Chrnb4 (cholinergic receptor, nicotinic, beta polypeptide 4) - Rat Genome Database

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Gene: Chrnb4 (cholinergic receptor, nicotinic, beta polypeptide 4) Mus musculus
Analyze
Symbol: Chrnb4
Name: cholinergic receptor, nicotinic, beta polypeptide 4
RGD ID: 732765
MGI Page MGI
Description: Enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential. Involved in positive regulation of transmission of nerve impulse. Acts upstream of or within several processes, including behavioral response to nicotine; neuronal action potential; and synaptic transmission involved in micturition. Is active in cholinergic synapse. Is expressed in several structures, including alimentary system; eye; genitourinary system; nervous system; and thymus. Human ortholog(s) of this gene implicated in cocaine abuse; lung cancer (multiple); and oral cavity cancer. Orthologous to human CHRNB4 (cholinergic receptor nicotinic beta 4 subunit).
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: Acr; Acrb; Acrb-4; Acrb4; neuronal acetylcholine receptor subunit beta-4; nicotinic acetylcholine receptor beta4 subunit
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39954,935,438 - 54,956,236 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl954,935,438 - 54,956,063 (-)EnsemblGRCm39 Ensembl
GRCm38955,028,154 - 55,048,953 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl955,028,154 - 55,048,779 (-)EnsemblGRCm38mm10GRCm38
MGSCv37954,875,963 - 54,896,351 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36954,826,293 - 54,846,681 (-)NCBIMGSCv36mm8
Celera952,271,558 - 52,291,872 (-)NCBICelera
Cytogenetic Map9BNCBI
cM Map929.84NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(S)-anabasine  (ISO)
(S)-nicotine  (EXP,ISO)
1,1-dimethyl-4-phenylpiperazinium iodide  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
17beta-estradiol 3-benzoate  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,4-dinitrotoluene  (ISO)
2,6-dinitrotoluene  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-nonylphenol  (ISO)
4-octylphenol  (ISO)
acetylcholine  (ISO)
acrylamide  (ISO)
aldicarb  (ISO)
ammonium chloride  (ISO)
atracurium  (ISO)
barium(0)  (ISO)
bendiocarb  (ISO)
benzalkonium chloride  (EXP)
benzo[a]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (ISO)
bisphenol F  (EXP)
butan-1-ol  (ISO)
butan-2-ol  (ISO)
carbachol  (ISO)
carbaryl  (ISO)
CGP 52608  (ISO)
chlorpyrifos  (ISO)
cisatracurium  (ISO)
coumarin  (ISO)
crotyl alcohol  (ISO)
Cuprizon  (ISO)
cytisine  (ISO)
decabromodiphenyl ether  (ISO)
dieldrin  (ISO)
diethylstilbestrol  (ISO)
dihydro-beta-erythroidine  (ISO)
dopamine  (ISO)
dorsomorphin  (ISO)
endosulfan  (ISO)
entinostat  (ISO)
epibatidine  (ISO)
EPTC  (ISO)
ethanol  (EXP)
fenoxycarb  (ISO)
fluoxetine  (ISO)
fulvestrant  (ISO)
gentamycin  (ISO)
Hexamethonium  (ISO)
imidacloprid  (ISO)
isobutanol  (ISO)
lead diacetate  (ISO)
Mecamylamine  (EXP,ISO)
mercury dichloride  (ISO)
Mivacurium  (ISO)
N'-Nitrosonornicotine  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
nickel atom  (ISO)
nicotine  (EXP,ISO)
NS-398  (EXP)
pancuronium  (ISO)
paracetamol  (ISO)
pentan-1-ol  (ISO)
propan-1-ol  (ISO)
propan-2-ol  (ISO)
propanal  (ISO)
propoxur  (ISO)
rocuronium  (ISO)
sarin  (ISO)
SB 431542  (ISO)
sodium arsenite  (EXP)
tamoxifen  (ISO)
tert-butanol  (ISO)
testosterone  (ISO)
Tetrachlorobisphenol A  (ISO)
thapsigargin  (ISO)
triptonide  (EXP)
tubocurarine  (ISO)
tunicamycin  (ISO)
valproic acid  (EXP,ISO)
varenicline  (ISO)
vecuronium bromide  (ISO)
vinclozolin  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Mammalian nicotinic acetylcholine receptors: from structure to function. Albuquerque EX, etal., Physiol Rev. 2009 Jan;89(1):73-120. doi: 10.1152/physrev.00015.2008.
2. Genetic variants in nicotine addiction and alcohol metabolism genes, oral cancer risk and the propensity to smoke and drink alcohol: a replication study in India. Anantharaman D, etal., PLoS One. 2014 Feb 5;9(2):e88240. doi: 10.1371/journal.pone.0088240. eCollection 2014.
3. Nicotinic cholinergic receptors in esophagus: Early alteration during carcinogenesis and prognostic value. Chianello Nicolau M, etal., World J Gastroenterol. 2016 Aug 21;22(31):7146-56. doi: 10.3748/wjg.v22.i31.7146.
4. Alterations in nicotinic receptor alpha5 subunit gene differentially impact early and later stages of cocaine addiction: a translational study in transgenic rats and patients. Forget B, etal., Prog Neurobiol. 2021 Feb;197:101898. doi: 10.1016/j.pneurobio.2020.101898. Epub 2020 Aug 22.
5. Down-regulation of cholinergic signaling in the habenula induces anhedonia-like behavior. Han S, etal., Sci Rep. 2017 Apr 18;7(1):900. doi: 10.1038/s41598-017-01088-6.
6. Fine mapping of chromosome 15q25.1 lung cancer susceptibility in African-Americans. Hansen HM, etal., Hum Mol Genet. 2010 Sep 15;19(18):3652-61. doi: 10.1093/hmg/ddq268. Epub 2010 Jun 29.
7. ASCL1 regulates the expression of the CHRNA5/A3/B4 lung cancer susceptibility locus. Improgo MR, etal., Mol Cancer Res. 2010 Feb;8(2):194-203. doi: 10.1158/1541-7786.MCR-09-0185. Epub 2010 Feb 2.
8. Polymorphisms of CHRNA5-CHRNA3-CHRNB4 Gene Cluster and NSCLC Risk in Chinese Population. Li Z, etal., Transl Oncol. 2012 Dec;5(6):448-52. doi: 10.1593/tlo.12304. Epub 2012 Dec 1.
9. Nicotinic cholinergic receptors in the rat retina: simple and mixed heteromeric subtypes. Marritt AM, etal., Mol Pharmacol. 2005 Dec;68(6):1656-68. Epub 2005 Aug 29.
10. Expression of acetylcholine receptors by experimental rat renal allografts. Meixner M, etal., Biomed Res Int. 2014;2014:289656. doi: 10.1155/2014/289656. Epub 2014 Jul 9.
11. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
12. MGDs mouse GO annotations MGD data from the GO Consortium
13. MGD IEA MGD IEA
14. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
15. Mouse MP Annotation Import Pipeline RGD automated import pipeline
16. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
17. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
18. Epigenetic screen identifies genotype-specific promoter DNA methylation and oncogenic potential of CHRNB4. Scherf DB, etal., Oncogene. 2013 Jul 11;32(28):3329-38. doi: 10.1038/onc.2012.344. Epub 2012 Sep 3.
19. Study on polymorphisms in CHRNA5/CHRNA3/CHRNB4 gene cluster and the associated with the risk of non-small cell lung cancer. Sun Y, etal., Oncotarget. 2017 Dec 20;9(2):2435-2444. doi: 10.18632/oncotarget.23459. eCollection 2018 Jan 5.
20. Unmethylation of the CHRNB4 gene is an unfavorable prognostic factor in non-small cell lung cancer. Yoo SS, etal., Lung Cancer. 2014 Oct;86(1):85-90. doi: 10.1016/j.lungcan.2014.08.002. Epub 2014 Aug 12.
Additional References at PubMed
PMID:1505988   PMID:2004777   PMID:8563774   PMID:8838678   PMID:8889548   PMID:10349636   PMID:10531434   PMID:10771006   PMID:11027228   PMID:11042159   PMID:11076861   PMID:11217851  
PMID:12225896   PMID:12477932   PMID:12606764   PMID:12867510   PMID:14681479   PMID:14681928   PMID:14996991   PMID:15275829   PMID:15489024   PMID:15537871   PMID:15694199   PMID:15922075  
PMID:15925141   PMID:15973160   PMID:16141072   PMID:16141073   PMID:16602821   PMID:16985005   PMID:17443806   PMID:17953485   PMID:18279314   PMID:18287559   PMID:18568021   PMID:19228980  
PMID:19474315   PMID:19481555   PMID:19906978   PMID:20377613   PMID:20496163   PMID:20696214   PMID:21485013   PMID:21555077   PMID:21677750   PMID:21768117   PMID:21873635   PMID:22009521  
PMID:22241831   PMID:22378897   PMID:22380605   PMID:22573727   PMID:23042983   PMID:23416040   PMID:23613527   PMID:23811311   PMID:23994392   PMID:24049141   PMID:24647947   PMID:24750073  
PMID:24952961   PMID:25031416   PMID:25948261   PMID:26585290   PMID:26904947   PMID:28381286   PMID:28398760   PMID:29791835   PMID:30353008   PMID:30891952   PMID:32140744   PMID:32184221  
PMID:32959891   PMID:34518365   PMID:35595472   PMID:36897571   PMID:37879250  


Genomics

Comparative Map Data
Chrnb4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39954,935,438 - 54,956,236 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl954,935,438 - 54,956,063 (-)EnsemblGRCm39 Ensembl
GRCm38955,028,154 - 55,048,953 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl955,028,154 - 55,048,779 (-)EnsemblGRCm38mm10GRCm38
MGSCv37954,875,963 - 54,896,351 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36954,826,293 - 54,846,681 (-)NCBIMGSCv36mm8
Celera952,271,558 - 52,291,872 (-)NCBICelera
Cytogenetic Map9BNCBI
cM Map929.84NCBI
CHRNB4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381578,624,111 - 78,661,641 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1578,624,111 - 78,727,754 (-)EnsemblGRCh38hg38GRCh38
GRCh371578,916,453 - 78,933,552 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361576,703,691 - 76,720,642 (-)NCBINCBI36Build 36hg18NCBI36
Build 341576,703,690 - 76,720,642NCBI
Celera1555,852,898 - 55,869,734 (-)NCBICelera
Cytogenetic Map15q25.1NCBI
HuRef1555,674,500 - 55,691,566 (-)NCBIHuRef
CHM1_11579,035,191 - 79,052,089 (-)NCBICHM1_1
T2T-CHM13v2.01576,487,585 - 76,519,049 (-)NCBIT2T-CHM13v2.0
Chrnb4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8864,312,644 - 64,333,319 (-)NCBIGRCr8
mRatBN7.2855,417,583 - 55,437,027 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl855,418,313 - 55,437,027 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx860,959,884 - 60,978,450 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0859,238,885 - 59,257,451 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0857,103,128 - 57,121,694 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0859,610,489 - 59,629,073 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl859,609,693 - 59,629,133 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0858,192,375 - 58,210,959 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4858,586,961 - 58,605,545 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1858,605,220 - 58,624,659 (-)NCBI
Celera854,902,516 - 54,921,100 (-)NCBICelera
RH 3.4 Map8614.4RGD
Cytogenetic Map8q24NCBI
Chrnb4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554501,013,607 - 1,030,282 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554501,013,897 - 1,030,232 (-)NCBIChiLan1.0ChiLan1.0
CHRNB4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21667,837,116 - 67,880,179 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11572,003,030 - 72,045,815 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01557,552,697 - 57,570,828 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11576,515,683 - 76,532,905 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1576,515,455 - 76,532,712 (-)Ensemblpanpan1.1panPan2
CHRNB4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11338,312,537 - 38,327,242 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1338,312,173 - 38,328,341 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1338,273,110 - 38,288,065 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01338,786,382 - 38,801,494 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1338,786,222 - 38,800,419 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11338,477,587 - 38,492,683 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01338,586,959 - 38,602,041 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01339,061,951 - 39,077,068 (+)NCBIUU_Cfam_GSD_1.0
Chrnb4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640118,560,402 - 118,577,508 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647136,408,447 - 36,426,021 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647136,408,471 - 36,425,571 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CHRNB4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1747,338,819 - 47,359,064 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2752,808,908 - 52,829,172 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CHRNB4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1264,700,217 - 4,717,363 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl264,701,321 - 4,719,319 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666048137,078,808 - 137,095,082 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Chrnb4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248942,305,820 - 2,322,505 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248942,305,815 - 2,322,264 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Chrnb4
735 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:907
Count of miRNA genes:500
Interacting mature miRNAs:600
Transcripts:ENSMUST00000034854
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
13208563Bmiq8_mbody mass index QTL 8 (mouse)92491129668907282Mouse
11532712Sluc39d_msusceptibility to lung cancer 39d (mouse)92558748559587581Mouse
11532696Sluc39c_msusceptibility to lung cancer 39c (mouse)92558748559587581Mouse
11532694Sluc39a_msusceptibility to lung cancer 39a (mouse)92558748559587581Mouse
11532695Sluc39b_msusceptibility to lung cancer 39b (mouse)92558748559587581Mouse
10043987Stheal13_msoft tissue heal 13 (mouse)Not determined92679642160796552Mouse
1300932Hdlq17_mHDL QTL 17 (mouse)Not determined92679642160796552Mouse
10043867Mtbcq9_mmultiple trait body composition QTL 9 (mouse)Not determined92679642160796552Mouse
10043878Adip20_madiposity 20 (mouse)Not determined92725119461251323Mouse
10043847Hdlq89_mHDL QTL 89 (mouse)Not determined92929292963293072Mouse
1301782Chol11_mcholesterol 11 (mouse)Not determined92929292963293072Mouse
1301365Ap5q_malcohol preference 5 QTL (mouse)Not determined93005316464053277Mouse
1357746Vtbt7_mvertebral trabecular bone trait 7 (mouse)Not determined93073991564740021Mouse
1302180Actd4_mactivity-distance traveled 4 (mouse)Not determined93243456366434857Mouse
4141148Cq5_mcholesterol QTL 5 (mouse)Not determined93245242166452546Mouse
1301692Hts_mhypothermia sensitivity (mouse)Not determined93251117266511421Mouse
4141323Ptnu3_mproteinuria 3 (mouse)Not determined93288970266889836Mouse
1357709Si5lq3_mserum IGFBP-5 level QTL 3 (mouse)Not determined93311102567111140Mouse
1558872Ibdq1_minflammatory bowel disease QTL 1 (mouse)Not determined93397884073439255Mouse
1301252Etohc3_methanol consumption 3 (mouse)Not determined93503447869034599Mouse
1301972Cocrb8_mcocaine related behavior 8 (mouse)Not determined93503447869034599Mouse
1558968Tbdr1_mbody temperature response to dietary restriction, QTL 1 (mouse)Not determined93503447869034599Mouse
4142042Alpq3_malcohol preference QTL 3 (mouse)Not determined93730619798701707Mouse
10043971Obq32_mobesity QTL 32 (mouse)Not determined93781952871819528Mouse
12790986Pcho9_mplasma cholesterol 9 (mouse)93809957572099575Mouse
12790992Arlsq1_maortic root lesion size QTL 1 (mouse)93809957572099575Mouse
12791002Arlsq2_maortic root lesion size QTL 2 (mouse)93809957572099575Mouse
12738449Spcq2_msperm count QTL 2 (mouse)93939988573399885Mouse
4141071Ath29_matherosclerosis 29 (mouse)Not determined94041959474607925Mouse
1301702Brm1_mbrachyury modifier 1 (mouse)Not determined94080504774805204Mouse
1301558Stheal8_msoft tissue heal 8 (mouse)Not determined94348071477480860Mouse
10045639Heal28_mwound healing/regeneration 28 (mouse)Not determined94348071477480860Mouse
1301435Trigq1_mtriglyceride QTL 1 (mouse)Not determined94442817478428262Mouse
4141572Ntta3_mneurotensin transcript abundance 3 (mouse)Not determined4659767165831177Mouse
4141754Fecq4_mfecundity QTL 4 (mouse)Not determined94754302457805204Mouse
1300563Pgia5_mproteoglycan induced arthritis 5 (mouse)Not determined94883105682831177Mouse
1300716Cd4ts4_mCD4 T cell subset 4 (mouse)Not determined94883105682831177Mouse
1301051Eae9_msusceptibility to experimental allergic encephalomyelitis 9 (mouse)Not determined94942029863239852Mouse
1301049El4_mepilepsy 4 (mouse)Not determined94942029867151448Mouse
4141224Dxmod_mdoxorubicin nephropathy modifier (mouse)Not determined49452421101406120Mouse
14746993Manh66_mmandible shape 66 (mouse)94981404883814048Mouse
1301184Bdln4_mbody length 4 (mouse)Not determined95015132084151448Mouse
1301241Renf1_mrenal failure 1 (mouse)Not determined95203447899792481Mouse
13525008Hrtiq1_mheart rate time index, QTL 1 (mouse)95242609868556008Mouse
12790990Tgl7_mtriglyceride 7 (mouse)95455996088559960Mouse

Markers in Region
Chrnb4  
Mouse AssemblyChrPosition (strand)SourceJBrowse
MGSCv37954,882,612 - 54,884,229UniSTSGRCm37
Celera952,278,191 - 52,279,808UniSTS
Cytogenetic Map9BUniSTS
cM Map9 UniSTS
D10Mit157.2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map6D1UniSTS
Cytogenetic Map16B4UniSTS
Cytogenetic Map18E2UniSTS
Cytogenetic Map4C3UniSTS
Cytogenetic Map7B2UniSTS
Cytogenetic Map4D2.3UniSTS
Cytogenetic Map11E1UniSTS
Cytogenetic Map14E2.2UniSTS
Cytogenetic Map4C7UniSTS
Cytogenetic Map2H4UniSTS
Cytogenetic Map1FUniSTS
Cytogenetic Map6C3UniSTS
Cytogenetic Map11DUniSTS
Cytogenetic Map3G2UniSTS
Cytogenetic Map17A1UniSTS
Cytogenetic Map9F2UniSTS
Cytogenetic Map12F1UniSTS
Cytogenetic Map19C2UniSTS
Cytogenetic Map3BUniSTS
Cytogenetic Map8C1UniSTS
Cytogenetic Map18A2UniSTS
Cytogenetic Map3F2UniSTS
Cytogenetic Map14C3UniSTS
Cytogenetic Map8E1UniSTS
Cytogenetic Map8E2UniSTS
Cytogenetic Map5B1UniSTS
Cytogenetic Map18B1UniSTS
Cytogenetic Map9CUniSTS
Cytogenetic Map14C2UniSTS
Cytogenetic Map6A1UniSTS
Cytogenetic Map10B4UniSTS
Cytogenetic Map13D2.1UniSTS
Cytogenetic Map5E5UniSTS
Cytogenetic Map11B1.3UniSTS
Cytogenetic Map4D1UniSTS
Cytogenetic Map9A5.2UniSTS
Cytogenetic Map3F1UniSTS
Cytogenetic Map17E3UniSTS
Cytogenetic Map11B3UniSTS
Cytogenetic Map1H4UniSTS
Cytogenetic Map6A3UniSTS
Cytogenetic Map5E4-E5UniSTS
Cytogenetic Map15E1UniSTS
Cytogenetic Map13DUniSTS
Cytogenetic Map14BUniSTS
Cytogenetic Map14D1UniSTS
Cytogenetic Map7B4UniSTS
Cytogenetic Map8D3UniSTS
Cytogenetic MapXDUniSTS
Cytogenetic Map17A3.3UniSTS
Cytogenetic Map7E2UniSTS
Cytogenetic Map1H2.3UniSTS
Cytogenetic Map7A2UniSTS
Cytogenetic Map7F3UniSTS
Cytogenetic Map9F1UniSTS
Cytogenetic Map10C1UniSTS
Cytogenetic Map4E2UniSTS
Cytogenetic Map16A1UniSTS
Cytogenetic Map8B3.3UniSTS
Cytogenetic Map8D2UniSTS
Cytogenetic Map3DUniSTS
Cytogenetic Map15D2UniSTS
Cytogenetic Map17B1UniSTS
Cytogenetic Map7A3UniSTS
Cytogenetic Map15F1UniSTS
Cytogenetic Map16B2UniSTS
Cytogenetic Map7CUniSTS
Cytogenetic Map3F2.1UniSTS
Cytogenetic Map6F3UniSTS
Cytogenetic Map1C4UniSTS
Cytogenetic Map11E2UniSTS
Cytogenetic Map11B5UniSTS
Cytogenetic Map9F3UniSTS
Cytogenetic Map2BUniSTS
Cytogenetic Map13B3UniSTS
Cytogenetic Map9A4UniSTS
Cytogenetic Map5A3UniSTS
Cytogenetic Map2H1UniSTS
Cytogenetic Map16B1UniSTS
Cytogenetic Map1A5UniSTS
Cytogenetic Map11CUniSTS
Cytogenetic Map9E1UniSTS
Cytogenetic Map6G1UniSTS
Cytogenetic MapXA2UniSTS
Cytogenetic Map13B1UniSTS
Cytogenetic Map5E2UniSTS
Cytogenetic Map12C1UniSTS
Cytogenetic Map5FUniSTS
Cytogenetic Map4D3UniSTS
Cytogenetic Map10C2UniSTS
Cytogenetic Map9BUniSTS
Cytogenetic Map5G2UniSTS
Cytogenetic Map7F1UniSTS
Cytogenetic Map12C3UniSTS
Cytogenetic Map10A4UniSTS
Cytogenetic Map8A2UniSTS
Cytogenetic Map18A1UniSTS
Cytogenetic Map12A1.1UniSTS
Cytogenetic Map1C2UniSTS
Cytogenetic Map11B2UniSTS
Cytogenetic Map6E3UniSTS
Cytogenetic Map5C3.3UniSTS
Cytogenetic Map1BUniSTS
Cytogenetic Map17A3.1UniSTS
Cytogenetic Map7A1UniSTS
Cytogenetic Map2E5UniSTS
Cytogenetic Map11A1UniSTS
Cytogenetic Map4B1UniSTS
Cytogenetic Map15A2UniSTS
Cytogenetic Map8C3UniSTS
Cytogenetic Map2A3UniSTS
Cytogenetic Map5G3UniSTS
Cytogenetic Map4A3UniSTS
Cytogenetic Map2H3UniSTS
Cytogenetic Map8A1UniSTS
Cytogenetic Map8A1.1UniSTS
Cytogenetic Map16A3UniSTS
Cytogenetic Map10B1UniSTS
Cytogenetic Map19AUniSTS
Cytogenetic Map10A1UniSTS
Cytogenetic Map13D1UniSTS
Cytogenetic Map4A1UniSTS
Cytogenetic Map9A3UniSTS
Cytogenetic Map17CUniSTS
Cytogenetic Map1DUniSTS
Cytogenetic Map5E3UniSTS
Cytogenetic Map15D3UniSTS
Cytogenetic Map2H2UniSTS
Cytogenetic Map7D3UniSTS
Cytogenetic Map2A1UniSTS
Cytogenetic Map14C1UniSTS
Cytogenetic Map14E5UniSTS
Cytogenetic Map10CUniSTS
Cytogenetic Map18B2UniSTS
Cytogenetic Map2F1UniSTS
Cytogenetic Map10D3UniSTS
Cytogenetic Map17A2UniSTS
Cytogenetic Map2C3UniSTS
Cytogenetic Map1C3UniSTS
Cytogenetic Map17B2UniSTS
Cytogenetic Map5B2UniSTS
Cytogenetic Map5G1UniSTS
Cytogenetic Map4C6UniSTS
Cytogenetic Map13C3UniSTS
Cytogenetic Map2E1UniSTS
Cytogenetic Map17A3.2-A3.3UniSTS
Cytogenetic Map19C3UniSTS
Cytogenetic Map7E3UniSTS
Cytogenetic Map13C1UniSTS
Cytogenetic Map9E3.1UniSTS
Cytogenetic Map15E3UniSTS
Cytogenetic Map6B1UniSTS
Cytogenetic MapXE3UniSTS
Cytogenetic Map4C4UniSTS
Cytogenetic Map3E3UniSTS
Cytogenetic Map11A4UniSTS
Cytogenetic Map4C5UniSTS
Cytogenetic Map18B3UniSTS
Cytogenetic Map9A2UniSTS
Cytogenetic Map7E1UniSTS
Cytogenetic Map5D-E1UniSTS
Cytogenetic Map5B3UniSTS
Cytogenetic Map13A2-A3UniSTS
Cytogenetic Map5A2UniSTS
Cytogenetic Map4B3UniSTS
Cytogenetic Map1E4UniSTS
Cytogenetic Map17E4UniSTS
Cytogenetic Map1G2UniSTS
Cytogenetic Map15B3.1UniSTS
Cytogenetic Map12EUniSTS
Cytogenetic MapXA5UniSTS
Cytogenetic Map6A3.3UniSTS
Cytogenetic Map6G3UniSTS
Cytogenetic Map6F2UniSTS
Cytogenetic Map5C1UniSTS
Cytogenetic Map4D2.1UniSTS
Cytogenetic Map4A5UniSTS
Cytogenetic Map3F2.2UniSTS
Cytogenetic Map1E3-E4UniSTS
Cytogenetic Map9F1-F3UniSTS
Cytogenetic Map1C1.1UniSTS
Cytogenetic Map14D2UniSTS
Cytogenetic Map12A2UniSTS
Cytogenetic Map17A3-BUniSTS
Cytogenetic Map7F5UniSTS
Cytogenetic Map14A3UniSTS
Cytogenetic Map5G1.1UniSTS
Cytogenetic MapXF2-F4UniSTS
Cytogenetic Map7D2UniSTS
Cytogenetic Map2F3UniSTS
Cytogenetic Map10A3UniSTS
Cytogenetic MapXA7.3UniSTS
Cytogenetic Map9F1-F2UniSTS
Cytogenetic Map13A3.2UniSTS
Cytogenetic Map10A2UniSTS
Cytogenetic Map1C1UniSTS
Cytogenetic Map1A1UniSTS
Cytogenetic Map12D3UniSTS
Cytogenetic Map1A3-A5UniSTS
Cytogenetic Map2A2UniSTS
Cytogenetic Map3A1UniSTS
Cytogenetic MapXA3.3UniSTS
Cytogenetic Map16A-B1UniSTS
Cytogenetic Map1D2.3UniSTS
Cytogenetic Map6B2.3UniSTS
Cytogenetic Map2G3UniSTS
Cytogenetic MapXA2-A3.1UniSTS
Cytogenetic Map9A5.3UniSTS
Cytogenetic Map14A2-BUniSTS
Cytogenetic Map8E1-E2UniSTS
Cytogenetic Map8A3UniSTS
Cytogenetic Map1G3-H1UniSTS
Cytogenetic Map8B3-C1UniSTS
Cytogenetic Map19C1UniSTS
Cytogenetic Map8C5UniSTS
Cytogenetic Map8A4UniSTS
Cytogenetic Map15F3UniSTS
Cytogenetic Map14E4UniSTS
Cytogenetic Map4D2.2UniSTS
Cytogenetic MapXF5UniSTS
cM Map1040.0UniSTS
Whitehead Genetic1033.9UniSTS
D8Wox29  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38955,029,121 - 55,029,334UniSTSGRCm38
MGSCv37954,876,928 - 54,877,141UniSTSGRCm37
Celera952,272,522 - 52,272,737UniSTS
Cytogenetic Map9BUniSTS
D9Ucl1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38955,036,616 - 55,036,818UniSTSGRCm38
MGSCv37954,884,423 - 54,884,625UniSTSGRCm37
Celera952,280,002 - 52,280,204UniSTS
Cytogenetic Map9BUniSTS
cM Map929.0UniSTS
Chrnb4  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38955,034,805 - 55,036,422UniSTSGRCm38
MGSCv37954,882,612 - 54,884,229UniSTSGRCm37
Celera952,278,191 - 52,279,808UniSTS
Cytogenetic Map9BUniSTS
cM Map9 UniSTS


Expression


Sequence


RefSeq Acc Id: ENSMUST00000034854   ⟹   ENSMUSP00000034854
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl954,935,438 - 54,956,063 (-)Ensembl
GRCm38.p6 Ensembl955,028,154 - 55,048,779 (-)Ensembl
RefSeq Acc Id: NM_148944   ⟹   NP_683746
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39954,935,440 - 54,955,828 (-)NCBI
GRCm38955,028,156 - 55,048,544 (-)NCBI
MGSCv37954,875,963 - 54,896,351 (-)RGD
Celera952,271,558 - 52,291,872 (-)RGD
cM Map9 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006510757   ⟹   XP_006510820
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39954,935,438 - 54,951,850 (-)NCBI
GRCm38955,028,154 - 55,044,567 (-)NCBI
Sequence:
RefSeq Acc Id: XM_011242655   ⟹   XP_011240957
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39954,935,438 - 54,956,236 (-)NCBI
GRCm38955,028,154 - 55,048,953 (-)NCBI
Sequence:
RefSeq Acc Id: NP_683746   ⟸   NM_148944
- Peptide Label: precursor
- UniProtKB: Q8VI06 (UniProtKB/Swiss-Prot),   Q8R493 (UniProtKB/Swiss-Prot),   Q3USV2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006510820   ⟸   XM_006510757
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_011240957   ⟸   XM_011242655
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSMUSP00000034854   ⟸   ENSMUST00000034854
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q8R493-F1-model_v2 AlphaFold Q8R493 1-495 view protein structure

Promoters
RGD ID:8669660
Promoter ID:EPDNEW_M12861
Type:initiation region
Name:Chrnb4_1
Description:Mus musculus cholinergic receptor, nicotinic, beta polypeptide4 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38955,048,540 - 55,048,600EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:87892 AgrOrtholog
Ensembl Genes ENSMUSG00000035200 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000034854 ENTREZGENE
  ENSMUST00000034854.8 UniProtKB/Swiss-Prot
Gene3D-CATH 1.20.58.390 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2.70.170.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Neur_chan_lig-bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Neur_chan_lig-bd_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Neur_channel UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Neuro-gated_channel_TM_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Neuro_actylchol_rec UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Neurotrans-gated_channel_TM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Neurotransmitter_ion_chnl_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Nicotinic_acetylcholine_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:108015 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:87892 ENTREZGENE
NCBI Gene 108015 ENTREZGENE
PANTHER NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT BETA-4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR18945 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Neur_chan_LBD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Neur_chan_memb UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB CHRNB4 RGD
PhenoGen Chrnb4 PhenoGen
PRINTS NICOTINICR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NRIONCHANNEL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE NEUROTR_ION_CHANNEL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF63712 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF90112 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt ACHB4_MOUSE UniProtKB/Swiss-Prot
  Q3TUU6_MOUSE UniProtKB/TrEMBL
  Q3USV2 ENTREZGENE, UniProtKB/TrEMBL
  Q8R493 ENTREZGENE
  Q8VI06 ENTREZGENE
UniProt Secondary Q8VI06 UniProtKB/Swiss-Prot