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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:Pentoxifylline
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Accession:CHEBI:7986 term browser browse the term
Definition:An oxopurine that has formula C13H18N4O3.
Synonyms:related_synonym: Formula=C13H18N4O3;   InChI=1S/C13H18N4O3/c1-9(18)6-4-5-7-17-12(19)10-11(14-8-15(10)2)16(3)13(17)20/h8H,4-7H2,1-3H3;   InChIKey=BYPFEZZEUUWMEJ-UHFFFAOYSA-N;   SMILES=CC(=O)CCCCn1c(=O)n(C)c2ncn(C)c2c1=O;   azupentat;   dimethyloxohexylxanthine;   oxpentifylline;   pentoxifyllin
 xref: CAS:6493-05-6;   Drug_Central:2099;   HMDB:HMDB0014944;   KEGG:C07424;   KEGG:D00501;   LINCS:LSM-3285
 xref_mesh: MESH:D010431
 xref: PDBeChem:PNX


show annotations for term's descendants           Sort by:
Pentoxifylline term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP-binding cassette, sub-family B member 1A decreases expression
multiple interactions		 ISO Pentoxifylline results in decreased expression of ABCB1 protein
[Pentoxifylline co-treated with Doxorubicin] results in decreased expression of ABCB1 protein		 CTD PMID:33775688 NCBI chr 5:8,617,091...8,798,575
Ensembl chr 5:8,710,077...8,798,575 		JBrowse link
G Abcc1 ATP-binding cassette, sub-family C member 1 multiple interactions ISO [Pentoxifylline co-treated with Doxorubicin] results in decreased expression of ABCC1 protein CTD PMID:33775688 NCBI chr16:14,179,317...14,292,743
Ensembl chr16:14,179,422...14,293,601 		JBrowse link
G Ache acetylcholinesterase decreases activity ISO Pentoxifylline results in decreased activity of ACHE protein CTD PMID:11981227 NCBI chr 5:137,286,516...137,292,728
Ensembl chr 5:137,285,781...137,292,728 		JBrowse link
G Acta2 actin alpha 2, smooth muscle, aorta decreases expression
multiple interactions		 ISO Pentoxifylline results in decreased expression of ACTA2 protein
Pentoxifylline promotes the reaction [Carbon Tetrachloride results in increased expression of ACTA2 mRNA]		 CTD PMID:14996430 PMID:18207697 NCBI chr19:34,217,736...34,232,985
Ensembl chr19:34,218,490...34,232,990 		JBrowse link
G Bax BCL2-associated X protein multiple interactions ISO Pentoxifylline inhibits the reaction [Streptozocin results in increased expression of BAX protein] CTD PMID:37431890 NCBI chr 7:45,111,124...45,116,332
Ensembl chr 7:45,111,121...45,116,322 		JBrowse link
G Bcl2 B cell leukemia/lymphoma 2 multiple interactions ISO [Rolipram co-treated with Pentoxifylline] inhibits the reaction [Streptozocin results in increased expression of BCL2 protein]; Pentoxifylline inhibits the reaction [Streptozocin results in increased expression of BCL2 protein] CTD PMID:37431890 NCBI chr 1:106,465,906...106,642,020
Ensembl chr 1:106,465,908...106,642,004 		JBrowse link
G Bcl2l1 BCL2-like 1 multiple interactions
decreases expression		 ISO [Pentoxifylline co-treated with TNFSF10 protein] results in decreased expression of BCL2L1 protein
Pentoxifylline results in decreased expression of BCL2L1 mRNA; Pentoxifylline results in decreased expression of BCL2L1 protein		 CTD PMID:18851957 PMID:20804743 NCBI chr 2:152,600,652...152,673,632
Ensembl chr 2:152,622,588...152,673,648 		JBrowse link
G Bid BH3 interacting domain death agonist multiple interactions ISO Pentoxifylline promotes the reaction [TNFSF10 protein results in increased cleavage of BID protein] CTD PMID:20804743 NCBI chr 6:120,870,080...120,894,074
Ensembl chr 6:120,868,891...120,893,814 		JBrowse link
G Birc2 baculoviral IAP repeat-containing 2 multiple interactions ISO [Pentoxifylline co-treated with TNFSF10 protein] results in decreased expression of BIRC2 protein CTD PMID:20804743 NCBI chr 9:7,818,227...7,837,123
Ensembl chr 9:7,818,228...7,837,065 		JBrowse link
G Birc3 baculoviral IAP repeat-containing 3 multiple interactions ISO [Pentoxifylline co-treated with TNFSF10 protein] results in decreased expression of BIRC3 protein CTD PMID:20804743 NCBI chr 9:7,848,698...7,873,199
Ensembl chr 9:7,848,700...7,873,187 		JBrowse link
G Braf Braf transforming gene multiple interactions ISO [Pentoxifylline results in increased abundance of Cyclic AMP] which results in increased activity of BRAF protein CTD PMID:21693435 NCBI chr 6:39,580,171...39,702,592
Ensembl chr 6:39,580,171...39,702,397 		JBrowse link
G Casp1 caspase 1 multiple interactions ISO Pentoxifylline inhibits the reaction [Glycerol results in increased cleavage of CASP1 protein] CTD PMID:36690085 NCBI chr 9:5,298,517...5,307,281
Ensembl chr 9:5,298,508...5,307,290 		JBrowse link
G Casp3 caspase 3 multiple interactions
increases activity		 EXP
ISO		 Pentoxifylline inhibits the reaction [Ethanol results in increased activity of CASP3 protein]
Pentoxifylline results in increased activity of CASP3 protein
[Pentoxifylline co-treated with Doxorubicin] results in increased cleavage of CASP3 protein
[Rolipram co-treated with Pentoxifylline] inhibits the reaction [Streptozocin results in increased cleavage of CASP3 protein]; Pentoxifylline inhibits the reaction [Streptozocin results in increased cleavage of CASP3 protein]		 CTD PMID:16317704 PMID:18851957 PMID:33775688 PMID:37431890 NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724 		JBrowse link
G Casp8 caspase 8 multiple interactions ISO Pentoxifylline promotes the reaction [TNFSF10 protein results in increased activity of CASP8 protein] CTD PMID:20804743 NCBI chr 1:58,834,553...58,886,663
Ensembl chr 1:58,834,533...58,886,662 		JBrowse link
G Casp9 caspase 9 multiple interactions ISO [Pentoxifylline co-treated with TNFSF10 protein] results in increased activity of CASP9 protein CTD PMID:20804743 NCBI chr 4:141,520,923...141,543,289
Ensembl chr 4:141,520,923...141,543,287 		JBrowse link
G Cat catalase multiple interactions EXP
ISO		 [Melatonin co-treated with Pentoxifylline] inhibits the reaction [Carbon Tetrachloride results in decreased activity of CAT protein]; Pentoxifylline inhibits the reaction [Carbon Tetrachloride results in decreased activity of CAT protein]
Pentoxifylline inhibits the reaction [Cyclophosphamide results in decreased activity of CAT protein]; Pentoxifylline inhibits the reaction [Malathion results in increased activity of CAT protein]		 CTD PMID:16703270 PMID:20194575 PMID:23695977 NCBI chr 2:103,284,249...103,315,498
Ensembl chr 2:103,284,194...103,315,505 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions
decreases expression
decreases secretion		 ISO Pentoxifylline inhibits the reaction [Streptozocin results in increased expression of CCL2 protein]
Pentoxifylline results in decreased expression of CCL2 mRNA
Pentoxifylline results in decreased secretion of CCL2 protein		 CTD PMID:14993492 PMID:18617301 PMID:19921414 NCBI chr11:81,926,403...81,928,278
Ensembl chr11:81,926,397...81,928,279 		JBrowse link
G Ccl5 C-C motif chemokine ligand 5 decreases expression ISO Pentoxifylline results in decreased expression of CCL5 mRNA CTD PMID:14993492 NCBI chr11:83,416,604...83,421,344
Ensembl chr11:83,416,604...83,421,344 		JBrowse link
G Ccn2 cellular communication network factor 2 decreases expression ISO Pentoxifylline results in decreased expression of CCN2 mRNA CTD PMID:11788567 NCBI chr10:24,471,340...24,474,581
Ensembl chr10:24,471,340...24,474,581 		JBrowse link
G Ccna2 cyclin A2 multiple interactions ISO Pentoxifylline inhibits the reaction [Mechlorethamine results in increased activity of [CCNA2 protein binds to CDK2 protein]] CTD PMID:8463339 NCBI chr 3:36,619,014...36,627,187
Ensembl chr 3:36,619,014...36,626,299 		JBrowse link
G Ccnb1 cyclin B1 multiple interactions ISO Pentoxifylline inhibits the reaction [Mechlorethamine results in decreased activity of [CCNB1 protein binds to CDK1 protein]] CTD PMID:8463339 NCBI chr13:100,915,247...100,922,994
Ensembl chr13:100,915,158...100,923,078 		JBrowse link
G Cd69 CD69 antigen decreases expression EXP Pentoxifylline results in decreased expression of CD69 protein CTD PMID:25433234 NCBI chr 6:129,244,287...129,252,332
Ensembl chr 6:129,244,288...129,252,399 		JBrowse link
G Cdk1 cyclin dependent kinase 1 multiple interactions ISO Pentoxifylline inhibits the reaction [Mechlorethamine results in decreased activity of [CCNB1 protein binds to CDK1 protein]] CTD PMID:8463339 NCBI chr10:69,170,976...69,188,742
Ensembl chr10:69,170,976...69,188,768 		JBrowse link
G Cdk2 cyclin dependent kinase 2 multiple interactions ISO Pentoxifylline inhibits the reaction [Mechlorethamine results in increased activity of [CCNA2 protein binds to CDK2 protein]] CTD PMID:8463339 NCBI chr10:128,533,807...128,540,920
Ensembl chr10:128,533,808...128,540,900 		JBrowse link
G Cdkn1b cyclin dependent kinase inhibitor 1B multiple interactions ISO [Pentoxifylline results in increased abundance of Cyclic AMP] which results in increased expression of CDKN1B protein CTD PMID:21693435 NCBI chr 6:134,897,364...134,902,488
Ensembl chr 6:134,897,364...134,902,476 		JBrowse link
G Cflar CASP8 and FADD-like apoptosis regulator multiple interactions
decreases expression		 ISO [Pentoxifylline co-treated with TNFSF10 protein] results in decreased expression of CFLAR protein
Pentoxifylline results in decreased expression of CFLAR protein		 CTD PMID:18851957 PMID:20804743 NCBI chr 1:58,750,353...58,798,043
Ensembl chr 1:58,750,667...58,798,043 		JBrowse link
G Ckm creatine kinase, muscle multiple interactions ISO Pentoxifylline inhibits the reaction [Glycerol results in increased secretion of CKM protein] CTD PMID:36690085 NCBI chr 7:19,145,019...19,155,508
Ensembl chr 7:19,138,701...19,156,766 		JBrowse link
G Col1a1 collagen, type I, alpha 1 multiple interactions
decreases expression		 ISO Pentoxifylline inhibits the reaction [Acetaldehyde results in increased expression of COL1A1 mRNA]
Pentoxifylline results in decreased expression of COL1A1 mRNA
Pentoxifylline promotes the reaction [Carbon Tetrachloride results in increased expression of COL1A1 mRNA]		 CTD PMID:7617123 PMID:11788567 PMID:12419648 PMID:14993492 PMID:17952619 More... NCBI chr11:94,827,050...94,843,868
Ensembl chr11:94,827,050...94,843,868 		JBrowse link
G Col3a1 collagen, type III, alpha 1 decreases expression ISO Pentoxifylline results in decreased expression of COL3A1 protein CTD PMID:11788567 NCBI chr 1:45,350,698...45,388,866
Ensembl chr 1:45,350,698...45,388,866 		JBrowse link
G Crp C-reactive protein, pentraxin-related decreases expression ISO Pentoxifylline results in decreased expression of CRP protein CTD PMID:14970111 NCBI chr 1:172,525,623...172,527,533
Ensembl chr 1:172,525,622...172,660,598 		JBrowse link
G Cxcl2 C-X-C motif chemokine ligand 2 multiple interactions ISO Pentoxifylline inhibits the reaction [[Ranitidine co-treated with Lipopolysaccharides] results in increased expression of CXCL2 protein] CTD PMID:17698507 NCBI chr 5:91,051,758...91,053,797
Ensembl chr 5:91,051,730...91,053,797 		JBrowse link
G Cycs cytochrome c, somatic increases secretion
multiple interactions		 ISO Pentoxifylline results in increased secretion of CYCS protein
Pentoxifylline promotes the reaction [TNFSF10 protein results in increased secretion of CYCS protein]		 CTD PMID:18851957 PMID:20804743 NCBI chr 6:50,539,543...50,543,549
Ensembl chr 6:50,539,543...50,543,518 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 decreases activity ISO Pentoxifylline results in decreased activity of CYP1A2 protein CTD PMID:11465391 NCBI chr 9:57,584,220...57,590,938
Ensembl chr 9:57,584,220...57,590,986 		JBrowse link
G Fas Fas cell surface death receptor increases expression
decreases expression		 ISO Pentoxifylline results in increased expression of FAS mRNA; Pentoxifylline results in increased expression of FAS protein
Pentoxifylline results in decreased expression of FAS protein		 CTD PMID:14970111 PMID:18851957 NCBI chr19:34,267,926...34,305,175
Ensembl chr19:34,268,066...34,305,172 		JBrowse link
G Fos FBJ osteosarcoma oncogene increases expression ISO Pentoxifylline results in increased expression of FOS mRNA CTD PMID:18851957 NCBI chr12:85,520,664...85,524,048
Ensembl chr12:85,520,664...85,524,047 		JBrowse link
G Gadd45a growth arrest and DNA-damage-inducible 45 alpha increases expression ISO Pentoxifylline results in increased expression of GADD45A mRNA CTD PMID:18851957 NCBI chr 6:67,012,080...67,014,391
Ensembl chr 6:67,012,080...67,014,441 		JBrowse link
G Gsdmd gasdermin D multiple interactions ISO Pentoxifylline inhibits the reaction [Glycerol results in increased cleavage of GSDMD protein] CTD PMID:36690085 NCBI chr15:75,733,990...75,739,257
Ensembl chr15:75,734,176...75,739,257 		JBrowse link
G Havcr1 hepatitis A virus cellular receptor 1 multiple interactions ISO Pentoxifylline inhibits the reaction [Cisplatin results in increased expression of and results in increased secretion of HAVCR1 protein] CTD PMID:32777238 NCBI chr11:46,630,644...46,670,405
Ensembl chr11:46,625,907...46,670,405 		JBrowse link
G Hmox1 heme oxygenase 1 decreases expression ISO Pentoxifylline results in decreased expression of HMOX1 protein CTD PMID:22461696 NCBI chr 8:75,820,246...75,827,221
Ensembl chr 8:75,820,249...75,827,217 		JBrowse link
G Icam1 intercellular adhesion molecule 1 decreases expression ISO Pentoxifylline results in decreased expression of ICAM1 mRNA CTD PMID:14993492 NCBI chr 9:20,927,236...20,940,110
Ensembl chr 9:20,927,281...20,940,113 		JBrowse link
G Il10 interleukin 10 multiple interactions EXP Pentoxifylline promotes the reaction [Zymosan results in increased expression of IL10 protein] CTD PMID:11301049 NCBI chr 1:130,947,459...130,952,707
Ensembl chr 1:130,947,582...130,952,711 		JBrowse link
G Il1b interleukin 1 beta multiple interactions EXP
ISO		 Pentoxifylline promotes the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]
Pentoxifylline inhibits the reaction [Cyclophosphamide results in increased expression of IL1B protein]; Pentoxifylline inhibits the reaction [Glycerol results in increased cleavage of IL1B protein]; Pentoxifylline inhibits the reaction [Indomethacin results in increased expression of IL1B protein]; Pentoxifylline inhibits the reaction [Ranitidine promotes the reaction [Lipopolysaccharides results in increased expression of IL1B protein]]; Pentoxifylline inhibits the reaction [Streptozocin results in increased expression of IL1B mRNA]		 CTD PMID:15711975 PMID:16133968 PMID:17167242 PMID:17698507 PMID:23695977 More... NCBI chr 2:129,206,490...129,213,059
Ensembl chr 2:129,206,490...129,213,059 		JBrowse link
G Il2ra interleukin 2 receptor, alpha chain multiple interactions
decreases expression
decreases secretion		 ISO
EXP		 N-(4-aminobutyl)-5-chloro-2-naphthalenesulfonamide inhibits the reaction [Pentoxifylline results in decreased expression of IL2RA protein]
Pentoxifylline results in decreased expression of IL2RA mRNA; Pentoxifylline results in decreased expression of IL2RA protein
Pentoxifylline results in decreased secretion of IL2RA protein		 CTD PMID:1709825 PMID:25433234 NCBI chr 2:11,647,603...11,698,005
Ensembl chr 2:11,647,618...11,698,004 		JBrowse link
G Il4 interleukin 4 increases expression ISO Pentoxifylline results in increased expression of IL4 mRNA CTD PMID:7589090 NCBI chr11:53,503,287...53,509,492
Ensembl chr11:53,493,809...53,509,496 		JBrowse link
G Il6 interleukin 6 multiple interactions
decreases expression		 EXP
ISO		 Pentoxifylline inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]; Pentoxifylline inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein]
Acetaldehyde promotes the reaction [Pentoxifylline results in decreased expression of IL6 mRNA]; Pentoxifylline inhibits the reaction [Acetaldehyde results in increased expression of IL6 mRNA]; Pentoxifylline inhibits the reaction [Cyclophosphamide results in increased expression of IL6 protein]; Pentoxifylline inhibits the reaction [Ranitidine promotes the reaction [Lipopolysaccharides results in increased expression of IL6 protein]]; Pentoxifylline inhibits the reaction [Streptozocin results in increased expression of IL6 mRNA]		 CTD PMID:12419648 PMID:15711975 PMID:17167242 PMID:17698507 PMID:17952619 More... NCBI chr 5:30,218,112...30,224,973
Ensembl chr 5:30,218,112...30,224,979 		JBrowse link
G Itgb2 integrin beta 2 affects expression ISO Pentoxifylline affects the expression of ITGB2 CTD PMID:1976392 NCBI chr10:77,366,164...77,401,542
Ensembl chr10:77,366,086...77,401,542 		JBrowse link
G Map1lc3b microtubule-associated protein 1 light chain 3 beta multiple interactions ISO Pentoxifylline inhibits the reaction [Cisplatin results in decreased expression of MAP1LC3B protein modified form] CTD PMID:32777238 NCBI chr 8:122,317,177...122,325,499
Ensembl chr 8:122,317,100...122,325,499 		JBrowse link
G Map3k7 mitogen-activated protein kinase kinase kinase 7 multiple interactions
affects binding		 ISO Pentoxifylline inhibits the reaction [Cisplatin results in increased expression of MAP3K7 protein]
Pentoxifylline binds to MAP3K7 protein		 CTD PMID:32777238 NCBI chr 4:31,963,659...32,023,470
Ensembl chr 4:31,964,097...32,023,467 		JBrowse link
G Mapk1 mitogen-activated protein kinase 1 multiple interactions ISO Pentoxifylline inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased phosphorylation of and results in increased activity of MAPK1 protein] CTD PMID:19697996 NCBI chr16:16,801,246...16,865,317
Ensembl chr16:16,801,246...16,865,317 		JBrowse link
G Mapk3 mitogen-activated protein kinase 3 multiple interactions ISO Pentoxifylline inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased phosphorylation of and results in increased activity of MAPK3 protein] CTD PMID:19697996 NCBI chr 7:126,358,798...126,364,988
Ensembl chr 7:126,358,773...126,364,991 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 increases expression ISO Pentoxifylline results in increased expression of MAPK8 protein; Pentoxifylline results in increased expression of MAPK8 protein modified form CTD PMID:20804743 NCBI chr14:33,099,855...33,169,213
Ensembl chr14:33,099,855...33,169,115 		JBrowse link
G Mapk9 mitogen-activated protein kinase 9 increases expression ISO Pentoxifylline results in increased expression of MAPK9 protein; Pentoxifylline results in increased expression of MAPK9 protein modified form CTD PMID:20804743 NCBI chr11:49,737,558...49,777,248
Ensembl chr11:49,737,578...49,777,248 		JBrowse link
G Mcl1 myeloid cell leukemia sequence 1 increases expression ISO Pentoxifylline results in increased expression of MCL1 mRNA CTD PMID:18851957 NCBI chr 3:95,564,017...95,583,553
Ensembl chr 3:95,566,099...95,570,487 		JBrowse link
G Mir26b microRNA 26b multiple interactions ISO Pentoxifylline inhibits the reaction [Cisplatin results in decreased expression of MIR26B mRNA] CTD PMID:32777238 NCBI chr 1:74,433,469...74,433,553
Ensembl chr 1:74,433,469...74,433,553 		JBrowse link
G Mir34a microRNA 34a multiple interactions ISO Pentoxifylline inhibits the reaction [Cisplatin results in increased expression of MIR34A mRNA] CTD PMID:32777238 NCBI chr 4:150,152,911...150,153,012
Ensembl chr 4:150,152,911...150,153,012 		JBrowse link
G Mirlet7b microRNA let7b multiple interactions ISO Pentoxifylline inhibits the reaction [Cisplatin results in decreased expression of MIRLET7B mRNA] CTD PMID:32777238 NCBI chr15:85,591,520...85,591,604
Ensembl chr15:85,591,520...85,591,604 		JBrowse link
G Mpo myeloperoxidase multiple interactions ISO Pentoxifylline inhibits the reaction [Indomethacin results in increased activity of MPO protein] CTD PMID:16133968 NCBI chr11:87,684,610...87,695,238
Ensembl chr11:87,684,407...87,695,239 		JBrowse link
G Mtor mechanistic target of rapamycin kinase multiple interactions ISO Pentoxifylline inhibits the reaction [Cisplatin results in increased expression of MTOR protein] CTD PMID:32777238 NCBI chr 4:148,533,039...148,642,142
Ensembl chr 4:148,533,068...148,642,140 		JBrowse link
G Myc myelocytomatosis oncogene multiple interactions ISO Pentoxifylline inhibits the reaction [Glycerol results in increased expression of MYC protein] CTD PMID:36690085 NCBI chr15:61,857,190...61,862,210
Ensembl chr15:61,857,240...61,862,223 		JBrowse link
G Nfkb1 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 multiple interactions ISO Pentoxifylline inhibits the reaction [Acetaldehyde results in increased activity of [NFKB1 protein binds to RELA protein]] CTD PMID:17952619 NCBI chr 3:135,290,416...135,397,422
Ensembl chr 3:135,290,416...135,397,308 		JBrowse link
G Nfkbia nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha multiple interactions ISO Pentoxifylline inhibits the reaction [Acetaldehyde results in decreased expression of NFKBIA protein]; Pentoxifylline inhibits the reaction [Acetaldehyde results in increased degradation of NFKBIA protein] CTD PMID:17952619 NCBI chr12:55,536,194...55,539,432
Ensembl chr12:55,536,195...55,539,432 		JBrowse link
G Nlrp3 NLR family, pyrin domain containing 3 multiple interactions ISO Pentoxifylline inhibits the reaction [Glycerol results in increased expression of NLRP3 protein] CTD PMID:36690085 NCBI chr11:59,432,395...59,457,781
Ensembl chr11:59,432,394...59,457,782 		JBrowse link
G Nos2 nitric oxide synthase 2, inducible multiple interactions ISO Pentoxifylline inhibits the reaction [Indomethacin results in increased expression of NOS2 protein] CTD PMID:16133968 NCBI chr11:78,811,613...78,851,052
Ensembl chr11:78,811,613...78,851,080 		JBrowse link
G Nppb natriuretic peptide type B decreases expression ISO Pentoxifylline results in decreased expression of NPPB protein CTD PMID:14970111 NCBI chr 4:148,070,264...148,071,662
Ensembl chr 4:148,070,245...148,071,662 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase family, member 1 multiple interactions
increases cleavage		 ISO [Pentoxifylline co-treated with Doxorubicin] results in increased cleavage of PARP1 protein; Pentoxifylline promotes the reaction [TNFSF10 protein results in increased cleavage of PARP1 protein]
Pentoxifylline results in increased cleavage of PARP1 protein		 CTD PMID:18851957 PMID:20804743 PMID:33775688 NCBI chr 1:180,396,456...180,428,564
Ensembl chr 1:180,396,489...180,428,819 		JBrowse link
G Prf1 perforin 1 (pore forming protein) decreases secretion ISO Pentoxifylline results in decreased secretion of PRF1 protein CTD PMID:17880773 NCBI chr10:61,133,530...61,140,463
Ensembl chr10:61,133,612...61,140,459 		JBrowse link
G Psma1 proteasome subunit alpha 1 multiple interactions ISO Pentoxifylline inhibits the reaction [Monocrotaline results in increased expression of PSMA1 mRNA] CTD PMID:18801959 NCBI chr 7:113,863,785...113,875,351
Ensembl chr 7:113,863,841...113,875,353 		JBrowse link
G Psma3 proteasome subunit alpha 3 multiple interactions ISO Pentoxifylline inhibits the reaction [Monocrotaline results in increased expression of PSMA3 mRNA] CTD PMID:18801959 NCBI chr12:71,016,082...71,042,651
Ensembl chr12:71,021,395...71,043,121 		JBrowse link
G Psmc6 proteasome (prosome, macropain) 26S subunit, ATPase, 6 multiple interactions ISO Pentoxifylline inhibits the reaction [Monocrotaline results in increased expression of PSMC6 mRNA] CTD PMID:18801959 NCBI chr14:45,567,285...45,587,150
Ensembl chr14:45,567,245...45,587,162 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO Pentoxifylline inhibits the reaction [Ifosfamide results in increased expression of PTGS2 protein] CTD PMID:17638016 NCBI chr 1:149,975,851...149,983,978
Ensembl chr 1:149,975,782...149,983,978 		JBrowse link
G Rap1b RAS related protein 1b multiple interactions ISO [Pentoxifylline results in increased abundance of Cyclic AMP] results in increased abundance of [RAP1B protein binds to Guanosine Triphosphate] CTD PMID:21693435 NCBI chr10:117,650,502...117,681,879
Ensembl chr10:117,649,776...117,681,940 		JBrowse link
G Rela v-rel reticuloendotheliosis viral oncogene homolog A (avian) multiple interactions EXP
ISO		 Pentoxifylline inhibits the reaction and results in decreased activity of Ethanol inhibits the reaction and results in decreased activity of RELA protein
Pentoxifylline inhibits the reaction [Acetaldehyde results in increased activity of [NFKB1 protein binds to RELA protein]]; Pentoxifylline inhibits the reaction [Cisplatin results in increased expression of RELA protein]
[Pentoxifylline co-treated with Doxorubicin] results in decreased phosphorylation of RELA protein		 CTD PMID:16317704 PMID:17952619 PMID:32777238 PMID:33775688 NCBI chr19:5,686,993...5,698,162
Ensembl chr19:5,687,511...5,698,158 		JBrowse link
G Serpine1 serine (or cysteine) peptidase inhibitor, clade E, member 1 multiple interactions ISO Pentoxifylline inhibits the reaction [Ranitidine promotes the reaction [Lipopolysaccharides results in increased expression of SERPINE1 protein]] CTD PMID:17698507 NCBI chr 5:137,090,358...137,101,126
Ensembl chr 5:137,090,358...137,101,122 		JBrowse link
G Spp1 secreted phosphoprotein 1 decreases expression ISO Pentoxifylline results in decreased expression of SPP1 mRNA CTD PMID:14993492 NCBI chr 5:104,582,977...104,588,919
Ensembl chr 5:104,582,984...104,588,916 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 decreases expression
multiple interactions		 ISO Pentoxifylline results in decreased expression of TGFB1 mRNA
Pentoxifylline inhibits the reaction [Cisplatin results in increased expression of TGFB1 protein]		 CTD PMID:11788567 PMID:32777238 NCBI chr 7:25,386,406...25,404,503
Ensembl chr 7:25,386,427...25,404,502 		JBrowse link
G Tgfbr1 transforming growth factor, beta receptor I affects binding
multiple interactions		 ISO Pentoxifylline binds to TGFBR1 protein
Pentoxifylline inhibits the reaction [Cisplatin results in increased expression of TGFBR1 mRNA]; Pentoxifylline inhibits the reaction [Cisplatin results in increased expression of TGFBR1 protein]		 CTD PMID:32777238 NCBI chr 4:47,353,258...47,414,926
Ensembl chr 4:47,353,222...47,414,931 		JBrowse link
G Timp1 tissue inhibitor of metalloproteinase 1 increases expression ISO Pentoxifylline results in increased expression of TIMP1 mRNA CTD PMID:11788567 NCBI chr  X:20,736,524...20,740,972
Ensembl chr  X:20,736,405...20,740,974 		JBrowse link
G Tlr4 toll-like receptor 4 multiple interactions ISO Pentoxifylline inhibits the reaction [Glycerol results in increased expression of TLR4 protein] CTD PMID:36690085 NCBI chr 4:66,745,788...66,765,338
Ensembl chr 4:66,745,821...66,848,521 		JBrowse link
G Tnf tumor necrosis factor decreases expression
multiple interactions
decreases secretion
increases expression		 ISO
EXP		 Pentoxifylline results in decreased expression of TNF mRNA; Pentoxifylline results in decreased expression of TNF protein
Pentoxifylline inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]
Pentoxifylline results in decreased secretion of TNF protein
Pentoxifylline results in increased expression of TNF protein
[Pentoxifylline results in decreased expression of TNF mRNA] results in decreased susceptibility to [lipopolysaccharide, E coli O55-B5 co-treated with trovafloxacin]; Pentoxifylline inhibits the reaction [endotoxin, Escherichia coli results in increased expression of TNF mRNA]; Pentoxifylline inhibits the reaction [endotoxin, Escherichia coli results in increased secretion of TNF protein]; Pentoxifylline inhibits the reaction [Ethanol results in increased expression of TNF protein]; Pentoxifylline inhibits the reaction [lead acetate promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of TNF protein]]; Pentoxifylline inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of TNF mRNA]; Pentoxifylline inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of TNF protein]; Pentoxifylline inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; Pentoxifylline inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]; Pentoxifylline inhibits the reaction [manganese chloride promotes the reaction [Lipopolysaccharides results in increased expression of TNF protein]]; Pentoxifylline inhibits the reaction [Zymosan results in increased expression of TNF protein]
Pentoxifylline inhibits the reaction [Ceruletide results in increased expression of TNF protein]; Pentoxifylline inhibits the reaction [Cyclophosphamide results in increased expression of TNF protein]; Pentoxifylline inhibits the reaction [Glycerol results in increased expression of TNF protein]; Pentoxifylline inhibits the reaction [Indomethacin results in increased expression of TNF protein]; Pentoxifylline inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]; Pentoxifylline inhibits the reaction [Mercuric Chloride results in increased expression of TNF mRNA]; Pentoxifylline inhibits the reaction [Streptozocin results in increased expression of TNF mRNA]		 CTD PMID:1593221 PMID:7589090 PMID:7769305 PMID:8741040 PMID:10773043 More... NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983 		JBrowse link
G Tnfrsf10b tumor necrosis factor receptor superfamily, member 10b increases expression ISO Pentoxifylline results in increased expression of TNFRSF10A protein CTD PMID:20804743 NCBI chr14:70,004,921...70,021,860
Ensembl chr14:70,004,921...70,021,860 		JBrowse link
G Tnfsf10 tumor necrosis factor (ligand) superfamily, member 10 multiple interactions
increases expression		 ISO [Pentoxifylline co-treated with TNFSF10 protein] results in decreased expression of BCL2L1 protein; [Pentoxifylline co-treated with TNFSF10 protein] results in decreased expression of BIRC2 protein; [Pentoxifylline co-treated with TNFSF10 protein] results in decreased expression of BIRC3 protein; [Pentoxifylline co-treated with TNFSF10 protein] results in decreased expression of CFLAR protein; [Pentoxifylline co-treated with TNFSF10 protein] results in decreased expression of XIAP protein; [Pentoxifylline co-treated with TNFSF10 protein] results in increased activity of CASP9 protein; Pentoxifylline promotes the reaction [TNFSF10 protein results in increased activity of CASP8 protein]; Pentoxifylline promotes the reaction [TNFSF10 protein results in increased cleavage of BID protein]; Pentoxifylline promotes the reaction [TNFSF10 protein results in increased cleavage of PARP1 protein]; Pentoxifylline promotes the reaction [TNFSF10 protein results in increased secretion of CYCS protein]
Pentoxifylline results in increased expression of TNFSF10 mRNA		 CTD PMID:18851957 PMID:20804743 NCBI chr 3:27,371,226...27,393,814
Ensembl chr 3:27,371,177...27,396,576 		JBrowse link
G Vcam1 vascular cell adhesion molecule 1 decreases expression ISO Pentoxifylline results in decreased expression of VCAM1 mRNA CTD PMID:14720322 NCBI chr 3:115,903,669...115,923,337
Ensembl chr 3:115,903,598...115,923,337 		JBrowse link
G Vegfa vascular endothelial growth factor A decreases expression ISO Pentoxifylline results in decreased expression of VEGFA mRNA CTD PMID:14720322 NCBI chr17:46,327,919...46,343,303
Ensembl chr17:46,327,919...46,343,295 		JBrowse link
G Xiap X-linked inhibitor of apoptosis multiple interactions ISO [Pentoxifylline co-treated with TNFSF10 protein] results in decreased expression of XIAP protein CTD PMID:20804743 NCBI chr  X:41,148,483...41,198,541
Ensembl chr  X:41,148,556...41,198,533 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 22205
    chemical entity 22204
      atom 22197
        nonmetal atom 22082
          nitrogen atom 20029
            nitrogen molecular entity 20029
              organonitrogen compound 19836
                organonitrogen heterocyclic compound 19088
                  imidazopyrimidine 7744
                    purines 7743
                      oxopurine 6369
                        Pentoxifylline 84
Path 2
Term Annotations click to browse term
  CHEBI ontology 22205
    subatomic particle 22197
      composite particle 22197
        hadron 22197
          baryon 22197
            nucleon 22169
              atomic nucleus 22197
                atom 22197
                  main group element atom 22131
                    p-block element atom 22131
                      carbon group element atom 21928
                        carbon atom 21854
                          organic molecular entity 21854
                            organic molecule 21671
                              organic cyclic compound 21276
                                organic heterocyclic compound 20346
                                  organic heteropolycyclic compound 19637
                                    organic heterobicyclic compound 18208
                                      imidazopyrimidine 7744
                                        purines 7743
                                          oxopurine 6369
                                            Pentoxifylline 84
paths to the root