The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
A 3-oxo Delta(4)-steroid that is androst-4-ene substituted by oxo groups at positions 3 and 17. It is a steroid hormone synthesized in the adrenal glands and gonads.
Androstenedione inhibits the reaction [ABCG2 protein results in increased uptake of estrone sulfate] Androstenedione results in decreased activity of ABCG2 protein
AKR1C3 protein results in increased metabolism of Androstenedione [AKR1C3 protein results in increased metabolism of Androstenedione] which results in increased chemical synthesis of Dihydrotestosterone; [AKR1C3 protein results in increased metabolism of Androstenedione] which results in increased chemical synthesis of Testosterone; [AKR1C3 protein results in increased reduction of Androstenedione] which results in increased chemical synthesis of Testosterone; Indomethacin analog inhibits the reaction [AKR1C3 protein results in increased reduction of Androstenedione]; Indomethacin inhibits the reaction [AKR1C3 protein results in increased reduction of Androstenedione]; N-(4-chlorobenzoyl)melatonin inhibits the reaction [AKR1C3 protein results in increased reduction of Androstenedione]
AKR1D1 protein results in increased reduction of Androstenedione AKR1D1 protein alternative form results in increased reduction of Androstenedione; AKR1D1 protein results in increased reduction of Androstenedione [AKR1D1 protein alternative form results in increased reduction of Androstenedione] which results in increased chemical synthesis of androstane-3,17-dione; [AKR1D1 protein alternative form results in increased reduction of Androstenedione] which results in increased chemical synthesis of Etiocholanolone; [AKR1D1 protein results in increased reduction of Androstenedione] which results in increased chemical synthesis of androstane-3,17-dione; [AKR1D1 protein results in increased reduction of Androstenedione] which results in increased chemical synthesis of Etiocholanolone
Androstenedione binds to AR protein AR mutant form inhibits the reaction [Androstenedione results in increased expression of NR5A2 mRNA] Androstenedione binds to and affects the activity of AR protein; Androstenedione binds to and results in increased activity of AR protein; Androstenedione inhibits the reaction [[Dihydrotestosterone binds to and results in increased activity of AR protein] which results in increased expression of KLK3 protein]; NCOA2 protein promotes the reaction [Androstenedione binds to and results in increased activity of AR protein]
CGA protein results in increased secretion of Androstenedione LEP protein inhibits the reaction [CGA protein results in increased secretion of Androstenedione]; Sodium Glutamate inhibits the reaction [CGA protein results in increased secretion of Androstenedione]
[Diethylstilbestrol results in decreased expression of CYP11A1 protein] which results in decreased abundance of Androstenedione; bicalutamide inhibits the reaction [Androstenedione results in increased expression of CYP11A1 protein]; Finasteride promotes the reaction [Androstenedione results in increased expression of CYP11A1 mRNA]; formestane promotes the reaction [Androstenedione results in increased expression of CYP11A1 mRNA]
Androstenedione results in decreased expression of CYP17A1 mRNA CYP17A1 protein affects the abundance of Androstenedione CYP17A1 protein affects the chemical synthesis of Androstenedione [CYP17A1 gene SNP affects the susceptibility to perfluorooctane sulfonic acid] which affects the abundance of Androstenedione; [CYP17A1 protein results in increased metabolism of 17-alpha-Hydroxyprogesterone] which results in increased chemical synthesis of Androstenedione; Duloxetine Hydrochloride inhibits the reaction [[CYP17A1 protein results in increased metabolism of 17-alpha-Hydroxyprogesterone] which results in increased chemical synthesis of Androstenedione]; TNF protein inhibits the reaction [CYP17A1 protein affects the chemical synthesis of Androstenedione]; Venlafaxine Hydrochloride inhibits the reaction [[CYP17A1 protein results in increased metabolism of 17-alpha-Hydroxyprogesterone] which results in increased chemical synthesis of Androstenedione]
CYP19A1 protein affects the metabolism of Androstenedione 2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane inhibits the reaction [CYP19A1 protein results in increased metabolism of Androstenedione]; [Fluconazole results in decreased activity of CYP19A1 protein] which results in decreased metabolism of Androstenedione; [Ketoconazole results in increased activity of CYP19A1 protein] which results in increased metabolism of Androstenedione; Atrazine promotes the reaction [CYP19A1 protein results in increased metabolism of Androstenedione]; bisphenol A affects the reaction [CYP19A1 protein results in increased metabolism of Androstenedione]; CYP19A1 protein binds to and results in increased metabolism of Androstenedione; Methoxychlor affects the reaction [CYP19A1 protein results in increased metabolism of Androstenedione]; Methyltestosterone inhibits the reaction [CYP19A1 protein affects the metabolism of Androstenedione]; Nandrolone inhibits the reaction [CYP19A1 protein affects the metabolism of Androstenedione]; Testosterone inhibits the reaction [CYP19A1 protein affects the metabolism of Androstenedione]; TNF protein promotes the reaction [CYP19A1 protein affects the metabolism of Androstenedione]; trestolone inhibits the reaction [CYP19A1 protein affects the metabolism of Androstenedione]; tributyltin inhibits the reaction [CYP19A1 protein binds to and results in increased metabolism of Androstenedione] Androstenedione results in increased expression of CYP19A1 mRNA [Androstenedione results in decreased expression of CYP19A1 mRNA] which results in decreased abundance of Estradiol; bicalutamide inhibits the reaction [Androstenedione results in increased expression of CYP19A1 protein]; Finasteride promotes the reaction [Androstenedione results in increased expression of CYP19A1 mRNA]; formestane promotes the reaction [Androstenedione results in increased expression of CYP19A1 mRNA]
Androstenedione inhibits the reaction [[Dihydrotestosterone binds to and results in increased activity of AR protein] which results in increased expression of KLK3 protein]
[letrozole co-treated with Everolimus] inhibits the reaction [Androstenedione affects the activity of MTOR protein]; Everolimus inhibits the reaction [Androstenedione affects the activity of MTOR protein]; letrozole inhibits the reaction [Androstenedione affects the activity of MTOR protein]
1,4-bis(2-(3,5-dichloropyridyloxy))benzene inhibits the reaction [Androstenedione inhibits the reaction [NR1I3 protein binds to NCOA1 protein]]; Androstenedione inhibits the reaction [NR1I3 protein binds to NCOA1 protein]; isopimpinellin inhibits the reaction [Androstenedione inhibits the reaction [NR1I3 protein binds to NCOA1 protein]]
1,4-bis(2-(3,5-dichloropyridyloxy))benzene inhibits the reaction [Androstenedione inhibits the reaction [NR1I3 protein binds to NCOA1 protein]]; 1,4-bis(2-(3,5-dichloropyridyloxy))benzene inhibits the reaction [Androstenedione results in decreased activity of NR1I3 protein]; Androstenedione inhibits the reaction [NR1I3 protein binds to NCOA1 protein]; isopimpinellin inhibits the reaction [Androstenedione inhibits the reaction [NR1I3 protein binds to NCOA1 protein]]; isopimpinellin inhibits the reaction [Androstenedione results in decreased activity of NR1I3 protein]
Androstenedione results in increased expression of NR5A2 mRNA AR mutant form inhibits the reaction [Androstenedione results in increased expression of NR5A2 mRNA]
TNF protein inhibits the reaction [CYP17A1 protein affects the chemical synthesis of Androstenedione]; TNF protein promotes the reaction [CYP19A1 protein affects the metabolism of Androstenedione]
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