SERPINA1 (serpin family A member 1) - Rat Genome Database

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Pathways
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Gene: SERPINA1 (serpin family A member 1) Chlorocebus sabaeus
Analyze
Symbol: SERPINA1
Name: serpin family A member 1
RGD ID: 18571751
Description: ENCODES a protein that exhibits endopeptidase inhibitor activity (ortholog); identical protein binding (ortholog); protease binding (ortholog); INVOLVED IN negative regulation of serine-type endopeptidase activity (ortholog); response to chromate (ortholog); response to cytokine (ortholog); PARTICIPATES IN forkhead class A signaling pathway; ASSOCIATED WITH achondrogenesis type IA (ortholog); acute kidney failure (ortholog); acute pancreatitis (ortholog); FOUND IN endoplasmic reticulum (ortholog); extracellular space (ortholog); Golgi apparatus (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: alpha-1-antitrypsin
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Pig
Alliance Orthologs
More Info more info ...
Latest Assembly: ChlSab1.1 - Green Monkey 1.1 Assembly
Position:
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12472,158,521 - 72,171,139 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2472,156,784 - 72,163,500 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605359,387,764 - 59,400,148 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
achondrogenesis type IA  (ISO)
acute kidney failure  (ISO)
acute pancreatitis  (ISO)
adenocarcinoma  (ISO)
alpha 1-antitrypsin deficiency  (ISO)
anxiety disorder  (ISO)
arteriosclerosis  (ISO)
asbestosis  (ISO)
asthma  (ISO)
bipolar disorder  (ISO)
Bronchial Hyperreactivity  (ISO)
bronchiectasis  (ISO)
Burns  (ISO)
Chemical and Drug Induced Liver Injury  (ISO)
chemical colitis  (ISO)
cholestasis  (ISO)
chronic obstructive pulmonary disease  (ISO)
colorectal cancer  (ISO)
coronary artery disease  (ISO)
COVID-19  (ISO)
cystic fibrosis  (ISO)
DICER1 syndrome  (ISO)
Drug-Related Side Effects and Adverse Reactions  (ISO)
Emphysema  (ISO)
Experimental Autoimmune Orchitis  (ISO)
Experimental Liver Neoplasms  (ISO)
Gastro-Enteropancreatic Neuroendocrine Tumor  (ISO)
genetic disease  (ISO)
Hemorrhage  (ISO)
hepatocellular carcinoma  (ISO)
human immunodeficiency virus infectious disease  (ISO)
hypertension  (ISO)
hypoglycemia  (ISO)
ileitis  (ISO)
Insulin Resistance  (ISO)
Kidney Reperfusion Injury  (ISO)
liver cirrhosis  (ISO)
liver disease  (ISO)
lung disease  (ISO)
Lung Neoplasms  (ISO)
metabolic dysfunction-associated steatotic liver disease  (ISO)
Myocardial Ischemia  (ISO)
Neoplasm Metastasis  (ISO)
neurodegenerative disease  (ISO)
Neurodevelopmental Disorders  (ISO)
nodular nonsuppurative panniculitis  (ISO)
osteoarthritis  (ISO)
otitis media  (ISO)
Otitis Media with Effusion  (ISO)
pancreatic cancer  (ISO)
pancreatic ductal carcinoma  (ISO)
pancreatitis  (ISO)
pleuropulmonary blastoma  (ISO)
pre-eclampsia  (ISO)
primary hyperaldosteronism  (ISO)
proteinuria  (ISO)
pulmonary emphysema  (ISO)
pulmonary fibrosis  (ISO)
pulmonary hypertension  (ISO)
squamous cell carcinoma  (ISO)
Stomach Neoplasms  (ISO)
thiamine deficiency disease  (ISO)
vasculitis  (ISO)
X-linked intellectual developmental disorder 109  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:30032202  


Genomics

Comparative Map Data
SERPINA1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12472,158,521 - 72,171,139 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2472,156,784 - 72,163,500 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605359,387,764 - 59,400,148 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
SERPINA1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381494,376,747 - 94,390,635 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1494,376,747 - 94,390,693 (-)EnsemblGRCh38hg38GRCh38
GRCh371494,843,084 - 94,856,972 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361493,914,451 - 93,926,782 (-)NCBINCBI36Build 36hg18NCBI36
Build 341493,914,450 - 93,926,782NCBI
Celera1474,898,987 - 74,912,932 (-)NCBICelera
Cytogenetic Map14q32.13NCBI
HuRef1475,022,652 - 75,036,601 (-)NCBIHuRef
CHM1_11494,780,885 - 94,794,830 (-)NCBICHM1_1
T2T-CHM13v2.01488,606,265 - 88,620,155 (-)NCBIT2T-CHM13v2.0
Serpina1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr86128,631,101 - 128,653,125 (-)NCBIGRCr8
mRatBN7.26122,866,314 - 122,888,339 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl6122,866,312 - 122,888,339 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx6123,007,214 - 123,029,250 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.06123,302,499 - 123,324,535 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.06122,639,411 - 122,661,452 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.06127,610,241 - 127,632,265 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6127,610,243 - 127,632,265 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.06136,828,856 - 136,850,880 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.46127,998,617 - 128,021,719 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.16128,002,364 - 128,025,466 (-)NCBI
Celera6120,346,394 - 120,368,519 (-)NCBICelera
Cytogenetic Map6q32NCBI
LOC102021597
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495543817,920,200 - 17,929,105 (+)NCBIChiLan1.0ChiLan1.0
SERPINA1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21595,525,119 - 95,539,108 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11494,741,624 - 94,755,614 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01475,001,714 - 75,014,214 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11494,334,258 - 94,347,085 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1494,334,258 - 94,345,419 (-)Ensemblpanpan1.1panPan2
SERPINA1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1863,388,498 - 63,400,377 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl863,376,945 - 63,398,435 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha862,965,044 - 62,974,971 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0863,654,807 - 63,666,723 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl863,654,816 - 63,664,785 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1863,330,666 - 63,340,582 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0863,382,963 - 63,392,890 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0863,713,659 - 63,723,574 (-)NCBIUU_Cfam_GSD_1.0
SERPINA1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl7115,583,043 - 115,614,645 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.17115,604,282 - 115,616,915 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.27122,616,080 - 122,628,726 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap7q24-q26NCBI


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

endocrine system hemolymphoid system nervous system
High
Medium 1
Low 36 19 60
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSCSAT00000009011   ⟹   ENSCSAP00000007144
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1 Ensembl2472,156,784 - 72,163,500 (-)Ensembl
RefSeq Acc Id: XM_007987698   ⟹   XP_007985889
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.12472,158,558 - 72,171,137 (-)NCBI
Vero_WHO_p1.0NW_02366605359,387,764 - 59,400,148 (-)NCBI
Sequence:
RefSeq Acc Id: XM_007987699   ⟹   XP_007985890
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.12472,158,521 - 72,169,067 (-)NCBI
Vero_WHO_p1.0NW_02366605359,387,764 - 59,398,967 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_007985889 (Get FASTA)   NCBI Sequence Viewer  
  XP_007985890 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCSAP00000007144.1
Reference Protein Sequences
RefSeq Acc Id: XP_007985890   ⟸   XM_007987699
- UniProtKB: A0A0D9REV5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_007985889   ⟸   XM_007987698
- UniProtKB: A0A0D9REV5 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCSAP00000007144   ⟸   ENSCSAT00000009011


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCSAG00000010926 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCSAT00000009011.1 UniProtKB/TrEMBL
Gene3D-CATH 2.30.39.10 UniProtKB/TrEMBL
  3.30.497.10 UniProtKB/TrEMBL
  Serpins superfamily UniProtKB/TrEMBL
InterPro Serpin_CS UniProtKB/TrEMBL
  Serpin_dom UniProtKB/TrEMBL
  Serpin_fam UniProtKB/TrEMBL
  Serpin_sf UniProtKB/TrEMBL
  Serpin_sf_1 UniProtKB/TrEMBL
  Serpin_sf_2 UniProtKB/TrEMBL
KEGG Report csab:103229609 UniProtKB/TrEMBL
NCBI Gene SERPINA1 ENTREZGENE
PANTHER ALPHA-1-ANTITRYPSIN UniProtKB/TrEMBL
  PTHR11461 UniProtKB/TrEMBL
Pfam Serpin UniProtKB/TrEMBL
PROSITE SERPIN UniProtKB/TrEMBL
SMART SERPIN UniProtKB/TrEMBL
Superfamily-SCOP SSF56574 UniProtKB/TrEMBL
UniProt A0A0D9REV5 ENTREZGENE, UniProtKB/TrEMBL