PPP3R1 (protein phosphatase 3 regulatory subunit B, alpha) - Rat Genome Database

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Gene: PPP3R1 (protein phosphatase 3 regulatory subunit B, alpha) Homo sapiens
Analyze
Symbol: PPP3R1
Name: protein phosphatase 3 regulatory subunit B, alpha
RGD ID: 1350432
HGNC Page HGNC:9317
Description: Enables cyclosporin A binding activity; phosphatase binding activity; and protein domain specific binding activity. Involved in calcineurin-NFAT signaling cascade and positive regulation of transcription by RNA polymerase II. Part of calcineurin complex. Implicated in Alzheimer's disease and dilated cardiomyopathy.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: calcineurin B, type I (19kDa); calcineurin subunit B type 1; CALNB1; CNB; CnB-alpha; CNB1; protein phosphatase 2B regulatory subunit 1; protein phosphatase 2B regulatory subunit B alpha; protein phosphatase 3 (formerly 2B), regulatory subunit B (19kD), alpha isoform (calcineurin B, type I); protein phosphatase 3 (formerly 2B), regulatory subunit B, 19kDa, alpha isoform (calcineurin B, type I); protein phosphatase 3 (formerly 2B), regulatory subunit B, alpha isoform
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38268,178,857 - 68,252,532 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl268,178,857 - 68,256,237 (-)EnsemblGRCh38hg38GRCh38
GRCh37268,405,989 - 68,479,664 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36268,259,493 - 68,333,155 (-)NCBINCBI36Build 36hg18NCBI36
Build 34268,317,639 - 68,391,302NCBI
Celera268,255,597 - 68,329,209 (-)NCBICelera
Cytogenetic Map2p14NCBI
HuRef268,143,447 - 68,181,703 (-)NCBIHuRef
CHM1_1268,336,792 - 68,410,397 (-)NCBICHM1_1
T2T-CHM13v2.0268,189,412 - 68,263,096 (-)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-pilocarpine  (ISO)
(S)-nicotine  (ISO)
1,2-dimethylhydrazine  (ISO)
1,3-dinitrobenzene  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
2,4-dinitrotoluene  (ISO)
2-hydroxypropanoic acid  (EXP)
2-methylcholine  (EXP)
3,4-methylenedioxymethamphetamine  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (EXP)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (EXP)
4-vinylcyclohexene dioxide  (ISO)
6-propyl-2-thiouracil  (ISO)
acrylamide  (EXP)
aflatoxin B1  (EXP,ISO)
aflatoxin M1  (EXP)
amiodarone  (EXP)
ammonium chloride  (ISO)
aristolochic acid A  (EXP)
atrazine  (EXP)
bisphenol A  (EXP,ISO)
bortezomib  (EXP)
Brodifacoum  (ISO)
cadmium atom  (EXP)
cadmium dichloride  (EXP)
calcidiol  (ISO)
calcium atom  (ISO)
calcium(0)  (ISO)
cannabidiol  (ISO)
cannabigerol  (ISO)
CGP 52608  (EXP)
chromium(6+)  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
copper(II) sulfate  (EXP)
Cuprizon  (ISO)
cyclosporin A  (ISO)
dexamethasone  (EXP)
dorsomorphin  (EXP)
doxorubicin  (EXP)
endosulfan  (ISO)
ethanol  (ISO)
fenvalerate  (ISO)
flutamide  (ISO)
folic acid  (ISO)
indometacin  (EXP)
ivermectin  (EXP)
lead diacetate  (ISO)
lithium chloride  (EXP)
methamphetamine  (ISO)
methoxychlor  (ISO)
methylmercury chloride  (EXP)
miconazole  (ISO)
monosodium L-glutamate  (ISO)
morphine  (ISO)
nefazodone  (ISO)
nickel atom  (EXP)
nicotine  (ISO)
O-palmitoylcarnitine  (ISO)
ochratoxin A  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perindopril  (ISO)
potassium dichromate  (EXP)
quercetin  (EXP)
quinolin-8-ol  (EXP)
rac-lactic acid  (EXP)
rotenone  (ISO)
SB 431542  (EXP)
silicon dioxide  (ISO)
tamoxifen  (ISO)
tetrachloromethane  (ISO)
thioacetamide  (ISO)
valproic acid  (EXP)
venlafaxine hydrochloride  (ISO)
vinclozolin  (ISO)
zinc atom  (EXP)
zinc(0)  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Phenotype Annotations     Click to see Annotation Detail View

Human Phenotype
References

References - curated
# Reference Title Reference Citation
1. Regional calcineurin subunit B isoform expression in rat hippocampus following a traumatic brain injury. Bales JW, etal., Brain Res. 2010 Oct 28;1358:211-20. doi: 10.1016/j.brainres.2010.08.029. Epub 2010 Aug 13.
2. Increased regulatory activity of the calcineurin/NFAT pathway in human heart failure. Diedrichs H, etal., Eur J Heart Fail. 2004 Jan;6(1):3-9.
3. Calcineurin and matrix protein expression in cardiac hypertrophy : Evidence for calcineurin B to control excessive hypertrophic signaling. Grammer JB, etal., Basic Res Cardiol. 2006 Jul;101(4):292-300. Epub 2006 May 10.
4. Integration of Notch 1 and calcineurin/NFAT signaling pathways in keratinocyte growth and differentiation control. Mammucari C, etal., Dev Cell. 2005 May;8(5):665-76.
5. Variants in PPP3R1 and MAPT are associated with more rapid functional decline in Alzheimer's disease: the Cache County Dementia Progression Study. Peterson D, etal., Alzheimers Dement. 2014 May;10(3):366-71. doi: 10.1016/j.jalz.2013.02.010. Epub 2013 May 30.
6. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
7. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
9. Differential expression and redox proteomics analyses of an Alzheimer disease transgenic mouse model: effects of the amyloid-β peptide of amyloid precursor protein. Robinson RA, etal., Neuroscience. 2011 Mar 17;177:207-22. doi: 10.1016/j.neuroscience.2011.01.005. Epub 2011 Jan 9.
10. Direct and indirect interactions between calcineurin-NFAT and MEK1-extracellular signal-regulated kinase 1/2 signaling pathways regulate cardiac gene expression and cellular growth. Sanna B, etal., Mol Cell Biol. 2005 Feb;25(3):865-78.
11. Cardioplegia prevents ischemia-induced transcriptional alterations of cytoprotective genes in rat hearts: a DNA microarray study. Schomisch SJ, etal., J Thorac Cardiovasc Surg. 2005 Oct;130(4):1151.
12. Identification of a novel 5-base pair deletion in calcineurin B (PPP3R1) promoter region and its association with left ventricular hypertrophy. Tang W, etal., Am Heart J. 2005 Oct;150(4):845-51.
13. Calcium-calcineurin signaling in the regulation of cardiac hypertrophy. Wilkins BJ and Molkentin JD, Biochem Biophys Res Commun. 2004 Oct 1;322(4):1178-91.
Additional References at PubMed
PMID:2558868   PMID:6330098   PMID:7541044   PMID:8524402   PMID:8631904   PMID:8978785   PMID:10195903   PMID:10493818   PMID:10520753   PMID:10959817   PMID:11108966   PMID:11123943  
PMID:11439183   PMID:11982754   PMID:12218175   PMID:12357034   PMID:12477932   PMID:12482669   PMID:12809556   PMID:15231831   PMID:15489334   PMID:15589160   PMID:15757646   PMID:15815621  
PMID:16473827   PMID:16648474   PMID:17038582   PMID:17237284   PMID:17640527   PMID:17761791   PMID:18034994   PMID:18296442   PMID:18343007   PMID:18422742   PMID:18755154   PMID:18818667  
PMID:18825932   PMID:19156168   PMID:19285944   PMID:19322201   PMID:19453261   PMID:19653005   PMID:19896943   PMID:19913121   PMID:20107831   PMID:20237496   PMID:20593291   PMID:20628086  
PMID:20639889   PMID:20647544   PMID:20862329   PMID:21047202   PMID:21256111   PMID:21516116   PMID:21565611   PMID:21674474   PMID:21722668   PMID:21873635   PMID:21910968   PMID:21988832  
PMID:22197822   PMID:22343722   PMID:22632162   PMID:22688515   PMID:22715070   PMID:22814600   PMID:22939629   PMID:23443559   PMID:23468591   PMID:23888774   PMID:24086760   PMID:24246042  
PMID:24954618   PMID:25416956   PMID:26186194   PMID:26264872   PMID:26471241   PMID:26496610   PMID:26794871   PMID:26871637   PMID:27090571   PMID:27107012   PMID:27880917   PMID:27907007  
PMID:27974827   PMID:28126489   PMID:28514442   PMID:28827117   PMID:29117863   PMID:29181737   PMID:29505169   PMID:29872149   PMID:32296183   PMID:32337552   PMID:32814053   PMID:32882262  
PMID:33961781   PMID:34446558   PMID:35271311   PMID:35831314   PMID:35914814   PMID:36901851  


Genomics

Comparative Map Data
PPP3R1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38268,178,857 - 68,252,532 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl268,178,857 - 68,256,237 (-)EnsemblGRCh38hg38GRCh38
GRCh37268,405,989 - 68,479,664 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36268,259,493 - 68,333,155 (-)NCBINCBI36Build 36hg18NCBI36
Build 34268,317,639 - 68,391,302NCBI
Celera268,255,597 - 68,329,209 (-)NCBICelera
Cytogenetic Map2p14NCBI
HuRef268,143,447 - 68,181,703 (-)NCBIHuRef
CHM1_1268,336,792 - 68,410,397 (-)NCBICHM1_1
T2T-CHM13v2.0268,189,412 - 68,263,096 (-)NCBIT2T-CHM13v2.0
Ppp3r1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391117,109,298 - 17,150,380 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1117,109,263 - 17,150,375 (+)EnsemblGRCm39 Ensembl
GRCm381117,159,298 - 17,200,380 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1117,159,263 - 17,200,375 (+)EnsemblGRCm38mm10GRCm38
MGSCv371117,059,301 - 17,100,383 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361117,059,301 - 17,100,383 (+)NCBIMGSCv36mm8
Celera1117,532,396 - 17,574,044 (+)NCBICelera
Cytogenetic Map11A2NCBI
cM Map119.71NCBI
Ppp3r1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81495,758,333 - 95,808,015 (+)NCBIGRCr8
mRatBN7.21491,556,743 - 91,606,391 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1491,604,121 - 91,606,907 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1495,875,569 - 95,913,609 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01497,119,906 - 97,157,946 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01493,584,970 - 93,623,011 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.014100,311,224 - 100,360,879 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl14100,311,173 - 100,360,879 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.014100,178,695 - 100,227,295 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41498,060,302 - 98,099,092 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11498,079,446 - 98,118,237 (+)NCBI
Celera1490,614,429 - 90,652,365 (+)NCBICelera
Cytogenetic Map14q22NCBI
Ppp3r1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542416,623,917 - 16,690,783 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495542416,624,214 - 16,690,783 (+)NCBIChiLan1.0ChiLan1.0
PPP3R1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21258,156,551 - 58,229,424 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12A58,160,135 - 58,233,372 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02A68,227,282 - 68,300,482 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PPP3R1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11067,242,552 - 67,308,469 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1067,244,329 - 67,275,487 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1067,135,373 - 67,199,366 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01068,263,516 - 68,327,586 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1068,261,752 - 68,325,387 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11067,946,324 - 68,012,242 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01068,243,919 - 68,309,976 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01068,541,451 - 68,605,689 (-)NCBIUU_Cfam_GSD_1.0
Ppp3r1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629215,826,513 - 15,947,768 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493649112,718,720 - 12,744,428 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0 EnsemblNW_00493649112,623,349 - 12,654,502 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493649112,623,931 - 12,654,463 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PPP3R1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl374,000,517 - 74,068,172 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1374,004,620 - 74,068,173 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2377,531,587 - 77,598,082 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PPP3R1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11438,832,976 - 38,907,425 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1438,832,809 - 38,905,321 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604573,068,593 - 73,142,887 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ppp3r1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247625,087,705 - 5,156,922 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247625,087,726 - 5,156,526 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in PPP3R1
6 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
NM_000945.4(PPP3R1):c.4-1055_4-1051del deletion not provided [RCV000144719] Chr2:68218182..68218186 [GRCh38]
Chr2:68445314..68445318 [GRCh37]
Chr2:2p14		 not provided
GRCh38/hg38 2p16.1-11.2(chr2:58279519-83586962)x3 copy number gain See cases [RCV000136053] Chr2:58279519..83586962 [GRCh38]
Chr2:58506654..83814086 [GRCh37]
Chr2:58360158..83667597 [NCBI36]
Chr2:2p16.1-11.2		 pathogenic
GRCh38/hg38 2p16.3-11.2(chr2:47620388-86702722)x3 copy number gain See cases [RCV000137586] Chr2:47620388..86702722 [GRCh38]
Chr2:47847527..86929845 [GRCh37]
Chr2:47701031..86783356 [NCBI36]
Chr2:2p16.3-11.2		 uncertain significance
GRCh38/hg38 2p14-13.3(chr2:64587095-69876311)x1 copy number loss See cases [RCV000140691] Chr2:64587095..69876311 [GRCh38]
Chr2:64814229..70103443 [GRCh37]
Chr2:64667733..69956947 [NCBI36]
Chr2:2p14-13.3		 likely pathogenic
GRCh38/hg38 2p25.1-11.2(chr2:7495123-87705899)x3 copy number gain See cases [RCV000141494] Chr2:7495123..87705899 [GRCh38]
Chr2:7635254..88005418 [GRCh37]
Chr2:7552705..87786533 [NCBI36]
Chr2:2p25.1-11.2		 benign
GRCh37/hg19 2p25.3-q37.3(chr2:14238-243048760)x3 copy number gain not provided [RCV000752802] Chr2:14238..243048760 [GRCh37]
Chr2:2p25.3-q37.3		 pathogenic
GRCh37/hg19 2p14-13.3(chr2:67491378-69679404) copy number loss not provided [RCV000767553] Chr2:67491378..69679404 [GRCh37]
Chr2:2p14-13.3		 pathogenic
GRCh37/hg19 2p15-11.2(chr2:62245236-86978895)x3 copy number gain See cases [RCV000448688] Chr2:62245236..86978895 [GRCh37]
Chr2:2p15-11.2		 pathogenic
GRCh37/hg19 2p25.3-q37.3(chr2:12771-242783384) copy number gain See cases [RCV000512056] Chr2:12771..242783384 [GRCh37]
Chr2:2p25.3-q37.3		 pathogenic
GRCh37/hg19 2p25.3-q37.3(chr2:12771-242783384)x3 copy number gain See cases [RCV000511212] Chr2:12771..242783384 [GRCh37]
Chr2:2p25.3-q37.3		 pathogenic
Single allele deletion not provided [RCV000714264] Chr2:40608411..146900718 [GRCh37]
Chr2:2p22.1-q22.3		 likely pathogenic
Single allele duplication not provided [RCV000677942] Chr2:63671346..85698002 [GRCh37]
Chr2:2p15-11.2		 pathogenic
GRCh37/hg19 2p25.3-q37.3(chr2:15672-243101834)x3 copy number gain not provided [RCV000752804] Chr2:15672..243101834 [GRCh37]
Chr2:2p25.3-q37.3		 pathogenic
GRCh37/hg19 2p14-13.3(chr2:68475209-68676657)x3 copy number gain Bilateral sensorineural hearing impairment [RCV001543347] Chr2:68475209..68676657 [GRCh37]
Chr2:2p14-13.3		 uncertain significance
NM_000945.4(PPP3R1):c.*169T>C single nucleotide variant not provided [RCV001698815] Chr2:68180794 [GRCh38]
Chr2:68407926 [GRCh37]
Chr2:2p14		 benign
GRCh37/hg19 2p25.3-q37.3(chr2:1-243199373) copy number gain Mosaic trisomy 2 [RCV002280628] Chr2:1..243199373 [GRCh37]
Chr2:2p25.3-q37.3		 pathogenic
NM_000945.4(PPP3R1):c.99C>T (p.Asp33=) single nucleotide variant not provided [RCV001538896] Chr2:68188635 [GRCh38]
Chr2:68415767 [GRCh37]
Chr2:2p14		 benign
GRCh37/hg19 2p25.1-q13(chr2:11504318-111365996)x1 copy number loss See cases [RCV002287563] Chr2:11504318..111365996 [GRCh37]
Chr2:2p25.1-q13		 pathogenic
GRCh37/hg19 2p14-13.3(chr2:65296579-71305638)x1 copy number loss not provided [RCV003223077] Chr2:65296579..71305638 [GRCh37]
Chr2:2p14-13.3		 uncertain significance
GRCh37/hg19 2p14-13.3(chr2:67702012-70506257)x1 copy number loss not specified [RCV003986387] Chr2:67702012..70506257 [GRCh37]
Chr2:2p14-13.3		 uncertain significance
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1280
Count of miRNA genes:733
Interacting mature miRNAs:848
Transcripts:ENST00000234310, ENST00000406334, ENST00000409377, ENST00000409752
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Markers in Region
D2S2724  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37268,407,660 - 68,407,984UniSTSGRCh37
Build 36268,261,164 - 68,261,488RGDNCBI36
Celera268,257,273 - 68,257,597RGD
Cytogenetic Map2p15UniSTS
HuRef268,145,123 - 68,145,447UniSTS
Whitehead-YAC Contig Map2 UniSTS
G44336  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37268,415,647 - 68,415,796UniSTSGRCh37
Build 36268,269,151 - 68,269,300RGDNCBI36
Celera268,265,261 - 68,265,410RGD
Cytogenetic Map2p15UniSTS
HuRef268,153,108 - 68,153,257UniSTS
G60033  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37268,406,940 - 68,407,232UniSTSGRCh37
Build 36268,260,444 - 68,260,736RGDNCBI36
Celera268,256,553 - 68,256,845RGD
Cytogenetic Map2p15UniSTS
HuRef268,144,403 - 68,144,695UniSTS
TNG Radiation Hybrid Map244016.0UniSTS
PPP3R1_8560  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37268,406,706 - 68,407,461UniSTSGRCh37
Build 36268,260,210 - 68,260,965RGDNCBI36
Celera268,256,319 - 68,257,074RGD
HuRef268,144,169 - 68,144,924UniSTS
RH120881  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37268,407,059 - 68,407,232UniSTSGRCh37
Build 36268,260,563 - 68,260,736RGDNCBI36
Celera268,256,672 - 68,256,845RGD
Cytogenetic Map2p15UniSTS
HuRef268,144,522 - 68,144,695UniSTS
GeneMap99-GB4 RH Map2212.52UniSTS
RH12230  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37268,405,852 - 68,406,044UniSTSGRCh37
Build 36268,259,356 - 68,259,548RGDNCBI36
Celera268,255,460 - 68,255,652RGD
Cytogenetic Map2p15UniSTS
HuRef268,143,310 - 68,143,502UniSTS
GeneMap99-GB4 RH Map2213.13UniSTS
SHGC-30955  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37268,458,526 - 68,458,678UniSTSGRCh37
Build 36268,312,030 - 68,312,182RGDNCBI36
Celera268,308,084 - 68,308,236RGD
Cytogenetic Map2p15UniSTS
HuRef268,196,050 - 68,196,202UniSTS
TNG Radiation Hybrid Map243997.0UniSTS
Stanford-G3 RH Map22792.0UniSTS
GeneMap99-GB4 RH Map2213.34UniSTS
Whitehead-RH Map2278.3UniSTS
NCBI RH Map2391.5UniSTS
GeneMap99-G3 RH Map22703.0UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component pharyngeal arch
High
Medium 2411 2689 1710 613 1920 455 4354 1973 3673 361 1442 1606 172 1203 2787 3
Low 28 302 16 11 30 10 2 223 61 58 18 7 3 1 1 1 3 2
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENST00000234310   ⟹   ENSP00000234310
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl268,178,857 - 68,252,532 (-)Ensembl
RefSeq Acc Id: ENST00000409377   ⟹   ENSP00000387148
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl268,180,947 - 68,251,148 (-)Ensembl
RefSeq Acc Id: ENST00000409752   ⟹   ENSP00000387216
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl268,180,804 - 68,256,237 (-)Ensembl
RefSeq Acc Id: NM_000945   ⟹   NP_000936
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38268,178,857 - 68,252,532 (-)NCBI
GRCh37268,405,979 - 68,483,392 (-)NCBI
Build 36268,259,493 - 68,333,155 (-)NCBI Archive
HuRef268,143,447 - 68,181,703 (-)ENTREZGENE
CHM1_1268,336,792 - 68,410,397 (-)NCBI
T2T-CHM13v2.0268,189,412 - 68,263,096 (-)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_000936   ⟸   NM_000945
- UniProtKB: Q08044 (UniProtKB/Swiss-Prot),   P15117 (UniProtKB/Swiss-Prot),   P06705 (UniProtKB/Swiss-Prot),   B5MDU4 (UniProtKB/Swiss-Prot),   B2RC10 (UniProtKB/Swiss-Prot),   Q53SL0 (UniProtKB/Swiss-Prot),   P63098 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSP00000234310   ⟸   ENST00000234310
RefSeq Acc Id: ENSP00000387216   ⟸   ENST00000409752
RefSeq Acc Id: ENSP00000387148   ⟸   ENST00000409377
Protein Domains
EF-hand

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P63098-F1-model_v2 AlphaFold P63098 1-170 view protein structure

Promoters
RGD ID:6860510
Promoter ID:EPDNEW_H3420
Type:initiation region
Name:PPP3R1_4
Description:protein phosphatase 3 regulatory subunit B, alpha
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H3421  EPDNEW_H3422  EPDNEW_H3423  EPDNEW_H3425  EPDNEW_H3426  EPDNEW_H3427  EPDNEW_H3429  
Experiment Methods:Single-end sequencing.; Paired-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh38268,179,770 - 68,179,830EPDNEW
RGD ID:6860512
Promoter ID:EPDNEW_H3421
Type:initiation region
Name:PPP3R1_5
Description:protein phosphatase 3 regulatory subunit B, alpha
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H3420  EPDNEW_H3422  EPDNEW_H3423  EPDNEW_H3425  EPDNEW_H3426  EPDNEW_H3427  EPDNEW_H3429  
Experiment Methods:Single-end sequencing.; Paired-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh38268,186,569 - 68,186,629EPDNEW
RGD ID:6860514
Promoter ID:EPDNEW_H3422
Type:initiation region
Name:PPP3R1_8
Description:protein phosphatase 3 regulatory subunit B, alpha
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H3420  EPDNEW_H3421  EPDNEW_H3423  EPDNEW_H3425  EPDNEW_H3426  EPDNEW_H3427  EPDNEW_H3429  
Experiment Methods:Single-end sequencing.; Paired-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh38268,188,949 - 68,189,009EPDNEW
RGD ID:6860516
Promoter ID:EPDNEW_H3423
Type:multiple initiation site
Name:PPP3R1_3
Description:protein phosphatase 3 regulatory subunit B, alpha
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H3420  EPDNEW_H3421  EPDNEW_H3422  EPDNEW_H3425  EPDNEW_H3426  EPDNEW_H3427  EPDNEW_H3429  
Experiment Methods:Single-end sequencing.; Paired-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh38268,218,670 - 68,218,730EPDNEW
RGD ID:6860520
Promoter ID:EPDNEW_H3425
Type:initiation region
Name:PPP3R1_6
Description:protein phosphatase 3 regulatory subunit B, alpha
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H3420  EPDNEW_H3421  EPDNEW_H3422  EPDNEW_H3423  EPDNEW_H3426  EPDNEW_H3427  EPDNEW_H3429  
Experiment Methods:Single-end sequencing.; Paired-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh38268,251,794 - 68,251,854EPDNEW
RGD ID:6860522
Promoter ID:EPDNEW_H3426
Type:initiation region
Name:PPP3R1_7
Description:protein phosphatase 3 regulatory subunit B, alpha
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H3420  EPDNEW_H3421  EPDNEW_H3422  EPDNEW_H3423  EPDNEW_H3425  EPDNEW_H3427  EPDNEW_H3429  
Experiment Methods:Single-end sequencing.; Paired-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh38268,252,270 - 68,252,330EPDNEW
RGD ID:6860524
Promoter ID:EPDNEW_H3427
Type:initiation region
Name:PPP3R1_1
Description:protein phosphatase 3 regulatory subunit B, alpha
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H3420  EPDNEW_H3421  EPDNEW_H3422  EPDNEW_H3423  EPDNEW_H3425  EPDNEW_H3426  EPDNEW_H3429  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh38268,252,532 - 68,252,592EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:9317 AgrOrtholog
COSMIC PPP3R1 COSMIC
Ensembl Genes ENSG00000221823 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENST00000234310 ENTREZGENE
  ENST00000234310.8 UniProtKB/Swiss-Prot
  ENST00000409377.1 UniProtKB/TrEMBL
  ENST00000409752.5 UniProtKB/TrEMBL
Gene3D-CATH EF-hand UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000221823 GTEx
HGNC ID HGNC:9317 ENTREZGENE
Human Proteome Map PPP3R1 Human Proteome Map
InterPro Calcineur_B UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EF-hand-dom_pair UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EF_Hand_1_Ca_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EF_hand_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:5534 UniProtKB/Swiss-Prot
NCBI Gene 5534 ENTREZGENE
OMIM 601302 OMIM
PANTHER CALCINEURIN SUBUNIT B TYPE 1 UniProtKB/TrEMBL
  PROTEIN PHOSPATASE 3 REGULATORY SUBUNIT B ALPHA ISOFORM TYPE 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR45942 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam EF-hand_7 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA33681 PharmGKB
PRINTS PARVALBUMIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE EF_HAND_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EF_HAND_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART EFh UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF47473 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt B2RC10 ENTREZGENE
  B5MDU4 ENTREZGENE
  CANB1_HUMAN UniProtKB/Swiss-Prot
  D3YTA9_HUMAN UniProtKB/TrEMBL
  F6U1T9_HUMAN UniProtKB/TrEMBL
  P06705 ENTREZGENE
  P15117 ENTREZGENE
  P63098 ENTREZGENE
  Q08044 ENTREZGENE
  Q53SL0 ENTREZGENE
UniProt Secondary B2RC10 UniProtKB/Swiss-Prot
  B5MDU4 UniProtKB/Swiss-Prot
  P06705 UniProtKB/Swiss-Prot
  P15117 UniProtKB/Swiss-Prot
  Q08044 UniProtKB/Swiss-Prot
  Q53SL0 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-11-24 PPP3R1  protein phosphatase 3 regulatory subunit B, alpha    protein phosphatase 3, regulatory subunit B, alpha  Symbol and/or name change 5135510 APPROVED
2011-07-27 PPP3R1  protein phosphatase 3, regulatory subunit B, alpha  PPP3R1  protein phosphatase 3 (formerly 2B), regulatory subunit B, alpha isoform  Symbol and/or name change 5135510 APPROVED