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Pathways
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ONTOLOGY REPORT - ANNOTATIONS

Term:T cell receptor signaling pathway
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Accession:GO:0050852 term browser browse the term
Definition:The series of molecular signals initiated by the cross-linking of an antigen receptor on a T cell.
Synonyms:exact_synonym: T lymphocyte receptor signaling pathway;   T lymphocyte receptor signalling pathway;   T-cell receptor signalling pathway;   TCR signaling pathway


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T cell receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abl1 c-abl oncogene 1, non-receptor tyrosine kinase acts_upstream_of_or_within IDA (PMID:18305217) MGI PMID:18305217 NCBI chr 2:31,578,256...31,697,105
Ensembl chr 2:31,578,388...31,694,239 		JBrowse link
G Ada adenosine deaminase acts_upstream_of IMP (PMID:11435465) MGI PMID:11435465 NCBI chr 2:163,565,703...163,592,154
Ensembl chr 2:163,568,504...163,592,159 		JBrowse link
G Bcl10 B cell leukemia/lymphoma 10 involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr 3:145,630,017...145,640,121
Ensembl chr 3:145,628,559...145,640,111 		JBrowse link
G Bcl2a1d B cell leukemia/lymphoma 2 related protein A1d acts_upstream_of_or_within IDA (PMID:15728238) MGI PMID:15728238 NCBI chr 9:88,605,341...88,613,903
Ensembl chr 9:88,605,338...88,613,967 		JBrowse link
G Braf Braf transforming gene acts_upstream_of_or_within IDA (PMID:18228248) MGI PMID:18228248 NCBI chr 6:39,580,171...39,702,592
Ensembl chr 6:39,580,171...39,702,397 		JBrowse link
G Btk Bruton agammaglobulinemia tyrosine kinase involved_in IBA GO_Central GO_REF:0000033 NCBI chr  X:133,443,083...133,484,366
Ensembl chr  X:133,443,085...133,484,319 		JBrowse link
G Btn1a1 butyrophilin, subfamily 1, member A1 involved_in IBA GO_Central GO_REF:0000033 NCBI chr13:23,641,154...23,650,084
Ensembl chr13:23,641,162...23,650,071 		JBrowse link
G Btn2a2 butyrophilin, subfamily 2, member A2 involved_in IBA GO_Central GO_REF:0000033 NCBI chr13:23,661,219...23,673,028
Ensembl chr13:23,661,846...23,673,027 		JBrowse link
G Btnl1 butyrophilin-like 1 involved_in IBA GO_Central GO_REF:0000033 NCBI chr17:34,596,097...34,605,136
Ensembl chr17:34,596,106...34,605,002 		JBrowse link
G Btnl10 butyrophilin-like 10 involved_in IBA GO_Central GO_REF:0000033 NCBI chr11:58,808,703...58,817,791
Ensembl chr11:58,808,734...58,817,984 		JBrowse link
G Btnl12 butyrophilin-like 12 involved_in IBA GO_Central GO_REF:0000033 NCBI chr16:37,671,268...37,681,552
Ensembl chr16:37,671,275...37,681,508 		JBrowse link
G Btnl2 butyrophilin-like 2 involved_in IBA GO_Central GO_REF:0000033 NCBI chr17:34,573,763...34,588,466
Ensembl chr17:34,573,796...34,588,469 		JBrowse link
G Btnl4 butyrophilin-like 4 involved_in IBA GO_Central GO_REF:0000033 NCBI chr17:34,687,320...34,696,402
Ensembl chr17:34,685,536...34,696,292 		JBrowse link
G Btnl6 butyrophilin-like 6 involved_in IBA GO_Central GO_REF:0000033 NCBI chr17:34,726,844...34,737,750
Ensembl chr17:34,726,778...34,736,326 		JBrowse link
G Btnl9 butyrophilin-like 9 involved_in IBA GO_Central GO_REF:0000033 NCBI chr11:49,059,152...49,077,916
Ensembl chr11:49,056,412...49,077,986 		JBrowse link
G Cacnb3 calcium channel, voltage-dependent, beta 3 subunit acts_upstream_of_or_within IMP (PMID:17028169) MGI PMID:17028169 NCBI chr15:98,526,317...98,542,410
Ensembl chr15:98,528,721...98,542,410 		JBrowse link
G Cacnb4 calcium channel, voltage-dependent, beta 4 subunit acts_upstream_of_or_within IMP (PMID:15637280), (PMID:17028169) MGI PMID:15637280 PMID:17028169 NCBI chr 2:52,318,332...52,566,816
Ensembl chr 2:52,318,337...52,566,843 		JBrowse link
G Carmil2 capping protein regulator and myosin 1 linker 2 acts_upstream_of_or_within IMP (PMID:23793062) MGI PMID:23793062 NCBI chr 8:106,412,642...106,424,827
Ensembl chr 8:106,412,906...106,424,819 		JBrowse link
G Cblb Casitas B-lineage lymphoma b acts_upstream_of_or_within IMP (PMID:12697763) MGI PMID:12697763 NCBI chr16:51,851,593...52,028,410
Ensembl chr16:51,851,588...52,028,411 		JBrowse link
G Cd247 CD247 antigen acts_upstream_of_or_within
involved_in		 IDA
IBA		 (PMID:11435465) MGI
GO_Central		 PMID:11435465 GO_REF:0000033 NCBI chr 1:165,607,514...165,698,722
Ensembl chr 1:165,616,250...165,704,846 		JBrowse link
G Cd276 CD276 antigen involved_in IBA GO_Central GO_REF:0000033 NCBI chr 9:58,431,581...58,463,437
Ensembl chr 9:58,431,581...58,462,720 		JBrowse link
G Cd28 CD28 antigen acts_upstream_of_or_within
involved_in		 IMP
IBA		 (PMID:23793062) MGI
GO_Central		 PMID:23793062 GO_REF:0000033 NCBI chr 1:60,785,547...60,812,521
Ensembl chr 1:60,755,959...60,812,518 		JBrowse link
G Cd2ap CD2-associated protein acts_upstream_of_or_within IMP (PMID:14512504) MGI PMID:14512504 NCBI chr17:43,059,857...43,187,593
Ensembl chr17:43,103,842...43,187,556 		JBrowse link
G Cd3e CD3 antigen, epsilon polypeptide acts_upstream_of_or_within IDA (PMID:10485657) MGI PMID:10485657 NCBI chr 9:44,910,033...44,920,961
Ensembl chr 9:44,910,038...44,920,925 		JBrowse link
G Cd8a CD8 subunit alpha involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr 6:71,350,411...71,356,155
Ensembl chr 6:71,350,411...71,356,157 		JBrowse link
G Cd8b1 CD8 subunit beta 1 involved_in ISO (PMID:17145893) ComplexPortal PMID:17145893 NCBI chr 6:71,299,772...71,314,476
Ensembl chr 6:71,299,772...71,314,478 		JBrowse link
G Clec2i C-type lectin domain family 2, member i acts_upstream_of_or_within IMP (PMID:16143319) MGI PMID:16143319 NCBI chr 6:128,864,550...128,875,131
Ensembl chr 6:128,864,551...128,875,130 		JBrowse link
G Crkl v-crk avian sarcoma virus CT10 oncogene homolog-like acts_upstream_of_or_within IDA (PMID:18305217) MGI PMID:18305217 NCBI chr16:17,269,849...17,305,304
Ensembl chr16:17,269,851...17,305,298 		JBrowse link
G Ctla4 cytotoxic T-lymphocyte-associated protein 4 involved_in IBA GO_Central GO_REF:0000033 NCBI chr 1:60,948,184...60,954,991
Ensembl chr 1:60,926,159...60,954,991 		JBrowse link
G Dennd1b DENN domain containing 1B involved_in IMP
IBA
ISO		 (MGI:5751612|PMID:26774822) UniProt
GO_Central
MGI		 PMID:26774822 GO_REF:0000033 GO_REF:0000119 MGI:4834177 MGI:5751612 NCBI chr 1:138,891,447...139,103,781
Ensembl chr 1:138,891,173...139,106,698 		JBrowse link
G Eif2b1 eukaryotic translation initiation factor 2B, subunit alpha involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr 5:124,708,277...124,717,194
Ensembl chr 5:124,708,276...124,717,194 		JBrowse link
G Eif2b2 eukaryotic translation initiation factor 2B, subunit 2 beta involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr12:85,266,255...85,273,402
Ensembl chr12:85,266,255...85,273,402 		JBrowse link
G Eif2b3 eukaryotic translation initiation factor 2B, subunit 3 involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr 4:116,876,559...116,944,049
Ensembl chr 4:116,876,599...116,944,503 		JBrowse link
G Eif2b4 eukaryotic translation initiation factor 2B, subunit 4 delta involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr 5:31,344,902...31,350,483
Ensembl chr 5:31,344,902...31,350,774 		JBrowse link
G Eif2b5 eukaryotic translation initiation factor 2B, subunit 5 epsilon involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr16:20,317,544...20,328,073
Ensembl chr16:20,317,567...20,328,073 		JBrowse link
G Ermap erythroblast membrane-associated protein involved_in IBA GO_Central GO_REF:0000033 NCBI chr 4:119,032,654...119,047,210
Ensembl chr 4:119,032,654...119,047,208 		JBrowse link
G Fcho1 FCH domain only 1 involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr 8:72,161,031...72,181,980
Ensembl chr 8:72,161,031...72,178,360 		JBrowse link
G Fosl2 fos-like antigen 2 acts_upstream_of_or_within IDA
IMP		 (PMID:32610127) MGI PMID:32610127 NCBI chr 5:32,292,599...32,315,184
Ensembl chr 5:32,293,145...32,315,186 		JBrowse link
G Foxp3 forkhead box P3 acts_upstream_of_or_within IMP (PMID:10072494), (PMID:11265635) MGI PMID:10072494 PMID:11265635 NCBI chr  X:7,445,915...7,461,482
Ensembl chr  X:7,439,883...7,461,484 		JBrowse link
G Fyb1 FYN binding protein 1 involved_in IBA GO_Central GO_REF:0000033 NCBI chr15:6,552,280...6,695,089
Ensembl chr15:6,552,334...6,692,794 		JBrowse link
G Fyb2 FYN binding protein 2 involved_in ISO
IBA		 MGI
GO_Central		 GO_REF:0000033 GO_REF:0000119 MGI:4834177 NCBI chr 4:104,692,431...104,874,061
Ensembl chr 4:104,770,653...104,874,060 		JBrowse link
G Fyn Fyn proto-oncogene involved_in ISO
IBA		 MGI
GO_Central		 GO_REF:0000033 GO_REF:0000119 MGI:4834177 NCBI chr10:39,245,735...39,441,377
Ensembl chr10:39,244,851...39,441,377 		JBrowse link
G Gata3 GATA binding protein 3 involved_in IDA (MGI:5285154|PMID:20696860) UniProt PMID:20696860 MGI:5285154 NCBI chr 2:9,861,889...9,894,845
Ensembl chr 2:9,861,889...9,894,845 		JBrowse link
G H2-Ab1 histocompatibility 2, class II antigen A, beta 1 involved_in ISO (PMID:32341563) UniProt PMID:32341563 NCBI chr17:34,482,201...34,488,392
Ensembl chr17:34,476,663...34,488,393 		JBrowse link
G H2-Eb1 histocompatibility 2, class II antigen E beta involved_in ISO (PMID:32341563) UniProt PMID:32341563 NCBI chr17:34,524,841...34,535,648
Ensembl chr17:34,524,841...34,535,648 		JBrowse link
G H2-Q1 histocompatibility 2, Q region locus 1 involved_in ISO (PMID:10435578) UniProt PMID:10435578 NCBI chr17:35,539,503...35,547,118
Ensembl chr17:35,539,381...35,544,075 		JBrowse link
G Hras Harvey rat sarcoma virus oncogene acts_upstream_of_or_within IMP (PMID:21444916) MGI PMID:21444916 NCBI chr 7:140,770,839...140,773,938
Ensembl chr 7:140,769,018...140,773,918 		JBrowse link
G Icosl icos ligand involved_in IBA GO_Central GO_REF:0000033 NCBI chr10:77,904,921...77,915,359
Ensembl chr10:77,905,136...77,919,747 		JBrowse link
G Ifng interferon gamma acts_upstream_of_or_within IDA (PMID:21444916) MGI PMID:21444916 NCBI chr10:118,276,951...118,281,799
Ensembl chr10:118,276,951...118,281,797 		JBrowse link
G Itk IL2 inducible T cell kinase involved_in IMP
IBA		 (MGI:1335923|PMID:10213685) UniProt
GO_Central		 PMID:10213685 GO_REF:0000033 MGI:1335923 NCBI chr11:46,215,975...46,280,342
Ensembl chr11:46,215,977...46,280,342 		JBrowse link
G Khdrbs1 KH domain containing, RNA binding, signal transduction associated 1 involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr 4:129,596,143...129,637,402
Ensembl chr 4:129,596,957...129,636,096 		JBrowse link
G Lat linker for activation of T cells involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr 7:125,962,999...125,968,877
Ensembl chr 7:125,962,996...125,968,742 		JBrowse link
G Lck lymphocyte protein tyrosine kinase involved_in ISO (PMID:8943371) UniProt PMID:8943371 NCBI chr 4:129,442,142...129,467,415
Ensembl chr 4:129,442,137...129,467,434 		JBrowse link
G Lcp2 lymphocyte cytosolic protein 2 involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr11:33,996,928...34,042,281
Ensembl chr11:33,996,920...34,042,295 		JBrowse link
G Lime1 Lck interacting transmembrane adaptor 1 involved_in IEA UniProt GO_REF:0000002 MGI:2152098 NCBI chr 2:181,023,028...181,025,421
Ensembl chr 2:181,021,871...181,025,421 		JBrowse link
G Malt1 MALT1 paracaspase involved_in IDA
IBA
ISO		 (MGI:6142401|PMID:25282160) UniProt
GO_Central
MGI		 PMID:25282160 GO_REF:0000033 GO_REF:0000119 MGI:4834177 MGI:6142401 NCBI chr18:65,564,010...65,612,138
Ensembl chr18:65,564,009...65,612,138 		JBrowse link
G Mapk1 mitogen-activated protein kinase 1 acts_upstream_of_or_within IDA (PMID:9064344) MGI PMID:9064344 NCBI chr16:16,801,246...16,865,317
Ensembl chr16:16,801,246...16,865,317 		JBrowse link
G Mog myelin oligodendrocyte glycoprotein involved_in IBA GO_Central GO_REF:0000033 NCBI chr17:37,321,632...37,334,290
Ensembl chr17:37,321,635...37,334,290 		JBrowse link
G Nfkbid nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, delta involved_in IMP (MGI:6142401|PMID:25282160) UniProt PMID:25282160 MGI:6142401 NCBI chr 7:30,121,156...30,128,173
Ensembl chr 7:30,121,157...30,128,171 		JBrowse link
G Nfkbiz nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, zeta involved_in IMP (MGI:6142401|PMID:25282160) UniProt PMID:25282160 MGI:6142401 NCBI chr16:55,631,740...55,659,018
Ensembl chr16:55,631,738...55,659,262 		JBrowse link
G Nras neuroblastoma ras oncogene acts_upstream_of_or_within IMP (PMID:21444916) MGI PMID:21444916 NCBI chr 3:102,965,643...102,975,230
Ensembl chr 3:102,965,601...102,975,230 		JBrowse link
G Pde4b phosphodiesterase 4B, cAMP specific involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr 4:101,944,529...102,464,459
Ensembl chr 4:101,944,740...102,464,456 		JBrowse link
G Pde4d phosphodiesterase 4D, cAMP specific involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr13:108,790,711...110,092,503
Ensembl chr13:108,586,482...110,089,995 		JBrowse link
G Plcg1 phospholipase C, gamma 1 acts_upstream_of_or_within IDA (PMID:15728238) MGI PMID:15728238 NCBI chr 2:160,573,230...160,617,680
Ensembl chr 2:160,573,220...160,617,680 		JBrowse link
G Plcg2 phospholipase C, gamma 2 acts_upstream_of_or_within IDA (PMID:15728238) MGI PMID:15728238 NCBI chr 8:118,225,014...118,361,881
Ensembl chr 8:118,225,030...118,361,881 		JBrowse link
G Pram1 PML-RAR alpha-regulated adaptor molecule 1 involved_in IBA GO_Central GO_REF:0000033 NCBI chr17:33,857,030...33,864,680
Ensembl chr17:33,857,030...33,864,680 		JBrowse link
G Prkd2 protein kinase D2 involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr 7:16,576,827...16,604,386
Ensembl chr 7:16,576,827...16,604,389 		JBrowse link
G Psen1 presenilin 1 acts_upstream_of_or_within IGI (PMID:17698590) MGI PMID:17698590 NCBI chr12:83,734,926...83,781,869
Ensembl chr12:83,734,926...83,781,973 		JBrowse link
G Psen2 presenilin 2 acts_upstream_of_or_within IGI (PMID:17698590) MGI PMID:17698590 NCBI chr 1:180,054,569...180,091,030
Ensembl chr 1:180,054,569...180,091,003 		JBrowse link
G Ptpn22 protein tyrosine phosphatase, non-receptor type 22 (lymphoid) acts_upstream_of_or_within
involved_in		 IMP
IBA		 (PMID:14752163) MGI
GO_Central		 PMID:14752163 GO_REF:0000033 NCBI chr 3:103,763,891...103,819,568
Ensembl chr 3:103,767,111...103,819,563 		JBrowse link
G Ptpn6 protein tyrosine phosphatase, non-receptor type 6 acts_upstream_of IMP (PMID:9064344) MGI PMID:9064344 NCBI chr 6:124,697,670...124,715,672
Ensembl chr 6:124,697,670...124,715,677 		JBrowse link
G Ptprc protein tyrosine phosphatase receptor type C involved_in IGI
ISO		 (MGI:6201809|PMID:12496963) ARUK-UCL
MGI		 PMID:12496963 GO_REF:0000096 GO_REF:0000119 MGI:4417868 MGI:4834177 MGI:6201809 NCBI chr 1:137,990,601...138,103,491
Ensembl chr 1:137,990,599...138,103,446 		JBrowse link
G Rbck1 RanBP-type and C3HC4-type zinc finger containing 1 involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr 2:152,158,254...152,174,592
Ensembl chr 2:152,158,254...152,174,573 		JBrowse link
G Rc3h1 RING CCCH (C3H) domains 1 involved_in IMP (MGI:6142401|PMID:25282160) UniProt PMID:25282160 MGI:6142401 NCBI chr 1:160,733,981...160,802,546
Ensembl chr 1:160,733,988...160,802,548 		JBrowse link
G Rc3h2 ring finger and CCCH-type zinc finger domains 2 involved_in IMP (MGI:6142401|PMID:25282160) UniProt PMID:25282160 MGI:6142401 NCBI chr 2:37,260,078...37,313,007
Ensembl chr 2:37,260,081...37,312,915 		JBrowse link
G Rftn1 raftlin lipid raft linker 1 involved_in IMP (MGI:3850290|PMID:19414744) UniProt PMID:19414744 MGI:3850290 NCBI chr17:50,300,287...50,497,525
Ensembl chr17:50,299,285...50,497,702 		JBrowse link
G Ripk2 receptor (TNFRSF)-interacting serine-threonine kinase 2 involved_in
acts_upstream_of_or_within		 IMP (MGI:5285496|PMID:21469090)
(PMID:11894098)		 UniProt
MGI		 PMID:11894098 PMID:21469090 MGI:5285496 NCBI chr 4:16,122,740...16,163,674
Ensembl chr 4:16,122,733...16,163,647 		JBrowse link
G Rnf31 ring finger protein 31 involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr14:55,829,199...55,841,131
Ensembl chr14:55,829,165...55,841,150 		JBrowse link
G Shb src homology 2 domain-containing transforming protein B acts_upstream_of_or_within IMP (PMID:24645804) MGI PMID:24645804 NCBI chr 4:45,423,278...45,530,804
Ensembl chr 4:45,423,278...45,532,470 		JBrowse link
G Skap1 src family associated phosphoprotein 1 involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr11:96,355,396...96,650,448
Ensembl chr11:96,355,419...96,649,956 		JBrowse link
G Skint1 selection and upkeep of intraepithelial T cells 1 involved_in IBA GO_Central GO_REF:0000033 NCBI chr 4:111,863,466...111,886,735
Ensembl chr 4:111,863,466...111,886,735 		JBrowse link
G Skint10 selection and upkeep of intraepithelial T cells 10 involved_in IBA GO_Central GO_REF:0000033 NCBI chr 4:112,568,027...112,632,058
Ensembl chr 4:112,568,344...112,632,063 		JBrowse link
G Skint11 selection and upkeep of intraepithelial T cells 11 involved_in IBA GO_Central GO_REF:0000033 NCBI chr 4:114,020,581...114,102,225
Ensembl chr 4:114,020,581...114,102,225 		JBrowse link
G Skint2 selection and upkeep of intraepithelial T cells 2 involved_in IBA GO_Central GO_REF:0000033 NCBI chr 4:112,470,917...112,509,447
Ensembl chr 4:112,414,391...112,509,445 		JBrowse link
G Skint3 selection and upkeep of intraepithelial T cells 3 involved_in IBA GO_Central GO_REF:0000033 NCBI chr 4:112,089,442...112,157,665
Ensembl chr 4:112,089,442...112,157,665 		JBrowse link
G Skint4 selection and upkeep of intraepithelial T cells 4 involved_in IBA GO_Central GO_REF:0000033 NCBI chr 4:111,929,213...112,025,273
Ensembl chr 4:111,929,213...112,025,273 		JBrowse link
G Skint5 selection and upkeep of intraepithelial T cells 5 involved_in IBA GO_Central GO_REF:0000033 NCBI chr 4:113,335,088...113,856,700
Ensembl chr 4:113,335,088...113,856,700 		JBrowse link
G Skint6 selection and upkeep of intraepithelial T cells 6 involved_in IBA GO_Central GO_REF:0000033 NCBI chr 4:112,661,813...113,144,170
Ensembl chr 4:112,661,813...113,144,170 		JBrowse link
G Skint7 selection and upkeep of intraepithelial T cells 7 involved_in IBA GO_Central GO_REF:0000033 NCBI chr 4:111,830,121...111,845,457
Ensembl chr 4:111,830,120...111,845,420 		JBrowse link
G Skint8 selection and upkeep of intraepithelial T cells 8 involved_in IBA GO_Central GO_REF:0000033 NCBI chr 4:111,776,643...111,807,558
Ensembl chr 4:111,776,589...111,807,555 		JBrowse link
G Skint9 selection and upkeep of intraepithelial T cells 9 involved_in IBA GO_Central GO_REF:0000033 NCBI chr 4:112,243,166...112,291,182
Ensembl chr 4:112,243,166...112,291,182 		JBrowse link
G Slc39a6 solute carrier family 39 (metal ion transporter), member 6 involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr18:24,712,938...24,736,874
Ensembl chr18:24,712,938...24,736,874 		JBrowse link
G Spn sialophorin involved_in ISO PMID:12496963 ARUK-UCL PMID:12496963 RGD:1358565 NCBI chr 7:126,731,404...126,743,785
Ensembl chr 7:126,731,404...126,736,995 		JBrowse link
G Sppl3 signal peptide peptidase 3 involved_in IDA
ISO		 (MGI:5640905|PMID:25384971) UniProt
MGI		 PMID:25384971 GO_REF:0000119 MGI:4834177 MGI:5640905 NCBI chr 5:115,149,204...115,236,849
Ensembl chr 5:115,149,196...115,236,849 		JBrowse link
G Stk11 serine/threonine kinase 11 acts_upstream_of_or_within IGI
IMP		 (PMID:21487392) MGI PMID:21487392 NCBI chr10:79,951,602...79,966,513
Ensembl chr10:79,951,637...79,966,516 		JBrowse link
G Stoml2 stomatin (Epb7.2)-like 2 acts_upstream_of_or_within ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr 4:43,027,690...43,031,402
Ensembl chr 4:43,027,690...43,031,710 		JBrowse link
G Tcrb T cell receptor beta chain acts_upstream_of_or_within IDA (PMID:9208839) MGI PMID:9208839 NCBI chr 6:40,868,230...41,535,305 JBrowse link
G Tec tec protein tyrosine kinase involved_in IBA GO_Central GO_REF:0000033 NCBI chr 5:72,913,061...73,025,997
Ensembl chr 5:72,913,059...73,025,826 		JBrowse link
G Themis thymocyte selection associated involved_in IMP
IBA		 (MGI:4352756|PMID:19597499), (MGI:4352757|PMID:19597498) UniProt
GO_Central		 PMID:19597498 PMID:19597499 GO_REF:0000033 MGI:4352756 MGI:4352757 NCBI chr10:28,544,356...28,759,816
Ensembl chr10:28,544,356...28,759,814 		JBrowse link
G Themis2 thymocyte selection associated family member 2 acts_upstream_of_or_within
involved_in		 IMP
IBA		 (PMID:22732588) MGI
GO_Central		 PMID:22732588 GO_REF:0000033 NCBI chr 4:132,509,148...132,523,675
Ensembl chr 4:132,509,154...132,523,698 		JBrowse link
G Themis3 thymocyte selection associated family member 3 involved_in IBA GO_Central GO_REF:0000033 NCBI chr17:66,861,519...66,901,642
Ensembl chr17:66,861,500...66,901,616 		JBrowse link
G Thy1 thymus cell antigen 1, theta involved_in ISO MGI GO_REF:0000096 MGI:4417868 NCBI chr 9:43,954,681...43,959,876
Ensembl chr 9:43,954,681...43,959,876 		JBrowse link
G Tnfrsf21 tumor necrosis factor receptor superfamily, member 21 involved_in IMP (MGI:2137821|PMID:11485735) UniProt PMID:11485735 MGI:2137821 NCBI chr17:43,327,446...43,400,079
Ensembl chr17:43,327,446...43,400,080 		JBrowse link
G Traf6 TNF receptor-associated factor 6 involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr 2:101,508,765...101,532,013
Ensembl chr 2:101,508,774...101,532,014 		JBrowse link
G Trav7-2 T cell receptor alpha variable 7-2 acts_upstream_of_or_within IDA (PMID:28561797) MGI PMID:28561797 NCBI chr14:53,628,090...53,628,593
Ensembl chr14:53,628,092...53,628,599 		JBrowse link
G Txk TXK tyrosine kinase involved_in IMP
IBA		 (MGI:1335923|PMID:10213685) UniProt
GO_Central		 PMID:10213685 GO_REF:0000033 MGI:1335923 NCBI chr 5:72,853,321...72,910,337
Ensembl chr 5:72,853,321...72,910,120 		JBrowse link
G Ube2n ubiquitin-conjugating enzyme E2N involved_in ISS
ISO		 (MGI:3715075|PMID:15125833) HGNC-UCL
MGI		 PMID:15125833 GO_REF:0000119 MGI:3715075 MGI:4834177 NCBI chr10:95,351,024...95,381,520
Ensembl chr10:95,351,007...95,381,519 		JBrowse link
G Vtcn1 V-set domain containing T cell activation inhibitor 1 involved_in IBA GO_Central GO_REF:0000033 NCBI chr 3:100,732,775...100,805,555
Ensembl chr 3:100,732,775...100,804,238 		JBrowse link
G Wnk1 WNK lysine deficient protein kinase 1 involved_in IMP (MGI:6141968|PMID:27400149) BHF-UCL PMID:27400149 MGI:6141968 NCBI chr 6:119,900,930...120,015,659
Ensembl chr 6:119,900,930...120,015,633 		JBrowse link
G Zap70 zeta-chain (TCR) associated protein kinase involved_in
acts_upstream_of_or_within		 ISO
IMP		 (PMID:9208839) MGI PMID:9208839 GO_REF:0000119 MGI:4834177 NCBI chr 1:36,800,912...36,821,899
Ensembl chr 1:36,800,879...36,821,899 		JBrowse link
G Zc3h12a zinc finger CCCH type containing 12A involved_in IDA
IMP		 (MGI:5706909|PMID:23185455)
(MGI:6142401|PMID:25282160)		 UniProt PMID:23185455 PMID:25282160 MGI:5706909 MGI:6142401 NCBI chr 4:125,012,207...125,021,674
Ensembl chr 4:125,012,216...125,021,633 		JBrowse link
G Zfp683 zinc finger protein 683 involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr 4:133,778,506...133,786,252
Ensembl chr 4:133,781,149...133,786,307 		JBrowse link
negative regulation of T cell receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Btn2a2 butyrophilin, subfamily 2, member A2 acts_upstream_of_or_within IDA (PMID:23589618) MGI PMID:23589618 NCBI chr13:23,661,219...23,673,028
Ensembl chr13:23,661,846...23,673,027 		JBrowse link
G Btnl2 butyrophilin-like 2 acts_upstream_of_or_within IMP (PMID:16751379) MGI PMID:16751379 NCBI chr17:34,573,763...34,588,466
Ensembl chr17:34,573,796...34,588,469 		JBrowse link
G Btrc beta-transducin repeat containing protein involved_in ISO (PMID:38225265) UniProt PMID:38225265 NCBI chr19:45,352,119...45,521,782
Ensembl chr19:45,352,173...45,518,452 		JBrowse link
G Cblb Casitas B-lineage lymphoma b acts_upstream_of_or_within IMP (PMID:14738763) MGI PMID:14738763 NCBI chr16:51,851,593...52,028,410
Ensembl chr16:51,851,588...52,028,411 		JBrowse link
G Cd160 CD160 antigen involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr 3:96,706,079...96,736,667
Ensembl chr 3:96,706,079...96,736,667 		JBrowse link
G Ceacam1 CEA cell adhesion molecule 1 involved_in ISO (PMID:18424730) UniProt PMID:18424730 NCBI chr 7:25,161,127...25,177,072
Ensembl chr 7:25,161,132...25,177,028 		JBrowse link
G Dgkz diacylglycerol kinase zeta involved_in IMP (MGI:2672999|PMID:12883552) UniProt PMID:12883552 MGI:2672999 NCBI chr 2:91,763,167...91,806,788
Ensembl chr 2:91,763,169...91,806,209 		JBrowse link
G Dusp22 dual specificity phosphatase 22 acts_upstream_of_or_within
involved_in		 IMP
ISO		 (PMID:24714587)
(PMID:38225265)		 MGI
UniProt		 PMID:24714587 PMID:38225265 NCBI chr13:30,844,042...30,895,215
Ensembl chr13:30,843,982...30,895,214 		JBrowse link
G Dusp3 dual specificity phosphatase 3 (vaccinia virus phosphatase VH1-related) involved_in ISO
IBA		 MGI
GO_Central		 GO_REF:0000033 GO_REF:0000119 MGI:4834177 NCBI chr11:101,861,967...101,877,839
Ensembl chr11:101,861,969...101,877,839 		JBrowse link
G Elf1 E74 like ETS transcription factor 1 acts_upstream_of_or_within IGI (PMID:14738763) MGI PMID:14738763 NCBI chr14:79,718,619...79,819,916
Ensembl chr14:79,718,634...79,819,934 		JBrowse link
G Ezr ezrin involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr17:7,005,530...7,050,179
Ensembl chr17:7,005,440...7,050,183 		JBrowse link
G Gbp2b guanylate binding protein 2b involved_in ISO (PMID:24337748) UniProt PMID:24337748 NCBI chr 3:142,300,577...142,324,940
Ensembl chr 3:142,300,608...142,324,940 		JBrowse link
G Laptm5 lysosomal-associated protein transmembrane 5 involved_in IMP (MGI:3803048|PMID:18619870) ARUK-UCL PMID:18619870 MGI:3803048 NCBI chr 4:130,640,627...130,663,459
Ensembl chr 4:130,640,436...130,663,452 		JBrowse link
G Lgals3 lectin, galactose binding, soluble 3 involved_in IMP (MGI:4355752|PMID:19706535) BHF-UCL PMID:19706535 MGI:4355752 NCBI chr14:47,611,317...47,623,624
Ensembl chr14:47,605,208...47,623,617 		JBrowse link
G Lilrb4a leukocyte immunoglobulin-like receptor, subfamily B, member 4A involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr10:51,366,999...51,372,709
Ensembl chr10:51,367,052...51,372,707 		JBrowse link
G Lilrb4b leukocyte immunoglobulin-like receptor, subfamily B, member 4B involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr10:51,356,757...51,362,417
Ensembl chr10:51,356,728...51,362,799 		JBrowse link
G Pawr PRKC, apoptosis, WT1, regulator acts_upstream_of_or_within IMP (PMID:12970181) MGI PMID:12970181 NCBI chr10:108,168,050...108,250,708
Ensembl chr10:108,167,982...108,250,101 		JBrowse link
G Phpt1 phosphohistidine phosphatase 1 involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr 2:25,463,442...25,465,528
Ensembl chr 2:25,463,442...25,465,236 		JBrowse link
G Prnp prion protein involved_in IMP (MGI:4943618|PMID:20145049) BHF-UCL PMID:20145049 MGI:4943618 NCBI chr 2:131,751,848...131,780,356
Ensembl chr 2:131,751,848...131,780,349 		JBrowse link
G Ptpn2 protein tyrosine phosphatase, non-receptor type 2 involved_in IMP (MGI:5320871|PMID:22080863) UniProt PMID:22080863 MGI:5320871 NCBI chr18:67,798,571...67,857,697
Ensembl chr18:67,798,581...67,857,665 		JBrowse link
G Ptpn22 protein tyrosine phosphatase, non-receptor type 22 (lymphoid) involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr 3:103,763,891...103,819,568
Ensembl chr 3:103,767,111...103,819,563 		JBrowse link
G Ptpn6 protein tyrosine phosphatase, non-receptor type 6 acts_upstream_of_or_within IMP (PMID:9064344) MGI PMID:9064344 NCBI chr 6:124,697,670...124,715,672
Ensembl chr 6:124,697,670...124,715,677 		JBrowse link
G Ptprj protein tyrosine phosphatase receptor type J involved_in IDA
ISO		 (MGI:4942249|PMID:12913111) UniProt
MGI		 PMID:12913111 GO_REF:0000119 MGI:4834177 MGI:4942249 NCBI chr 2:90,260,100...90,411,102
Ensembl chr 2:90,260,098...90,410,991 		JBrowse link
G Pvrig poliovirus receptor related immunoglobulin domain containing involved_in ISO
IBA		 MGI
GO_Central		 GO_REF:0000033 GO_REF:0000119 MGI:4834177 NCBI chr 5:138,340,193...138,346,953
Ensembl chr 5:138,340,223...138,341,819 		JBrowse link
G Sh2d1a SH2 domain containing 1A involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr  X:41,591,442...41,610,974
Ensembl chr  X:41,591,330...41,618,207 		JBrowse link
G Sla2 Src-like-adaptor 2 involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr 2:156,716,071...156,729,161
Ensembl chr 2:156,714,377...156,729,112 		JBrowse link
G Thy1 thymus cell antigen 1, theta involved_in IDA (MGI:1096761|PMID:9285719) UniProt PMID:9285719 MGI:1096761 NCBI chr 9:43,954,681...43,959,876
Ensembl chr 9:43,954,681...43,959,876 		JBrowse link
G Ubash3a ubiquitin associated and SH3 domain containing, A involved_in
acts_upstream_of_or_within		 IBA
IGI		 (PMID:14738763) GO_Central
MGI		 PMID:14738763 GO_REF:0000033 NCBI chr17:31,426,842...31,478,655
Ensembl chr17:31,426,847...31,465,866 		JBrowse link
positive regulation of T cell receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ada adenosine deaminase acts_upstream_of_or_within IMP (PMID:11435465) MGI PMID:11435465 NCBI chr 2:163,565,703...163,592,154
Ensembl chr 2:163,568,504...163,592,159 		JBrowse link
G Bcl10 B cell leukemia/lymphoma 10 involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr 3:145,630,017...145,640,121
Ensembl chr 3:145,628,559...145,640,111 		JBrowse link
G Card11 caspase recruitment domain family, member 11 involved_in IMP
ISO		 (MGI:6695669|PMID:12154356) UniProt
MGI		 PMID:12154356 GO_REF:0000119 MGI:4834177 MGI:6695669 NCBI chr 5:140,858,109...140,986,398
Ensembl chr 5:140,858,745...140,986,337 		JBrowse link
G Ccr7 C-C motif chemokine receptor 7 involved_in IMP (MGI:3847607|PMID:17785582) BHF-UCL PMID:17785582 MGI:3847607 NCBI chr11:99,035,025...99,045,903
Ensembl chr11:99,035,022...99,045,903 		JBrowse link
G Cd226 CD226 antigen involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr18:89,195,078...89,290,356
Ensembl chr18:89,195,091...89,290,353 		JBrowse link
G Cd81 CD81 antigen involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr 7:142,606,487...142,621,667
Ensembl chr 7:142,606,476...142,621,671 		JBrowse link
G Cyld CYLD lysine 63 deubiquitinase acts_upstream_of_or_within IMP (PMID:16501569) MGI PMID:16501569 NCBI chr 8:89,423,506...89,478,574
Ensembl chr 8:89,423,675...89,478,573 		JBrowse link
G Ikbkg inhibitor of kappaB kinase gamma involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr  X:73,436,883...73,498,013
Ensembl chr  X:73,436,896...73,497,460 		JBrowse link
G Kcnn4 potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4 involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr 7:24,069,750...24,084,635
Ensembl chr 7:24,069,688...24,086,115 		JBrowse link
G Lipa lysosomal acid lipase A acts_upstream_of_or_within IMP (PMID:19179613) MGI PMID:19179613 NCBI chr19:34,469,716...34,504,874
Ensembl chr19:34,469,718...34,504,874 		JBrowse link
G Nectin2 nectin cell adhesion molecule 2 involved_in ISO
IBA		 MGI
GO_Central		 GO_REF:0000033 GO_REF:0000119 MGI:4834177 NCBI chr 7:19,450,569...19,483,498
Ensembl chr 7:19,450,569...19,484,408 		JBrowse link
G Prkd2 protein kinase D2 involved_in IMP (MGI:4849903|PMID:20819079) UniProt PMID:20819079 MGI:4849903 NCBI chr 7:16,576,827...16,604,386
Ensembl chr 7:16,576,827...16,604,389 		JBrowse link
G Rab29 RAB29, member RAS oncogene family involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr 1:131,795,004...131,801,003
Ensembl chr 1:131,794,962...131,800,625 		JBrowse link
G Rela v-rel reticuloendotheliosis viral oncogene homolog A (avian) involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr19:5,686,993...5,698,162
Ensembl chr19:5,687,511...5,698,158 		JBrowse link
G Rps3 ribosomal protein S3 involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr 7:99,127,103...99,132,916
Ensembl chr 7:99,127,103...99,132,945 		JBrowse link
G Tespa1 thymocyte expressed, positive selection associated 1 involved_in IMP
IBA		 (MGI:5432321|PMID:22561606) UniProt
GO_Central		 PMID:22561606 GO_REF:0000033 MGI:5432321 NCBI chr10:130,158,696...130,199,338
Ensembl chr10:130,158,739...130,199,980 		JBrowse link
G Trat1 T cell receptor associated transmembrane adaptor 1 involved_in
acts_upstream_of_or_within		 IBA
ISO		 (PMID:11390434) GO_Central
MGI		 PMID:11390434 GO_REF:0000033 NCBI chr16:48,551,137...48,630,883
Ensembl chr16:48,551,137...48,592,384 		JBrowse link
G Ubr2 ubiquitin protein ligase E3 component n-recognin 2 involved_in ISO (PMID:38225265) UniProt PMID:38225265 NCBI chr17:47,239,217...47,321,812
Ensembl chr17:47,239,221...47,321,482 		JBrowse link
G Usp12 ubiquitin specific peptidase 12 acts_upstream_of_or_within ISO (PMID:26811477) MGI PMID:26811477 NCBI chr 5:146,671,619...146,731,817
Ensembl chr 5:146,671,619...146,731,816 		JBrowse link
G Usp46 ubiquitin specific peptidase 46 acts_upstream_of_or_within ISO (PMID:26811477) MGI PMID:26811477 NCBI chr 5:74,159,387...74,229,070
Ensembl chr 5:74,159,114...74,229,092 		JBrowse link
regulation of T cell receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bcl10 B cell leukemia/lymphoma 10 acts_upstream_of_or_within IMP (PMID:14614861) MGI PMID:14614861 NCBI chr 3:145,630,017...145,640,121
Ensembl chr 3:145,628,559...145,640,111 		JBrowse link
G Cblb Casitas B-lineage lymphoma b acts_upstream_of_or_within ISO (PMID:26811477) MGI PMID:26811477 NCBI chr16:51,851,593...52,028,410
Ensembl chr16:51,851,588...52,028,411 		JBrowse link
G Cd300a CD300A molecule involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr11:114,780,006...114,792,772
Ensembl chr11:114,780,867...114,795,480 		JBrowse link
G Cyld CYLD lysine 63 deubiquitinase acts_upstream_of_or_within ISO (PMID:26811477) MGI PMID:26811477 NCBI chr 8:89,423,506...89,478,574
Ensembl chr 8:89,423,675...89,478,573 		JBrowse link
G Lck lymphocyte protein tyrosine kinase acts_upstream_of_or_within IDA (PMID:14752163) MGI PMID:14752163 NCBI chr 4:129,442,142...129,467,415
Ensembl chr 4:129,442,137...129,467,434 		JBrowse link
G Malt1 MALT1 paracaspase acts_upstream_of_or_within IMP (PMID:14614861) MGI PMID:14614861 NCBI chr18:65,564,010...65,612,138
Ensembl chr18:65,564,009...65,612,138 		JBrowse link
G Ptpn22 protein tyrosine phosphatase, non-receptor type 22 (lymphoid) involved_in IEA UniProt GO_REF:0000002 MGI:2152098 NCBI chr 3:103,763,891...103,819,568
Ensembl chr 3:103,767,111...103,819,563 		JBrowse link
G Rc3h1 RING CCCH (C3H) domains 1 involved_in IMP (MGI:3580753|PMID:15917799) BHF-UCL PMID:15917799 MGI:3580753 NCBI chr 1:160,733,981...160,802,546
Ensembl chr 1:160,733,988...160,802,548 		JBrowse link
G Tespa1 thymocyte expressed, positive selection associated 1 acts_upstream_of IMP
IDA		 (PMID:28598420) MGI PMID:28598420 NCBI chr10:130,158,696...130,199,338
Ensembl chr10:130,158,739...130,199,980 		JBrowse link
G Usp9x ubiquitin specific peptidase 9, X chromosome acts_upstream_of_or_within ISO (PMID:26811477) MGI PMID:26811477 NCBI chr  X:12,937,221...13,039,567
Ensembl chr  X:12,937,737...13,039,567 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 28576
    immune system process 3142
      activation of immune response 604
        immune response-activating signaling pathway 510
          immune response-activating cell surface receptor signaling pathway 320
            antigen receptor-mediated signaling pathway 200
              T cell receptor signaling pathway 153
                negative regulation of T cell receptor signaling pathway + 28
                positive regulation of T cell receptor signaling pathway 20
                regulation of T cell receptor signaling pathway + 53
                termination of T cell signal transduction 0
Path 2
Term Annotations click to browse term
  biological_process 28576
    biological regulation 13125
      regulation of biological process 12730
        regulation of immune system process 1786
          positive regulation of immune system process 1246
            positive regulation of immune response 837
              activation of immune response 604
                immune response-activating signaling pathway 510
                  immune response-activating cell surface receptor signaling pathway 320
                    antigen receptor-mediated signaling pathway 200
                      T cell receptor signaling pathway 153
                        negative regulation of T cell receptor signaling pathway + 28
                        positive regulation of T cell receptor signaling pathway 20
                        regulation of T cell receptor signaling pathway + 53
                        termination of T cell signal transduction 0
paths to the root