RGD Reference Report - Alpha 1-antitrypsin and survival in pancreatic cancer. - Rat Genome Database

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Alpha 1-antitrypsin and survival in pancreatic cancer.

Authors: Trichopoulos, D  Tzonou, A  Kalapothaki, V  Sparos, L  Kremastinou, T  Skoutari, M 
Citation: Trichopoulos D, etal., Int J Cancer. 1990 Apr 15;45(4):685-6.
RGD ID: 2324960
Pubmed: PMID:2323846   (View Abstract at PubMed)

The association between serum levels of alpha 1-antitrypsin (a1AT) at the time of diagnosis and survival was studied in a group of 44 patients with confirmed pancreas cancer. All 44 patients were followed until time of death, which occurred in all cases from pancreas cancer, with a median time of 3 months and a range of 0.5 to 16 months. Cox's proportional hazards model was utilized in the analysis controlling for sex, age and tobacco smoking. Males, older patients and smokers have higher fatality rates, but none of these relations was statistically significant. By contrast, there was a statistically highly significant association of increased levels of serum a1AT, at the time of diagnosis of the cancer of pancreas, with shorter survival; patients with serum a1AT higher by 100mg/100ml had a 57% higher fatality rate. These results indicate that serum a1AT represents a clinically interesting prognostic factor in pancreas cancer.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
pancreatic cancer disease_progressionIEP 2324960 RGD 
pancreatic cancer disease_progressionISOSERPINA1 (Homo sapiens)2324960; 2324960 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Serpina1  (serpin family A member 1)

Genes (Mus musculus)
Serpina1e  (serine (or cysteine) peptidase inhibitor, clade A, member 1E)

Genes (Homo sapiens)
SERPINA1  (serpin family A member 1)


Additional Information