PMID:8717357 PMID:12809985 PMID:16672662 GO_REF:0000119 MGI:4834177 MGI:78784 NCBI chr 3:80,750,905...80,820,994
Ensembl chr 3:80,750,906...80,820,967 		JBrowse link
extracellularly glycine-gated ion channel activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Glra1 glycine receptor, alpha 1 subunit enables ISO MGI
RGD		 PMID:15574743 GO_REF:0000096 MGI:4417868 RGD:1598572 NCBI chr11:55,405,065...55,499,024
Ensembl chr11:55,405,064...55,499,024 		JBrowse link
G Glrb glycine receptor, beta subunit enables ISS
ISO		 (MGI:78784|PMID:8717357) UniProt
MGI
RGD		 PMID:8717357 PMID:15574743 GO_REF:0000096 GO_REF:0000119 MGI:4417868 MGI:4834177 MGI:78784 RGD:1598572 NCBI chr 3:80,750,905...80,820,994
Ensembl chr 3:80,750,906...80,820,967 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 28831
    transporter activity 1198
      transmembrane transporter activity 1108
        monoatomic ion transmembrane transporter activity 733
          monoatomic ion channel activity 445
            ligand-gated monoatomic ion channel activity 184
              extracellular ligand-gated monoatomic ion channel activity 72
                excitatory extracellular ligand-gated monoatomic ion channel activity 39
                  acetylcholine-gated monoatomic cation-selective channel activity 16
                  extracellularly ATP-gated monoatomic cation channel activity 7
                  extracellularly glutamate-gated ion channel activity + 7
                  extracellularly glycine-gated ion channel activity + 6
Path 2
Term Annotations click to browse term
  molecular_function 28831
    transporter activity 1198
      transmembrane transporter activity 1108
        passive transmembrane transporter activity 513
          channel activity 513
            gated channel activity 323
              ligand-gated channel activity 188
                ligand-gated monoatomic ion channel activity 184
                  extracellular ligand-gated monoatomic ion channel activity 72
                    excitatory extracellular ligand-gated monoatomic ion channel activity 39
                      acetylcholine-gated monoatomic cation-selective channel activity 16
                      extracellularly ATP-gated monoatomic cation channel activity 7
                      extracellularly glutamate-gated ion channel activity + 7
                      extracellularly glycine-gated ion channel activity + 6
paths to the root