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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:nilotinib
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Accession:CHEBI:52172 term browser browse the term
Definition:A carboxamide that has formula C28H22F3N7O.
Synonyms:exact_synonym: 4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl]-3-[(4-pyridin-3-ylpyrimidin-2-yl)amino]benzamide
 related_synonym: AMN 107;   AMN107;   Formula=C28H22F3N7O;   InChI=1S/C28H22F3N7O/c1-17-5-6-19(10-25(17)37-27-33-9-7-24(36-27)20-4-3-8-32-14-20)26(39)35-22-11-21(28(29,30)31)12-23(13-22)38-15-18(2)34-16-38/h3-16H,1-2H3,(H,35,39)(H,33,36,37);   InChIKey=HHZIURLSWUIHRB-UHFFFAOYSA-N;   SMILES=Cc1cn(cn1)-c1cc(NC(=O)c2ccc(C)c(Nc3nccc(n3)-c3cccnc3)c2)cc(c1)C(F)(F)F;   nilotinibum
 alt_id: MESH:C498826
 xref: CAS:641571-10-0;   DrugBank:DB04868;   Drug_Central:1932;   KEGG:D08953;   LINCS:LSM-1099
 xref_mesh: MESH:C498826
 xref: Wikipedia:Nilotinib


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nilotinib term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A affects response to substance ISO ABCB1 protein affects the susceptibility to nilotinib CTD PMID:28623111 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709 		JBrowse link
G Abcc10 ATP binding cassette subfamily C member 10 multiple interactions ISO nilotinib inhibits the reaction [ABCC10 protein results in decreased abundance of and results in increased secretion of Paclitaxel]; nilotinib inhibits the reaction [ABCC10 protein results in decreased susceptibility to Paclitaxel]; nilotinib inhibits the reaction [ABCC10 protein results in decreased susceptibility to Vincristine] CTD PMID:19841739 NCBI chr 9:14,657,242...14,677,178
Ensembl chr 9:14,657,264...14,677,178 		JBrowse link
G Abcg2 ATP binding cassette subfamily G member 2 affects response to substance ISO ABCG2 protein affects the susceptibility to nilotinib CTD PMID:24954033 NCBI chr 4:87,676,241...87,802,757
Ensembl chr 4:87,745,319...87,802,409 		JBrowse link
G Abl1 ABL proto-oncogene 1, non-receptor tyrosine kinase multiple interactions
decreases phosphorylation		 ISO [nilotinib co-treated with Arsenic Trioxide] results in decreased phosphorylation of ABL1 protein; nilotinib inhibits the reaction [[BCR protein mutant form binds to ABL1 protein mutant form] which results in increased chemical synthesis of Histamine]; nilotinib inhibits the reaction [[BCR protein mutant form binds to ABL1 protein mutant form] which results in increased expression of HDC mRNA]; nilotinib inhibits the reaction [ABL1 protein mutant form results in increased phosphorylation of CRKL protein]; nilotinib inhibits the reaction [ABL1 protein results in increased phosphorylation of ABL1 protein]
nilotinib results in decreased phosphorylation of ABL1 protein; nilotinib results in decreased phosphorylation of ABL1 protein mutant form		 CTD PMID:16849647 PMID:19878872 PMID:23883479 NCBI chr 3:14,979,853...15,083,065
Ensembl chr 3:14,979,853...15,083,065 		JBrowse link
G Acaca acetyl-CoA carboxylase alpha increases phosphorylation ISO nilotinib results in increased phosphorylation of ACACA protein CTD PMID:23707608 NCBI chr10:69,014,261...69,276,453
Ensembl chr10:69,014,170...69,276,457 		JBrowse link
G Aldh1a2 aldehyde dehydrogenase 1 family, member A2 decreases expression ISO nilotinib results in decreased expression of ALDH1A2 mRNA CTD PMID:31711903 NCBI chr 8:71,877,850...71,957,107
Ensembl chr 8:71,877,850...71,957,107 		JBrowse link
G Ap2m1 adaptor related protein complex 2 subunit mu 1 multiple interactions ISO [Arsenic Trioxide co-treated with nilotinib] affects the expression of AP2M1 mRNA CTD PMID:28786057 NCBI chr11:80,355,307...80,364,218
Ensembl chr11:80,328,041...80,364,140 		JBrowse link
G Atf6 activating transcription factor 6 multiple interactions
decreases expression		 ISO Arsenic Trioxide promotes the reaction [nilotinib results in decreased expression of ATF6 protein] CTD PMID:23883479 NCBI chr13:82,927,579...83,106,381
Ensembl chr13:82,930,034...83,107,177 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions ISO
EXP		 nilotinib inhibits the reaction [Folic Acid results in increased expression of BAX protein]
nilotinib inhibits the reaction [Cyclosporine results in increased expression of BAX mRNA]; nilotinib inhibits the reaction [Cyclosporine results in increased expression of BAX protein]		 CTD PMID:31593741 PMID:33710703 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression ISO nilotinib results in decreased expression of BCL2 protein CTD PMID:26549707 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Bcr BCR activator of RhoGEF and GTPase multiple interactions
decreases phosphorylation		 ISO nilotinib inhibits the reaction [[BCR protein mutant form binds to ABL1 protein mutant form] which results in increased chemical synthesis of Histamine]; nilotinib inhibits the reaction [[BCR protein mutant form binds to ABL1 protein mutant form] which results in increased expression of HDC mRNA]
nilotinib results in decreased phosphorylation of BCR protein mutant form		 CTD PMID:16849647 PMID:19878872 NCBI chr20:13,469,325...13,596,942
Ensembl chr20:13,471,668...13,597,016 		JBrowse link
G C3 complement C3 decreases expression ISO nilotinib results in decreased expression of C3 mRNA CTD PMID:32771489 NCBI chr 9:2,087,437...2,114,366
Ensembl chr 9:2,087,437...2,114,429 		JBrowse link
G Casp3 caspase 3 increases cleavage
increases activity
multiple interactions
increases expression		 ISO
EXP		 nilotinib results in increased cleavage of CASP3 protein
nilotinib results in increased activity of CASP3 protein
benzoylcarbonyl-aspartyl-glutamyl-valyl-aspartyl-fluoromethyl ketone inhibits the reaction [nilotinib results in increased cleavage of CASP3 protein]; benzyloxycarbonyl-valyl-alanyl-aspartic acid analog inhibits the reaction [nilotinib results in increased cleavage of CASP3 protein]
nilotinib inhibits the reaction [Folic Acid results in increased expression of CASP3 protein]
nilotinib results in increased expression of CASP3 protein
nilotinib inhibits the reaction [Cyclosporine results in increased expression of CASP3 mRNA]; nilotinib inhibits the reaction [Cyclosporine results in increased expression of CASP3 protein]		 CTD PMID:23707608 PMID:23883479 PMID:26549707 PMID:31593741 PMID:32771489 More... NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp7 caspase 7 increases activity
increases cleavage		 ISO nilotinib results in increased activity of CASP7 protein
nilotinib results in increased cleavage of CASP7 protein		 CTD PMID:23707608 PMID:23883479 NCBI chr 1:255,437,438...255,476,737
Ensembl chr 1:255,437,172...255,476,729 		JBrowse link
G Casp9 caspase 9 increases cleavage ISO nilotinib results in increased cleavage of CASP9 protein CTD PMID:26549707 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626 		JBrowse link
G Cltc clathrin heavy chain multiple interactions ISO [Arsenic Trioxide co-treated with nilotinib] affects the expression of CLTC mRNA CTD PMID:28786057 NCBI chr10:71,517,661...71,574,591
Ensembl chr10:71,517,663...71,573,737 		JBrowse link
G Crkl CRK like proto-oncogene, adaptor protein decreases phosphorylation
multiple interactions		 ISO nilotinib results in decreased phosphorylation of CRKL protein
[nilotinib co-treated with Arsenic Trioxide] results in decreased phosphorylation of CRKL protein; nilotinib inhibits the reaction [ABL1 protein mutant form results in increased phosphorylation of CRKL protein]		 CTD PMID:19878872 PMID:23883479 NCBI chr11:83,528,788...83,563,214
Ensembl chr11:83,526,530...83,563,238 		JBrowse link
G Ddit3 DNA-damage inducible transcript 3 increases expression
multiple interactions		 ISO nilotinib results in increased expression of DDIT3 mRNA
Arsenic Trioxide promotes the reaction [nilotinib results in increased expression of DDIT3 mRNA]		 CTD PMID:23883479 NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201 		JBrowse link
G Ddr1 discoidin domain receptor tyrosine kinase 1 decreases expression
affects phosphorylation		 ISO nilotinib decreased expression of Ddr1 in 3T3 and GD25 cells
nilotinib decreases expression of DDR1 mRNA and protein in human pituitary adenoma cells
nilotinib inhibits collagen mediated DDR1 tyrosine phosphorylation in human cancer cell lines		 RGD PMID:28199848 PMID:26286316 PMID:29438985 RGD:151347403, RGD:11065574, RGD:151347685 NCBI chr20:3,042,494...3,064,442
Ensembl chr20:3,044,320...3,064,468 		JBrowse link
G Dnm2 dynamin 2 multiple interactions ISO [Arsenic Trioxide co-treated with nilotinib] affects the expression of DNM2 mRNA CTD PMID:28786057 NCBI chr 8:19,978,313...20,060,162
Ensembl chr 8:19,978,400...20,060,157 		JBrowse link
G Edem1 ER degradation enhancing alpha-mannosidase like protein 1 increases expression
multiple interactions		 ISO nilotinib results in increased expression of EDEM1 mRNA
Arsenic Trioxide promotes the reaction [nilotinib results in increased expression of EDEM1 mRNA]		 CTD PMID:23883479 NCBI chr 4:141,797,631...141,829,717
Ensembl chr 4:141,797,701...141,829,717 		JBrowse link
G Esr1 estrogen receptor 1 decreases expression ISO nilotinib results in decreased expression of ESR1 protein CTD PMID:32771489 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002 		JBrowse link
G Eya1 EYA transcriptional coactivator and phosphatase 1 decreases expression ISO nilotinib results in decreased expression of EYA1 mRNA CTD PMID:31711903 NCBI chr 5:4,863,501...5,101,483
Ensembl chr 5:4,955,543...5,101,483 		JBrowse link
G Fcer1g Fc epsilon receptor Ig multiple interactions ISO [Arsenic Trioxide co-treated with nilotinib] affects the expression of FCER1G mRNA CTD PMID:28786057 NCBI chr13:83,649,447...83,654,248
Ensembl chr13:83,649,449...83,671,443 		JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit increases expression
multiple interactions		 ISO nilotinib results in increased expression of FOS mRNA; nilotinib results in increased expression of FOS protein
Arsenic Trioxide promotes the reaction [nilotinib results in increased expression of FOS mRNA]; Arsenic Trioxide promotes the reaction [nilotinib results in increased expression of FOS protein]		 CTD PMID:23883479 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036 		JBrowse link
G Foxc2 forkhead box C2 decreases expression ISO nilotinib results in decreased expression of FOXC2 mRNA CTD PMID:31711903 NCBI chr19:49,186,034...49,188,736
Ensembl chr19:49,185,662...49,188,737 		JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit multiple interactions
increases expression		 ISO Arsenic Trioxide promotes the reaction [nilotinib results in increased expression of GCLM mRNA] CTD PMID:23883479 NCBI chr 2:210,347,482...210,367,537
Ensembl chr 2:210,347,482...210,367,535 		JBrowse link
G Gpt glutamic--pyruvic transaminase increases secretion
multiple interactions		 ISO
EXP		 nilotinib results in increased secretion of GPT protein
nilotinib inhibits the reaction [Cyclosporine results in increased activity of GPT protein]		 CTD PMID:29655783 PMID:33710703 NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494 		JBrowse link
G Gsr glutathione-disulfide reductase multiple interactions EXP nilotinib inhibits the reaction [Cyclosporine results in decreased activity of GSR protein] CTD PMID:33710703 NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661 		JBrowse link
G Hdc histidine decarboxylase decreases expression
multiple interactions		 ISO nilotinib results in decreased expression of HDC mRNA
nilotinib inhibits the reaction [[BCR protein mutant form binds to ABL1 protein mutant form] which results in increased expression of HDC mRNA]		 CTD PMID:16849647 NCBI chr 3:113,847,256...113,865,334
Ensembl chr 3:113,847,260...113,865,341 		JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions EXP nilotinib inhibits the reaction [Cyclosporine results in decreased expression of HMOX1 mRNA] CTD PMID:33710703 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Hoxb7 homeo box B7 increases expression ISO nilotinib results in increased expression of HOXB7 mRNA CTD PMID:31711903 NCBI chr10:81,252,616...81,256,034
Ensembl chr10:81,252,553...81,256,034 		JBrowse link
G Hoxb9 homeo box B9 increases expression ISO nilotinib results in increased expression of HOXB9 mRNA CTD PMID:31711903 NCBI chr10:81,237,312...81,240,818
Ensembl chr10:81,237,312...81,240,818 		JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 increases expression
multiple interactions		 ISO nilotinib results in increased expression of HSPA5 mRNA
Arsenic Trioxide promotes the reaction [nilotinib results in increased expression of HSPA5 mRNA]		 CTD PMID:23883479 NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891 		JBrowse link
G Il18 interleukin 18 multiple interactions ISO nilotinib inhibits the reaction [Folic Acid results in increased expression of IL18 protein] CTD PMID:31593741 NCBI chr 8:50,904,630...50,932,887
Ensembl chr 8:50,906,960...50,932,887 		JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO
EXP		 nilotinib inhibits the reaction [[Galactosamine co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased expression of IL1B protein]; nilotinib inhibits the reaction [Folic Acid results in increased expression of IL1B protein]
nilotinib inhibits the reaction [Cyclosporine results in increased expression of IL1B protein]		 CTD PMID:28125915 PMID:31593741 PMID:33710703 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il2 interleukin 2 multiple interactions EXP nilotinib inhibits the reaction [Cyclosporine results in decreased expression of IL2 protein] CTD PMID:33710703 NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566 		JBrowse link
G Il6 interleukin 6 multiple interactions EXP nilotinib inhibits the reaction [Cyclosporine results in increased expression of IL6 protein] CTD PMID:33710703 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions
increases expression		 ISO Arsenic Trioxide promotes the reaction [nilotinib results in increased expression of JUN mRNA]; Arsenic Trioxide promotes the reaction [nilotinib results in increased expression of JUN protein]; nilotinib results in increased expression of and results in increased phosphorylation of JUN protein
nilotinib results in increased expression of JUN mRNA; nilotinib results in increased expression of JUN protein		 CTD PMID:23883479 NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656 		JBrowse link
G Junb JunB proto-oncogene, AP-1 transcription factor subunit increases expression
multiple interactions		 ISO nilotinib results in increased expression of JUNB mRNA; nilotinib results in increased expression of JUNB protein
Arsenic Trioxide promotes the reaction [nilotinib results in increased expression of JUNB mRNA]; Arsenic Trioxide promotes the reaction [nilotinib results in increased expression of JUNB protein]		 CTD PMID:23883479 NCBI chr19:23,176,265...23,178,049
Ensembl chr19:23,176,294...23,178,035 		JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases activity
multiple interactions
decreases expression		 ISO nilotinib results in decreased activity of KCNH2 protein
N-butanoylsphingosine inhibits the reaction [nilotinib results in decreased expression of KCNH2 protein modified form]; nilotinib results in decreased expression of and results in decreased activity of KCNH2 protein		 CTD PMID:23707608 PMID:35680041 NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008 		JBrowse link
G Meox1 mesenchyme homeobox 1 decreases expression ISO nilotinib results in decreased expression of MEOX1 mRNA CTD PMID:31711903 NCBI chr10:86,818,450...86,837,563
Ensembl chr10:86,818,478...86,837,660 		JBrowse link
G Mesp2 mesoderm posterior bHLH transcription factor 2 decreases expression ISO nilotinib results in decreased expression of MESP2 mRNA CTD PMID:31711903 NCBI chr 1:133,756,601...133,759,207
Ensembl chr 1:133,756,601...133,759,198 		JBrowse link
G Neurog2 neurogenin 2 increases expression ISO nilotinib results in increased expression of NEUROG2 mRNA CTD PMID:31711903 NCBI chr 2:216,092,709...216,095,276
Ensembl chr 2:216,093,363...216,094,154 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 multiple interactions EXP nilotinib inhibits the reaction [Cyclosporine results in decreased expression of NFE2L2 protein] CTD PMID:33710703 NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737 		JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions EXP nilotinib inhibits the reaction [Cyclosporine results in decreased expression of NFKBIA mRNA] CTD PMID:33710703 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941 		JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions EXP nilotinib inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of NOS2 mRNA] CTD PMID:21473879 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210 		JBrowse link
G Olig3 oligodendrocyte transcription factor 3 increases expression ISO nilotinib results in increased expression of OLIG3 mRNA CTD PMID:31711903 NCBI chr 1:14,081,259...14,083,336
Ensembl chr 1:14,081,328...14,082,149 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases cleavage
multiple interactions		 ISO nilotinib results in increased cleavage of PARP1 protein
benzoylcarbonyl-aspartyl-glutamyl-valyl-aspartyl-fluoromethyl ketone inhibits the reaction [nilotinib results in increased cleavage of PARP1 protein]; benzyloxycarbonyl-valyl-alanyl-aspartic acid analog inhibits the reaction [nilotinib results in increased cleavage of PARP1 protein]		 CTD PMID:26549707 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404 		JBrowse link
G Pax3 paired box 3 decreases expression ISO nilotinib results in decreased expression of PAX3 mRNA CTD PMID:31711903 NCBI chr 9:79,567,455...79,664,042
Ensembl chr 9:79,568,634...79,664,042 		JBrowse link
G Pax6 paired box 6 increases expression ISO nilotinib results in increased expression of PAX6 mRNA CTD PMID:31711903 NCBI chr 3:92,128,772...92,157,022
Ensembl chr 3:92,135,637...92,157,014 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO nilotinib inhibits the reaction [Folic Acid results in increased expression of RELA protein] CTD PMID:31593741 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Sacs sacsin molecular chaperone increases expression ISO nilotinib results in increased expression of SACS mRNA CTD PMID:29901742 NCBI chr15:35,285,783...35,370,335
Ensembl chr15:35,285,782...35,370,335 		JBrowse link
G Sec24b SEC24 homolog B, COPII coat complex component multiple interactions ISO [Arsenic Trioxide co-treated with nilotinib] affects the expression of SEC24B mRNA CTD PMID:28786057 NCBI chr 2:218,562,670...218,632,753
Ensembl chr 2:218,562,676...218,632,699 		JBrowse link
G Tcf15 transcription factor 15 decreases expression ISO nilotinib results in decreased expression of TCF15 mRNA CTD PMID:31711903 NCBI chr 3:140,638,984...140,644,766
Ensembl chr 3:140,638,984...140,644,766 		JBrowse link
G Tff1 trefoil factor 1 decreases expression ISO nilotinib results in decreased expression of TFF1 mRNA CTD PMID:32771489 NCBI chr20:9,235,736...9,239,597
Ensembl chr20:9,235,736...9,239,597 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions EXP nilotinib inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of TGFB1 mRNA] CTD PMID:21473879 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847 		JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP
ISO		 nilotinib inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of TNF mRNA]
nilotinib inhibits the reaction [[Galactosamine co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased expression of TNF protein]; nilotinib inhibits the reaction [Folic Acid results in increased expression of TNF protein]		 CTD PMID:21473879 PMID:28125915 PMID:31593741 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tnfsf12 TNF superfamily member 12 multiple interactions ISO nilotinib inhibits the reaction [Folic Acid results in increased expression of TNFSF12 protein] CTD PMID:31593741 NCBI chr10:54,403,870...54,413,213
Ensembl chr10:54,403,870...54,413,213 		JBrowse link
G Tp53 tumor protein p53 increases secretion ISO nilotinib results in increased secretion of TP53 protein CTD PMID:29370077 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 decreases activity ISO nilotinib results in decreased activity of UGT1A1 protein CTD PMID:26875642 NCBI chr 9:88,801,344...88,808,465
Ensembl chr 9:88,713,184...88,808,465 		JBrowse link
G Uncx UNC homeobox decreases expression ISO nilotinib results in decreased expression of UNCX mRNA CTD PMID:31711903 NCBI chr12:15,092,779...15,097,300
Ensembl chr12:15,092,784...15,097,300 		JBrowse link
G Xbp1 X-box binding protein 1 increases expression ISO nilotinib results in increased expression of XBP1 mRNA alternative form CTD PMID:23883479 NCBI chr14:80,390,629...80,395,713
Ensembl chr14:80,390,643...80,395,693 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19808
    role 19784
      biological role 19782
        antimicrobial agent 18141
          antiviral agent 11069
            anticoronaviral agent 9658
              nilotinib 63
Path 2
Term Annotations click to browse term
  CHEBI ontology 19808
    subatomic particle 19806
      composite particle 19806
        hadron 19806
          baryon 19806
            nucleon 19806
              atomic nucleus 19806
                atom 19806
                  main group element atom 19756
                    p-block element atom 19756
                      carbon group element atom 19705
                        carbon atom 19702
                          organic molecular entity 19702
                            heteroorganic entity 19460
                              organochalcogen compound 19224
                                organooxygen compound 19141
                                  carbon oxoacid 18612
                                    carboxylic acid 18609
                                      carboacyl group 17677
                                        univalent carboacyl group 17677
                                          carbamoyl group 17526
                                            carboxamide 17526
                                              secondary carboxamide 1219
                                                nilotinib 63
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