ITIH3 (inter-alpha-trypsin inhibitor heavy chain 3) - Rat Genome Database

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Gene: ITIH3 (inter-alpha-trypsin inhibitor heavy chain 3) Chlorocebus sabaeus
Analyze
Symbol: ITIH3
Name: inter-alpha-trypsin inhibitor heavy chain 3
RGD ID: 18341594
Description: ENCODES a protein that exhibits serine-type endopeptidase inhibitor activity (inferred); INVOLVED IN hyaluronan metabolic process (inferred); ASSOCIATED WITH congenital disorder of glycosylation In (ortholog); hepatocellular carcinoma (ortholog); FOUND IN extracellular region (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: inter-alpha-trypsin inhibitor heavy chain H3
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: ChlSab1.1 - Green Monkey 1.1 Assembly
Position:
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12214,176,656 - 14,191,256 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2214,177,334 - 14,191,353 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666041152,706,611 - 152,721,211 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:22301074  


Genomics

Comparative Map Data
ITIH3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12214,176,656 - 14,191,256 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2214,177,334 - 14,191,353 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666041152,706,611 - 152,721,211 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
ITIH3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38352,794,796 - 52,808,797 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl352,794,768 - 52,808,799 (+)EnsemblGRCh38hg38GRCh38
GRCh37352,828,812 - 52,842,813 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36352,803,824 - 52,818,065 (+)NCBINCBI36Build 36hg18NCBI36
Build 34352,803,853 - 52,817,854NCBI
Celera352,807,505 - 52,821,742 (+)NCBICelera
Cytogenetic Map3p21.1NCBI
HuRef352,890,445 - 52,904,683 (+)NCBIHuRef
CHM1_1352,780,986 - 52,795,224 (+)NCBICHM1_1
T2T-CHM13v2.0352,827,705 - 52,841,707 (+)NCBIT2T-CHM13v2.0
Itih3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391430,630,529 - 30,645,748 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1430,630,529 - 30,645,717 (-)EnsemblGRCm39 Ensembl
GRCm381430,908,572 - 30,923,787 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1430,908,572 - 30,923,760 (-)EnsemblGRCm38mm10GRCm38
MGSCv371431,721,758 - 31,736,773 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361429,737,582 - 29,752,553 (-)NCBIMGSCv36mm8
Celera1427,165,744 - 27,180,756 (-)NCBICelera
Cytogenetic Map14BNCBI
cM Map1419.09NCBI
Itih3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8166,108,378 - 6,123,609 (-)NCBIGRCr8
mRatBN7.2166,101,922 - 6,117,154 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl166,101,930 - 6,116,924 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx166,113,241 - 6,128,042 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0167,258,702 - 7,273,506 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0166,120,667 - 6,135,331 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0166,983,779 - 7,007,288 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl166,992,062 - 7,007,287 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0166,910,530 - 6,933,416 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4166,341,043 - 6,358,767 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1166,341,044 - 6,358,765 (-)NCBI
Celera169,072,721 - 9,087,644 (+)NCBICelera
Cytogenetic Map16p16NCBI
Itih3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554302,753,996 - 2,767,324 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554302,753,974 - 2,767,436 (+)NCBIChiLan1.0ChiLan1.0
ITIH3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2252,786,787 - 52,803,297 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1352,791,574 - 52,807,958 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0352,733,966 - 52,750,198 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1353,961,476 - 53,976,065 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl353,961,451 - 53,976,065 (+)Ensemblpanpan1.1panPan2
ITIH3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12037,032,485 - 37,035,941 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2037,003,374 - 37,017,395 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02037,372,140 - 37,386,102 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2037,372,141 - 37,386,063 (-)EnsemblROS_Cfam_1.0 Ensembl
UNSW_CanFamBas_1.02037,144,184 - 37,158,164 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02037,421,715 - 37,435,675 (-)NCBIUU_Cfam_GSD_1.0
Itih3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118170,414,614 - 170,430,165 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364733,553,210 - 3,568,636 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364733,553,210 - 3,568,636 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ITIH3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1334,906,538 - 34,933,706 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11334,911,104 - 34,924,881 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21338,106,334 - 38,120,182 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Itih3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248224,416,074 - 4,429,623 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248224,415,962 - 4,429,660 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

endocrine system hemolymphoid system nervous system
High
Medium
Low 22 12 6
Below cutoff 14 5 49

Sequence


Reference Sequences
RefSeq Acc Id: ENSCSAT00000011328   ⟹   ENSCSAP00000009406
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1 Ensembl2214,177,334 - 14,191,353 (+)Ensembl
RefSeq Acc Id: XM_007984553   ⟹   XP_007982744
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.12214,177,668 - 14,191,256 (+)NCBI
Vero_WHO_p1.0NW_023666041152,706,611 - 152,719,075 (-)NCBI
Sequence:
RefSeq Acc Id: XM_007984556   ⟹   XP_007982747
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.12214,176,656 - 14,191,256 (+)NCBI
Vero_WHO_p1.0NW_023666041152,706,611 - 152,721,211 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_007982744 (Get FASTA)   NCBI Sequence Viewer  
  XP_007982747 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCSAP00000009406.1
Reference Protein Sequences
RefSeq Acc Id: XP_007982747   ⟸   XM_007984556
- Peptide Label: isoform X2
- UniProtKB: A0A0D9RLB7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_007982744   ⟸   XM_007984553
- Peptide Label: isoform X1
- UniProtKB: A0A0D9RLB7 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCSAP00000009406   ⟸   ENSCSAT00000011328


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCSAG00000013238 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCSAT00000011328.1 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.410 UniProtKB/TrEMBL
InterPro ITI_HC_C UniProtKB/TrEMBL
  VIT UniProtKB/TrEMBL
  VWF_A UniProtKB/TrEMBL
  vWFA_dom_sf UniProtKB/TrEMBL
NCBI Gene ITIH3 ENTREZGENE
PANTHER INTER-ALPHA-TRYPSIN INHIBITOR HEAVY CHAIN FAMILY MEMBER UniProtKB/TrEMBL
  INTER-ALPHA-TRYPSIN INHIBITOR HEAVY CHAIN H3 UniProtKB/TrEMBL
Pfam ITI_HC_C UniProtKB/TrEMBL
  VIT UniProtKB/TrEMBL
  VWA UniProtKB/TrEMBL
PROSITE VIT UniProtKB/TrEMBL
  VWFA UniProtKB/TrEMBL
SMART VIT UniProtKB/TrEMBL
  VWA UniProtKB/TrEMBL
Superfamily-SCOP SSF53300 UniProtKB/TrEMBL
UniProt A0A0D9RLB7 ENTREZGENE, UniProtKB/TrEMBL