SPINT4 (serine peptidase inhibitor, Kunitz type 4)

Gene: SPINT4 (serine peptidase inhibitor, Kunitz type 4) Chlorocebus sabaeus

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Symbol:

SPINT4

Name:

serine peptidase inhibitor, Kunitz type 4

RGD ID:

18472058

Description:

ENCODES a protein that exhibits serine-type endopeptidase inhibitor activity (inferred); ASSOCIATED WITH focal epilepsy (ortholog); T-Cell Immunodeficiency, Recurrent Infections, and Autoimmunity with or without Cardiac Malformations (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

kunitz-type protease inhibitor 4

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

ChlSab1.1 - Green Monkey 1.1 Assembly

Position:

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	2	18,138,111 - 18,140,563 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	2	18,138,328 - 18,140,101 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666050	66,779,313 - 66,781,098 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

focal epilepsy (ISO)

T-Cell Immunodeficiency, Recurrent Infections, and Autoimmunity with or without Cardiac Malformations (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Molecular Function

serine-type endopeptidase inhibitor activity (IEA)

References

Additional References at PubMed

PMID:22301074

Genomics

Comparative Map Data

SPINT4
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	2	18,138,111 - 18,140,563 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	2	18,138,328 - 18,140,101 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666050	66,779,313 - 66,781,098 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

SPINT4
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	20	45,722,347 - 45,725,830 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	20	45,722,347 - 45,725,830 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	20	44,350,986 - 44,354,469 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	20	43,784,402 - 43,787,749 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Celera	20	41,059,492 - 41,062,839 (+)	NCBI		Celera
Cytogenetic Map	20	q13.12	NCBI
HuRef	20	41,092,437 - 41,095,784 (+)	NCBI		HuRef
CHM1_1	20	44,253,675 - 44,257,070 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	20	47,458,621 - 47,462,103 (+)	NCBI		T2T-CHM13v2.0

Spint4
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	2	164,540,421 - 164,544,368 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	2	164,540,421 - 164,544,373 (+)	Ensembl		GRCm39 Ensembl
GRCm38	2	164,698,501 - 164,702,448 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	2	164,698,501 - 164,702,453 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	2	164,524,001 - 164,527,948 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	2	164,389,706 - 164,393,653 (+)	NCBI		MGSCv36	mm8
Celera	2	170,636,197 - 170,640,142 (+)	NCBI		Celera
Cytogenetic Map	2	H3	NCBI
cM Map	2	85.26	NCBI

Spint4
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	3	173,849,986 - 173,852,174 (+)	NCBI		GRCr8
mRatBN7.2	3	153,430,633 - 153,432,821 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	3	153,430,633 - 153,433,439 (+)	Ensembl		mRatBN7.2 Ensembl
Rnor_6.0	3	161,160,920 - 161,165,386 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	3	161,160,920 - 161,163,720 (+)	NCBI	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	3	167,338,173 - 167,342,165 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	3	155,712,895 - 155,717,145 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	3	152,039,041 - 152,043,507 (+)	NCBI		Celera
Cytogenetic Map	3	q42	NCBI

SPINT4
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	21	51,463,882 - 51,465,576 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	20	51,456,991 - 51,458,685 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	20	42,061,390 - 42,063,084 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	20	43,149,701 - 43,151,395 (+)	NCBI	panpan1.1	PanPan1.1	panPan2

SPINT4
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	24	33,035,050 - 33,037,192 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	24	33,034,698 - 33,036,124 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	24	32,561,323 - 32,563,465 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	24	33,744,196 - 33,746,338 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	24	33,744,125 - 33,745,270 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	24	33,003,078 - 33,005,220 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	24	33,118,886 - 33,121,028 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	24	33,657,516 - 33,659,656 (+)	NCBI		UU_Cfam_GSD_1.0

SPINT4
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1	17	47,960,786 - 47,963,417 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1

Spint4
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624790	8,812,003 - 8,818,205 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	hemolymphoid system	nervous system
High
Medium
Low	11	3
Below cutoff	5	8

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_008015819	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JACDXN010000018	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSCSAT00000012569 ⟹ ENSCSAP00000010602

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
ChlSab1.1 Ensembl	2	18,138,328 - 18,140,101 (-)	Ensembl

RefSeq Acc Id:

XM_008015819 ⟹ XP_008014010

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
ChlSab1.1	2	18,138,111 - 18,140,563 (-)	NCBI
Vero_WHO_p1.0	NW_023666050	66,779,313 - 66,781,098 (-)	NCBI

Sequence:

show sequence

ACTTAAAAATAGCACCTGGAATTAAGTAGTACTCTAGGTTATAACCAACCCTGTTACTATTATT
ATAGTGCTTACTGCACAGTTTCTCTTGTGCCATGATTAGTTCCTTCTGTGCATAAAAGGCCAAA
AAGAGAAAGGAAGAAGGCCAAAAAGAGAGAGGAAGAAATCCTTTTTTAATTCCTTGCTCTGATG
ATTCTACCCTTCATGACTAAATATATGCAGAACCTCTGATCCTTAAGTTTCTATTGCTTCTAGA
TGAACATAGGACTTGCTATCAAAGGTCTAATCAGTTTGGGGCCTTCAGCTTCATGGCTGGGTAC
CCAAGCACTCACGGTTCAACTCAACACCTAGTAATGTCCAGTCCTGGCCCTTGGGGTAGGTGGG
CTCAACCGTCTCAAGTATCAAGCCCAAAATATAACATCAGGTGATACCACAACTATCCTGCCTG
CTGCTTGCTGCACCATGAAGTCTGCCAAGCTGGGATTTCTTCTAAGGTTCTTCATCTTCTGCTC
ATTGAATACCCTATTATTGGGTGGTGTTAATAAAATTGCTGAGAAGATATGTGGAGACCTCAAA
GATCCCTGCCAATTGGACATGAATGTTGGAAGCTGCTATGAAGTTCACTTTAGATATTTCTACA
ACAGAACCTCCAGAAGATGTGAACCTTTTGTCTTCTCTGGCTGTGATGGCAACCTTAACAACTT
CAAGCTTAAATTAGAATGTGATGTAACCTGTGTTACAAAATACAAACCACCGGAAGGAATCTAA
TCCTGTCCTTGGTCCTTGGGGTGAGTAAAAGAAGAGGTTTTGACATCCTAAGATAGGGAAAATT
GATCAGGGGCTAACCTTGCTTGGAGTGGGAAGAGGGAGGATTGCTCTAATAAAAAGTTTTAAAA
GGCCAGGCATGGTGGCTCATGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGTGGGCGGATCAC
CTGAGGTTGGGAG

hide sequence

Protein Sequences


Protein RefSeqs	XP_008014010	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCSAP00000010602
	ENSCSAP00000010602.1

RefSeq Acc Id:	XP_008014010 ⟸ XM_008015819
- UniProtKB:	A0A0D9RPR3 (UniProtKB/TrEMBL)

RefSeq Acc Id:

ENSCSAP00000010602 ⟸ ENSCSAT00000012569

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCSAG00000014479	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCSAT00000012569.1	UniProtKB/TrEMBL
Gene3D-CATH	4.10.410.10	UniProtKB/TrEMBL
InterPro	Kunitz_BPTI	UniProtKB/TrEMBL
	Kunitz_BPTI_sf	UniProtKB/TrEMBL
	Prtase_inh_Kunz-CS	UniProtKB/TrEMBL
	SPINT4	UniProtKB/TrEMBL
NCBI Gene	SPINT4	ENTREZGENE
PANTHER	KUNITZ-TYPE PROTEASE INHIBITOR 4	UniProtKB/TrEMBL
	PTHR47898	UniProtKB/TrEMBL
Pfam	Kunitz_BPTI	UniProtKB/TrEMBL
PRINTS	BASICPTASE	UniProtKB/TrEMBL
PROSITE	BPTI_KUNITZ_1	UniProtKB/TrEMBL
	BPTI_KUNITZ_2	UniProtKB/TrEMBL
SMART	SM00131	UniProtKB/TrEMBL
Superfamily-SCOP	SSF57362	UniProtKB/TrEMBL
UniProt	A0A0D9RPR3	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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