RGD Reference Report - [Influence of escharectomy and skin grafting during early burn stage on acute-phase response in severely burned rats and its significance] - Rat Genome Database

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[Influence of escharectomy and skin grafting during early burn stage on acute-phase response in severely burned rats and its significance]

Authors: Chai, J  Wu, Y  Sheng, Z 
Citation: Chai J, etal., Zhonghua Yi Xue Za Zhi. 2002 Oct 25;82(20):1420-3.
RGD ID: 1643164
Pubmed: PMID:12509927   (View Abstract at PubMed)

OBJECTIVE: To investigate the influence of escharectomy and skin-grafting during early burn stage on the production of acute-phase reactants by the liver in severely burned rats. METHODS: Ninety-six Wistar rats were randomly divided into three groups: normal control group (C), escharectomy on postburn day (PBD) 1 group (0) and escharectomy on PBD4 group (F). 30% III degrees (total body surface area full-thickness) burn injury was caused by immersing the back in boiling water for 10 seconds. Escharectomy and skin grafting with cryopreserved allogeneic skin were performed one day or 4 days after the burn injury. ON days 1, 2, 4, 5 and 7 after burn injury blood was withdrawn from the abdominal aorta of 8 rats for each experimental group. The serum contents al-antitrypsin (AT), al-acid glycoprotein (AGP), C-reactive protein (CRP), albumin (Alb), and transferrin (Trf) were measured by turbidimetry. RESULTS: Significant increase in concentrations of positive acute-phase reactant, CRP, AGP, and AT, was observed in group O and group F as compared with normal control, (P < 0.05), while the concentrations of negative acute-phase reactants, Alb and Trf, decreased markedly (P < 0.05). The serum concentrations of AT and AGP in group O began to decrease significantly on PBD 5 and PBD7 respectively in comparison with that of the group F (P < 0.05), however, they still maintained a rather higher levels on PBD7. The concentration of CRP in group O began to decrease on PBD4, and the values on PBD4, 5, and 7 were significantly lower than those of the group F (P < 0.05). The concentration of CRP in PBD1 group reached the normal level on PBD7, however, the concentration of CRP in group F kept increasing till PBD5, and remained significantly higher than that in group C (P < 0.05). The concentration of Alb in group O was significantly higher on PBD7 than that in group F (P < 0.05). The concentration of Trf in group O on PBD5 and PBD7 was significantly higher than those in group F (P < 0.05). CONCLUSION: Escharectomy and skin grafting during early burn stage attenuates acute-phase response after burn injury and are beneficial to the organism.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Burns  ISOSerpina1 (Rattus norvegicus)1643164protein:increased expression:serumRGD 
Burns  IEP 1643164protein:increased expression:serumRGD 

Objects Annotated

Genes (Rattus norvegicus)
Serpina1  (serpin family A member 1)

Genes (Homo sapiens)
SERPINA1  (serpin family A member 1)


Additional Information