Enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential. Involved in positive regulation of transmission of nerve impulse. Acts upstream of or within several processes, including behavioral response to nicotine; neuronal action potential; and synaptic transmission involved in micturition. Is active in cholinergic synapse. Is expressed in several structures, including alimentary system; eye; genitourinary system; nervous system; and thymus. Human ortholog(s) of this gene implicated in cocaine abuse; lung cancer (multiple); and oral cavity cancer. Orthologous to human CHRNB4 (cholinergic receptor nicotinic beta 4 subunit).
Ethinyl Estradiol inhibits the reaction [Acetylcholine affects the activity of [CHRNA3 protein binds to CHRNB4 protein]] and Ethinyl Estradiol inhibits the reaction [Tamoxifen inhibits the reaction [Acetylcholine affects the activity of [CHRNA3 protein binds to CHRNB4 protein]]]
4-nonylphenol inhibits the reaction [Acetylcholine affects the activity of [CHRNA3 protein binds to CHRNB4 protein]] and 4-nonylphenol promotes the reaction [Tamoxifen inhibits the reaction [Acetylcholine affects the activity of [CHRNA3 protein binds to CHRNB4 protein]]]
1-Butanol affects the reaction [Acetylcholine promotes the reaction [[CHRNA2 protein binds to CHRNB4 protein] which results in increased transport of Barium]] more ...
1-Butanol affects the reaction [Acetylcholine promotes the reaction [[CHRNA2 protein binds to CHRNB4 protein] which results in increased transport of Barium]] more ...
bisphenol A inhibits the reaction [Acetylcholine affects the activity of [CHRNA3 protein binds to CHRNB4 protein]] and bisphenol A promotes the reaction [Tamoxifen inhibits the reaction [Acetylcholine affects the activity of [CHRNA3 protein binds to CHRNB4 protein]]]
1-Butanol affects the reaction [Acetylcholine promotes the reaction [[CHRNA2 protein binds to CHRNB4 protein] which results in increased transport of Barium]]
2-butanol affects the reaction [Acetylcholine promotes the reaction [[CHRNA2 protein binds to CHRNB4 protein] which results in increased transport of Barium]]
Carbaryl results in decreased activity of [CHRNA3 protein binds to CHRNB4 protein] and Carbaryl results in decreased activity of [CHRNA4 protein binds to CHRNB4 protein]
crotonyl alcohol inhibits the reaction [Acetylcholine promotes the reaction [[CHRNA2 protein binds to CHRNB4 protein] which results in increased transport of Barium]]
Diethylstilbestrol inhibits the reaction [Acetylcholine affects the activity of [CHRNA3 protein binds to CHRNB4 protein]] and Diethylstilbestrol promotes the reaction [Tamoxifen inhibits the reaction [Acetylcholine affects the activity of [CHRNA3 protein binds to CHRNB4 protein]]]
[NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CHRNB4 mRNA
[NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CHRNB4 mRNA
EPTC results in decreased activity of [CHRNA3 protein binds to CHRNB4 protein] and EPTC results in decreased activity of [CHRNA4 protein binds to CHRNB4 protein]
fenoxycarb results in decreased activity of [CHRNA3 protein binds to CHRNB4 protein] and fenoxycarb results in decreased activity of [CHRNA4 protein binds to CHRNB4 protein]
imidacloprid results in increased activity of [CHRNA3 protein binds to CHRNB4 protein] and imidacloprid results in increased activity of [CHRNA4 protein binds to CHRNB4 protein]
isobutyl alcohol affects the reaction [Acetylcholine promotes the reaction [[CHRNA2 protein binds to CHRNB4 protein] which results in increased transport of Barium]]
[Mercuric Chloride co-treated with Acetylcholine] affects the activity of [CHRNA3 protein binds to CHRNB4 protein] and [Mercuric Chloride co-treated with Acetylcholine] affects the activity of [CHRNA4 protein binds to CHRNB4 protein]
n-pentanol inhibits the reaction [Acetylcholine promotes the reaction [[CHRNA2 protein binds to CHRNB4 protein] which results in increased transport of Barium]]
1-Propanol promotes the reaction [Acetylcholine promotes the reaction [[CHRNA2 protein binds to CHRNB4 protein] which results in increased transport of Barium]]
2-Propanol promotes the reaction [Acetylcholine promotes the reaction [[CHRNA2 protein binds to CHRNB4 protein] which results in increased transport of Barium]]
[NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CHRNB4 mRNA
4-nonylphenol promotes the reaction [Tamoxifen inhibits the reaction [Acetylcholine affects the activity of [CHRNA3 protein binds to CHRNB4 protein]]] more ...
tert-Butyl Alcohol inhibits the reaction [Acetylcholine promotes the reaction [[CHRNA2 protein binds to CHRNB4 protein] which results in increased transport of Barium]]
Tubocurarine inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB4 protein]] and Tubocurarine inhibits the reaction [desnitroimidacloprid results in increased activity of [CHRNA3 protein binds to CHRNB4 protein]]
Genetic variants in nicotine addiction and alcohol metabolism genes, oral cancer risk and the propensity to smoke and drink alcohol: a replication study in India.
Alterations in nicotinic receptor alpha5 subunit gene differentially impact early and later stages of cocaine addiction: a translational study in transgenic rats and patients.