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ONTOLOGY REPORT - ANNOTATIONS

Term:serine-type endopeptidase inhibitor activity
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Accession:GO:0004867 term browser browse the term
Definition:Binds to and stops, prevents or reduces the activity of a serine-type endopeptidase.
Synonyms:narrow_synonym: serine protease inhibitor activity;   serine proteinase inhibitor activity;   serpin activity
 xref: reactome:R-HSA-158795 "fibrin multimer, crosslinked:tissue plasminogen activator (one-chain) + plasminogen activator inhibitor 1 -> fibrin multimer, crosslinked:tissue plasminogen activator (one-chain):plasminogen activator inhibitor 1";   reactome:R-HSA-158800 "fibrin multimer, crosslinked:tissue plasminogen activator (two-chain) + plasminogen activator inhibitor 1 -> fibrin multimer, crosslinked:tissue plasminogen activator (two-chain):plasminogen activator inhibitor 1";   reactome:R-HSA-158893 "alpha-2-antiplasmin + plasmin -> alpha-2-antiplasmin:plasmin";   reactome:R-HSA-159001 "urokinase plasminogen activator (two-chain):uPAR + plasminogen activator inhibitor 2 (PAI-2) -> PAI-2:urokinase plasminogen activator (two-chain):uPAR";   reactome:R-HSA-159005 "urokinase plasminogen activator (two-chain):uPAR + plasminogen activator inhibitor 1 (PAI-1) -> PAI-1:urokinase plasminogen activator (two-chain):uPAR"

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serine-type endopeptidase inhibitor activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G A2ML1 alpha-2-macroglobulin like 1 enables IEA UniProt GO_REF:0000043 NCBI chr11:8,638,320...8,695,696
Ensembl chr11:8,638,826...8,693,355 		JBrowse link
G AGT angiotensinogen enables IEA InterPro
TreeGrafter		 GO_REF:0000002 GO_REF:0000118 NCBI chr25:67,964,840...67,977,006
Ensembl chr25:67,962,401...67,973,324 		JBrowse link
G AMBP alpha-1-microglobulin/bikunin precursor enables ISO
IEA		 RGD
InterPro		 PMID:11307954 GO_REF:0000002 RGD:6904220 NCBI chr12:25,508,516...25,526,821
Ensembl chr12:25,508,682...25,527,016 		JBrowse link
G ANOS1 anosmin 1 enables ISO (MGI:4830019|PMID:20709948) CACAO PMID:20709948 MGI:4830019 NCBI chr  X:7,012,410...7,223,223 JBrowse link
G ANOS1 anosmin 1 enables IEA UniProt GO_REF:0000043 Ensembl chr  X:7,015,529...7,070,274 JBrowse link
G ANXA2 annexin A2 enables ISO (PMID:22848640) BHF-UCL PMID:22848640 NCBI chr26:23,100,000...23,147,687
Ensembl chr26:23,099,992...23,145,457 		JBrowse link
G APLP2 amyloid beta precursor like protein 2 enables IEA InterPro
Ensembl		 GO_REF:0000002 GO_REF:0000107 NCBI chr 1:121,150,296...121,224,511
Ensembl chr 1:121,150,291...121,224,534 		JBrowse link
G APP amyloid beta precursor protein enables IEA UniProt
Ensembl
InterPro		 GO_REF:0000002 GO_REF:0000043 GO_REF:0000107 NCBI chr 2:66,037,224...66,320,860
Ensembl chr 2:66,037,261...66,321,306 		JBrowse link
G CD109 CD109 molecule enables IEA UniProt GO_REF:0000043 NCBI chr17:1,322,681...1,461,945
Ensembl chr17:1,324,105...1,416,491 		JBrowse link
G COL28A1 collagen type XXVIII alpha 1 chain enables IEA InterPro GO_REF:0000002 NCBI chr21:50,667,287...50,844,773
Ensembl chr21:50,671,247...50,843,083 		JBrowse link
G COL6A3 collagen type VI alpha 3 chain enables IEA InterPro GO_REF:0000002 NCBI chr10:123,326,337...123,418,836
Ensembl chr10:123,327,102...123,400,114 		JBrowse link
G COL7A1 collagen type VII alpha 1 chain enables IEA InterPro GO_REF:0000002 NCBI chr22:9,964,652...9,996,785
Ensembl chr22:9,964,651...9,996,626 		JBrowse link
G CPAMD8 C3 and PZP like alpha-2-macroglobulin domain containing 8 enables IEA UniProt GO_REF:0000043 NCBI chr 6:15,401,910...15,521,797
Ensembl chr 6:15,402,051...15,521,390 		JBrowse link
G CRIM1 cysteine rich transmembrane BMP regulator 1 enables IEA InterPro GO_REF:0000002 NCBI chr14:70,868,523...71,067,086
Ensembl chr14:70,870,839...71,067,215 		JBrowse link
G FURIN furin, paired basic amino acid cleaving enzyme enables ISO (PMID:10567353) BHF-UCL PMID:10567353 NCBI chr29:8,980,367...8,992,257
Ensembl chr29:8,979,720...8,988,235 		JBrowse link
G HRG histidine rich glycoprotein enables IEA TreeGrafter GO_REF:0000118 NCBI chr15:2,753,819...2,766,946
Ensembl chr15:2,753,810...2,766,478 		JBrowse link
G ITIH1 inter-alpha-trypsin inhibitor heavy chain 1 enables IEA InterPro GO_REF:0000002 NCBI chr22:14,159,702...14,174,627
Ensembl chr22:14,160,680...14,174,641 		JBrowse link
G ITIH2 inter-alpha-trypsin inhibitor heavy chain 2 enables IEA InterPro
UniProt		 GO_REF:0000002 GO_REF:0000043 NCBI chr 9:7,748,818...7,794,932
Ensembl chr 9:7,749,464...7,794,933 		JBrowse link
G ITIH3 inter-alpha-trypsin inhibitor heavy chain 3 enables IEA InterPro
UniProt		 GO_REF:0000002 GO_REF:0000043 NCBI chr22:14,176,656...14,191,256
Ensembl chr22:14,177,334...14,191,353 		JBrowse link
G ITIH4 inter-alpha-trypsin inhibitor heavy chain 4 enables IEA UniProt
InterPro		 GO_REF:0000002 GO_REF:0000043 NCBI chr22:14,194,979...14,216,180
Ensembl chr22:14,195,701...14,213,603 		JBrowse link
G ITIH5 inter-alpha-trypsin inhibitor heavy chain 5 enables IEA UniProt
InterPro		 GO_REF:0000002 GO_REF:0000043 NCBI chr 9:7,621,779...7,723,731
Ensembl chr 9:7,617,999...7,723,662 		JBrowse link
G ITIH6 inter-alpha-trypsin inhibitor heavy chain family member 6 enables IEA UniProt
InterPro		 GO_REF:0000002 GO_REF:0000043 NCBI chr  X:50,847,762...50,889,414
Ensembl chr  X:50,848,078...50,888,786 		JBrowse link
G LOC103218542 alpha-2-macroglobulin enables IEA UniProt
Ensembl		 GO_REF:0000043 GO_REF:0000107 NCBI chr11:8,885,903...8,934,503
Ensembl chr11:8,883,181...8,934,638 		JBrowse link
G LOC103218553 ovostatin homolog 2-like enables IEA UniProt GO_REF:0000043 NCBI chr11:9,399,627...9,447,366 JBrowse link
G LOC103229611 putative alpha-1-antitrypsin-related protein enables IEA InterPro
TreeGrafter		 GO_REF:0000002 GO_REF:0000118 NCBI chr24:72,140,258...72,148,478
Ensembl chr24:72,139,965...72,145,320 		JBrowse link
G LOC103241700 collagen alpha-4(VI) chain-like enables IEA InterPro GO_REF:0000002 NCBI chr15:59,894,622...59,995,003 JBrowse link
G LOC103244145 serpin B8 enables IEA Ensembl
InterPro		 GO_REF:0000002 GO_REF:0000107 NCBI chr18:15,766,510...15,787,350
Ensembl chr18:15,765,671...15,787,370 		JBrowse link
G LOC103244151 serpin B6 enables IEA InterPro GO_REF:0000002 NCBI chr18:15,799,445...15,844,430 JBrowse link
G LOC103244154 serpin B4 enables IEA InterPro
TreeGrafter		 GO_REF:0000002 GO_REF:0000118 NCBI chr18:16,127,267...16,133,698 JBrowse link
G LOC103245345 eppin enables IEA InterPro
UniProt		 GO_REF:0000002 GO_REF:0000043 NCBI chr 2:18,289,659...18,295,622
Ensembl chr 2:18,290,916...18,295,317 		JBrowse link
G MANSC4 MANSC domain containing 4 enables IEA TreeGrafter GO_REF:0000118 Ensembl chr11:27,483,063...27,488,507 JBrowse link
G PAPLN papilin, proteoglycan like sulfated glycoprotein enables IEA InterPro GO_REF:0000002 NCBI chr24:50,479,932...50,528,284
Ensembl chr24:50,493,117...50,526,322 		JBrowse link
G PCSK1N proprotein convertase subtilisin/kexin type 1 inhibitor enables ISO (PMID:10632593) MGI PMID:10632593 NCBI chr  X:45,957,760...45,962,588
Ensembl chr  X:45,957,715...45,962,601 		JBrowse link
G PI3 peptidase inhibitor 3 enables IEA UniProt
TreeGrafter		 GO_REF:0000043 GO_REF:0000118 NCBI chr 2:18,649,456...18,652,660
Ensembl chr 2:18,649,353...18,651,148 		JBrowse link
G PZP PZP alpha-2-macroglobulin like enables IEA UniProt GO_REF:0000043 NCBI chr11:8,963,883...9,023,148
Ensembl chr11:8,963,461...9,014,957 		JBrowse link
G SERPINA1 serpin family A member 1 enables ISO
IEA		 RGD
TreeGrafter
UniProt
InterPro		 PMID:19240864 GO_REF:0000002 GO_REF:0000043 GO_REF:0000118 RGD:7411612 NCBI chr24:72,158,521...72,171,139
Ensembl chr24:72,156,784...72,163,500 		JBrowse link
G SERPINA10 serpin family A member 10 enables IEA InterPro GO_REF:0000002 NCBI chr24:72,059,523...72,069,989
Ensembl chr24:72,058,780...72,069,085 		JBrowse link
G SERPINA11 serpin family A member 11 enables IEA InterPro
TreeGrafter		 GO_REF:0000002 GO_REF:0000118 NCBI chr24:72,223,849...72,236,880
Ensembl chr24:72,223,638...72,232,543 		JBrowse link
G SERPINA12 serpin family A member 12 enables IEA InterPro
TreeGrafter		 GO_REF:0000002 GO_REF:0000118 NCBI chr24:72,273,041...72,285,367
Ensembl chr24:72,273,186...72,285,157 		JBrowse link
G SERPINA3 serpin family A member 3 enables IEA InterPro
TreeGrafter		 GO_REF:0000002 GO_REF:0000118 NCBI chr24:72,388,948...72,415,746
Ensembl chr24:72,402,560...72,415,507 		JBrowse link
G SERPINA4 serpin family A member 4 enables IEA InterPro
TreeGrafter		 GO_REF:0000002 GO_REF:0000118 NCBI chr24:72,345,566...72,356,257
Ensembl chr24:72,347,261...72,356,416 		JBrowse link
G SERPINA5 serpin family A member 5 enables ISO
IEA		 RGD
TreeGrafter
InterPro
Ensembl		 PMID:16088033 GO_REF:0000002 GO_REF:0000107 GO_REF:0000118 RGD:1580291 NCBI chr24:72,369,082...72,388,439
Ensembl chr24:72,381,119...72,384,903 		JBrowse link
G SERPINA6 serpin family A member 6 enables IEA InterPro
TreeGrafter		 GO_REF:0000002 GO_REF:0000118 NCBI chr24:72,079,084...72,098,549
Ensembl chr24:72,077,274...72,098,154 		JBrowse link
G SERPINA7 serpin family A member 7 enables IEA InterPro
TreeGrafter		 GO_REF:0000002 GO_REF:0000118 NCBI chr  X:93,895,103...93,899,718
Ensembl chr  X:93,894,788...93,898,738 		JBrowse link
G SERPINA9 serpin family A member 9 enables IEA InterPro
TreeGrafter
Ensembl		 GO_REF:0000002 GO_REF:0000107 GO_REF:0000118 NCBI chr24:72,247,517...72,255,199
Ensembl chr24:72,248,001...72,254,999 		JBrowse link
G SERPINB1 serpin family B member 1 enables IEA InterPro
TreeGrafter		 GO_REF:0000002 GO_REF:0000118 NCBI chr17:69,318,919...69,327,733
Ensembl chr17:69,319,302...69,328,865 		JBrowse link
G SERPINB10 serpin family B member 10 enables IEA InterPro GO_REF:0000002 NCBI chr18:15,878,552...15,903,891
Ensembl chr18:15,878,191...15,894,609 		JBrowse link
G SERPINB11 serpin family B member 11 enables IEA InterPro
TreeGrafter		 GO_REF:0000002 GO_REF:0000118 NCBI chr18:16,075,310...16,096,437
Ensembl chr18:16,075,796...16,088,987 		JBrowse link
G SERPINB12 serpin family B member 12 enables IEA InterPro
TreeGrafter
Ensembl		 GO_REF:0000002 GO_REF:0000107 GO_REF:0000118 NCBI chr18:16,193,673...16,208,866
Ensembl chr18:16,194,694...16,206,029 		JBrowse link
G SERPINB13 serpin family B member 13 NOT|enables ISO
IEA		 (PMID:12504904) UniProt
InterPro		 PMID:12504904 GO_REF:0000002 NCBI chr18:16,163,247...16,175,953
Ensembl chr18:16,165,054...16,173,438 		JBrowse link
G SERPINB2 serpin family B member 2 enables IEA InterPro GO_REF:0000002 NCBI chr18:15,906,461...15,922,636
Ensembl chr18:15,906,469...15,922,594 		JBrowse link
G SERPINB5 serpin family B member 5 enables IEA InterPro
TreeGrafter		 GO_REF:0000002 GO_REF:0000118 NCBI chr18:16,256,700...16,284,410
Ensembl chr18:16,256,552...16,283,764 		JBrowse link
G SERPINB6 serpin family B member 6 enables IEA InterPro
Ensembl		 GO_REF:0000002 GO_REF:0000107 NCBI chr17:69,204,019...69,219,020
Ensembl chr17:69,207,684...69,219,016 		JBrowse link
G SERPINB7 serpin family B member 7 enables IEA InterPro
TreeGrafter		 GO_REF:0000002 GO_REF:0000118 NCBI chr18:15,992,154...16,020,001
Ensembl chr18:15,992,186...16,044,650 		JBrowse link
G SERPINB9 serpin family B member 9 enables IEA Ensembl
InterPro		 GO_REF:0000002 GO_REF:0000107 NCBI chr17:69,258,377...69,272,954
Ensembl chr17:69,259,258...69,272,501 		JBrowse link
G SERPINC1 serpin family C member 1 ISO RGD PMID:7362830 RGD:1599342 NCBI chr25:55,271,823...55,289,855 JBrowse link
G SERPIND1 serpin family D member 1 enables IEA InterPro
TreeGrafter		 GO_REF:0000002 GO_REF:0000118 NCBI chr19:4,709,896...4,724,620
Ensembl chr19:4,715,806...4,726,111 		JBrowse link
G SERPINE1 serpin family E member 1 enables ISO
IEA		 tissue plasminogen activator RGD
InterPro		 PMID:9316343 GO_REF:0000002 RGD:8547951 NCBI chr28:12,047,520...12,060,662
Ensembl chr28:12,047,529...12,060,202 		JBrowse link
G SERPINE2 serpin family E member 2 enables ISO
IEA		 RGD
TreeGrafter
InterPro
Ensembl		 PMID:19167525 GO_REF:0000002 GO_REF:0000107 GO_REF:0000118 RGD:2317918 NCBI chr10:109,921,619...109,988,137
Ensembl chr10:109,921,598...109,987,513 		JBrowse link
G SERPINE3 serpin family E member 3 enables IEA InterPro GO_REF:0000002 NCBI chr 3:29,227,812...29,251,219
Ensembl chr 3:29,228,049...29,249,397 		JBrowse link
G SERPINF1 serpin family F member 1 enables IEA InterPro
TreeGrafter		 GO_REF:0000002 GO_REF:0000118 Ensembl chr16:1,413,894...1,424,077 JBrowse link
G SERPINF2 serpin family F member 2 enables ISO
IEA		 RGD
TreeGrafter
InterPro		 PMID:6438828 GO_REF:0000002 GO_REF:0000118 RGD:1625542 NCBI chr16:1,392,562...1,404,574
Ensembl chr16:1,392,571...1,404,636 		JBrowse link
G SERPING1 serpin family G member 1 enables IEA Ensembl
TreeGrafter
InterPro		 GO_REF:0000002 GO_REF:0000107 GO_REF:0000118 NCBI chr 1:15,617,122...15,634,540
Ensembl chr 1:15,616,674...15,633,855 		JBrowse link
G SERPINH1 serpin family H member 1 enables IEA InterPro GO_REF:0000002 NCBI chr 1:66,787,978...66,798,930
Ensembl chr 1:66,788,240...66,799,072 		JBrowse link
G SERPINI1 serpin family I member 1 enables ISO
IEA		 RGD
TreeGrafter
InterPro
Ensembl		 PMID:12438159 GO_REF:0000002 GO_REF:0000107 GO_REF:0000118 RGD:633912 NCBI chr15:21,610,545...21,696,611
Ensembl chr15:21,610,791...21,645,701 		JBrowse link
G SERPINI2 serpin family I member 2 enables ISO
IEA		 RGD
TreeGrafter
InterPro		 PMID:12438159 GO_REF:0000002 GO_REF:0000118 RGD:633912 NCBI chr15:21,968,046...21,997,835
Ensembl chr15:21,968,760...21,997,907 		JBrowse link
G SLPI secretory leukocyte peptidase inhibitor enables IEA Ensembl
TreeGrafter
UniProt		 GO_REF:0000043 GO_REF:0000107 GO_REF:0000118 NCBI chr 2:18,579,549...18,581,897
Ensembl chr 2:18,579,515...18,582,076 		JBrowse link
G SPINK1 serine peptidase inhibitor Kazal type 1 enables ISO
IEA		 RGD
InterPro
UniProt		 PMID:12771515 GO_REF:0000002 GO_REF:0000043 RGD:724699 NCBI chr23:50,365,686...50,373,300
Ensembl chr23:50,365,269...50,372,814 		JBrowse link
G SPINK2 serine peptidase inhibitor Kazal type 2 enables IEA InterPro GO_REF:0000002 NCBI chr 7:11,850,394...11,862,084 JBrowse link
G SPINK4 serine peptidase inhibitor Kazal type 4 enables IEA InterPro GO_REF:0000002 Ensembl chr12:47,024,174...47,031,002 JBrowse link
G SPINK5 serine peptidase inhibitor Kazal type 5 enables IEA Ensembl GO_REF:0000107 NCBI chr23:50,587,698...50,667,219
Ensembl chr23:50,592,412...50,663,302 		JBrowse link
G SPINK6 serine peptidase inhibitor Kazal type 6 enables ISO (PMID:24352040) MGI PMID:24352040 NCBI chr23:50,735,387...50,747,343 JBrowse link
G SPINK6 serine peptidase inhibitor Kazal type 6 enables IEA UniProt
InterPro		 GO_REF:0000002 GO_REF:0000043 Ensembl chr23:50,746,087...50,747,039 JBrowse link
G SPINK9 serine peptidase inhibitor Kazal type 9 enables IEA Ensembl GO_REF:0000107 NCBI chr23:50,972,629...50,976,856
Ensembl chr23:50,973,280...50,977,838 		JBrowse link
G SPINT1 serine peptidase inhibitor, Kunitz type 1 enables ISO
IEA		 RGD
TreeGrafter
InterPro		 PMID:18048349 GO_REF:0000002 GO_REF:0000118 RGD:10043098 NCBI chr26:42,136,749...42,150,125
Ensembl chr26:42,134,536...42,150,118 		JBrowse link
G SPINT2 serine peptidase inhibitor, Kunitz type 2 enables IEA InterPro
TreeGrafter		 GO_REF:0000002 GO_REF:0000118 NCBI chr 6:32,902,336...32,935,681
Ensembl chr 6:32,902,946...32,939,136 		JBrowse link
G SPINT3 serine peptidase inhibitor, Kunitz type 3 enables IEA InterPro
TreeGrafter		 GO_REF:0000002 GO_REF:0000118 NCBI chr 2:18,320,557...18,324,159
Ensembl chr 2:18,320,887...18,323,976 		JBrowse link
G SPINT4 serine peptidase inhibitor, Kunitz type 4 enables IEA InterPro GO_REF:0000002 NCBI chr 2:18,138,111...18,140,563
Ensembl chr 2:18,138,328...18,140,101 		JBrowse link
G TFPI tissue factor pathway inhibitor enables IEA UniProt
TreeGrafter
InterPro		 GO_REF:0000002 GO_REF:0000043 GO_REF:0000104 GO_REF:0000118 NCBI chr10:73,004,762...73,105,772
Ensembl chr10:73,002,522...73,105,858 		JBrowse link
G TFPI2 tissue factor pathway inhibitor 2 enables IEA InterPro
UniProt		 GO_REF:0000002 GO_REF:0000043 GO_REF:0000104 NCBI chr21:55,134,921...55,139,862
Ensembl chr21:55,135,198...55,140,801 		JBrowse link
G UMODL1 uromodulin like 1 enables IEA UniProt GO_REF:0000043 NCBI chr 2:85,894,102...86,023,577
Ensembl chr 2:85,959,746...86,019,950 		JBrowse link
G WFDC1 WAP four-disulfide core domain 1 enables IEA UniProt GO_REF:0000043 NCBI chr 5:69,700,984...69,734,682
Ensembl chr 5:69,701,470...69,731,823 		JBrowse link
G WFDC10A WAP four-disulfide core domain 10A enables IEA UniProt GO_REF:0000043 NCBI chr 2:18,213,757...18,218,101
Ensembl chr 2:18,215,355...18,216,548 		JBrowse link
G WFDC12 WAP four-disulfide core domain 12 enables IEA UniProt GO_REF:0000043 NCBI chr 2:18,693,251...18,694,443
Ensembl chr 2:18,693,580...18,694,182 		JBrowse link
G WFDC2 WAP four-disulfide core domain 2 enables IEA UniProt
TreeGrafter		 GO_REF:0000043 GO_REF:0000118 NCBI chr 2:18,351,063...18,361,893
Ensembl chr 2:18,351,043...18,361,868 		JBrowse link
G WFDC3 WAP four-disulfide core domain 3 enables IEA UniProt
TreeGrafter		 GO_REF:0000043 GO_REF:0000118 NCBI chr 2:18,098,111...18,115,053
Ensembl chr 2:18,100,770...18,115,044 		JBrowse link
G WFDC5 WAP four-disulfide core domain 5 enables IEA UniProt
TreeGrafter		 GO_REF:0000043 GO_REF:0000118 NCBI chr 2:18,702,404...18,708,119
Ensembl chr 2:18,702,644...18,707,188 		JBrowse link
G WFDC6 WAP four-disulfide core domain 6 enables IEA InterPro
UniProt		 GO_REF:0000002 GO_REF:0000043 Ensembl chr 2:18,297,275...18,301,516 JBrowse link
G WFDC8 WAP four-disulfide core domain 8 enables IEA InterPro
UniProt		 GO_REF:0000002 GO_REF:0000043 NCBI chr 2:18,261,347...18,287,264
Ensembl chr 2:18,275,771...18,286,403 		JBrowse link
G WFIKKN1 WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 1 enables IEA UniProt
InterPro		 GO_REF:0000002 GO_REF:0000043 NCBI chr 5:547,499...554,080
Ensembl chr 5:547,795...554,019 		JBrowse link
G WFIKKN2 WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2 enables IEA UniProt
InterPro		 GO_REF:0000002 GO_REF:0000043 NCBI chr16:42,503,547...42,513,355
Ensembl chr16:42,504,880...42,509,647 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 18050
    molecular function regulator activity 1901
      enzyme regulator activity 1195
        enzyme inhibitor activity 339
          peptidase inhibitor activity 148
            endopeptidase inhibitor activity 143
              serine-type endopeptidase inhibitor activity 91
paths to the root