SERPINA3 (serpin family A member 3) - Rat Genome Database

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Gene: SERPINA3 (serpin family A member 3) Chlorocebus sabaeus
Analyze
Symbol: SERPINA3
Name: serpin family A member 3
RGD ID: 18604967
Description: ENCODES a protein that exhibits serine-type endopeptidase inhibitor activity (inferred); ASSOCIATED WITH adult respiratory distress syndrome (ortholog); Arterial Occlusive Diseases (ortholog); Cerebral Hemorrhage (ortholog); FOUND IN extracellular space (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: alpha-1-antichymotrypsin
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: ChlSab1.1 - Green Monkey 1.1 Assembly
Position:
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12472,388,948 - 72,415,746 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2472,402,560 - 72,415,507 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605359,607,697 - 59,632,854 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:30032202  


Genomics

Comparative Map Data
SERPINA3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12472,388,948 - 72,415,746 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2472,402,560 - 72,415,507 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605359,607,697 - 59,632,854 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
SERPINA3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381494,612,391 - 94,624,053 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1494,612,384 - 94,624,055 (+)EnsemblGRCh38hg38GRCh38
GRCh371495,078,728 - 95,090,390 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361494,148,467 - 94,160,143 (+)NCBINCBI36Build 36hg18NCBI36
Build 341494,148,479 - 94,160,142NCBI
Celera1475,134,849 - 75,146,525 (+)NCBICelera
Cytogenetic Map14q32.13NCBI
HuRef1475,259,097 - 75,270,773 (+)NCBIHuRef
CHM1_11495,016,470 - 95,028,146 (+)NCBICHM1_1
T2T-CHM13v2.01488,842,378 - 88,854,040 (+)NCBIT2T-CHM13v2.0
Serpina3b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3912104,094,245 - 104,105,805 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl12104,094,255 - 104,105,804 (+)EnsemblGRCm39 Ensembl
GRCm3812104,127,986 - 104,139,546 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl12104,127,996 - 104,139,545 (+)EnsemblGRCm38mm10GRCm38
MGSCv3712105,366,206 - 105,377,755 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3612104,529,046 - 104,540,595 (+)NCBIMGSCv36mm8
Celera12105,346,286 - 105,357,828 (+)NCBICelera
Cytogenetic Map12ENCBI
cM Map1253.4NCBI
Serpina3m
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr86128,829,569 - 128,836,844 (-)NCBIGRCr8
mRatBN7.26123,064,796 - 123,072,087 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl6123,064,796 - 123,072,066 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx6123,205,731 - 123,212,956 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.06123,501,031 - 123,508,256 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.06122,837,927 - 122,845,245 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.06127,808,785 - 127,816,067 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6127,808,785 - 127,816,055 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.06137,027,387 - 137,034,657 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.46128,197,796 - 128,205,050 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.16128,201,548 - 128,206,796 (-)NCBI
Celera6120,544,447 - 120,551,717 (-)NCBICelera
Cytogenetic Map6q32NCBI
Serpina3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543817,758,718 - 17,766,180 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495543817,758,763 - 17,766,113 (-)NCBIChiLan1.0ChiLan1.0
SERPINA3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21595,743,876 - 95,773,071 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11494,960,381 - 94,989,576 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01475,220,252 - 75,247,996 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11494,551,934 - 94,579,515 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1494,551,934 - 94,579,515 (+)Ensemblpanpan1.1panPan2
SERPINA3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1863,588,188 - 63,596,955 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl863,587,891 - 63,596,954 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha863,164,917 - 63,175,512 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0863,855,220 - 63,865,896 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl863,854,919 - 63,864,061 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1863,530,462 - 63,541,144 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0863,582,830 - 63,592,195 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0863,913,509 - 63,922,278 (+)NCBIUU_Cfam_GSD_1.0
Serpina3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864010,844,028 - 10,859,398 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936846174,233 - 182,203 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936846174,411 - 182,053 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LOC396684
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.17115,871,489 - 115,880,323 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.27122,933,477 - 122,938,468 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap7q23-q26NCBI
Serpina3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247347,259,949 - 7,267,261 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247347,260,666 - 7,267,831 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

endocrine system hemolymphoid system nervous system
High
Medium 36 21
Low 16 28
Below cutoff 4 11

Sequence


Reference Sequences
RefSeq Acc Id: ENSCSAT00000008823   ⟹   ENSCSAP00000006959
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1 Ensembl2472,402,560 - 72,415,507 (+)Ensembl
RefSeq Acc Id: XM_037984451   ⟹   XP_037840379
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_02366605359,621,063 - 59,632,854 (+)NCBI
RefSeq Acc Id: XM_037984452   ⟹   XP_037840380
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_02366605359,621,126 - 59,632,854 (+)NCBI
RefSeq Acc Id: XM_037984453   ⟹   XP_037840381
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_02366605359,607,697 - 59,632,854 (+)NCBI
Protein Sequences
Protein RefSeqs XP_037840379 (Get FASTA)   NCBI Sequence Viewer  
  XP_037840380 (Get FASTA)   NCBI Sequence Viewer  
  XP_037840381 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCSAP00000006959.1
Reference Protein Sequences
RefSeq Acc Id: ENSCSAP00000006959   ⟸   ENSCSAT00000008823
RefSeq Acc Id: XP_037840381   ⟸   XM_037984453
- Peptide Label: isoform X2
- UniProtKB: A0A0D9REC0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_037840379   ⟸   XM_037984451
- Peptide Label: isoform X1
- UniProtKB: A0A0D9REC0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_037840380   ⟸   XM_037984452
- Peptide Label: isoform X2
- UniProtKB: A0A0D9REC0 (UniProtKB/TrEMBL)


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCSAG00000010790 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCSAT00000008823.1 UniProtKB/TrEMBL
Gene3D-CATH 2.30.39.10 UniProtKB/TrEMBL
  3.30.497.10 UniProtKB/TrEMBL
InterPro Serpin_CS UniProtKB/TrEMBL
  Serpin_dom UniProtKB/TrEMBL
  Serpin_fam UniProtKB/TrEMBL
  Serpin_sf UniProtKB/TrEMBL
  Serpin_sf_1 UniProtKB/TrEMBL
  Serpin_sf_2 UniProtKB/TrEMBL
KEGG Report csab:103229619 UniProtKB/TrEMBL
NCBI Gene SERPINA3 ENTREZGENE
PANTHER ALPHA-1-ANTICHYMOTRYPSIN UniProtKB/TrEMBL
  PTHR11461 UniProtKB/TrEMBL
Pfam Serpin UniProtKB/TrEMBL
PROSITE SERPIN UniProtKB/TrEMBL
SMART SERPIN UniProtKB/TrEMBL
Superfamily-SCOP SSF56574 UniProtKB/TrEMBL
UniProt A0A0D9REC0 ENTREZGENE, UniProtKB/TrEMBL