SERPINB2 (serpin family B member 2)

Gene: SERPINB2 (serpin family B member 2) Chlorocebus sabaeus

Analyze

Symbol:

SERPINB2

Name:

serpin family B member 2

RGD ID:

18661526

Description:

ENCODES a protein that exhibits serine-type endopeptidase inhibitor activity (inferred); INVOLVED IN negative regulation of apoptotic process (inferred); PARTICIPATES IN fibrinolysis pathway; ASSOCIATED WITH Breast Neoplasms (ortholog); chromosome 18q deletion syndrome (ortholog); genetic disease (ortholog); FOUND IN cornified envelope (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

plasminogen activator inhibitor 2

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

ChlSab1.1 - Green Monkey 1.1 Assembly

Position:

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	18	15,906,461 - 15,922,636 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	18	15,906,469 - 15,922,594 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666060	9,770,527 - 9,786,645 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Breast Neoplasms (ISO)

chromosome 18q deletion syndrome (ISO)

genetic disease (ISO)

metabolic dysfunction-associated steatotic liver disease (ISO)

multiple congenital anomalies-hypotonia-seizures syndrome 1 (ISO)

peripheral nervous system disease (ISO)

Stomach Neoplasms (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

negative regulation of apoptotic process (IEA)

Cellular Component

cornified envelope (IEA,ISO)

extracellular space (IEA)

Molecular Function

serine-type endopeptidase inhibitor activity (IEA)

Molecular Pathway Annotations Click to see Annotation Detail View

fibrinolysis pathway (ISO)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

SERPINB2
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	18	15,906,461 - 15,922,636 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	18	15,906,469 - 15,922,594 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666060	9,770,527 - 9,786,645 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

SERPINB2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	18	63,887,705 - 63,903,888 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	18	63,871,692 - 63,903,888 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	18	61,554,939 - 61,571,122 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	18	59,705,922 - 59,722,100 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	18	59,705,921 - 59,722,100	NCBI
Celera	18	58,275,397 - 58,291,583 (+)	NCBI		Celera
Cytogenetic Map	18	q21.33-q22.1	NCBI
HuRef	18	58,256,074 - 58,272,260 (+)	NCBI		HuRef
CHM1_1	18	61,551,138 - 61,567,323 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	18	64,092,785 - 64,108,961 (+)	NCBI		T2T-CHM13v2.0

Serpinb2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	1	107,439,153 - 107,453,330 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	1	107,439,153 - 107,463,208 (+)	Ensembl		GRCm39 Ensembl
GRCm38	1	107,500,892 - 107,525,600 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	1	107,511,423 - 107,535,478 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	1	109,408,000 - 109,422,177 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	1	109,343,020 - 109,353,145 (+)	NCBI		MGSCv36	mm8
Celera	1	110,350,054 - 110,364,218 (+)	NCBI		Celera
Cytogenetic Map	1	E2.1	NCBI
cM Map	1	50.34	NCBI

Serpinb2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	13	24,051,933 - 24,065,032 (+)	NCBI		GRCr8
mRatBN7.2	13	23,537,312 - 23,551,823 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	13	23,541,400 - 23,550,408 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	13	23,911,693 - 23,920,701 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	13	25,196,153 - 25,205,159 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	13	23,881,884 - 23,890,888 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	13	27,449,907 - 27,463,015 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	13	27,449,934 - 27,463,010 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	13	32,599,834 - 32,612,855 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	13	13,632,596 - 13,641,605 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	13	13,607,205 - 13,616,214 (+)	NCBI
Celera	13	23,386,792 - 23,395,714 (+)	NCBI		Celera
Cytogenetic Map	13	p11	NCBI

Serpinb2
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955402	47,711,215 - 47,720,755 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955402	47,707,182 - 47,720,688 (+)	NCBI	ChiLan1.0	ChiLan1.0

SERPINB2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	17	81,394,008 - 81,410,303 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	18	67,086,750 - 67,102,914 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	18	57,242,498 - 57,258,676 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	18	60,553,350 - 60,569,509 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	18	60,553,323 - 60,569,594 (+)	Ensembl	panpan1.1		panPan2

SERPINB2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	1	13,260,288 - 13,276,727 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	1	13,260,387 - 13,272,980 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	1	14,221,011 - 14,237,472 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	1	13,115,363 - 13,131,846 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	1	13,115,383 - 13,128,076 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	1	13,153,943 - 13,170,407 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	1	13,083,198 - 13,099,654 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	1	13,332,245 - 13,348,711 (-)	NCBI		UU_Cfam_GSD_1.0

Serpinb2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404944	26,566,424 - 26,579,970 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936497	1,805,957 - 1,814,911 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936497	1,805,957 - 1,814,911 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

SERPINB2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	1	157,872,212 - 157,886,602 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	1	157,871,919 - 157,886,525 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	1	175,502,720 - 175,517,267 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	endocrine system	hemolymphoid system	nervous system
High
Medium
Low		16
Below cutoff	8	4	9

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_008013838	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JACDXN010000028	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSCSAT00000016303 ⟹ ENSCSAP00000014222

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
ChlSab1.1 Ensembl	18	15,906,469 - 15,922,594 (-)	Ensembl

RefSeq Acc Id:

XM_008013838 ⟹ XP_008012029

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
ChlSab1.1	18	15,906,461 - 15,922,636 (-)	NCBI
Vero_WHO_p1.0	NW_023666060	9,770,527 - 9,786,645 (+)	NCBI

Sequence:

show sequence

GGGGCAGAGCTGTATAAAACCAGTCATTACCATGTCTGAACTGTAACAACTCTCAGAGGAGCAT
TGCCCGTCAGACAGCAACTCAGCGAATAACCAGAGAACAACCAGATTGAAACAATGGAGGACCT
TTGTGTAGCAAACACACTCTTTGCCCTCAATTTATTCAAGCATCTGGCAAAAGCAAGCCCCACC
CAGAACCTCTTCTTCTCCCCATGGAGCATCTCGTCCACCATGGCCATGGTCTACATGGGCTCCA
GGGGCAGCACCCAAGACCAGATGGCCAAGGTGCTTCAGTTTAATGAAGTGGGAGCCAATGCAGT
TACCCCTGTGACTCCAGAGAACTTGACCAGCTGTGAGCTCATGCAGCAGATCCAGAAGGGTACT
TATCCTGACGCGATTTTGCAGGCACAAGCTGCAGATAAAATCCATTCATCCTTCCGCTCTCTCA
GCTCTGCAATCAATGCATCCACAGGGGATTATTTACTGGAAAGTGTCAATAAACTGTTTGGTGA
GAAGTCTGCAAGCTTCAGGGAAGAATATATTCGACTCTGTCAGAAATATTACTCCTCAGAACCC
CAGGCAGTAGACTTCCTAGAATATGCAGAAGAAGCCAGAAAAAAGATTAATTCCTGGGTCAAGA
CTCAAACCCAAGGCAAAATCCTAAACTTGTTACCTGAAGGGTCTGTAGATGGGGATACCAGGAT
GGTCCTGGTGAATGCTGTTTACTTCAAAGGAAAGTGGAAAACTCCATTTGAGAAGAAACTAAAT
GGGCTTTATCCTTTCCGTGTGAACTCGACTCAGCATACACCTGTACAGATGATGTACTTGCGTG
AAAAGCTAAACATTGGATACATAGAAGACCTGAAGGCTCAGATTCTAGAACTCCCATATGCTGG
AGATGTTAGCATGTTCCTGTTGCTTCCAGATGAAATTGCCGATGTGTCCACTGGCTTGGAACTG
CTGGAAAGTGAAATAACCTATGACAAACTCAACAAGTGGACCAGCAAAGACACAATGGCTGAAG
ATGATGTTGAGGTATATATACCCCAGTTCAAATTAGAAGAGCATTATGAACTCAAATCCATTCT
GAGAAGCATGGGCATGGAGGATGCCTTCGACAAGGGACAAGCCAATTTCTCAGGGATGTCGGAG
CGGAATGACTTGTTTCTTTCTGAAGTGTTCCACCAAGCCATGGTGGATGTGAATGAGGAGGGCA
CTGAAGCAGCCGCTGGCACAGGAGGCGTTATGTCAGGGAGAACCGGTCATGGAGGCCCACAGTT
TGTGGCAGATCATCCTTTTCTTTTCCTTATTACGCATAAAATAACCAAGTGCATTTTATTTTTT
GGCAAATTTTCCTCACCCTAAAACCAAAACGTGCTGTTTCTGCAAAAGATTTTTGTAGATGAGC
TGTGTGCCTCAGAATTGCTATTTCAAATCGCCAAAAATTTAGAGATGTTTTCTACGTATTTCTG
TTCTTCTGAACAACTTCTGCTACACACTAAATAAAAACACGGAAATAATTAGACAATTGTCTAT
TATAACATGACAACCCCATTAATCATTTGGTCTTCTAAAATGGGATGAAGCCCTTTTAGATTTT
CCTTACTCTCAGTTTATTTTTATAACATTAACTTTTACTTTGTTATTTATTATTTTATATAATG
GTGAGTTTTTAAATTATTGCTCACTGTCTATTGAATGTAGCTAATAAAGTTATAGAAGCAGATG
ATCAGTTAATTTCCTATCTAAAAAATGCGTTTACTTGTTCTCATAATGAAGAATAAGTAGGTAT
CCCTCCATGTCCTTCTATAGAATATCTAGAAAAAACATTAAACAATAGGCAAATATATGTTATA
TGCATTTCTAGCAATACATACCACATACATATGTCTGTATCATATATTCAATTGCAAGTATATA
ATAAATAAACCTGCTTCCAAACAACAATA

hide sequence

Protein Sequences


Protein RefSeqs	XP_008012029	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCSAP00000014222.1

RefSeq Acc Id:	XP_008012029 ⟸ XM_008013838
- UniProtKB:	A0A0D9S033 (UniProtKB/TrEMBL)

RefSeq Acc Id:

ENSCSAP00000014222 ⟸ ENSCSAT00000016303

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCSAG00000018206	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCSAT00000016303.1	UniProtKB/TrEMBL
Gene3D-CATH	2.30.39.10	UniProtKB/TrEMBL
	3.30.497.10	UniProtKB/TrEMBL
InterPro	PAI-2	UniProtKB/TrEMBL
	Serpin_CS	UniProtKB/TrEMBL
	Serpin_dom	UniProtKB/TrEMBL
	Serpin_fam	UniProtKB/TrEMBL
	Serpin_sf	UniProtKB/TrEMBL
	Serpin_sf_1	UniProtKB/TrEMBL
	Serpin_sf_2	UniProtKB/TrEMBL
KEGG Report	csab:103244147	UniProtKB/TrEMBL
NCBI Gene	SERPINB2	ENTREZGENE
PANTHER	PTHR11461	UniProtKB/TrEMBL
	PTHR11461:SF61	UniProtKB/TrEMBL
Pfam	Serpin	UniProtKB/TrEMBL
PROSITE	SERPIN	UniProtKB/TrEMBL
SMART	SERPIN	UniProtKB/TrEMBL
Superfamily-SCOP	SSF56574	UniProtKB/TrEMBL
UniProt	A0A0D9S033	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

RGD Manual Annotations

Send us a Message

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

RGD Manual Annotations