RGD Reference Report - ACE2 overexpression ameliorates left ventricular remodeling and dysfunction in a rat model of myocardial infarction. - Rat Genome Database

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ACE2 overexpression ameliorates left ventricular remodeling and dysfunction in a rat model of myocardial infarction.

Authors: Zhao, YX  Yin, HQ  Yu, QT  Qiao, Y  Dai, HY  Zhang, MX  Zhang, L  Liu, YF  Wang, LC  Liu de, S  Deng, BP  Zhang, YH  Pan, CM  Song, HD  Qu, X  Jiang, H  Liu, CX  Lu, XT  Liu, B  Gao, F  Dong, B 
Citation: Zhao YX, etal., Hum Gene Ther. 2010 Nov;21(11):1545-54. doi: 10.1089/hum.2009.160.
RGD ID: 9685439
Pubmed: PMID:20507236   (View Abstract at PubMed)
DOI: DOI:10.1089/hum.2009.160   (Journal Full-text)

The purpose of this study was to test the hypothesis that overexpression of angiotensin-converting enzyme 2 (ACE2) may favorably affect left ventricular (LV) remodeling and function after myocardial infarction (MI). The left anterior descending coronary artery was ligated to produce anterior MI in 100 Wistar-Kyoto rats that were randomly divided into Ad-ACE2, Ad-ACE2+A779, Ad-EGFP, model, and sham groups. Two weeks later, rats in the Ad-ACE2 and Ad-EGFP groups received direct intramyocardial injection of Ad-ACE2 and Ad-EGFP, respectively. Rats in the Ad-ACE2+A779 group received both intramyocardial injection of Ad-ACE2 and a continuous intravenous infusion of A779 for 15 days. LV volume and systolic function, the extent of myocardial fibrosis, and levels of ACE2, angiotensin II (Ang II), and collagen I protein expression were evaluated. Four weeks after ACE2 gene transfer, the Ad-ACE2 group showed reduced LV volume, extent of myocardial fibrosis, and expression levels of ACE, Ang II, and collagen I in the myocardium, and increased LV ejection fraction and levels of ACE2 activity and expression in comparison with the Ad-EGFP and model groups. These results suggest that ACE2 overexpression attenuated LV fibrosis and improved LV remodeling and systolic function. In conclusion, overexpression of ACE2 favorably affected the pathological process of LV remodeling after MI by inhibiting ACE activity, reducing AngII levels, and up-regulating Ang-(1-7) expression, thus providing a potential therapeutic target in the treatment of heart failure.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Ventricular Remodeling treatmentISOAce2 (Mus musculus)9685439; 9685439associated with Myocardial InfarctionRGD 
Ventricular Remodeling treatmentIMP 9685439associated with Myocardial InfarctionRGD 

Objects Annotated

Genes (Rattus norvegicus)
Ace2  (angiotensin converting enzyme 2)

Genes (Mus musculus)
Ace2  (angiotensin converting enzyme 2)

Genes (Homo sapiens)
ACE2  (angiotensin converting enzyme 2)


Additional Information