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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:Ventricular Remodeling
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Accession:DOID:9007174 term browser browse the term
Definition:The geometric and structural changes that the HEART VENTRICLES undergo, usually following MYOCARDIAL INFARCTION. It comprises expansion of the infarct and dilatation of the healthy ventricle segments. While most prevalent in the left ventricle, it can also occur in the right ventricle.
Synonyms:exact_synonym: Left Ventricle Remodeling;   Left Ventricle Remodelings;   Left Ventricular Remodeling;   Left Ventricular Remodelings;   Ventricle Remodeling;   Ventricle Remodelings;   Ventricular Cardiac Remodeling;   Ventricular Cardiac Remodelings;   Ventricular Myocardial Remodeling;   Ventricular Myocardial Remodelings;   Ventricular Remodelings
 primary_id: MESH:D020257


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Ventricular Remodeling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ace angiotensin I converting enzyme treatment IDA associated with Acute Kidney Injury RGD PMID:18223026 RGD:9685440 NCBI chr10:90,910,316...90,930,437
Ensembl chr10:90,910,316...90,931,131 		JBrowse link
G Ace2 angiotensin converting enzyme 2 treatment ISO
IEP		 associated with Diabetic Cardiomyopathies
associated with Myocardial Infarction
associated with Acute Kidney Injury		 RGD PMID:22340266 PMID:20507236 PMID:18223026 RGD:9685428, RGD:9685439, RGD:9685440 NCBI chr  X:30,293,597...30,340,961
Ensembl chr  X:30,293,589...30,340,977 		JBrowse link
G Adra1a adrenoceptor alpha 1A ISO CTD Direct Evidence: marker/mechanism CTD PMID:20668454 NCBI chr15:40,830,125...40,935,902
Ensembl chr15:40,832,534...40,927,500 		JBrowse link
G Agt angiotensinogen ISO CTD Direct Evidence: marker/mechanism CTD PMID:29353218 NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977 		JBrowse link
G Agtr1a angiotensin II receptor, type 1a IEP RGD PMID:18252761 RGD:10047108 NCBI chr17:34,173,446...34,226,892
Ensembl chr17:34,174,429...34,226,946 		JBrowse link
G Ahr aryl hydrocarbon receptor IEP associated with diesel exhaust particulates exposure; protein:increased expression:heart left ventricle (rat) RGD PMID:23887904 RGD:401794424 NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568 		JBrowse link
G Axin2 axin 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:29394407 NCBI chr10:93,893,830...93,927,042
Ensembl chr10:93,899,245...93,926,231 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator ameliorates ISO associated with myocardial infarction RGD PMID:25726944 RGD:11252030 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl2 BCL2, apoptosis regulator ameliorates ISO associated with myocardial infarction RGD PMID:25726944 RGD:11252030 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Casp3 caspase 3 ameliorates ISO associated with myocardial infarction RGD PMID:25726944 RGD:11252030 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Ctnnb1 catenin beta 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:29394407 NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 IEP associated with diesel exhaust particulates exposure; protein:increased expression:heart left ventricle (rat) RGD PMID:23887904 RGD:401794424 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125 		JBrowse link
G Dstn destrin, actin depolymerizing factor ISO CTD Direct Evidence: marker/mechanism CTD PMID:29394407 NCBI chr 3:131,284,647...131,311,361
Ensembl chr 3:131,284,648...131,311,379 		JBrowse link
G Fis1 fission, mitochondrial 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20886221 NCBI chr12:19,708,560...19,723,392
Ensembl chr12:19,708,558...19,723,377 		JBrowse link
G Gata4 GATA binding protein 4 ISO CTD Direct Evidence: marker/mechanism CTD PMID:29394407 NCBI chr15:37,459,601...37,531,291
Ensembl chr15:37,459,601...37,505,636 		JBrowse link
G Gdf1 growth differentiation factor 1 ameliorates ISO associated with myocardial infarction RGD PMID:25726944 RGD:11252030 NCBI chr16:19,097,309...19,112,519
Ensembl chr16:19,097,314...19,112,519 		JBrowse link
G Gsn gelsolin ameliorates ISO RGD PMID:19246681 RGD:329333014 NCBI chr 3:18,585,166...18,638,404
Ensembl chr 3:18,585,172...18,638,402 		JBrowse link
G Hand2 heart and neural crest derivatives expressed 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:29394407 NCBI chr16:32,917,448...32,920,791
Ensembl chr16:32,917,823...32,919,891 		JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha IEP associated with diesel exhaust particulates exposure; protein:decreased expression:heart left ventricle (rat) RGD PMID:23887904 RGD:401794424 NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261 		JBrowse link
G Kcnn4 potassium calcium-activated channel subfamily N member 4 ameliorates ISO associated with myocardial infarction RGD PMID:26160442 RGD:329969895 NCBI chr 1:79,956,380...79,974,354
Ensembl chr 1:79,959,322...79,974,340 		JBrowse link
G Ltbp2 latent transforming growth factor beta binding protein 2 ISO mRNA:increased expression:heart (mouse) RGD PMID:31364721 RGD:213230159 NCBI chr 6:104,429,947...104,530,498
Ensembl chr 6:104,429,947...104,526,208 		JBrowse link
G Map3k5 mitogen-activated protein kinase kinase kinase 5 ISO protein:increased activity:heart: RGD PMID:14665690 RGD:10412322 NCBI chr 1:14,685,776...14,904,935
Ensembl chr 1:14,685,492...14,904,800 		JBrowse link
G Mfn2 mitofusin 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20886221 NCBI chr 5:158,304,285...158,335,502
Ensembl chr 5:158,304,287...158,335,342 		JBrowse link
G Mir140 microRNA 140 ameliorates IEP RGD PMID:28922712 RGD:329347824 NCBI chr19:35,465,577...35,465,675
Ensembl chr19:35,465,577...35,465,675 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 ISO CTD Direct Evidence: therapeutic CTD PMID:29353218 NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737 		JBrowse link
G Nos1 nitric oxide synthase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16344403 NCBI chr12:38,615,111...38,795,492
Ensembl chr12:38,626,714...38,710,945 		JBrowse link
G Nppa natriuretic peptide A ameliorates ISO CTD Direct Evidence: marker/mechanism
associated with myocardial infarction		 CTD
RGD		 PMID:20886221 PMID:25726944 RGD:11252030 NCBI chr 5:158,429,042...158,430,351
Ensembl chr 5:158,429,042...158,430,351 		JBrowse link
G Nppb natriuretic peptide B ameliorates ISO CTD Direct Evidence: marker/mechanism
associated with myocardial infarction		 CTD
RGD		 PMID:29394407 PMID:25726944 RGD:11252030 NCBI chr 5:158,416,813...158,418,175
Ensembl chr 5:158,416,866...158,418,168 		JBrowse link
G Opa1 OPA1, mitochondrial dynamin like GTPase ISO CTD Direct Evidence: marker/mechanism CTD PMID:20886221 NCBI chr11:71,108,100...71,185,170
Ensembl chr11:71,109,873...71,185,109 		JBrowse link
G Rock2 Rho-associated coiled-coil containing protein kinase 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:29394407 NCBI chr 6:39,679,116...39,774,033
Ensembl chr 6:39,679,082...39,774,031 		JBrowse link
G Sirt6 sirtuin 6 ISO CTD Direct Evidence: therapeutic CTD PMID:34713381 NCBI chr 7:8,082,312...8,087,776
Ensembl chr 7:8,082,364...8,098,914 		JBrowse link
G Slc9a1 solute carrier family 9 member A1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20886221 NCBI chr 5:145,576,341...145,629,630
Ensembl chr 5:145,576,334...145,629,624 		JBrowse link
G Smad2 SMAD family member 2 ameliorates ISO CTD Direct Evidence: marker/mechanism
associated with myocardial infarction		 CTD
RGD		 PMID:16635409 PMID:25726944 RGD:11252030 NCBI chr18:69,849,884...69,918,926
Ensembl chr18:69,850,377...69,912,323 		JBrowse link
G Smad3 SMAD family member 3 ameliorates ISO CTD Direct Evidence: marker/mechanism
associated with myocardial infarction		 CTD
RGD		 PMID:16635409 PMID:25726944 RGD:11252030 NCBI chr 8:64,126,829...64,236,960
Ensembl chr 8:64,110,039...64,236,960 		JBrowse link
G Tbx20 T-box transcription factor 20 ISO CTD Direct Evidence: marker/mechanism CTD PMID:29394407 NCBI chr 8:23,200,104...23,258,218
Ensembl chr 8:23,204,507...23,258,175 		JBrowse link
G Tcf7l2 transcription factor 7 like 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:29394407 NCBI chr 1:254,785,956...254,978,967
Ensembl chr 1:254,786,091...254,978,967 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16635409 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847 		JBrowse link
G Tnnt2 troponin T2, cardiac type IEP associated with diesel exhaust particulates exposure; protein:increased expression:heart left ventricle (rat) RGD PMID:23887904 RGD:401794424 NCBI chr13:47,267,325...47,285,390
Ensembl chr13:47,267,204...47,285,388 		JBrowse link
G Vegfa vascular endothelial growth factor A IEP associated with diesel exhaust particulates exposure; protein:decreased expression:heart left ventricle (rat) RGD PMID:23887904 RGD:401794424 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641 		JBrowse link
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  disease 18976
    Pathological Conditions, Signs and Symptoms 13376
      Anatomical Pathological Conditions 2664
        Ventricular Remodeling 39
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