CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: venlafaxine hydrochloride
Accession: CHEBI:9944
browse the term
Definition: A hydrochloride that has formula C17H27NO2.HCl.
Synonyms: exact_synonym: 1-[2-(dimethylamino)-1-(4-methoxyphenyl)ethyl]cyclohexanol hydrochloride
related_synonym: (+-)-1-(alpha-((Dimethylamino)methyl)-p-methoxybenzyl)cyclohexanol hydrochloride; Formula=C17H27NO2.HCl; InChI=1S/C17H27NO2.ClH/c1-18(2)13-16(17(19)11-5-4-6-12-17)14-7-9-15(20-3)10-8-14;/h7-10,16,19H,4-6,11-13H2,1-3H3;1H; InChIKey=QYRYFNHXARDNFZ-UHFFFAOYSA-N; SMILES=[H+].[Cl-].COc1ccc(cc1)C(CN(C)C)C1(O)CCCCC1; Venlafaxine HCl; Wy 45030
xref: Beilstein:4240401; CAS:99300-78-4; DrugBank:DB00285; KEGG:D00821
xref_mesh: MESH:D000069470
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ABCB1
ATP binding cassette subfamily B member 1
increases expression increases export
EXP ISO
Venlafaxine Hydrochloride results in increased expression of ABCB1 mRNA ABCB1 protein results in increased export of Venlafaxine Hydrochloride
CTD
PMID:14550684 PMID:17191263
NCBI chr 7:87,503,017...87,713,295
Ensembl chr 7:87,503,017...87,713,323
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ABCC1
ATP binding cassette subfamily C member 1 (ABCC1 blood group)
increases expression
EXP
Venlafaxine Hydrochloride results in increased expression of ABCC1 mRNA
CTD
PMID:17191263
NCBI chr16:15,949,143...16,143,053
Ensembl chr16:15,949,138...16,143,257
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ACE
angiotensin I converting enzyme
increases expression
ISO
Venlafaxine Hydrochloride results in increased expression of ACE mRNA
CTD
PMID:25423262
NCBI chr17:63,477,061...63,498,373
Ensembl chr17:63,477,061...63,498,380
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ACP5
acid phosphatase 5, tartrate resistant
decreases expression
EXP
Venlafaxine Hydrochloride results in decreased expression of ACP5 mRNA
CTD
PMID:16341940
NCBI chr19:11,574,660...11,578,975
Ensembl chr19:11,574,653...11,579,993
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ACTA2
actin alpha 2, smooth muscle
multiple interactions
ISO
Chloroquine inhibits the reaction [Venlafaxine Hydrochloride inhibits the reaction [Rotenone results in increased expression of ACTA2 protein]]; Venlafaxine Hydrochloride inhibits the reaction [Rotenone results in increased expression of ACTA2 protein]
CTD
PMID:35104487
NCBI chr10:88,935,074...88,991,337
Ensembl chr10:88,934,822...88,991,339
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ACVR1C
activin A receptor type 1C
increases expression
ISO
Venlafaxine Hydrochloride results in increased expression of ACVR1C mRNA
CTD
PMID:25423262
NCBI chr 2:157,526,767...157,628,864
Ensembl chr 2:157,526,767...157,628,864
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ADAM10
ADAM metallopeptidase domain 10
increases expression
ISO
Venlafaxine Hydrochloride results in increased expression of ADAM10 mRNA
CTD
PMID:25423262
NCBI chr15:58,588,809...58,749,707
Ensembl chr15:58,588,809...58,749,791
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ADGRL1
adhesion G protein-coupled receptor L1
affects expression
ISO
Venlafaxine Hydrochloride affects the expression of ADGRL1 mRNA
CTD
PMID:25423262
NCBI chr19:14,147,743...14,206,169
Ensembl chr19:14,147,743...14,206,187
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AGO2
argonaute RISC catalytic component 2
increases expression
ISO
Venlafaxine Hydrochloride results in increased expression of AGO2 mRNA
CTD
PMID:25423262
NCBI chr 8:140,520,156...140,642,313
Ensembl chr 8:140,520,156...140,635,633
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AHR
aryl hydrocarbon receptor
increases expression
ISO
Venlafaxine Hydrochloride results in increased expression of AHR mRNA
CTD
PMID:25423262
NCBI chr 7:17,298,652...17,346,147
Ensembl chr 7:16,916,359...17,346,152
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AKAP5
A-kinase anchoring protein 5
increases expression
ISO
Venlafaxine Hydrochloride results in increased expression of AKAP5 mRNA
CTD
PMID:25423262
NCBI chr14:64,465,499...64,474,503
Ensembl chr14:64,465,499...64,474,503
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AKT1
AKT serine/threonine kinase 1
increases expression
ISO
Venlafaxine Hydrochloride results in increased expression of AKT1 protein
CTD
PMID:18511088
NCBI chr14:104,769,349...104,795,748
Ensembl chr14:104,769,349...104,795,759
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ALB
albumin
multiple interactions
ISO
Venlafaxine Hydrochloride inhibits the reaction [Cisplatin results in decreased expression of ALB protein]
CTD
PMID:29852128
NCBI chr 4:73,404,287...73,421,482
Ensembl chr 4:73,397,114...73,421,482
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ALCAM
activated leukocyte cell adhesion molecule
increases expression
ISO
Venlafaxine Hydrochloride results in increased expression of ALCAM mRNA
CTD
PMID:25423262
NCBI chr 3:105,366,909...105,576,900
Ensembl chr 3:105,366,909...105,576,900
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ANKRD55
ankyrin repeat domain 55
increases expression
EXP
Venlafaxine Hydrochloride results in increased expression of ANKRD55 mRNA
CTD
PMID:16341940
NCBI chr 5:56,099,680...56,233,330
Ensembl chr 5:56,099,680...56,233,330
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AP2B1
adaptor related protein complex 2 subunit beta 1
decreases expression
ISO
Venlafaxine Hydrochloride results in decreased expression of AP2B1 mRNA
CTD
PMID:25423262
NCBI chr17:35,587,322...35,726,413
Ensembl chr17:35,578,046...35,726,413
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AR
androgen receptor
decreases expression
ISO
Venlafaxine Hydrochloride results in decreased expression of AR protein
CTD
PMID:36063371
NCBI chr X:67,544,021...67,730,619
Ensembl chr X:67,544,021...67,730,619
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ARC
activity regulated cytoskeleton associated protein
increases expression
ISO
Venlafaxine Hydrochloride results in increased expression of ARC mRNA; Venlafaxine Hydrochloride results in increased expression of ARC protein
CTD
PMID:14580947 PMID:15087240 PMID:15838995
NCBI chr 8:142,611,049...142,614,479
Ensembl chr 8:142,611,049...142,614,479
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ARF3
ADP ribosylation factor 3
decreases expression
ISO
Venlafaxine Hydrochloride results in decreased expression of ARF3 mRNA
CTD
PMID:25423262
NCBI chr12:48,935,723...48,957,487
Ensembl chr12:48,935,723...48,957,487
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ARHGAP10
Rho GTPase activating protein 10
increases expression
EXP
Venlafaxine Hydrochloride results in increased expression of ARHGAP10 mRNA
CTD
PMID:16341940
NCBI chr 4:147,732,088...148,072,776
Ensembl chr 4:147,732,063...148,072,776
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ARHGEF9
Cdc42 guanine nucleotide exchange factor 9
increases expression
ISO
Venlafaxine Hydrochloride results in increased expression of ARHGEF9 mRNA
CTD
PMID:25423262
NCBI chr X:63,634,967...63,785,214
Ensembl chr X:63,634,967...63,809,274
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ASCL1
achaete-scute family bHLH transcription factor 1
increases expression decreases expression
ISO
Venlafaxine Hydrochloride results in increased expression of ASCL1 mRNA Venlafaxine Hydrochloride results in decreased expression of ASCL1 mRNA
CTD
PMID:25423262
NCBI chr12:102,957,674...102,960,513
Ensembl chr12:102,957,674...102,960,513
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ATP2B3
ATPase plasma membrane Ca2+ transporting 3
increases expression
ISO
Venlafaxine Hydrochloride results in increased expression of ATP2B3 mRNA
CTD
PMID:25423262
NCBI chr X:153,517,642...153,582,929
Ensembl chr X:153,517,642...153,582,939
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ATRX
ATRX chromatin remodeler
increases expression
ISO
Venlafaxine Hydrochloride results in increased expression of ATRX mRNA
CTD
PMID:25423262
NCBI chr X:77,504,880...77,786,216
Ensembl chr X:77,504,880...77,786,233
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BAX
BCL2 associated X, apoptosis regulator
multiple interactions
ISO
Chloroquine inhibits the reaction [Venlafaxine Hydrochloride inhibits the reaction [Rotenone results in increased expression of BAX protein]]; Venlafaxine Hydrochloride inhibits the reaction [Cisplatin results in increased expression of BAX protein]; Venlafaxine Hydrochloride inhibits the reaction [Rotenone results in increased expression of BAX protein]
CTD
PMID:29852128 PMID:35104487
NCBI chr19:48,954,875...48,961,798
Ensembl chr19:48,954,815...48,961,798
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BCL2
BCL2 apoptosis regulator
decreases expression multiple interactions
ISO
Venlafaxine Hydrochloride results in decreased expression of BCL2 mRNA Chloroquine inhibits the reaction [Venlafaxine Hydrochloride inhibits the reaction [Rotenone results in decreased expression of BCL2 protein]]; Venlafaxine Hydrochloride inhibits the reaction [Cisplatin results in decreased expression of BCL2 protein]; Venlafaxine Hydrochloride inhibits the reaction [Rotenone results in decreased expression of BCL2 protein]
CTD
PMID:25423262 PMID:29852128 PMID:35104487
NCBI chr18:63,123,346...63,320,090
Ensembl chr18:63,123,346...63,320,128
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BDNF
brain derived neurotrophic factor
increases expression
ISO
Venlafaxine Hydrochloride results in increased expression of BDNF mRNA
CTD
PMID:17950272
NCBI chr11:27,654,893...27,722,030
Ensembl chr11:27,654,893...27,722,058
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BECN1
beclin 1
multiple interactions
ISO
Chloroquine inhibits the reaction [Venlafaxine Hydrochloride inhibits the reaction [Rotenone results in decreased expression of BECN1 protein]]; Venlafaxine Hydrochloride inhibits the reaction [Rotenone results in decreased expression of BECN1 protein]
CTD
PMID:35104487
NCBI chr17:42,810,132...42,824,282
Ensembl chr17:42,810,134...42,833,350
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BRINP3
BMP/retinoic acid inducible neural specific 3
increases expression
EXP
Venlafaxine Hydrochloride results in increased expression of BRINP3 mRNA
CTD
PMID:16341940
NCBI chr 1:190,097,658...190,477,864
Ensembl chr 1:190,097,658...190,478,404
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CACNB4
calcium voltage-gated channel auxiliary subunit beta 4
increases expression
ISO
Venlafaxine Hydrochloride results in increased expression of CACNB4 mRNA
CTD
PMID:25423262
NCBI chr 2:151,832,771...152,099,167
Ensembl chr 2:151,832,771...152,099,167
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CALM3
calmodulin 3
decreases expression
ISO
Venlafaxine Hydrochloride results in decreased expression of CALM3 mRNA
CTD
PMID:25423262
NCBI chr19:46,601,074...46,610,782
Ensembl chr19:46,601,074...46,610,782
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CAMK2A
calcium/calmodulin dependent protein kinase II alpha
increases expression
ISO
Venlafaxine Hydrochloride results in increased expression of CAMK2A mRNA
CTD
PMID:25423262
NCBI chr 5:150,219,491...150,290,130
Ensembl chr 5:150,219,491...150,290,093
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CAMK2B
calcium/calmodulin dependent protein kinase II beta
affects expression
ISO
Venlafaxine Hydrochloride affects the expression of CAMK2B mRNA
CTD
PMID:25423262
NCBI chr 7:44,217,154...44,326,013
Ensembl chr 7:44,210,019...44,334,577
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CAMK2G
calcium/calmodulin dependent protein kinase II gamma
affects expression
ISO
Venlafaxine Hydrochloride affects the expression of CAMK2G mRNA
CTD
PMID:25423262
NCBI chr10:73,812,501...73,874,555
Ensembl chr10:73,812,501...73,874,591
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CASP3
caspase 3
multiple interactions
ISO
Chloroquine inhibits the reaction [Venlafaxine Hydrochloride inhibits the reaction [Rotenone results in increased expression of CASP3 protein]]; Venlafaxine Hydrochloride inhibits the reaction [Cisplatin results in increased cleavage of CASP3 protein]; Venlafaxine Hydrochloride inhibits the reaction [Rotenone results in increased expression of CASP3 protein]
CTD
PMID:29852128 PMID:35104487
NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,650,062
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CAT
catalase
multiple interactions
ISO
Nitric Oxide promotes the reaction [Venlafaxine Hydrochloride inhibits the reaction [3-nitropropionic acid results in decreased activity of CAT protein]]; Venlafaxine Hydrochloride inhibits the reaction [3-nitropropionic acid results in decreased activity of CAT protein]; Venlafaxine Hydrochloride inhibits the reaction [Cisplatin results in decreased activity of CAT protein]
CTD
PMID:20305041 PMID:29852128
NCBI chr11:34,438,934...34,472,060
Ensembl chr11:34,438,934...34,472,060
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CD47
CD47 molecule
decreases expression
ISO
Venlafaxine Hydrochloride results in decreased expression of CD47 mRNA
CTD
PMID:25423262
NCBI chr 3:108,043,091...108,091,031
Ensembl chr 3:108,043,091...108,091,862
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CDH22
cadherin 22
affects expression
ISO
Venlafaxine Hydrochloride affects the expression of CDH22 mRNA
CTD
PMID:25423262
NCBI chr20:46,173,739...46,308,498
Ensembl chr20:46,173,739...46,308,498
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CELF2
CUGBP Elav-like family member 2
increases expression
ISO
Venlafaxine Hydrochloride results in increased expression of CELF2 mRNA
CTD
PMID:25423262
NCBI chr10:10,462,550...11,336,675
Ensembl chr10:10,798,397...11,336,675
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CLNS1A
chloride nucleotide-sensitive channel 1A
decreases expression
ISO
Venlafaxine Hydrochloride results in decreased expression of CLNS1A mRNA
CTD
PMID:25423262
NCBI chr11:77,614,530...77,637,794
Ensembl chr11:77,514,936...77,637,794
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CLSTN2
calsyntenin 2
decreases expression
ISO
Venlafaxine Hydrochloride results in decreased expression of CLSTN2 mRNA
CTD
PMID:25423262
NCBI chr 3:139,935,185...140,577,397
Ensembl chr 3:139,935,185...140,577,397
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CNBP
CCHC-type zinc finger nucleic acid binding protein
increases expression
ISO
Venlafaxine Hydrochloride results in increased expression of CNBP mRNA
CTD
PMID:25423262
NCBI chr 3:129,167,827...129,183,896
Ensembl chr 3:129,167,827...129,183,922
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CNR1
cannabinoid receptor 1
increases expression
ISO
Venlafaxine Hydrochloride results in increased expression of CNR1 mRNA
CTD
PMID:25423262
NCBI chr 6:88,139,864...88,167,349
Ensembl chr 6:88,139,864...88,166,347
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CNTN2
contactin 2
increases expression
ISO
Venlafaxine Hydrochloride results in increased expression of CNTN2 mRNA
CTD
PMID:25423262
NCBI chr 1:205,042,949...205,078,289
Ensembl chr 1:205,042,937...205,078,289
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COX17
cytochrome c oxidase copper chaperone COX17
increases expression
ISO
Venlafaxine Hydrochloride results in increased expression of COX17 mRNA
CTD
PMID:25423262
NCBI chr 3:119,663,975...119,677,406
Ensembl chr 3:119,654,513...119,677,454
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CPD
carboxypeptidase D
increases expression
ISO
Venlafaxine Hydrochloride results in increased expression of CPD mRNA
CTD
PMID:25423262
NCBI chr17:30,378,927...30,469,989
Ensembl chr17:30,378,927...30,469,989
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CTNNB1
catenin beta 1
increases expression
ISO
Venlafaxine Hydrochloride results in increased expression of CTNNB1 protein
CTD
PMID:18511088
NCBI chr 3:41,199,505...41,240,443
Ensembl chr 3:41,194,741...41,260,096
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CXXC4
CXXC finger protein 4
increases expression
ISO
Venlafaxine Hydrochloride results in increased expression of CXXC4 mRNA
CTD
PMID:25423262
NCBI chr 4:104,468,308...104,494,894
Ensembl chr 4:104,468,308...104,494,901
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CYP17A1
cytochrome P450 family 17 subfamily A member 1
decreases activity multiple interactions
EXP
Venlafaxine Hydrochloride results in decreased activity of CYP17A1 protein Venlafaxine Hydrochloride inhibits the reaction [[CYP17A1 protein results in increased hydroxylation of Pregnenolone] which results in increased chemical synthesis of 17-alpha-Hydroxypregnenolone]; Venlafaxine Hydrochloride inhibits the reaction [[CYP17A1 protein results in increased hydroxylation of Progesterone] which results in increased chemical synthesis of 17-alpha-Hydroxyprogesterone]; Venlafaxine Hydrochloride inhibits the reaction [[CYP17A1 protein results in increased metabolism of 17-alpha-Hydroxypregnenolone] which results in increased chemical synthesis of Dehydroepiandrosterone]; Venlafaxine Hydrochloride inhibits the reaction [[CYP17A1 protein results in increased metabolism of 17-alpha-Hydroxyprogesterone] which results in increased chemical synthesis of Androstenedione]; Venlafaxine Hydrochloride inhibits the reaction [CYP17A1 protein results in increased hydroxylation of Pregnenolone]; Venlafaxine Hydrochloride inhibits the reaction [CYP17A1 protein results in increased hydroxylation of Progesterone]; Venlafaxine Hydrochloride inhibits the reaction [CYP17A1 protein results in increased metabolism of 17-alpha-Hydroxypregnenolone]; Venlafaxine Hydrochloride inhibits the reaction [CYP17A1 protein results in increased metabolism of 17-alpha-Hydroxyprogesterone]
CTD
PMID:29100959
NCBI chr10:102,830,531...102,837,413
Ensembl chr10:102,830,531...102,837,472
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CYP2C19
cytochrome P450 family 2 subfamily C member 19
affects methylation decreases methylation
EXP
CYP2C19 gene polymorphism affects the methylation of Venlafaxine Hydrochloride CYP2C19 protein results in decreased methylation of Venlafaxine Hydrochloride
CTD
PMID:10877013
NCBI chr10:94,762,681...94,855,547
Ensembl chr10:94,762,681...94,855,547
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CYP2D6
cytochrome P450 family 2 subfamily D member 6
affects metabolic processing affects methylation affects response to substance decreases methylation increases metabolic processing decreases activity
EXP
CYP2D6 gene mutant form affects the metabolism of Venlafaxine Hydrochloride; CYP2D6 gene polymorphism affects the metabolism of Venlafaxine Hydrochloride CYP2D6 gene polymorphism affects the methylation of Venlafaxine Hydrochloride CYP2D6 protein affects the susceptibility to Venlafaxine Hydrochloride CYP2D6 protein results in decreased methylation of Venlafaxine Hydrochloride CYP2D6 protein results in increased metabolism of Venlafaxine Hydrochloride Venlafaxine Hydrochloride results in decreased activity of CYP2D6 protein
CTD
PMID:10774634 PMID:10877013 PMID:10933885 PMID:15632378 PMID:16044105 PMID:16958828 PMID:17803873 PMID:18214456 More...
NCBI chr22:42,126,499...42,130,810
Ensembl chr22:42,126,499...42,130,865
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DAB2
DAB adaptor protein 2
increases expression
ISO
Venlafaxine Hydrochloride results in increased expression of DAB2 mRNA
CTD
PMID:25423262
NCBI chr 5:39,371,677...39,424,980
Ensembl chr 5:39,371,675...39,462,300
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DDAH1
dimethylarginine dimethylaminohydrolase 1
increases expression
ISO
Venlafaxine Hydrochloride results in increased expression of DDAH1 mRNA
CTD
PMID:25423262
NCBI chr 1:85,318,485...85,578,200
Ensembl chr 1:85,318,481...85,578,363
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DMAC1
distal membrane arm assembly component 1
increases expression
EXP
Venlafaxine Hydrochloride results in increased expression of DMAC1 mRNA
CTD
PMID:16341940
NCBI chr 9:7,796,500...7,799,778
Ensembl chr 9:7,796,500...7,888,380
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DNMT3A
DNA methyltransferase 3 alpha
increases expression
ISO
Venlafaxine Hydrochloride results in increased expression of DNMT3A mRNA
CTD
PMID:25423262
NCBI chr 2:25,227,874...25,342,590
Ensembl chr 2:25,227,855...25,342,590
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DPP4
dipeptidyl peptidase 4
increases expression
ISO
Venlafaxine Hydrochloride results in increased expression of DPP4 mRNA
CTD
PMID:25423262
NCBI chr 2:161,992,245...162,074,215
Ensembl chr 2:161,992,245...162,074,394
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EDNRB
endothelin receptor type B
increases expression
ISO
Venlafaxine Hydrochloride results in increased expression of EDNRB mRNA
CTD
PMID:25423262
NCBI chr13:77,895,481...77,975,527
Ensembl chr13:77,895,481...77,975,529
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ENPP1
ectonucleotide pyrophosphatase/phosphodiesterase 1
decreases expression
ISO
Venlafaxine Hydrochloride results in decreased expression of ENPP1 mRNA
CTD
PMID:25423262
NCBI chr 6:131,808,020...131,895,155
Ensembl chr 6:131,808,016...131,895,155
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EPHA5
EPH receptor A5
decreases expression
ISO
Venlafaxine Hydrochloride results in decreased expression of EPHA5 mRNA
CTD
PMID:25423262
NCBI chr 4:65,319,567...65,670,489
Ensembl chr 4:65,319,563...65,670,495
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FMNL1
formin like 1
increases expression
EXP
Venlafaxine Hydrochloride results in increased expression of FMNL1 mRNA
CTD
PMID:16341940
NCBI chr17:45,221,885...45,247,318
Ensembl chr17:45,221,444...45,247,319
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GABRB1
gamma-aminobutyric acid type A receptor subunit beta1
increases expression
ISO
Venlafaxine Hydrochloride results in increased expression of GABRB1 mRNA
CTD
PMID:25423262
NCBI chr 4:46,993,647...47,426,447
Ensembl chr 4:46,993,723...47,426,447
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GABRB2
gamma-aminobutyric acid type A receptor subunit beta2
increases expression
ISO
Venlafaxine Hydrochloride results in increased expression of GABRB2 mRNA
CTD
PMID:25423262
NCBI chr 5:161,288,436...161,548,404
Ensembl chr 5:161,288,429...161,549,044
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GAD2
glutamate decarboxylase 2
decreases expression
ISO
Venlafaxine Hydrochloride results in decreased expression of GAD2 mRNA
CTD
PMID:25423262
NCBI chr10:26,216,372...26,304,558
Ensembl chr10:26,216,665...26,304,558
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GAS2
growth arrest specific 2
decreases expression
ISO
Venlafaxine Hydrochloride results in decreased expression of GAS2 mRNA
CTD
PMID:25423262
NCBI chr11:22,626,002...22,813,055
Ensembl chr11:22,625,509...22,813,001
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GAS6
growth arrest specific 6
increases expression
ISO
Venlafaxine Hydrochloride results in increased expression of GAS6 mRNA
CTD
PMID:25423262
NCBI chr13:113,820,549...113,864,076
Ensembl chr13:113,820,549...113,864,076
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GDA
guanine deaminase
increases expression
ISO
Venlafaxine Hydrochloride results in increased expression of GDA mRNA
CTD
PMID:25423262
NCBI chr 9:72,114,608...72,259,869
Ensembl chr 9:72,114,595...72,257,193
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GFAP
glial fibrillary acidic protein
increases expression
ISO
Venlafaxine Hydrochloride results in increased expression of GFAP mRNA
CTD
PMID:25423262
NCBI chr17:44,903,159...44,915,500
Ensembl chr17:44,903,159...44,916,937
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GLP1R
glucagon like peptide 1 receptor
decreases expression
ISO
Venlafaxine Hydrochloride results in decreased expression of GLP1R mRNA
CTD
PMID:25423262
NCBI chr 6:39,048,781...39,091,303
Ensembl chr 6:39,048,781...39,091,303
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GNAO1
G protein subunit alpha o1
increases expression
ISO
Venlafaxine Hydrochloride results in increased expression of GNAO1 mRNA
CTD
PMID:25423262
NCBI chr16:56,191,489...56,357,444
Ensembl chr16:56,189,660...56,357,444
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GNAQ
G protein subunit alpha q
affects expression
ISO
Venlafaxine Hydrochloride affects the expression of GNAQ mRNA
CTD
PMID:25423262
NCBI chr 9:77,716,097...78,031,811
Ensembl chr 9:77,716,097...78,031,811
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GRIA1
glutamate ionotropic receptor AMPA type subunit 1
increases expression
ISO
Venlafaxine Hydrochloride results in increased expression of GRIA1 mRNA
CTD
PMID:25423262
NCBI chr 5:153,489,615...153,813,869
Ensembl chr 5:153,489,615...153,813,869
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GRIA3
glutamate ionotropic receptor AMPA type subunit 3
decreases expression
ISO
Venlafaxine Hydrochloride results in decreased expression of GRIA3 mRNA
CTD
PMID:25423262
NCBI chr X:123,184,278...123,490,915
Ensembl chr X:123,184,153...123,490,915
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GRIN2A
glutamate ionotropic receptor NMDA type subunit 2A
affects expression
ISO
Venlafaxine Hydrochloride affects the expression of GRIN2A mRNA
CTD
PMID:25423262
NCBI chr16:9,753,404...10,182,908
Ensembl chr16:9,753,404...10,182,928
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GRIN2B
glutamate ionotropic receptor NMDA type subunit 2B
affects expression
ISO
Venlafaxine Hydrochloride affects the expression of GRIN2B mRNA
CTD
PMID:25423262
NCBI chr12:13,537,337...13,982,134
Ensembl chr12:13,437,942...13,982,002
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HCN1
hyperpolarization activated cyclic nucleotide gated potassium channel 1
decreases expression
ISO
Venlafaxine Hydrochloride results in decreased expression of HCN1 mRNA
CTD
PMID:25423262
NCBI chr 5:45,254,948...45,696,380
Ensembl chr 5:45,254,948...45,696,498
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HDAC6
histone deacetylase 6
multiple interactions
ISO
Chloroquine inhibits the reaction [Venlafaxine Hydrochloride inhibits the reaction [Rotenone results in increased expression of HDAC6 protein]]; Venlafaxine Hydrochloride inhibits the reaction [Rotenone results in decreased expression of HDAC6 protein]; Venlafaxine Hydrochloride inhibits the reaction [Rotenone results in increased expression of HDAC6 protein]
CTD
PMID:35104487
NCBI chr X:48,801,398...48,824,982
Ensembl chr X:48,801,377...48,824,982
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HOOK2
hook microtubule tethering protein 2
increases expression
ISO
Venlafaxine Hydrochloride results in increased expression of HOOK2 mRNA
CTD
PMID:25423262
NCBI chr19:12,763,003...12,792,350
Ensembl chr19:12,763,003...12,872,740
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IL1RAPL1
interleukin 1 receptor accessory protein like 1
increases expression
ISO
Venlafaxine Hydrochloride results in increased expression of IL1RAPL1 mRNA
CTD
PMID:25423262
NCBI chr X:28,587,446...29,956,718
Ensembl chr X:28,587,446...29,956,718
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KCNC2
potassium voltage-gated channel subfamily C member 2
increases expression
ISO
Venlafaxine Hydrochloride results in increased expression of KCNC2 mRNA
CTD
PMID:25423262
NCBI chr12:75,040,078...75,209,839
Ensembl chr12:75,040,077...75,209,839
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KCNH2
potassium voltage-gated channel subfamily H member 2
decreases activity
EXP
Venlafaxine Hydrochloride results in decreased activity of KCNH2 protein
CTD
PMID:21158687
NCBI chr 7:150,944,961...150,978,321
Ensembl chr 7:150,944,961...150,978,321
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KCNJ3
potassium inwardly rectifying channel subfamily J member 3
multiple interactions
ISO
Venlafaxine Hydrochloride affects the activity of [KCNJ3 mRNA co-treated with KCNJ5 mRNA]; Venlafaxine Hydrochloride affects the activity of [KCNJ3 mRNA co-treated with KCNJ6 mRNA]
CTD
PMID:22164246
NCBI chr 2:154,698,695...154,858,354
Ensembl chr 2:154,697,855...154,858,354
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KCNJ5
potassium inwardly rectifying channel subfamily J member 5
multiple interactions
ISO
Venlafaxine Hydrochloride affects the activity of [KCNJ3 mRNA co-treated with KCNJ5 mRNA]
CTD
PMID:22164246
NCBI chr11:128,891,356...128,921,163
Ensembl chr11:128,891,356...128,921,163
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KCNJ6
potassium inwardly rectifying channel subfamily J member 6
multiple interactions
ISO
Venlafaxine Hydrochloride affects the activity of [KCNJ3 mRNA co-treated with KCNJ6 mRNA]
CTD
PMID:22164246
NCBI chr21:37,607,373...37,916,457
Ensembl chr21:37,607,373...38,121,345
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KCNK1
potassium two pore domain channel subfamily K member 1
increases expression
ISO
Venlafaxine Hydrochloride results in increased expression of KCNK1 mRNA
CTD
PMID:25423262
NCBI chr 1:233,614,106...233,672,514
Ensembl chr 1:233,614,106...233,672,514
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KIF1B
kinesin family member 1B
decreases expression
ISO
Venlafaxine Hydrochloride results in decreased expression of KIF1B mRNA
CTD
PMID:25423262
NCBI chr 1:10,210,570...10,381,603
Ensembl chr 1:10,210,570...10,381,603
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KIF2B
kinesin family member 2B
decreases expression
ISO
Venlafaxine Hydrochloride results in decreased expression of KIF2B mRNA
CTD
PMID:25423262
NCBI chr17:53,822,927...53,825,193
Ensembl chr17:53,822,927...53,825,193
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KIF5A
kinesin family member 5A
decreases expression
ISO
Venlafaxine Hydrochloride results in decreased expression of KIF5A mRNA
CTD
PMID:25423262
NCBI chr12:57,550,044...57,586,633
Ensembl chr12:57,546,026...57,586,633
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KLF6
KLF transcription factor 6
increases expression
ISO
Venlafaxine Hydrochloride results in increased expression of KLF6 mRNA
CTD
PMID:25423262
NCBI chr10:3,775,996...3,785,209
Ensembl chr10:3,775,996...3,785,281
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KLHL24
kelch like family member 24
increases expression
ISO
Venlafaxine Hydrochloride results in increased expression of KLHL24 mRNA
CTD
PMID:25423262
NCBI chr 3:183,635,623...183,684,519
Ensembl chr 3:183,635,610...183,684,519
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KLK10
kallikrein related peptidase 10
decreases expression
EXP
Venlafaxine Hydrochloride results in decreased expression of KLK10 mRNA
CTD
PMID:16341940
NCBI chr19:51,012,739...51,020,097
Ensembl chr19:51,012,739...51,020,175
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LARGE1
LARGE xylosyl- and glucuronyltransferase 1
decreases expression
EXP
Venlafaxine Hydrochloride results in decreased expression of LARGE1 mRNA
CTD
PMID:16341940
NCBI chr22:33,066,663...33,922,824
Ensembl chr22:33,162,226...33,922,841
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LIPG
lipase G, endothelial type
increases expression
EXP
Venlafaxine Hydrochloride results in increased expression of LIPG mRNA
CTD
PMID:16341940
NCBI chr18:49,561,479...49,599,185
Ensembl chr18:49,560,699...49,599,185
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LMAN1
lectin, mannose binding 1
increases expression
ISO
Venlafaxine Hydrochloride results in increased expression of LMAN1 mRNA
CTD
PMID:25423262
NCBI chr18:59,327,823...59,359,265
Ensembl chr18:59,327,823...59,359,265
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LMO7
LIM domain 7
decreases expression
EXP
Venlafaxine Hydrochloride results in decreased expression of LMO7 mRNA
CTD
PMID:16341940
NCBI chr13:75,620,434...75,859,870
Ensembl chr13:75,620,434...75,859,870
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LPL
lipoprotein lipase
increases expression
ISO
Venlafaxine Hydrochloride results in increased expression of LPL mRNA
CTD
PMID:25423262
NCBI chr 8:19,939,253...19,967,259
Ensembl chr 8:19,901,717...19,967,259
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MAGI2
membrane associated guanylate kinase, WW and PDZ domain containing 2
increases expression
ISO
Venlafaxine Hydrochloride results in increased expression of MAGI2 mRNA
CTD
PMID:25423262
NCBI chr 7:78,017,055...79,453,667
Ensembl chr 7:78,017,055...79,453,667
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MAP1LC3B
microtubule associated protein 1 light chain 3 beta
multiple interactions
ISO
Chloroquine inhibits the reaction [Venlafaxine Hydrochloride inhibits the reaction [Rotenone results in decreased lipidation of MAP1LC3B protein]]; Venlafaxine Hydrochloride inhibits the reaction [Rotenone results in decreased lipidation of MAP1LC3B protein]
CTD
PMID:35104487
NCBI chr16:87,392,336...87,404,774
Ensembl chr16:87,383,953...87,404,779
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MAP2
microtubule associated protein 2
increases expression
ISO
Venlafaxine Hydrochloride results in increased expression of MAP2 mRNA
CTD
PMID:25423262
NCBI chr 2:209,424,047...209,734,112
Ensembl chr 2:209,424,047...209,734,147
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MAPK1
mitogen-activated protein kinase 1
increases phosphorylation
ISO
Venlafaxine Hydrochloride results in increased phosphorylation of MAPK1 protein
CTD
PMID:18511088
NCBI chr22:21,759,657...21,867,680
Ensembl chr22:21,759,657...21,867,680
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MAPK3
mitogen-activated protein kinase 3
increases phosphorylation
ISO
Venlafaxine Hydrochloride results in increased phosphorylation of MAPK3 protein
CTD
PMID:18511088
NCBI chr16:30,114,105...30,123,220
Ensembl chr16:30,114,105...30,123,506
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MFNG
MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
decreases expression
ISO
Venlafaxine Hydrochloride results in decreased expression of MFNG mRNA
CTD
PMID:25423262
NCBI chr22:37,469,063...37,486,384
Ensembl chr22:37,469,063...37,486,393
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MMP9
matrix metallopeptidase 9
decreases expression
ISO
Venlafaxine Hydrochloride results in decreased expression of MMP9 mRNA
CTD
PMID:25423262
NCBI chr20:46,008,908...46,016,561
Ensembl chr20:46,008,908...46,016,561
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MPP2
MAGUK p55 scaffold protein 2
increases expression
ISO
Venlafaxine Hydrochloride results in increased expression of MPP2 mRNA
CTD
PMID:25423262
NCBI chr17:43,875,360...43,909,711
Ensembl chr17:43,875,357...43,909,711
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MVP
major vault protein
decreases expression
EXP
Venlafaxine Hydrochloride results in decreased expression of MVP mRNA
CTD
PMID:16341940
NCBI chr16:29,820,394...29,848,039
Ensembl chr16:29,820,394...29,848,039
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MYO5A
myosin VA
decreases expression
ISO
Venlafaxine Hydrochloride results in decreased expression of MYO5A mRNA
CTD
PMID:25423262
NCBI chr15:52,307,283...52,529,050
Ensembl chr15:52,307,281...52,529,132
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NASP
nuclear autoantigenic sperm protein
increases expression
EXP
Venlafaxine Hydrochloride results in increased expression of NASP mRNA
CTD
PMID:16341940
NCBI chr 1:45,584,041...45,618,893
Ensembl chr 1:45,583,846...45,618,904
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NEGR1
neuronal growth regulator 1
decreases expression
ISO
Venlafaxine Hydrochloride results in decreased expression of NEGR1 mRNA
CTD
PMID:25423262
NCBI chr 1:71,395,943...72,282,539
Ensembl chr 1:71,395,943...72,282,539
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NELL2
neural EGFL like 2
increases expression
ISO
Venlafaxine Hydrochloride results in increased expression of NELL2 mRNA
CTD
PMID:25423262
NCBI chr12:44,508,275...44,921,848
Ensembl chr12:44,508,275...44,921,848
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NEUROD1
neuronal differentiation 1
increases expression
ISO
Venlafaxine Hydrochloride results in increased expression of NEUROD1 mRNA
CTD
PMID:25423262
NCBI chr 2:181,668,295...181,680,517
Ensembl chr 2:181,668,295...181,680,827
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NFIX
nuclear factor I X
increases expression
ISO
Venlafaxine Hydrochloride results in increased expression of NFIX mRNA
CTD
PMID:25423262
NCBI chr19:12,995,475...13,098,796
Ensembl chr19:12,995,475...13,098,796
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NPTXR
neuronal pentraxin receptor
decreases expression
ISO
Venlafaxine Hydrochloride results in decreased expression of NPTXR mRNA
CTD
PMID:25423262
NCBI chr22:38,818,452...38,844,028
Ensembl chr22:38,818,452...38,844,028
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NR3C1
nuclear receptor subfamily 3 group C member 1
decreases expression
ISO
Venlafaxine Hydrochloride results in decreased expression of NR3C1 mRNA
CTD
PMID:11406320
NCBI chr 5:143,277,931...143,435,512
Ensembl chr 5:143,277,931...143,435,512
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NR3C2
nuclear receptor subfamily 3 group C member 2
decreases expression
ISO
Venlafaxine Hydrochloride results in decreased expression of NR3C2 mRNA
CTD
PMID:11406320
NCBI chr 4:148,078,764...148,445,508
Ensembl chr 4:148,078,762...148,444,698
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NSUN2
NOP2/Sun RNA methyltransferase 2
decreases expression
EXP
Venlafaxine Hydrochloride results in decreased expression of NSUN2 mRNA
CTD
PMID:16341940
NCBI chr 5:6,599,239...6,633,044
Ensembl chr 5:6,599,239...6,633,291
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NTRK2
neurotrophic receptor tyrosine kinase 2
decreases expression
ISO
Venlafaxine Hydrochloride results in decreased expression of NTRK2 mRNA
CTD
PMID:25423262
NCBI chr 9:84,668,522...85,027,054
Ensembl chr 9:84,668,375...85,095,751
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NTRK3
neurotrophic receptor tyrosine kinase 3
decreases expression
ISO
Venlafaxine Hydrochloride results in decreased expression of NTRK3 mRNA
CTD
PMID:25423262
NCBI chr15:87,859,751...88,256,739
Ensembl chr15:87,859,751...88,256,791
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PDAP1
PDGFA associated protein 1
decreases expression
ISO
Venlafaxine Hydrochloride results in decreased expression of PDAP1 mRNA
CTD
PMID:25423262
NCBI chr 7:99,394,673...99,408,597
Ensembl chr 7:99,392,048...99,408,597
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PDE4B
phosphodiesterase 4B
increases expression
ISO
Venlafaxine Hydrochloride results in increased expression of PDE4B mRNA
CTD
PMID:25423262
NCBI chr 1:65,792,510...66,374,579
Ensembl chr 1:65,792,514...66,374,579
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PDE4D
phosphodiesterase 4D
increases expression
ISO
Venlafaxine Hydrochloride results in increased expression of PDE4D mRNA
CTD
PMID:25423262
NCBI chr 5:58,969,038...60,522,128
Ensembl chr 5:58,969,038...60,522,120
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PDIA3
protein disulfide isomerase family A member 3
decreases expression
ISO
Venlafaxine Hydrochloride results in decreased expression of PDIA3 mRNA
CTD
PMID:25423262
NCBI chr15:43,746,438...43,773,278
Ensembl chr15:43,746,394...43,773,279
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PDPK1
3-phosphoinositide dependent protein kinase 1
affects expression
ISO
Venlafaxine Hydrochloride affects the expression of PDPK1 mRNA
CTD
PMID:25423262
NCBI chr16:2,538,021...2,603,188
Ensembl chr16:2,537,979...2,603,188
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PEX2
peroxisomal biogenesis factor 2
affects expression
ISO
Venlafaxine Hydrochloride affects the expression of PEX2 mRNA
CTD
PMID:25423262
NCBI chr 8:76,980,258...77,001,044
Ensembl chr 8:76,980,258...77,001,044
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PGRMC1
progesterone receptor membrane component 1
decreases expression
ISO
Venlafaxine Hydrochloride results in decreased expression of PGRMC1 mRNA
CTD
PMID:25423262
NCBI chr X:119,236,285...119,244,466
Ensembl chr X:119,236,245...119,244,466
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PIM3
Pim-3 proto-oncogene, serine/threonine kinase
decreases expression
ISO
Venlafaxine Hydrochloride results in decreased expression of PIM3 mRNA
CTD
PMID:25423262
NCBI chr22:49,960,772...49,964,072
Ensembl chr22:49,960,768...49,964,072
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POU3F2
POU class 3 homeobox 2
increases expression
ISO
Venlafaxine Hydrochloride results in increased expression of POU3F2 mRNA
CTD
PMID:25423262
NCBI chr 6:98,834,574...98,839,458
Ensembl chr 6:98,834,574...98,839,458
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PPP1CA
protein phosphatase 1 catalytic subunit alpha
increases expression
ISO
Venlafaxine Hydrochloride results in increased expression of PPP1CA mRNA
CTD
PMID:25423262
NCBI chr11:67,398,183...67,401,858
Ensembl chr11:67,398,181...67,421,183
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PPP1R3A
protein phosphatase 1 regulatory subunit 3A
increases expression
ISO
Venlafaxine Hydrochloride results in increased expression of PPP1R3A mRNA
CTD
PMID:25423262
NCBI chr 7:113,876,777...113,919,009
Ensembl chr 7:113,876,777...114,075,920
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PPP1R9B
protein phosphatase 1 regulatory subunit 9B
decreases expression
ISO
Venlafaxine Hydrochloride results in decreased expression of PPP1R9B mRNA
CTD
PMID:25423262
NCBI chr17:50,133,737...50,150,677
Ensembl chr17:50,133,737...50,150,677
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PPP3R1
protein phosphatase 3 regulatory subunit B, alpha
decreases expression
ISO
Venlafaxine Hydrochloride results in decreased expression of PPP3R1 mRNA
CTD
PMID:25423262
NCBI chr 2:68,178,857...68,252,532
Ensembl chr 2:68,178,857...68,256,237
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PRAP1
proline rich acidic protein 1
decreases expression
ISO
Venlafaxine Hydrochloride results in decreased expression of PRAP1 mRNA
CTD
PMID:25423262
NCBI chr10:133,347,373...133,352,683
Ensembl chr10:133,347,368...133,352,683
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PRDX1
peroxiredoxin 1
decreases expression
ISO
Venlafaxine Hydrochloride results in decreased expression of PRDX1 mRNA
CTD
PMID:25423262
NCBI chr 1:45,511,051...45,522,890
Ensembl chr 1:45,510,914...45,542,732
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PREX2
phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 2
decreases expression
EXP
Venlafaxine Hydrochloride results in decreased expression of PREX2 mRNA
CTD
PMID:16341940
NCBI chr 8:67,952,046...68,237,032
Ensembl chr 8:67,952,046...68,237,032
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PRKCE
protein kinase C epsilon
increases expression
ISO
Venlafaxine Hydrochloride results in increased expression of PRKCE mRNA
CTD
PMID:25423262
NCBI chr 2:45,651,279...46,187,990
Ensembl chr 2:45,651,345...46,187,990
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PRKG2
protein kinase cGMP-dependent 2
increases expression
ISO
Venlafaxine Hydrochloride results in increased expression of PRKG2 mRNA
CTD
PMID:25423262
NCBI chr 4:81,087,370...81,217,836
Ensembl chr 4:81,087,370...81,215,222
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PRKN
parkin RBR E3 ubiquitin protein ligase
multiple interactions
ISO
Chloroquine inhibits the reaction [Venlafaxine Hydrochloride inhibits the reaction [Rotenone results in decreased expression of PRKN protein]]; Venlafaxine Hydrochloride inhibits the reaction [Rotenone results in decreased expression of PRKN protein]
CTD
PMID:35104487
NCBI chr 6:161,347,417...162,727,766
Ensembl chr 6:161,347,417...162,727,775
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PRL
prolactin
increases expression
EXP
Venlafaxine Hydrochloride results in increased expression of PRL protein
CTD
PMID:17606668
NCBI chr 6:22,287,246...22,302,835
Ensembl chr 6:22,287,244...22,302,826
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PYY
peptide YY
increases expression
ISO
Venlafaxine Hydrochloride results in increased expression of PYY mRNA
CTD
PMID:25423262
NCBI chr17:43,952,733...44,004,445
Ensembl chr17:43,952,733...44,004,469
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RAB14
RAB14, member RAS oncogene family
increases expression
ISO
Venlafaxine Hydrochloride results in increased expression of RAB14 mRNA
CTD
PMID:25423262
NCBI chr 9:121,178,133...121,201,869
Ensembl chr 9:121,178,133...121,223,014
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RAB4B
RAB4B, member RAS oncogene family
increases expression
ISO
Venlafaxine Hydrochloride results in increased expression of RAB4B mRNA
CTD
PMID:25423262
NCBI chr19:40,778,247...40,796,942
Ensembl chr19:40,778,216...40,796,942
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RCC1
regulator of chromosome condensation 1
increases expression
EXP
Venlafaxine Hydrochloride results in increased expression of RCC1 mRNA
CTD
PMID:16341940
NCBI chr 1:28,506,043...28,538,989
Ensembl chr 1:28,505,943...28,539,300
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RELA
RELA proto-oncogene, NF-kB subunit
multiple interactions
ISO
Venlafaxine Hydrochloride inhibits the reaction [Cisplatin results in increased expression of RELA protein]
CTD
PMID:29852128
NCBI chr11:65,653,601...65,663,857
Ensembl chr11:65,653,599...65,663,090
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RIMS1
regulating synaptic membrane exocytosis 1
decreases expression
ISO
Venlafaxine Hydrochloride results in decreased expression of RIMS1 mRNA
CTD
PMID:25423262
NCBI chr 6:71,886,550...72,403,145
Ensembl chr 6:71,886,550...72,403,150
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RING1
ring finger protein 1
increases expression
EXP
Venlafaxine Hydrochloride results in increased expression of RING1 mRNA
CTD
PMID:16341940
NCBI chr 6:33,208,500...33,212,716
Ensembl chr 6:33,208,500...33,212,722
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RPH3A
rabphilin 3A
decreases expression
ISO
Venlafaxine Hydrochloride results in decreased expression of RPH3A mRNA
CTD
PMID:25423262
NCBI chr12:112,575,236...112,898,881
Ensembl chr12:112,570,380...112,898,881
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SALL1
spalt like transcription factor 1
increases expression
EXP
Venlafaxine Hydrochloride results in increased expression of SALL1 mRNA
CTD
PMID:16341940
NCBI chr16:51,135,982...51,152,334
Ensembl chr16:51,135,982...51,152,334
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SERPINI1
serpin family I member 1
increases expression
ISO
Venlafaxine Hydrochloride results in increased expression of SERPINI1 mRNA
CTD
PMID:16637596
NCBI chr 3:167,735,721...167,825,569
Ensembl chr 3:167,735,243...167,825,569
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SGTB
small glutamine rich tetratricopeptide repeat co-chaperone beta
increases expression
ISO
Venlafaxine Hydrochloride results in increased expression of SGTB mRNA
CTD
PMID:25423262
NCBI chr 5:65,665,928...65,723,013
Ensembl chr 5:65,665,928...65,723,035
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SHANK2
SH3 and multiple ankyrin repeat domains 2
increases expression
ISO
Venlafaxine Hydrochloride results in increased expression of SHANK2 mRNA
CTD
PMID:25423262
NCBI chr11:70,467,854...71,253,228
Ensembl chr11:70,467,854...71,252,577
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SIPA1L1
signal induced proliferation associated 1 like 1
increases expression
ISO
Venlafaxine Hydrochloride results in increased expression of SIPA1L1 mRNA
CTD
PMID:25423262
NCBI chr14:71,320,476...71,741,209
Ensembl chr14:71,320,449...71,741,229
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SLC26A3
solute carrier family 26 member 3
increases expression
ISO
Venlafaxine Hydrochloride results in increased expression of SLC26A3 mRNA
CTD
PMID:25423262
NCBI chr 7:107,765,469...107,803,223
Ensembl chr 7:107,765,467...107,803,225
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SLC2A4
solute carrier family 2 member 4
decreases expression
ISO
Venlafaxine Hydrochloride results in decreased expression of SLC2A4 mRNA
CTD
PMID:25423262
NCBI chr17:7,281,718...7,288,257
Ensembl chr17:7,281,718...7,288,257
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SLC4A4
solute carrier family 4 member 4
increases expression
ISO
Venlafaxine Hydrochloride results in increased expression of SLC4A4 mRNA
CTD
PMID:25423262
NCBI chr 4:71,062,660...71,572,083
Ensembl chr 4:71,062,667...71,572,087
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SLC5A1
solute carrier family 5 member 1
increases expression
ISO
Venlafaxine Hydrochloride results in increased expression of SLC5A1 mRNA
CTD
PMID:25423262
NCBI chr22:32,043,261...32,113,029
Ensembl chr22:32,043,261...32,113,029
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SLC6A4
solute carrier family 6 member 4
affects response to substance
EXP
SLC6A4 gene polymorphism affects the susceptibility to Venlafaxine Hydrochloride
CTD
PMID:17503984
NCBI chr17:30,194,319...30,235,697
Ensembl chr17:30,194,319...30,236,002
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SLC6A6
solute carrier family 6 member 6
increases expression
ISO
Venlafaxine Hydrochloride results in increased expression of SLC6A6 mRNA
CTD
PMID:25423262
NCBI chr 3:14,402,576...14,489,349
Ensembl chr 3:14,402,576...14,489,349
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SOD1
superoxide dismutase 1
increases expression
ISO
Venlafaxine Hydrochloride results in increased expression of SOD1 mRNA
CTD
PMID:10721683
NCBI chr21:31,659,693...31,668,931
Ensembl chr21:31,659,666...31,668,931
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SPN
sialophorin
increases expression
ISO
Venlafaxine Hydrochloride results in increased expression of SPN mRNA
CTD
PMID:25423262
NCBI chr16:29,662,963...29,670,876
Ensembl chr16:29,662,979...29,670,876
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SQSTM1
sequestosome 1
decreases expression multiple interactions
ISO
Venlafaxine Hydrochloride results in decreased expression of SQSTM1 mRNA Chloroquine inhibits the reaction [Venlafaxine Hydrochloride inhibits the reaction [Rotenone results in decreased expression of SQSTM1 protein]]; Venlafaxine Hydrochloride inhibits the reaction [Rotenone results in decreased expression of SQSTM1 protein]
CTD
PMID:25423262 PMID:35104487
NCBI chr 5:179,806,393...179,838,078
Ensembl chr 5:179,806,398...179,838,078
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STAU2
staufen double-stranded RNA binding protein 2
increases expression
ISO
Venlafaxine Hydrochloride results in increased expression of STAU2 mRNA
CTD
PMID:25423262
NCBI chr 8:73,420,369...73,747,480
Ensembl chr 8:73,420,369...73,747,708
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STK39
serine/threonine kinase 39
increases expression
ISO
Venlafaxine Hydrochloride results in increased expression of STK39 mRNA
CTD
PMID:25423262
NCBI chr 2:167,954,022...168,247,595
Ensembl chr 2:167,954,020...168,247,595
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SV2B
synaptic vesicle glycoprotein 2B
affects expression
ISO
Venlafaxine Hydrochloride affects the expression of SV2B mRNA
CTD
PMID:25423262
NCBI chr15:91,099,588...91,302,565
Ensembl chr15:91,099,950...91,302,565
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SYN2
synapsin II
decreases expression
ISO
Venlafaxine Hydrochloride results in decreased expression of SYN2 mRNA
CTD
PMID:25423262
NCBI chr 3:12,004,388...12,192,032
Ensembl chr 3:12,004,388...12,192,032
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SYNJ2
synaptojanin 2
affects expression
ISO
Venlafaxine Hydrochloride affects the expression of SYNJ2 mRNA
CTD
PMID:25423262
NCBI chr 6:157,981,296...158,099,176
Ensembl chr 6:157,981,863...158,099,176
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SYP
synaptophysin
increases expression
ISO
Venlafaxine Hydrochloride results in increased expression of SYP mRNA
CTD
PMID:17950272
NCBI chr X:49,187,815...49,200,193
Ensembl chr X:49,187,815...49,200,218
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SYT4
synaptotagmin 4
increases expression
EXP
Venlafaxine Hydrochloride results in increased expression of SYT4 mRNA
CTD
PMID:16341940
NCBI chr18:43,267,892...43,277,490
Ensembl chr18:43,267,892...43,277,535
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TACR3
tachykinin receptor 3
increases expression
ISO
Venlafaxine Hydrochloride results in increased expression of TACR3 mRNA
CTD
PMID:25423262
NCBI chr 4:103,586,031...103,719,985
Ensembl chr 4:103,586,031...103,719,985
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TCF12
transcription factor 12
decreases expression
EXP
Venlafaxine Hydrochloride results in decreased expression of TCF12 mRNA
CTD
PMID:16341940
NCBI chr15:56,918,090...57,291,310
Ensembl chr15:56,918,623...57,299,281
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TCF4
transcription factor 4
increases expression
ISO
Venlafaxine Hydrochloride results in increased expression of TCF4 mRNA
CTD
PMID:25423262
NCBI chr18:55,222,185...55,635,957
Ensembl chr18:55,222,185...55,664,787
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THBD
thrombomodulin
decreases expression
ISO
Venlafaxine Hydrochloride results in decreased expression of THBD mRNA
CTD
PMID:25423262
NCBI chr20:23,045,633...23,049,672
Ensembl chr20:23,045,633...23,049,672
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TP53
tumor protein p53
multiple interactions
ISO
Venlafaxine Hydrochloride inhibits the reaction [Cisplatin results in increased expression of TP53 protein]
CTD
PMID:29852128
NCBI chr17:7,668,421...7,687,490
Ensembl chr17:7,661,779...7,687,546
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TRIM13
tripartite motif containing 13
decreases expression
EXP
Venlafaxine Hydrochloride results in decreased expression of TRIM13 mRNA
CTD
PMID:16341940
NCBI chr13:49,997,042...50,018,467
Ensembl chr13:49,995,888...50,020,481
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TSHR
thyroid stimulating hormone receptor
increases expression
ISO
Venlafaxine Hydrochloride results in increased expression of TSHR mRNA
CTD
PMID:25423262
NCBI chr14:80,955,621...81,146,306
Ensembl chr14:80,954,989...81,146,306
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TXN2
thioredoxin 2
decreases expression
ISO
Venlafaxine Hydrochloride results in decreased expression of TXN2 mRNA
CTD
PMID:25423262
NCBI chr22:36,467,046...36,481,640
Ensembl chr22:36,467,046...36,481,640
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UBE2Q1
ubiquitin conjugating enzyme E2 Q1
decreases expression
EXP
Venlafaxine Hydrochloride results in decreased expression of UBE2Q1 mRNA
CTD
PMID:16341940
NCBI chr 1:154,548,577...154,558,662
Ensembl chr 1:154,548,577...154,559,028
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UCP3
uncoupling protein 3
decreases expression
ISO
Venlafaxine Hydrochloride results in decreased expression of UCP3 mRNA
CTD
PMID:25423262
NCBI chr11:74,000,277...74,009,085
Ensembl chr11:74,000,277...74,009,085
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UNC13B
unc-13 homolog B
decreases expression
ISO
Venlafaxine Hydrochloride results in decreased expression of UNC13B mRNA
CTD
PMID:25423262
NCBI chr 9:35,162,009...35,405,335
Ensembl chr 9:35,161,992...35,405,338
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VAMP1
vesicle associated membrane protein 1
decreases expression
ISO
Venlafaxine Hydrochloride results in decreased expression of VAMP1 mRNA
CTD
PMID:25423262
NCBI chr12:6,462,237...6,470,677
Ensembl chr12:6,462,237...6,470,677
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VCPIP1
valosin containing protein interacting protein 1
increases expression
ISO
Venlafaxine Hydrochloride results in increased expression of VCPIP1 mRNA
CTD
PMID:25423262
NCBI chr 8:66,628,487...66,667,231
Ensembl chr 8:66,628,487...66,667,231
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VDAC1
voltage dependent anion channel 1
increases expression
ISO
Venlafaxine Hydrochloride results in increased expression of VDAC1 mRNA
CTD
PMID:25423262
NCBI chr 5:133,971,871...134,114,540
Ensembl chr 5:133,971,871...134,004,975
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VEGFB
vascular endothelial growth factor B
decreases expression
ISO
Venlafaxine Hydrochloride results in decreased expression of VEGFB mRNA
CTD
PMID:25423262
NCBI chr11:64,234,584...64,239,264
Ensembl chr11:64,234,584...64,239,264
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WDFY1
WD repeat and FYVE domain containing 1
increases expression
ISO
Venlafaxine Hydrochloride results in increased expression of WDFY1 mRNA
CTD
PMID:25423262
NCBI chr 2:223,875,348...223,945,335
Ensembl chr 2:223,855,716...223,945,357
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ZNF24
zinc finger protein 24
increases expression
ISO
Venlafaxine Hydrochloride results in increased expression of ZFP24 mRNA
CTD
PMID:25423262
NCBI chr18:35,332,227...35,344,420
Ensembl chr18:35,332,227...35,345,482
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