Psen2 (presenilin 2) - Rat Genome Database

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Keyword

Gene: Psen2 (presenilin 2) Mus musculus

Symbol:

Psen2

Name:

presenilin 2

Description:

This gene encodes a member of the presenilin family. Presenilins are catalytic components of the multi-subunit gamma-secretase complex, which mediates critical cellular processes through cleavage of type I transmembrane proteins including Notch receptors and the amyloid precursor protein. The encoded protein contains eight transmembrane domains and is localized to the endoplasmic reticulum, where it may play a role in calcium homeostasis. Following assembly of the gamma-secretase complex, the encoded protein is cleaved into N- and C-terminal fragments and the activated complex is released from the endoplasmic reticulum. Inactivation of this gene results in impaired synaptic function in a mouse model for Alzheimer's disease. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Apr 2011]

Type:

protein-coding

RefSeq Status:

REVIEWED

Also known as:

Ad4h; AI266870; ALG-3; Alg3; OTTMUSP00000023891; OTTMUSP00000023892; OTTMUSP00000023893; OTTMUSP00000023894; OTTMUSP00000023895; presenilin-2; PS-2; PS2; Psnl2; STM2

Orthologs:

Homo sapiens : PSEN2 (presenilin 2 (Alzheimer disease 4)) HGNC
Rattus norvegicus : Psen2 (presenilin 2)

Latest Assembly:

Mouse Genome Assembly Build 37

Position:

Map	Chr	Position	Strand	Source
Mouse Genome Assembly GRCm38	1	180,227,004 - 180,256,300	-	NCBI
Mouse cM Map	1	84.19		NCBI
Mouse Celera Assembly	1	187,291,668 - 187,320,266	-	NCBI
Mouse Genome Assembly Build 37	1	182,157,135 - 182,186,431	-	NCBI
Mouse Genome Assembly Build 36.1	1	182,157,137 - 182,176,032	-	NCBI
Mouse Cytogenetic Map	1	H4		NCBI