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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:mebendazole
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Accession:CHEBI:6704 term browser browse the term
Definition:A carbamate ester that is methyl 1H-benzimidazol-2-ylcarbamate substituted by a benzoyl group at position 5.
Synonyms:exact_synonym: methyl (5-benzoyl-1H-benzimidazol-2-yl)carbamate
 related_synonym: (5-benzoyl-1H-benzimidazol-2-yl)-carbamic acid methyl ester;   Formula=C16H13N3O3;   InChI=1S/C16H13N3O3/c1-22-16(21)19-15-17-12-8-7-11(9-13(12)18-15)14(20)10-5-3-2-4-6-10/h2-9H,1H3,(H2,17,18,19,21);   InChIKey=OPXLLQIJSORQAM-UHFFFAOYSA-N;   MBDZ;   SMILES=COC(=O)Nc1nc2cc(ccc2[nH]1)C(=O)c1ccccc1;   Vermox
 xref: Beilstein:759809;   CAS:31431-39-7;   DrugBank:DB00643;   Drug_Central:1641;   KEGG:D00368;   LINCS:LSM-3749
 xref_mesh: MESH:D008463
 xref: PMID:6126101;   Reaxys:759809;   Wikipedia:Mebendazole


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mebendazole term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A decreases expression ISO Mebendazole results in decreased expression of ABCB1 mRNA; Mebendazole results in decreased expression of ABCB1 protein CTD PMID:28606429 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709 		JBrowse link
G Abcc1 ATP binding cassette subfamily C member 1 decreases expression ISO Mebendazole results in decreased expression of ABCC1 mRNA CTD PMID:28606429 NCBI chr10:528,961...655,179
Ensembl chr10:531,812...655,114 		JBrowse link
G Ager advanced glycosylation end product-specific receptor increases expression ISO Mebendazole results in increased expression of AGER mRNA CTD PMID:24747151 NCBI chr20:4,148,150...4,151,361
Ensembl chr20:4,147,890...4,151,078 		JBrowse link
G Arhgef2 Rho/Rac guanine nucleotide exchange factor 2 decreases expression ISO Mebendazole results in decreased expression of ARHGEF2 protein CTD PMID:30075109 NCBI chr 2:174,061,126...174,118,355
Ensembl chr 2:174,062,976...174,118,355 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions ISO [Mebendazole results in increased phosphorylation of BCL2 protein] inhibits the reaction [BCL2 protein binds to BAX protein] CTD PMID:18667591 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl2 BCL2, apoptosis regulator affects response to substance
increases phosphorylation
multiple interactions		 ISO BCL2 protein affects the susceptibility to Mebendazole
Mebendazole results in increased phosphorylation of BCL2 protein
[Mebendazole results in increased phosphorylation of BCL2 protein] inhibits the reaction [BCL2 protein binds to BAX protein]		 CTD PMID:18667591 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Bmp6 bone morphogenetic protein 6 increases expression ISO Mebendazole results in increased expression of BMP6 mRNA CTD PMID:32816093 NCBI chr17:26,318,121...26,469,691
Ensembl chr17:26,318,569...26,470,365 		JBrowse link
G Casp3 caspase 3 increases activity ISO Mebendazole results in increased activity of CASP3 protein CTD PMID:37473966 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp7 caspase 7 increases activity ISO Mebendazole results in increased activity of CASP7 protein CTD PMID:37473966 NCBI chr 1:255,437,438...255,476,737
Ensembl chr 1:255,437,172...255,476,729 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 increases expression ISO Mebendazole results in increased expression of CCL2 protein CTD PMID:20116850 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226 		JBrowse link
G Cdh1 cadherin 1 multiple interactions ISO Mebendazole inhibits the reaction [TGFB1 protein results in increased expression of CDH1 protein] CTD PMID:30075109 NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775 		JBrowse link
G Cdh2 cadherin 2 multiple interactions ISO Mebendazole inhibits the reaction [TGFB1 protein results in increased expression of CDH2 protein] CTD PMID:30075109 NCBI chr18:7,776,704...7,990,934
Ensembl chr18:7,776,704...7,990,167 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases expression ISO
EXP		 Mebendazole results in increased expression of CYP1A1 mRNA; Mebendazole results in increased expression of CYP1A1 protein CTD PMID:9860486 PMID:12841937 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases expression ISO
EXP		 Mebendazole results in increased expression of CYP1A2 protein CTD PMID:12841937 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312 		JBrowse link
G Ereg epiregulin increases expression ISO Mebendazole results in increased expression of EREG mRNA CTD PMID:32816093 NCBI chr14:17,027,287...17,041,062
Ensembl chr14:17,027,287...17,041,062 		JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit increases expression ISO Mebendazole results in increased expression of FOS mRNA CTD PMID:12730611 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036 		JBrowse link
G Gapdh glyceraldehyde-3-phosphate dehydrogenase decreases expression
affects binding		 ISO Mebendazole results in decreased expression of GAPDH mRNA
Mebendazole binds to GAPDH protein		 CTD PMID:37473966 NCBI chr 4:157,962,312...157,967,158
Ensembl chr 4:157,962,343...157,966,235 		JBrowse link
G Gstp1 glutathione S-transferase pi 1 multiple interactions ISO Mebendazole inhibits the reaction [GSTP1 protein results in increased metabolism of 1-chloro-2,4-dinitrobenzene-glutathione conjugate] CTD PMID:23769903 NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226 		JBrowse link
G Hes1 hes family bHLH transcription factor 1 decreases expression ISO Mebendazole results in decreased expression of HES1 protein CTD PMID:32277947 NCBI chr11:70,705,763...70,708,176
Ensembl chr11:70,705,764...70,708,192 		JBrowse link
G Hk1 hexokinase 1 affects binding
decreases expression		 ISO Mebendazole binds to HK1 protein
Mebendazole results in decreased expression of HK1 mRNA		 CTD PMID:37473966 NCBI chr20:30,230,488...30,332,099
Ensembl chr20:30,230,486...30,332,131 		JBrowse link
G Il1a interleukin 1 alpha increases expression ISO Mebendazole results in increased expression of IL1A mRNA CTD PMID:32816093 NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822 		JBrowse link
G Il1b interleukin 1 beta increases expression ISO Mebendazole results in increased expression of IL1B mRNA CTD PMID:32816093 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il24 interleukin 24 increases expression ISO Mebendazole results in increased expression of IL24 mRNA CTD PMID:32816093 NCBI chr13:42,353,089...42,358,487
Ensembl chr13:42,353,090...42,358,487 		JBrowse link
G Il6r interleukin 6 receptor increases expression ISO Mebendazole results in increased expression of IL6R protein modified form CTD PMID:20116850 NCBI chr 2:175,289,157...175,347,719
Ensembl chr 2:175,298,686...175,347,536 		JBrowse link
G Ldha lactate dehydrogenase A decreases activity
decreases expression
affects binding		 ISO Mebendazole results in decreased activity of LDHA protein
Mebendazole results in decreased expression of LDHA mRNA
Mebendazole binds to LDHA protein		 CTD PMID:37473966 NCBI chr 1:97,371,823...97,381,247
Ensembl chr 1:97,366,021...97,433,472 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases phosphorylation ISO Mebendazole results in increased phosphorylation of MAPK1 protein CTD PMID:20848085 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases phosphorylation ISO Mebendazole results in increased phosphorylation of MAPK3 protein CTD PMID:20848085 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 increases phosphorylation ISO Mebendazole results in increased phosphorylation of MAPK8 protein CTD PMID:20848085 NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981 		JBrowse link
G Mapk9 mitogen-activated protein kinase 9 increases phosphorylation ISO Mebendazole results in increased phosphorylation of MAPK9 protein CTD PMID:20848085 NCBI chr10:34,169,661...34,211,138
Ensembl chr10:34,169,675...34,210,178 		JBrowse link
G Mapt microtubule-associated protein tau decreases expression ISO Mebendazole results in decreased expression of MAPT protein CTD PMID:16930453 NCBI chr10:89,138,644...89,236,137
Ensembl chr10:89,138,627...89,236,129 		JBrowse link
G Met MET proto-oncogene, receptor tyrosine kinase increases expression ISO Mebendazole results in increased expression of MET mRNA CTD PMID:32816093 NCBI chr 4:45,790,456...45,898,139
Ensembl chr 4:45,790,791...45,897,876 		JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor decreases expression ISO Mebendazole results in decreased expression of MYC mRNA; Mebendazole results in decreased expression of MYC protein CTD PMID:31207347 PMID:32277947 NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630 		JBrowse link
G Nlrp3 NLR family, pyrin domain containing 3 increases expression ISO Mebendazole results in increased expression of NLRP3 mRNA CTD PMID:24747151 NCBI chr10:44,326,770...44,353,814
Ensembl chr10:44,328,566...44,352,811 		JBrowse link
G Notch1 notch receptor 1 decreases expression ISO Mebendazole results in decreased expression of NOTCH1 protein CTD PMID:32277947 NCBI chr 3:9,277,955...9,323,531
Ensembl chr 3:9,278,086...9,323,531 		JBrowse link
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 multiple interactions ISO Mebendazole inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein] CTD PMID:25257666 NCBI chr 7:23,846,122...23,942,085
Ensembl chr 7:23,846,122...23,942,047 		JBrowse link
G Pid1 phosphotyrosine interaction domain containing 1 increases expression ISO Mebendazole results in increased expression of PID1 mRNA CTD PMID:32816093 NCBI chr 9:85,284,335...85,503,035
Ensembl chr 9:85,284,335...85,503,044 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 increases expression ISO Mebendazole results in increased expression of PTGS2 mRNA CTD PMID:32816093 NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Ptk2 protein tyrosine kinase 2 decreases expression ISO Mebendazole results in decreased expression of PTK2 protein CTD PMID:30075109 NCBI chr 7:105,126,725...105,331,848
Ensembl chr 7:105,126,728...105,331,783 		JBrowse link
G Rac1 Rac family small GTPase 1 decreases expression ISO Mebendazole results in decreased expression of RAC1 protein CTD PMID:30075109 NCBI chr12:11,037,028...11,057,251
Ensembl chr12:11,036,698...11,057,251 		JBrowse link
G Rhoa ras homolog family member A decreases expression ISO Mebendazole results in decreased expression of RHOA protein CTD PMID:30075109 NCBI chr 8:108,991,926...109,025,746
Ensembl chr 8:108,991,954...109,025,746 		JBrowse link
G S100a8 S100 calcium binding protein A8 increases expression ISO Mebendazole results in increased expression of S100A8 mRNA CTD PMID:24747151 NCBI chr 2:176,166,517...176,167,645
Ensembl chr 2:176,167,124...176,167,643 		JBrowse link
G S100a9 S100 calcium binding protein A9 increases expression ISO Mebendazole results in increased expression of S100A9 mRNA CTD PMID:24747151 NCBI chr 2:176,190,361...176,193,182
Ensembl chr 2:176,190,361...176,193,230 		JBrowse link
G Slc2a1 solute carrier family 2 member 1 affects binding
decreases expression		 ISO Mebendazole binds to SLC2A1 protein
Mebendazole results in decreased expression of SLC2A1 mRNA		 CTD PMID:37473966 NCBI chr 5:132,717,196...132,745,416
Ensembl chr 5:132,717,196...132,745,416 		JBrowse link
G Slc47a1 solute carrier family 47 member 1 decreases expression ISO Mebendazole results in decreased expression of SLC47A1 mRNA CTD PMID:28606429 NCBI chr10:46,034,115...46,088,617
Ensembl chr10:46,034,122...46,087,637 		JBrowse link
G Slc7a11 solute carrier family 7 member 11 increases expression ISO Mebendazole results in increased expression of SLC7A11 mRNA CTD PMID:32816093 NCBI chr 2:134,382,002...134,517,622
Ensembl chr 2:133,963,107...134,517,536 		JBrowse link
G Slpi secretory leukocyte peptidase inhibitor increases expression ISO Mebendazole results in increased expression of SLPI mRNA CTD PMID:32816093 NCBI chr 3:153,082,208...153,084,457
Ensembl chr 3:153,082,369...153,084,453 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions ISO Mebendazole inhibits the reaction [TGFB1 protein results in increased expression of CDH1 protein]; Mebendazole inhibits the reaction [TGFB1 protein results in increased expression of CDH2 protein] CTD PMID:30075109 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847 		JBrowse link
G Thra thyroid hormone receptor alpha multiple interactions ISO Mebendazole binds to and results in decreased activity of THRA protein CTD PMID:25752796 NCBI chr10:83,701,885...83,729,408
Ensembl chr10:83,700,755...83,729,936 		JBrowse link
G Tnf tumor necrosis factor multiple interactions
increases secretion
increases expression		 ISO U 0126 inhibits the reaction [Mebendazole results in increased secretion of TNF protein]
Mebendazole results in increased expression of TNF mRNA		 CTD PMID:20848085 PMID:24747151 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Vegfa vascular endothelial growth factor A increases expression ISO Mebendazole results in increased expression of VEGFA protein CTD PMID:20116850 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641 		JBrowse link
Term paths to the root
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Term Annotations click to browse term
  CHEBI ontology 19808
    role 19784
      biological role 19782
        pharmacological role 19026
          tubulin modulator 2678
            mebendazole 50
Path 2
Term Annotations click to browse term
  CHEBI ontology 19808
    subatomic particle 19806
      composite particle 19806
        hadron 19806
          baryon 19806
            nucleon 19806
              atomic nucleus 19806
                atom 19806
                  main group element atom 19756
                    p-block element atom 19756
                      carbon group element atom 19705
                        carbon atom 19702
                          organic molecular entity 19702
                            organic molecule 19655
                              organic cyclic compound 19468
                                organic heterocyclic compound 18848
                                  organic heteropolycyclic compound 18278
                                    organic heterobicyclic compound 17216
                                      benzimidazoles 1176
                                        benzimidazole 378
                                          1H-benzimidazole 375
                                            mebendazole 50
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