Zap70 (zeta-chain (TCR) associated protein kinase) - Rat Genome Database

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Gene: Zap70 (zeta-chain (TCR) associated protein kinase) Mus musculus
Analyze
Symbol: Zap70
Name: zeta-chain (TCR) associated protein kinase
RGD ID: 11501
MGI Page MGI
Description: Enables ATP binding activity; phosphotyrosine residue binding activity; and protein tyrosine kinase activity. Acts upstream of or within several processes, including T cell receptor signaling pathway; T cell selection; and positive regulation of alpha-beta T cell activation. Located in cell-cell junction; cytosol; and immunological synapse. Is expressed in brain; gut; hemolymphoid system gland; liver; and lung epithelium. Used to study rheumatoid arthritis. Human ortholog(s) of this gene implicated in immunodeficiency 48 and severe combined immunodeficiency. Orthologous to human ZAP70 (zeta chain of T cell receptor associated protein kinase 70).
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: 70 kDa zeta-associated protein; 70 kDa zeta-chain associated protein; 70kDa; AI327364; mrtle; mur; S; Srk; syk-related tyrosine kinase; tyrosine-protein kinase ZAP-70; TZK; ZAP-; ZAP-70
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39136,800,912 - 36,821,899 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl136,800,879 - 36,821,899 (+)EnsemblGRCm39 Ensembl
GRCm38136,761,798 - 36,782,821 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl136,761,798 - 36,782,818 (+)EnsemblGRCm38mm10GRCm38
MGSCv37136,818,706 - 36,839,661 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36136,706,407 - 36,727,362 (+)NCBIMGSCv36mm8
Celera136,542,193 - 36,563,340 (+)NCBICelera
Cytogenetic Map1BNCBI
cM Map115.41NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (ISO)
(1->4)-beta-D-glucan  (EXP)
1,2-dimethylhydrazine  (EXP)
17beta-estradiol  (ISO)
17beta-estradiol 3-benzoate  (ISO)
2,3,4,7,8-Pentachlorodibenzofuran  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
2-amino-4,6-dinitrotoluene  (ISO)
3,3',4,4'-tetrachlorobiphenyl  (EXP)
4,4'-sulfonyldiphenol  (EXP)
6-propyl-2-thiouracil  (ISO)
7,12-dimethyltetraphene  (ISO)
acetamide  (ISO)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
aldehydo-D-glucose  (EXP)
amphetamine  (ISO)
antirheumatic drug  (ISO)
benzo[a]pyrene  (EXP,ISO)
bisphenol A  (EXP,ISO)
cadmium dichloride  (ISO)
calciol  (EXP)
camptothecin  (ISO)
carbon nanotube  (EXP)
cerium trichloride  (EXP)
CGP 52608  (ISO)
chromium(6+)  (EXP)
cisplatin  (EXP)
clofibrate  (EXP)
copper(II) sulfate  (ISO)
cyclophosphamide  (EXP)
D-glucose  (EXP)
dexamethasone  (EXP)
dibutyl phthalate  (ISO)
diethylstilbestrol  (EXP)
dimethylarsinic acid  (EXP)
disodium selenite  (ISO)
entinostat  (ISO)
fructose  (EXP)
fulvestrant  (ISO)
fumonisin B1  (EXP)
furan  (ISO)
gentamycin  (ISO)
glucose  (EXP)
inulin  (EXP)
lead diacetate  (EXP)
methylarsonic acid  (EXP)
N-ethyl-N-nitrosourea  (EXP)
nevirapine  (ISO)
nickel atom  (ISO)
oxaliplatin  (ISO)
paracetamol  (EXP,ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (ISO)
phenobarbital  (EXP)
phenytoin  (EXP)
pirinixic acid  (EXP)
silicon dioxide  (EXP)
sodium arsenate  (EXP)
sodium arsenite  (EXP)
tert-butyl hydroperoxide  (ISO)
testosterone  (ISO)
tetrachloromethane  (ISO)
thioacetamide  (ISO)
topotecan  (ISO)
trichloroethene  (ISO)
triptonide  (EXP)
valproic acid  (ISO)
vanadium atom  (ISO)
vanadium(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal CD4-positive, alpha beta T cell morphology  (IAGP)
abnormal CD8-positive, alpha-beta T cell differentiation  (IAGP)
abnormal class switch recombination  (IAGP)
abnormal cytokine secretion  (IAGP)
abnormal double-positive T cell morphology  (IAGP)
abnormal humoral immune response  (IAGP)
abnormal lymph node cell ratio  (IAGP)
abnormal positive T cell selection  (IAGP)
abnormal pro-B cell differentiation  (IAGP)
abnormal regulatory T cell number  (IAGP)
abnormal regulatory T cell physiology  (IAGP)
abnormal splenic cell ratio  (IAGP)
abnormal T cell activation  (IEA)
abnormal T cell clonal deletion  (IAGP)
abnormal T cell differentiation  (IAGP)
abnormal T cell morphology  (IAGP)
abnormal T cell physiology  (IAGP)
abnormal T cell proliferation  (IAGP)
abnormal T cell selection  (IAGP)
abnormal T cell subpopulation ratio  (IEA)
abnormal thymocyte activation  (IAGP)
abnormal thymus cell ratio  (IAGP)
absent CD4-positive, alpha-beta T cells  (IEA)
absent CD8-positive, alpha-beta T cells  (IEA)
absent T cells  (IEA)
arrested T cell differentiation  (IAGP)
arthritis  (IAGP)
chronic joint inflammation  (IAGP)
decreased CD4-positive, alpha-beta T cell number  (IAGP)
decreased CD4-positive, CD25-positive, alpha-beta regulatory T cell number  (IEA)
decreased CD8-positive, alpha-beta T cell number  (IAGP)
decreased CD8-positive, naive alpha-beta T cell number  (IEA)
decreased IgG level  (IAGP)
decreased interleukin-2 secretion  (IAGP)
decreased regulatory T cell number  (IAGP)
decreased susceptibility to induced arthritis  (IAGP)
decreased T cell number  (IAGP)
decreased T cell proliferation  (IAGP)
fused joints  (IAGP)
impaired hematopoiesis  (IEA)
impaired humoral immune response  (IEA)
increased activated T cell number  (IAGP)
increased autoantibody level  (IAGP)
increased B cell number  (IAGP)
increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number  (IEA)
increased central memory CD4-positive, alpha-beta T cell number  (IEA)
increased central memory CD8 positive, alpha-beta T cell number  (IEA)
increased double-positive T cell number  (IAGP)
increased effector memory CD4-positive, alpha-beta T cell number  (IEA)
increased IgE level  (IAGP)
increased IgG1 level  (IAGP)
increased IgG2b level  (IEA)
increased immunoglobulin level  (IAGP)
increased interleukin-17 secretion  (IAGP)
increased memory T cell number  (IAGP)
increased susceptibility to induced arthritis  (IAGP)
joint dislocation  (IAGP)
joint swelling  (IAGP)
lung inflammation  (IAGP)
mixed cellular infiltration to dermis  (IAGP)
no abnormal phenotype detected  (IAGP)
osteoporosis  (IAGP)
rheumatoid arthritis  (IAGP)
small lymph nodes  (IAGP)
thymus hypoplasia  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. Defective T cell receptor signaling and CD8+ thymic selection in humans lacking zap-70 kinase. Arpaia E, etal., Cell. 1994 Mar 11;76(5):947-58.
2. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
3. MGDs mouse GO annotations MGD data from the GO Consortium
4. MGD IEA MGD IEA
5. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
6. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
7. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
8. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
9. Mouse MP Annotation Import Pipeline RGD automated import pipeline
10. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
11. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
12. Localization of Zap70, the gene for a T cell-specific protein tyrosine kinase, to mouse and rat chromosomes by fluorescence in situ hybridization and molecular genetic linkage analyses. Saito T, etal., Mamm Genome 1997 Jan;8(1):45-6
Additional References at PubMed
PMID:7553892   PMID:7630421   PMID:8082894   PMID:8176201   PMID:8196616   PMID:8551236   PMID:8798454   PMID:9169414   PMID:9182527   PMID:9208839   PMID:9275205   PMID:9324357  
PMID:9794398   PMID:9878110   PMID:10190908   PMID:10349636   PMID:10358158   PMID:10646608   PMID:10662792   PMID:10689303   PMID:10781838   PMID:10963813   PMID:11005864   PMID:11042159  
PMID:11076861   PMID:11114734   PMID:11217851   PMID:11238119   PMID:11514605   PMID:11514606   PMID:11567635   PMID:11836527   PMID:11891219   PMID:12024036   PMID:12244310   PMID:12477932  
PMID:12697763   PMID:12705855   PMID:14515253   PMID:14647385   PMID:14734724   PMID:14738763   PMID:14770180   PMID:14985102   PMID:15143214   PMID:15314695   PMID:15365098   PMID:15536084  
PMID:15599401   PMID:15699074   PMID:15735648   PMID:15735649   PMID:15740591   PMID:15750595   PMID:15781585   PMID:15944285   PMID:16027224   PMID:16116204   PMID:16141072   PMID:16141073  
PMID:16273097   PMID:16327786   PMID:16390939   PMID:16501569   PMID:16602821   PMID:17028588   PMID:17227914   PMID:17606633   PMID:17767948   PMID:17785805   PMID:17878336   PMID:18093540  
PMID:18209059   PMID:18356083   PMID:18408722   PMID:18446234   PMID:18465772   PMID:18711120   PMID:18799150   PMID:19449311   PMID:19841086   PMID:20040762   PMID:20118929   PMID:20298671  
PMID:20332428   PMID:20479941   PMID:20547827   PMID:20641039   PMID:20644168   PMID:20720513   PMID:20846526   PMID:20861360   PMID:20945976   PMID:21037577   PMID:21103055   PMID:21245479  
PMID:21248251   PMID:21393235   PMID:21873635   PMID:21895656   PMID:22242145   PMID:22496360   PMID:22544394   PMID:22732588   PMID:22761313   PMID:23267019   PMID:23305740   PMID:23337809  
PMID:23494777   PMID:23620790   PMID:23793062   PMID:23858460   PMID:24034254   PMID:24164480   PMID:24241693   PMID:24266404   PMID:24312539   PMID:24498279   PMID:24584089   PMID:24596147  
PMID:24760155   PMID:24908390   PMID:25048686   PMID:25092893   PMID:25136127   PMID:25477210   PMID:25601273   PMID:26114424   PMID:26139098   PMID:26390156   PMID:26818004   PMID:26903241  
PMID:26936881   PMID:27040161   PMID:27100879   PMID:27122172   PMID:27195291   PMID:27288531   PMID:27427418   PMID:27533013   PMID:27869819   PMID:28159798   PMID:28455312   PMID:28664612  
PMID:28745977   PMID:28768156   PMID:29202478   PMID:29915297   PMID:29980684   PMID:30150283   PMID:30992398   PMID:31019063   PMID:31137740   PMID:31337738   PMID:31455730   PMID:31641113  
PMID:31911947   PMID:31919358   PMID:33974042   PMID:34161759   PMID:34669443   PMID:35058288   PMID:35999236  


Genomics

Comparative Map Data
Zap70
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39136,800,912 - 36,821,899 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl136,800,879 - 36,821,899 (+)EnsemblGRCm39 Ensembl
GRCm38136,761,798 - 36,782,821 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl136,761,798 - 36,782,818 (+)EnsemblGRCm38mm10GRCm38
MGSCv37136,818,706 - 36,839,661 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36136,706,407 - 36,727,362 (+)NCBIMGSCv36mm8
Celera136,542,193 - 36,563,340 (+)NCBICelera
Cytogenetic Map1BNCBI
cM Map115.41NCBI
ZAP70
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38297,713,576 - 97,756,364 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl297,713,576 - 97,739,862 (+)EnsemblGRCh38hg38GRCh38
GRCh37298,330,039 - 98,356,323 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36297,696,463 - 97,722,755 (+)NCBINCBI36Build 36hg18NCBI36
Build 34297,809,386 - 97,814,841NCBI
Celera292,533,995 - 92,560,286 (+)NCBICelera
Cytogenetic Map2q11.2NCBI
HuRef292,095,689 - 92,121,947 (+)NCBIHuRef
CHM1_1298,334,370 - 98,360,661 (+)NCBICHM1_1
T2T-CHM13v2.0298,171,200 - 98,202,543 (+)NCBIT2T-CHM13v2.0
Zap70
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8946,485,605 - 46,507,552 (+)NCBIGRCr8
mRatBN7.2938,989,750 - 39,011,701 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl938,989,750 - 39,011,700 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx947,492,671 - 47,514,535 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0952,608,543 - 52,630,495 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0950,890,437 - 50,912,386 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0943,331,149 - 43,353,097 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl943,331,155 - 43,353,113 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0942,980,050 - 43,002,015 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4935,693,089 - 35,715,071 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera936,755,106 - 36,777,088 (+)NCBICelera
Cytogenetic Map9q21NCBI
Zap70
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554704,386,311 - 4,396,419 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554704,379,260 - 4,397,851 (+)NCBIChiLan1.0ChiLan1.0
LOC100971372
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21230,715,251 - 30,745,868 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12A30,718,013 - 30,748,630 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02A101,582,567 - 101,613,175 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12A98,613,740 - 98,639,742 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A98,613,740 - 98,639,088 (+)Ensemblpanpan1.1panPan2
ZAP70
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11044,887,416 - 44,913,845 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1044,887,433 - 44,900,071 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1044,814,558 - 44,845,740 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01045,763,554 - 45,794,709 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1045,763,556 - 45,786,952 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11045,475,442 - 45,506,585 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01045,761,536 - 45,792,714 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01045,944,828 - 45,975,965 (-)NCBIUU_Cfam_GSD_1.0
LOC101971458
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629283,747,123 - 83,759,795 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049367441,000,105 - 1,012,433 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049367441,000,105 - 1,012,712 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ZAP70
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl356,515,449 - 56,541,740 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1356,515,446 - 56,541,806 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2359,135,457 - 59,151,701 (-)NCBISscrofa10.2Sscrofa10.2susScr3
LOC103241092
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1141,403,294 - 1,430,205 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl141,404,325 - 1,431,015 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666041168,846,354 - 168,873,240 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
LOC101716577
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247492,893,601 - 2,901,035 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247492,893,601 - 2,901,256 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Zap70
729 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:161
Count of miRNA genes:146
Interacting mature miRNAs:154
Transcripts:ENSMUST00000027291
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1301275Sle10_msystematic lupus erythematosus susceptibility 10 (mouse)Not determined1288219436882352Mouse
1301370Adip1_madiposity 1 (mouse)Not determined1288219436882352Mouse
13824984Twq5_mtestis weight QTL 5 (mouse)13069992184732197Mouse
15092044Wtgrme1_mweek ten growth rate, maternal effect 1 (mouse)1328014237782236Mouse
15092046Wngrme1_mweek nine growth rate, maternal effect 1 (mouse)1328014237782236Mouse
15092048Wsigrme1_mweek six growth rate, maternal effect 1 (mouse)1328014237782236Mouse
15092050Wsegrme1_mweek seven growth rate, maternal effect 1 (mouse)1328014237782236Mouse
15092051Wegrme1_mweek eight growth rate, maternal effect 1 (mouse)1328014237782236Mouse
15092055Lgrme1_mlate growth rate, maternal effect 1 (mouse)1328014237782236Mouse
11039528Ccc3_mcolitis susceptibility in the Collaborative Cross 3 (mouse)13680142195051546Mouse
1301471Obq2_mobesity QTL 2 (mouse)Not determined1394162037941887Mouse
10043970Obq23_mobesity QTL 23 (mouse)Not determined1501266539012665Mouse
1301011Cplaq4_mcircadian period of locomotor activity 4 (mouse)Not determined1967344243673601Mouse
14700685Civq2_mcerebral infarct volume QTL 2 (mouse)11134048245340482Mouse
1301073Orch5_mautoimmune orchitis resistance 5 (mouse)Not determined11906535153065454Mouse
1301756Pgia1_mproteoglycan induced arthritis 1 (mouse)Not determined11906535153065454Mouse
1301240Sluc15_msusceptibility to lung cancer 15 (mouse)Not determined11906535153065454Mouse
12880407V125Dq2_mvitamin D active form serum level QTL 2 (mouse)11933908153339081Mouse
1357475w3q13_mweight 3 weeks QTL 13 (mouse)Not determined12310959173976915Mouse
4142433Hbnr1_mHeligmosomoides bakeri nematode resistance 1 (mouse)Not determined2555019158273271Mouse
11100001Col4a1m1_mcollagen, type IV, alpha 1 modifier 1 (mouse)12555019162946882Mouse
12880409V125Dq1_mvitamin D active form serum level QTL 1 (mouse)12603916060039160Mouse
1357824Estoq4_membryo survival total QTL 4 (mouse)Not determined13476013873976915Mouse
39128207Lwq16_mliver weight QTL 16 (mouse)13476013873976915Mouse
1357759W3q12_mweight 3 weeks QTL 12 (mouse)Not determined13476013873976915Mouse
1357651Lgq5_mlate growth QTL 5 (mouse)Not determined13476013873976915Mouse
1357506W10q6_mweight 10 weeks QTL 6 (mouse)Not determined13476013873976915Mouse
1357524W6q14_mweight 6 weeks QTL 14 (mouse)Not determined13476013873976915Mouse
1357753Kidq2_mkidney weight QTL 2 (mouse)Not determined134760138150193871Mouse
1357488Splq3_mspleen weight QTL 3 (mouse)Not determined134760138150193871Mouse
1558860W10q7_mweight 10 weeks QTL 7 (mouse)Not determined134760138150193871Mouse

Markers in Region
AI327364  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38136,782,608 - 36,782,745UniSTSGRCm38
MGSCv37136,839,453 - 36,839,590UniSTSGRCm37
Celera136,563,132 - 36,563,269UniSTS
Cytogenetic Map1A4-C1UniSTS
Whitehead/MRC_RH1606.8UniSTS


Expression


Sequence


RefSeq Acc Id: ENSMUST00000027291   ⟹   ENSMUSP00000027291
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl136,800,879 - 36,821,899 (+)Ensembl
GRCm38.p6 Ensembl136,761,798 - 36,782,818 (+)Ensembl
RefSeq Acc Id: ENSMUST00000185871   ⟹   ENSMUSP00000139990
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl136,806,015 - 36,810,148 (+)Ensembl
GRCm38.p6 Ensembl136,766,934 - 36,771,067 (+)Ensembl
RefSeq Acc Id: ENSMUST00000186624
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl136,810,073 - 36,811,456 (+)Ensembl
GRCm38.p6 Ensembl136,770,992 - 36,772,375 (+)Ensembl
RefSeq Acc Id: ENSMUST00000190128
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl136,818,065 - 36,821,896 (+)Ensembl
GRCm38.p6 Ensembl136,778,984 - 36,782,815 (+)Ensembl
RefSeq Acc Id: NM_001289612   ⟹   NP_001276541
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39136,818,065 - 36,821,899 (+)NCBI
GRCm38136,778,984 - 36,782,820 (+)NCBI
Celera136,542,130 - 36,563,344 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001289765   ⟹   NP_001276694
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39136,806,156 - 36,821,899 (+)NCBI
GRCm38136,766,934 - 36,782,820 (+)NCBI
Celera136,542,130 - 36,563,344 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001289766   ⟹   NP_001276695
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39136,803,599 - 36,821,899 (+)NCBI
GRCm38136,764,515 - 36,782,820 (+)NCBI
Celera136,542,130 - 36,563,344 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001420650   ⟹   NP_001407579
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39136,806,500 - 36,821,899 (+)NCBI
RefSeq Acc Id: NM_009539   ⟹   NP_033565
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39136,800,912 - 36,821,899 (+)NCBI
GRCm38136,761,798 - 36,782,820 (+)NCBI
MGSCv37136,818,706 - 36,839,661 (+)RGD
Celera136,542,130 - 36,563,344 (+)NCBI
cM Map1 ENTREZGENE
Sequence:
RefSeq Acc Id: NP_033565   ⟸   NM_009539
- Peptide Label: isoform a
- UniProtKB: Q80VV2 (UniProtKB/Swiss-Prot),   P97455 (UniProtKB/Swiss-Prot),   Q8CHJ3 (UniProtKB/Swiss-Prot),   P43404 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001276695   ⟸   NM_001289766
- Peptide Label: isoform b
- Sequence:
RefSeq Acc Id: NP_001276694   ⟸   NM_001289765
- Peptide Label: isoform a
- UniProtKB: Q80VV2 (UniProtKB/Swiss-Prot),   P97455 (UniProtKB/Swiss-Prot),   Q8CHJ3 (UniProtKB/Swiss-Prot),   P43404 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001276541   ⟸   NM_001289612
- Peptide Label: isoform TZK
- UniProtKB: P43404 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSMUSP00000027291   ⟸   ENSMUST00000027291
RefSeq Acc Id: ENSMUSP00000139990   ⟸   ENSMUST00000185871
RefSeq Acc Id: NP_001407579   ⟸   NM_001420650
- Peptide Label: isoform a
- UniProtKB: Q8CHJ3 (UniProtKB/Swiss-Prot),   Q80VV2 (UniProtKB/Swiss-Prot),   P97455 (UniProtKB/Swiss-Prot),   P43404 (UniProtKB/Swiss-Prot)
Protein Domains
Protein kinase   SH2

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P43404-F1-model_v2 AlphaFold P43404 1-618 view protein structure

Promoters
RGD ID:6873460
Promoter ID:EPDNEW_M181
Type:initiation region
Name:Zap70_1
Description:Mus musculus zeta-chain associated protein kinase , transcriptvariant 2, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M182  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38136,761,831 - 36,761,891EPDNEW
RGD ID:6873462
Promoter ID:EPDNEW_M182
Type:single initiation site
Name:Zap70_2
Description:Mus musculus zeta-chain associated protein kinase , transcriptvariant 2, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M181  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38136,770,424 - 36,770,484EPDNEW
RGD ID:6818723
Promoter ID:MM_KWN:457
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Spleen
Transcripts:NM_009539
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36136,818,456 - 36,818,956 (+)MPROMDB
RGD ID:6818724
Promoter ID:MM_KWN:458
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Liver
Transcripts:ENSMUST00000070299,   UC007ARA.1,   UC007ARB.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36136,835,556 - 36,836,056 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:99613 AgrOrtholog
Ensembl Genes ENSMUSG00000026117 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000027291 ENTREZGENE
  ENSMUST00000027291.7 UniProtKB/Swiss-Prot
  ENSMUST00000185871.2 UniProtKB/TrEMBL
  ENSMUST00000190128 ENTREZGENE
Gene3D-CATH 3.30.505.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Transferase(Phosphotransferase) domain 1 UniProtKB/Swiss-Prot
InterPro Kinase-like_dom_sf UniProtKB/Swiss-Prot
  Kinase_SYK/ZAP-70_inter-SH2_sf UniProtKB/Swiss-Prot
  Prot_kinase_dom UniProtKB/Swiss-Prot
  Protein_kinase_ATP_BS UniProtKB/Swiss-Prot
  Ser-Thr/Tyr_kinase_cat_dom UniProtKB/Swiss-Prot
  SH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH2_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SYK/ZAP-70_N_SH2 UniProtKB/Swiss-Prot
  Tyr_kinase_AS UniProtKB/Swiss-Prot
  Tyr_kinase_cat_dom UniProtKB/Swiss-Prot
  Tyr_kinase_non-rcpt_SYK/ZAP70 UniProtKB/Swiss-Prot
KEGG Report mmu:22637 UniProtKB/Swiss-Prot
MGD MGI:99613 ENTREZGENE
NCBI Gene 22637 ENTREZGENE
PANTHER TYROSINE-PROTEIN KINASE UniProtKB/Swiss-Prot
  TYROSINE-PROTEIN KINASE ZAP-70 UniProtKB/Swiss-Prot
Pfam Pkinase_Tyr UniProtKB/Swiss-Prot
  SH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Zap70 PhenoGen
PIRSF TyrPK_SYK UniProtKB/Swiss-Prot
PRINTS SH2DOMAIN UniProtKB/Swiss-Prot
  TYRKINASE UniProtKB/Swiss-Prot
PROSITE PROTEIN_KINASE_ATP UniProtKB/Swiss-Prot
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot
  PROTEIN_KINASE_TYR UniProtKB/Swiss-Prot
  SH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART SH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TyrKc UniProtKB/Swiss-Prot
Superfamily-SCOP SSF55550 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF56112 UniProtKB/Swiss-Prot
UniProt A0A087WQ05_MOUSE UniProtKB/TrEMBL
  P43404 ENTREZGENE
  P97455 ENTREZGENE
  Q80VV2 ENTREZGENE
  Q8CHJ3 ENTREZGENE
  ZAP70_MOUSE UniProtKB/Swiss-Prot
UniProt Secondary P97455 UniProtKB/Swiss-Prot
  Q80VV2 UniProtKB/Swiss-Prot
  Q8CHJ3 UniProtKB/Swiss-Prot