Crkl (v-crk avian sarcoma virus CT10 oncogene homolog-like) - Rat Genome Database

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Pathways
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Gene: Crkl (v-crk avian sarcoma virus CT10 oncogene homolog-like) Mus musculus
Analyze
Symbol: Crkl
Name: v-crk avian sarcoma virus CT10 oncogene homolog-like
RGD ID: 1318358
MGI Page MGI
Description: Enables signaling adaptor activity. Involved in several processes, including positive regulation of Rac protein signal transduction; positive regulation of skeletal muscle acetylcholine-gated channel clustering; and postsynaptic specialization assembly. Acts upstream of or within several processes, including cell surface receptor signaling pathway; circulatory system development; and nervous system development. Located in synapse. Part of protein-containing complex. Is active in neuromuscular junction. Is extrinsic component of postsynaptic membrane. Is expressed in several structures, including branchial arch; central nervous system; genitourinary system; immune system; and musculature. Used to study DiGeorge syndrome and velocardiofacial syndrome. Human ortholog(s) of this gene implicated in chronic myeloid leukemia. Orthologous to human CRKL (CRK like proto-oncogene, adaptor protein).
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: 1110025F07Rik; AA589403; AI325100; Cr; crk-like protein; Crkol; snoop; v-crk sarcoma virus CT10 oncogene homolog (avian)-like; v-crk sarcoma virus CT10 oncogene homolog-like
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391617,269,849 - 17,305,304 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1617,269,851 - 17,305,298 (+)EnsemblGRCm39 Ensembl
GRCm381617,451,985 - 17,487,440 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1617,451,987 - 17,487,434 (+)EnsemblGRCm38mm10GRCm38
MGSCv371617,452,080 - 17,486,348 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361617,365,550 - 17,399,818 (+)NCBIMGSCv36mm8
Celera1618,025,071 - 18,059,338 (+)NCBICelera
Cytogenetic Map16A3NCBI
cM Map1610.82NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
acetylcholine receptor signaling pathway  (IGI)
animal organ morphogenesis  (IMP)
anterior/posterior pattern specification  (IGI)
B cell apoptotic process  (IMP)
blood vessel development  (IGI)
cell chemotaxis  (IGI)
cell migration  (IBA)
cellular response to interleukin-7  (IDA)
cellular response to transforming growth factor beta stimulus  (ISO)
cellular response to xenobiotic stimulus  (IDA)
cerebellar neuron development  (IGI)
cerebral cortex development  (IGI)
chordate pharynx development  (IMP)
cranial skeletal system development  (IMP)
dendrite development  (IGI)
endothelin receptor signaling pathway  (IMP)
enzyme-linked receptor protein signaling pathway  (IBA,IDA,IGI,IMP)
establishment of cell polarity  (IGI)
fibroblast growth factor receptor signaling pathway  (IMP)
heart development  (IGI)
helper T cell diapedesis  (IGI)
hippocampus development  (IGI)
lipid metabolic process  (IGI)
male gonad development  (IMP)
negative regulation of gene expression  (ISO)
negative regulation of protein phosphorylation  (ISO)
neuron migration  (IGI,IMP)
outflow tract morphogenesis  (IMP)
parathyroid gland development  (IGI)
pattern specification process  (IGI)
positive regulation of cell population proliferation  (ISO)
positive regulation of ERK1 and ERK2 cascade  (IBA,IMP,ISO)
positive regulation of glial cell migration  (ISO)
positive regulation of MAPK cascade  (IDA)
positive regulation of protein phosphorylation  (ISO)
positive regulation of Rac protein signal transduction  (IMP)
positive regulation of skeletal muscle acetylcholine-gated channel clustering  (IDA,IGI,IMP)
positive regulation of substrate adhesion-dependent cell spreading  (ISO)
postsynaptic specialization assembly  (IDA,IMP)
reelin-mediated signaling pathway  (IGI,IMP)
regulation of cell adhesion mediated by integrin  (IGI)
regulation of cell growth  (IDA)
regulation of dendrite development  (IGI)
regulation of gene expression  (IMP)
regulation of leukocyte migration  (IGI)
regulation of skeletal muscle acetylcholine-gated channel clustering  (IGI)
regulation of T cell migration  (IGI)
response to fibroblast growth factor  (IMP)
retinoic acid receptor signaling pathway  (IMP)
single fertilization  (IMP)
spermatogenesis  (IMP)
T cell receptor signaling pathway  (IDA)
thymus development  (IGI)
urogenital system development  (IMP)

Cellular Component

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
aberrant origin of the right subclavian artery  (IAGP)
abnormal aortic arch morphology  (IAGP)
abnormal auditory bulla morphology  (IAGP)
abnormal basisphenoid bone morphology  (IAGP)
abnormal caudal vertebrae morphology  (IAGP)
abnormal cerebellar foliation  (IAGP)
abnormal cerebellum development  (IAGP)
abnormal cerebral cortex morphology  (IAGP)
abnormal cerebral cortex pyramidal cell morphology  (IAGP)
abnormal cortical plate morphology  (IAGP)
abnormal cranial ganglia morphology  (IAGP)
abnormal craniofacial morphology  (IAGP)
abnormal dentate gyrus morphology  (IAGP)
abnormal eye development  (IAGP)
abnormal forebrain morphology  (IAGP)
abnormal glossopharyngeal ganglion morphology  (IAGP)
abnormal heart left atrium morphology  (IAGP)
abnormal heart morphology  (IAGP)
abnormal hippocampus morphology  (IAGP)
abnormal hippocampus pyramidal cell layer  (IAGP)
abnormal liver morphology  (IAGP)
abnormal mandible morphology  (IAGP)
abnormal nasal bone morphology  (IAGP)
abnormal oral cavity morphology  (IAGP)
abnormal palatal shelf morphology  (IAGP)
abnormal palatine bone morphology  (IAGP)
abnormal parathyroid gland development  (IAGP)
abnormal pharynx morphology  (IAGP)
abnormal placenta morphology  (IAGP)
abnormal Purkinje cell dendrite morphology  (IAGP)
abnormal thymus development  (IAGP)
abnormal thyroid gland development  (IAGP)
abnormal trigeminal ganglion morphology  (IAGP)
abnormal vagus ganglion morphology  (IAGP)
abnormal zygomatic arch morphology  (IAGP)
absent mandible  (IAGP)
absent tongue  (IAGP)
anophthalmia  (IAGP)
basisphenoid bone hypoplasia  (IAGP)
cleft secondary palate  (IAGP)
cyclopia  (IAGP)
decreased body weight  (IAGP)
decreased cranium height  (IAGP)
decreased mouth size  (IAGP)
delayed palatal shelf elevation  (IAGP)
dilated heart right atrium  (IAGP)
double outlet right ventricle  (IAGP)
ectopic cerebellar granule cells  (IAGP)
embryonic lethality, complete penetrance  (IAGP)
holoprosencephaly  (IAGP)
increased B cell derived lymphoma incidence  (IAGP)
increased cranium width  (IAGP)
increased leukemia incidence  (IAGP)
increased palatal shelf size  (IAGP)
interrupted aortic arch  (IAGP)
kinked tail  (IAGP)
lethality throughout fetal growth and development, complete penetrance  (IAGP)
mandible hypoplasia  (IAGP)
maxilla hypoplasia  (IAGP)
microphthalmia  (IAGP)
ocular hypertelorism  (IAGP)
ocular hypotelorism  (IAGP)
otic hypertelorism  (IAGP)
overriding aortic valve  (IAGP)
pallor  (IAGP)
perinatal lethality, incomplete penetrance  (IAGP)
postnatal growth retardation  (IAGP)
postnatal lethality  (IAGP)
postnatal lethality, incomplete penetrance  (IAGP)
premature death  (IAGP)
premaxilla hypoplasia  (IAGP)
proboscis  (IAGP)
short frontal bone  (IAGP)
small cerebellum  (IAGP)
thin cerebellar molecular layer  (IAGP)
tongue hypoplasia  (IAGP)
ventricular septal defect  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. Met, metastasis, motility and more. Birchmeier C, etal., Nat Rev Mol Cell Biol. 2003 Dec;4(12):915-25.
2. Phosphorylation levels of BCR-ABL, CrkL, AKT and STAT5 in imatinib-resistant chronic myeloid leukemia cells implicate alternative pathway usage as a survival strategy. Jilani I, etal., Leuk Res. 2008 Apr;32(4):643-9. doi: 10.1016/j.leukres.2007.08.009. Epub 2007 Sep 27.
3. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
4. MGDs mouse GO annotations MGD data from the GO Consortium
5. MGD IEA MGD IEA
6. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
7. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
8. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
9. Mouse MP Annotation Import Pipeline RGD automated import pipeline
10. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
11. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
12. Active (p)CrkL is overexpressed in human malignancies: potential role as a surrogate parameter for therapeutic tyrosine kinase inhibition. Singer CF, etal., Oncol Rep. 2006 Feb;15(2):353-9.
13. Overexpression of CRKL correlates with malignant cell proliferation in breast cancer. Zhao T, etal., Tumour Biol. 2013 Oct;34(5):2891-7. doi: 10.1007/s13277-013-0851-7. Epub 2013 May 19.
Additional References at PubMed
PMID:7478571   PMID:8653787   PMID:8889548   PMID:8978305   PMID:9067577   PMID:9315092   PMID:10349636   PMID:10391678   PMID:10922068   PMID:11031258   PMID:11042159   PMID:11069064  
PMID:11076861   PMID:11242111   PMID:11245441   PMID:11443118   PMID:11804588   PMID:12082638   PMID:12477932   PMID:12665586   PMID:12671687   PMID:12697763   PMID:14515252   PMID:14610273  
PMID:14614146   PMID:14622576   PMID:15062102   PMID:15110774   PMID:15316068   PMID:15345747   PMID:15592455   PMID:15778864   PMID:15782199   PMID:16141072   PMID:16141073   PMID:16399079  
PMID:16399080   PMID:16443220   PMID:16602821   PMID:16778019   PMID:17394141   PMID:17967808   PMID:18287559   PMID:18305217   PMID:18477607   PMID:18848351   PMID:18957220   PMID:19074029  
PMID:19307307   PMID:19587446   PMID:19823681   PMID:20136656   PMID:20697350   PMID:20807813   PMID:20884876   PMID:21041412   PMID:21267068   PMID:21700719   PMID:21873635   PMID:21879738  
PMID:22244889   PMID:22251701   PMID:22253690   PMID:22921202   PMID:23469164   PMID:24166500   PMID:24472646   PMID:24499776   PMID:24586749   PMID:25557916   PMID:25565927   PMID:25621495  
PMID:25658046   PMID:25661331   PMID:25960220   PMID:26370502   PMID:26527617   PMID:27807028   PMID:28121514   PMID:28378742   PMID:28439006   PMID:29360039   PMID:29581031   PMID:30333137  
PMID:30457570   PMID:30538176   PMID:31138677   PMID:32041892   PMID:32325033   PMID:32736680   PMID:33269541   PMID:33768715   PMID:34163073   PMID:34273377   PMID:34686881   PMID:35559672  
PMID:36417873   PMID:37702066  


Genomics

Comparative Map Data
Crkl
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391617,269,849 - 17,305,304 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1617,269,851 - 17,305,298 (+)EnsemblGRCm39 Ensembl
GRCm381617,451,985 - 17,487,440 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1617,451,987 - 17,487,434 (+)EnsemblGRCm38mm10GRCm38
MGSCv371617,452,080 - 17,486,348 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361617,365,550 - 17,399,818 (+)NCBIMGSCv36mm8
Celera1618,025,071 - 18,059,338 (+)NCBICelera
Cytogenetic Map16A3NCBI
cM Map1610.82NCBI
CRKL
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382220,917,407 - 20,953,747 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2220,917,407 - 20,953,747 (+)EnsemblGRCh38hg38GRCh38
GRCh372221,271,695 - 21,308,035 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362219,601,714 - 19,637,890 (+)NCBINCBI36Build 36hg18NCBI36
Build 342219,596,267 - 19,632,443NCBI
Celera224,763,059 - 4,799,374 (+)NCBICelera
Cytogenetic Map22q11.21ENTREZGENE
HuRef224,539,711 - 4,576,600 (+)NCBIHuRef
CHM1_12221,271,912 - 21,308,243 (+)NCBICHM1_1
T2T-CHM13v2.02221,326,128 - 21,362,450 (+)NCBIT2T-CHM13v2.0
Crkl
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81197,033,033 - 97,067,457 (-)NCBIGRCr8
mRatBN7.21183,528,788 - 83,563,214 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1183,526,530 - 83,563,238 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1192,256,298 - 92,290,727 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01184,917,451 - 84,951,879 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01183,971,055 - 84,005,485 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01187,338,606 - 87,356,644 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1187,778,312 - 87,815,043 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01190,397,653 - 90,408,448 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41185,520,244 - 85,554,667 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11185,560,841 - 85,595,264 (-)NCBI
Celera1182,297,248 - 82,331,672 (-)NCBICelera
Cytogenetic Map11q23NCBI
Crkl
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544219,358,081 - 19,388,815 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495544219,358,202 - 19,388,552 (-)NCBIChiLan1.0ChiLan1.0
CRKL
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22330,622,858 - 30,660,228 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12233,172,806 - 33,209,143 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0223,141,147 - 3,177,448 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12219,632,359 - 19,668,858 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2219,632,359 - 19,668,858 (+)Ensemblpanpan1.1panPan2
CRKL
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12630,542,276 - 30,582,479 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2630,545,311 - 30,581,964 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2630,499,506 - 30,540,212 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02631,950,077 - 31,990,503 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2631,950,075 - 31,990,495 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12629,995,836 - 30,036,268 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02629,619,771 - 29,660,610 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02630,708,885 - 30,749,836 (-)NCBIUU_Cfam_GSD_1.0
Crkl
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118140,267,911 - 140,306,379 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366192,447,614 - 2,479,805 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366192,447,686 - 2,479,589 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CRKL
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1450,528,955 - 50,558,662 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11450,528,950 - 50,558,664 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21453,977,699 - 54,007,396 (+)NCBISscrofa10.2Sscrofa10.2susScr3
LOC103222955
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1194,855,633 - 4,889,674 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl194,855,611 - 4,890,302 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660852,080,371 - 2,099,812 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Crkl
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624945734,532 - 767,168 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624945734,532 - 767,184 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Crkl
921 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:819
Count of miRNA genes:537
Interacting mature miRNAs:637
Transcripts:ENSMUST00000006293
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4141060Pbwg19_mpostnatal body weight growth 19 (mouse)Not determined16120780888Mouse
1300632Loca2_mlocomotor activity 2 (mouse)Not determined16122500574Mouse
10043879Adip25_madiposity 25 (mouse)Not determined16122520318Mouse
1301575Tanidd3_mtally ho associated non-insulin dependednt diabetes mellitus 3 (mouse)Not determined16122897739Mouse
4141468Nhdlq10_mnon-HDL QTL 10 (mouse)Not determined16124263853Mouse
1301970Heal11_mwound healing/regeneration 11 (mouse)Not determined16124263853Mouse
1301384Dice1_mdetermination of interleukin 4 commitment 1 (mouse)Not determined16128434358Mouse
10402497Lmr23_mleishmaniasis resistance 23 (mouse)Not determined16129674200Mouse
1301559Bbaa19_mB.burgdorferi-associated arthritis 19 (mouse)Not determined16130066977Mouse
10412289Ppsl_mplasma P-selectin levels (mouse)Not determined16130814572Mouse
27095908Scvln7_msacral vertebrae length 2, 5 week (mouse)16331786439820362Mouse
27226768Tibl9_mtibia length 9, 5 week (mouse)16331786451420363Mouse
27226785Feml12_mfemur length 12, 5 week (mouse)16331786464620363Mouse
26884432Zlq7_mzygomatic length QTL 7, 10 week (mouse)16381786464620363Mouse
38501069Tip4_mtuberculosis immunophenotype 4, IFN-g level (mouse)16431786444520363Mouse
1301443Mopkd2_mmodifier of polycystic kidney disease progression 2 (mouse)Not determined16464631438646414Mouse
1300656Bgeq15_mbody growth early QTL 15 (mouse)Not determined16577525239775440Mouse
1301945Skl7_mskeletal size (tail length) 7 (mouse)Not determined16577525239775440Mouse
1300943Skts9_mskin tumor susceptibility 9 (mouse)Not determined16577525239775440Mouse
1300987Skull23_mskull morphology 23 (mouse)Not determined16577525239775440Mouse
4141010Bbq1_mbrain and behavior QTL 1 (mouse)Not determined16647700935021216Mouse
1357763Lp1_mlymphocyte proliferation 1 (mouse)Not determined16654297965466552Mouse
4142460Nilac10_mnicotine induced locomotor activity 10 (mouse)Not determined16713690629225471Mouse
11251724Ewc6_methanol withdrawal and consumption 6 (mouse)16822605242226052Mouse
26884376Skwq4_mskull length QTL 4, 5 week (mouse)16841786490896888Mouse
10043978Obq35_mobesity QTL 35 (mouse)Not determined16988163143881631Mouse
1301086Lprm5_mlymphoproliferation modifier 5 (mouse)Not determined161184882445848923Mouse
1301841Lrnx9_mlearning-contextual 9 (mouse)Not determined161222536046225471Mouse
15092082Igly9_mIgG glycosylation 9, GP17b (mouse)161477522320103513Mouse
10045614Rapop6_mradiation-induced apoptosis 6 (mouse)Not determined161480292148803032Mouse
4142236Pstc4_mperiosteal circumference 4 (mouse)Not determined161552290949523112Mouse

Markers in Region
Crkl  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map16A3UniSTS
cM Map16 UniSTS
AI325100  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381617,486,986 - 17,487,070UniSTSGRCm38
MGSCv371617,487,079 - 17,487,163UniSTSGRCm37
Celera1618,060,069 - 18,060,153UniSTS
Cytogenetic Map16A3UniSTS
Whitehead/MRC_RH16135.37UniSTS
RH124950  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381617,486,724 - 17,486,999UniSTSGRCm38
MGSCv371617,486,817 - 17,487,092UniSTSGRCm37
Celera1618,059,807 - 18,060,082UniSTS
Cytogenetic Map16A3UniSTS
Crkl  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map16A3UniSTS
cM Map16 UniSTS


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001277231 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_007764 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC113006 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK003911 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK048641 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK052315 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK087977 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK163981 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK190177 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK194029 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK199065 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK199724 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK200954 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK202766 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK204273 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AW541802 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC023080 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC131984 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC131986 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BF453354 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BF464821 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BY471344 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CA328740 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466521 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ714536 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X90648 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSMUST00000006293   ⟹   ENSMUSP00000006293
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1617,269,851 - 17,305,298 (+)Ensembl
GRCm38.p6 Ensembl1617,451,987 - 17,487,434 (+)Ensembl
RefSeq Acc Id: ENSMUST00000231228   ⟹   ENSMUSP00000155860
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1617,269,903 - 17,286,889 (+)Ensembl
GRCm38.p6 Ensembl1617,452,039 - 17,469,025 (+)Ensembl
RefSeq Acc Id: ENSMUST00000231629   ⟹   ENSMUSP00000156063
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1617,270,340 - 17,301,991 (+)Ensembl
GRCm38.p6 Ensembl1617,452,476 - 17,484,127 (+)Ensembl
RefSeq Acc Id: NM_001277231   ⟹   NP_001264160
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391617,269,849 - 17,305,304 (+)NCBI
GRCm381617,451,985 - 17,487,440 (+)NCBI
Celera1618,025,069 - 18,060,523 (+)NCBI
Sequence:
RefSeq Acc Id: NM_007764   ⟹   NP_031790
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391617,269,849 - 17,305,304 (+)NCBI
GRCm381617,451,985 - 17,487,440 (+)NCBI
MGSCv371617,452,080 - 17,486,348 (+)RGD
Celera1618,025,069 - 18,060,523 (+)NCBI
cM Map16 ENTREZGENE
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_031790   ⟸   NM_007764
- Peptide Label: isoform 1
- UniProtKB: Q3TQ18 (UniProtKB/Swiss-Prot),   Q8BGC5 (UniProtKB/Swiss-Prot),   P47941 (UniProtKB/Swiss-Prot),   A2RS58 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001264160   ⟸   NM_001277231
- Peptide Label: isoform 2
- UniProtKB: A0A338P6Q0 (UniProtKB/TrEMBL),   Q8R5B8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000006293   ⟸   ENSMUST00000006293
RefSeq Acc Id: ENSMUSP00000156063   ⟸   ENSMUST00000231629
RefSeq Acc Id: ENSMUSP00000155860   ⟸   ENSMUST00000231228
Protein Domains
SH2   SH3

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P47941-F1-model_v2 AlphaFold P47941 1-303 view protein structure

Promoters
RGD ID:6826939
Promoter ID:MM_KWN:20307
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:NM_007764
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361617,451,811 - 17,452,637 (+)MPROMDB
RGD ID:8685610
Promoter ID:EPDNEW_M20836
Type:initiation region
Name:Crkl_1
Description:Mus musculus v-crk avian sarcoma virus CT10 oncogene homolog-like, transcript variant 2, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381617,452,023 - 17,452,083EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:104686 AgrOrtholog
Ensembl Genes ENSMUSG00000006134 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000006293 ENTREZGENE
  ENSMUST00000006293.5 UniProtKB/Swiss-Prot
  ENSMUST00000231228.2 UniProtKB/TrEMBL
  ENSMUST00000231629 ENTREZGENE
  ENSMUST00000231629.2 UniProtKB/TrEMBL
Gene3D-CATH 3.30.505.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3 Domains UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro CRK_SH3_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CRK_SH3_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH2_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3_domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:12929 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:104686 ENTREZGENE
NCBI Gene 12929 ENTREZGENE
PANTHER CRK-LIKE PROTEIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH2-SH3 ADAPTOR PROTEIN-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam SH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Crkl PhenoGen
PRINTS SH2DOMAIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3DOMAIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE SH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART SH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF50044 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF55550 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A338P675_MOUSE UniProtKB/TrEMBL
  A0A338P6Q0 ENTREZGENE, UniProtKB/TrEMBL
  A2RS58 ENTREZGENE, UniProtKB/TrEMBL
  CRKL_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q3TQ18 ENTREZGENE
  Q8BGC5 ENTREZGENE
  Q8R5B8 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary Q3TQ18 UniProtKB/Swiss-Prot
  Q8BGC5 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-12-22 Crkl  v-crk avian sarcoma virus CT10 oncogene homolog-like    v-crk sarcoma virus CT10 oncogene homolog (avian)-like  Symbol and/or name change 5135510 APPROVED