Rhein - Ontology Report - Rat Genome Database

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CHEBI ONTOLOGY - ANNOTATIONS

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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:	Rhein	go back to main search page
Accession:	CHEBI:8825	browse the term
Definition:	A dihydroxyanthraquinone that has formula C15H8O6.
Synonyms:	related_synonym:	Formula=C15H8O6; InChI=1S/C15H8O6/c16-9-3-1-2-7-11(9)14(19)12-8(13(7)18)4-6(15(20)21)5-10(12)17/h1-5,16-17H,(H,20,21); InChIKey=FCDLCPWAQCPTKC-UHFFFAOYSA-N; SMILES=OC(=O)c1cc(O)c2C(=O)c3c(O)cccc3C(=O)c2c1
	xref:	CAS:478-43-3; HMDB:HMDB0032876; KEGG:C10401; KNApSAcK:C00002861; LINCS:LSM-20950
	xref_mesh:	MESH:C020491

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Genes (39)

Rhein

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily B member 11

multiple interactions

Enzymes and Coenzymes inhibits the reaction [rhein promotes the reaction [ABCB11 protein results in increased transport of Taurodeoxycholic Acid]]; rhein metabolite inhibits the reaction [ABCB11 protein results in increased transport of Taurodeoxycholic Acid]; rhein promotes the reaction [ABCB11 protein results in increased transport of Taurodeoxycholic Acid]

NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730

G

actin alpha 2, smooth muscle

multiple interactions

rhein inhibits the reaction [Carbon Tetrachloride results in increased expression of ACTA2 protein]

NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554

G

adhesion G protein-coupled receptor E1

multiple interactions

rhein inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of ADGRE1 protein]

NCBI chr 9:2,242,476...2,398,000
Ensembl chr 9:2,242,474...2,398,000

G

aryl hydrocarbon receptor

multiple interactions

rhein inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of AHR protein]

NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568

G

alkB homolog 2, alpha-ketoglutarate-dependent dioxygenase

decreases activity

rhein results in decreased activity of ALKBH2 protein

NCBI chr12:42,494,187...42,500,929
Ensembl chr12:42,496,300...42,500,914

G

BCL2 associated X, apoptosis regulator

increases expression

rhein results in increased expression of BAX protein

NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368

G

beclin 1

decreases expression

rhein results in decreased expression of BECN1 protein

NCBI chr10:86,231,387...86,246,742
Ensembl chr10:86,231,388...86,246,742

G

caspase 1

multiple interactions

rhein inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased cleavage of CASP1 protein]

NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:2,587,831...2,597,383

G

caspase 3

decreases expression

rhein results in decreased expression of CASP3 protein

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

G

caspase 8

increases cleavage

rhein results in increased cleavage of CASP8 protein

NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542

G

caspase 9

decreases expression

rhein results in decreased expression of CASP9 protein

NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626

G

cytochrome P450, family 1, subfamily a, polypeptide 1

decreases activity

rhein results in decreased activity of CYP1A1 protein

NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125

G

cytochrome P450, family 1, subfamily a, polypeptide 2

decreases activity

rhein results in decreased activity of CYP1A2 protein

PMID:27633141 PMID:33438235

NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312

G

cytochrome P450, family 2, subfamily C, polypeptide 6

decreases activity

rhein results in decreased activity of CYP2C19 protein

NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596

G

cytochrome P450, family 2, subfamily d, polypeptide 4

decreases activity

rhein results in decreased activity of CYP2D6 protein

NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759

G

epidermal growth factor

decreases expression

rhein results in decreased expression of EGF protein

NCBI chr 2:218,219,408...218,302,359
Ensembl chr 2:218,219,415...218,302,064

G

erb-b2 receptor tyrosine kinase 2

decreases expression

rhein results in decreased expression of ERBB2 protein

NCBI chr10:83,411,197...83,435,078
Ensembl chr10:83,411,313...83,435,078

G

glutamic--pyruvic transaminase

multiple interactions

rhein inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of GPT protein]

NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494

G

hypoxia inducible factor 1 subunit alpha

decreases expression
multiple interactions

rhein results in decreased expression of HIF1A protein
rhein inhibits the reaction [cobaltous chloride results in increased expression of HIF1A protein]

NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261

G

interferon gamma

increases expression
multiple interactions

rhein results in increased expression of IFNG protein
rhein inhibits the reaction [Lipopolysaccharides results in increased expression of IFNG protein]

NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375

G

interleukin 10

multiple interactions

rhein inhibits the reaction [Lipopolysaccharides results in increased expression of IL10 protein]

NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313

G

interleukin 17A

increases expression

rhein results in increased expression of IL17A protein

NCBI chr 9:23,144,402...23,147,889
Ensembl chr 9:23,144,402...23,147,889

G

interleukin 18

multiple interactions

rhein inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of IL18 protein]

NCBI chr 8:50,904,630...50,932,887
Ensembl chr 8:50,906,960...50,932,887

G

interleukin 1 beta

multiple interactions

rhein inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of IL1B mRNA]; rhein inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of IL1B protein]

NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415

G

interleukin 2

increases expression

rhein results in increased expression of IL2 protein

NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566

G

interleukin 6

multiple interactions

rhein inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of IL6 protein]; rhein inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein]

PMID:26784856 PMID:37023836

NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178

G

nuclear factor kappa B subunit 1

affects localization
decreases activity
multiple interactions

rhein affects the localization of NFKB1 protein
rhein results in decreased activity of NFKB1 protein
rhein inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of NFKB1 mRNA]

PMID:21457705 PMID:37023836

NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404

G

NLR family, pyrin domain containing 3

multiple interactions

rhein inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of NLRP3 mRNA]

NCBI chr10:44,326,770...44,353,814
Ensembl chr10:44,328,566...44,352,811

G

prostaglandin-endoperoxide synthase 2

decreases expression

rhein results in decreased expression of PTGS2 protein

NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188

G

RELA proto-oncogene, NF-kB subunit

decreases activity
multiple interactions
affects localization

rhein results in decreased activity of RELA protein
cobaltous chloride promotes the reaction [rhein affects the localization of RELA protein]
rhein inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of RELA protein]

PMID:21457705 PMID:37023836

NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484

G

solute carrier family 22 member 6

multiple interactions

rhein inhibits the reaction [SLC22A6 protein results in increased uptake of p-Aminohippuric Acid]; rhein metabolite inhibits the reaction [SLC22A6 protein results in increased uptake of Methotrexate]; rhein metabolite inhibits the reaction [SLC22A6 protein results in increased uptake of p-Aminohippuric Acid]

NCBI chr 1:205,522,579...205,531,179
Ensembl chr 1:205,522,729...205,531,173

G

solute carrier family 22 member 8

multiple interactions

rhein inhibits the reaction [SLC22A8 protein results in increased uptake of estrone sulfate]; rhein metabolite inhibits the reaction [SLC22A8 protein results in increased uptake of estrone sulfate]; rhein metabolite inhibits the reaction [SLC22A8 protein results in increased uptake of Methotrexate]

NCBI chr 1:205,496,331...205,516,378
Ensembl chr 1:205,498,084...205,517,450

G

sequestosome 1

increases expression

rhein results in increased expression of SQSTM1 protein

NCBI chr10:34,525,517...34,536,670
Ensembl chr10:34,525,519...34,536,673

G

sulfotransferase family 1A member 1

decreases activity

rhein results in decreased activity of SULT1A1 protein

NCBI chr 1:181,272,022...181,276,750
Ensembl chr 1:181,272,023...181,275,562

G

transforming growth factor, beta 1

multiple interactions

rhein inhibits the reaction [Carbon Tetrachloride results in increased expression of TGFB1 protein]

NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847

G

tumor necrosis factor

increases expression
multiple interactions

rhein results in increased expression of TNF protein
rhein inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of TNF mRNA]; rhein inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of TNF protein]; rhein inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]

PMID:26784856 PMID:31436023 PMID:37023836

NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629

G

TNFRSF1A-associated via death domain

increases expression

rhein results in increased expression of TRADD protein

NCBI chr19:33,136,148...33,142,714
Ensembl chr19:33,136,138...33,142,638

G

TNF receptor-associated factor 1

increases expression

rhein results in increased expression of TRAF1 protein

NCBI chr 3:18,222,024...18,242,163
Ensembl chr 3:18,222,054...18,241,807

G

vascular endothelial growth factor A

decreases expression
decreases response to substance

rhein results in decreased expression of VEGFA protein
rhein results in decreased susceptibility to VEGFA protein

NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641

Term paths to the root

Path 1
Term	Annotations
CHEBI ontology	19808
chemical entity	19806
molecular entity	19806
polyatomic entity	19764
heteroatomic molecular entity	19720
hydroxides	19299
organic hydroxy compound	18923
phenols	18605
hydroxyanthraquinones	502
dihydroxyanthraquinone	350
Rhein	39
Path 2
Term	Annotations
CHEBI ontology	19808
subatomic particle	19806
composite particle	19806
hadron	19806
baryon	19806
nucleon	19806
atomic nucleus	19806
atom	19806
main group element atom	19756
p-block element atom	19756
carbon group element atom	19705
carbon atom	19702
organic molecular entity	19702
heteroorganic entity	19460
organochalcogen compound	19224
organooxygen compound	19141
carbonyl compound	18869
ketone	17165
cyclic ketone	15685
quinone	8644
acenoquinone	7719
anthraquinone	514
hydroxyanthraquinones	502
dihydroxyanthraquinone	350
Rhein	39

paths to the root