Pdk4 (pyruvate dehydrogenase kinase 4) - Rat Genome Database

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Gene: Pdk4 (pyruvate dehydrogenase kinase 4) Rattus norvegicus
Analyze
Symbol: Pdk4
Name: pyruvate dehydrogenase kinase 4
RGD ID: 69061
Description: Enables ATP binding activity and pyruvate dehydrogenase (acetyl-transferring) kinase activity. Predicted to be involved in several processes, including insulin receptor signaling pathway; negative regulation of anoikis; and regulation of fatty acid metabolic process. Predicted to be located in mitochondrial matrix. Predicted to be active in mitochondrion. Orthologous to human PDK4 (pyruvate dehydrogenase kinase 4); PARTICIPATES IN pyruvate metabolic pathway; INTERACTS WITH 17beta-estradiol; 2,2',4,4'-Tetrabromodiphenyl ether; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial; [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 4, mitochondrial; pyruvate dehydrogenase kinase isoenzyme 4; pyruvate dehydrogenase kinase, isoenzyme 4; pyruvate dehydrogenase kinase, isozyme 4; pyruvate dehydrogenate kinase 4
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8434,558,327 - 34,568,329 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl434,556,330 - 34,568,381 (-)EnsemblGRCr8
mRatBN7.2433,591,796 - 33,601,798 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl433,589,799 - 33,601,850 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx438,550,814 - 38,560,816 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0434,476,968 - 34,486,970 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0432,886,756 - 32,896,758 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0430,546,772 - 30,556,774 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl430,546,664 - 30,556,814 (-)Ensemblrn6Rnor6.0
Rnor_5.0430,453,698 - 30,463,700 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4430,235,296 - 30,245,298 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera429,118,393 - 29,128,395 (-)NCBICelera
RGSC_v3.1430,279,190 - 30,289,193 (-)NCBI
RH 3.4 Map4811.93RGD
Cytogenetic Map4q21NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(Z)-ligustilide  (ISO)
1,2-dimethylhydrazine  (ISO)
1-[(2,3,4-trimethoxyphenyl)methyl]piperazine  (ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
2-amino-2-deoxy-D-glucopyranose  (ISO)
2-palmitoylglycerol  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,3',5-triiodo-L-thyronine  (EXP,ISO)
3,4-dichloroaniline  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3-[3-(tert-butylsulfanyl)-1-(4-chlorobenzyl)-5-(propan-2-yl)-1H-indol-2-yl]-2,2-dimethylpropanoic acid  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-azacytidine  (ISO)
6-(4-chlorophenyl)imidazo[2,1-b][1,3]thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime  (ISO)
6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide  (ISO)
aconitine  (EXP)
acrolein  (EXP)
acrylamide  (EXP,ISO)
afimoxifene  (ISO)
aflatoxin B1  (EXP,ISO)
aldehydo-D-glucosamine  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
alpha-Zearalanol  (EXP)
amiodarone  (ISO)
ammonium chloride  (EXP)
amphetamine  (EXP)
amphibole asbestos  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
antimycin A  (ISO)
aristolochic acid A  (EXP,ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
atorvastatin calcium  (EXP)
azoxystrobin  (ISO)
benazepril  (EXP)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[b]fluoranthene  (ISO)
berberine  (ISO)
beta-D-glucosamine  (ISO)
beta-naphthoflavone  (EXP,ISO)
bexarotene  (EXP)
bezafibrate  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
boron nitride  (ISO)
bromobenzene  (EXP)
Butylbenzyl phthalate  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
calcium atom  (ISO)
calcium(0)  (ISO)
captan  (ISO)
carbon nanotube  (ISO)
celastrol  (ISO)
CGP 52608  (ISO)
chaetocin  (ISO)
chlorambucil  (ISO)
chloroacetaldehyde  (ISO)
chloroprene  (EXP,ISO)
chlorpromazine  (EXP)
choline  (ISO)
chromium(6+)  (ISO)
cidofovir anhydrous  (ISO)
ciguatoxin CTX1B  (ISO)
ciprofibrate  (EXP,ISO)
cisplatin  (ISO)
clenbuterol  (ISO)
clodronic acid  (ISO)
clofibrate  (EXP,ISO)
cobalt dichloride  (EXP,ISO)
copper(II) chloride  (ISO)
corosolic acid  (ISO)
crocidolite asbestos  (ISO)
cyclosporin A  (EXP,ISO)
D-glucose  (ISO)
DDE  (ISO)
dexamethasone  (EXP,ISO)
Di-n-octyl phthalate  (ISO)
dibenz[a,h]anthracene  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (ISO)
dichloroacetic acid  (ISO)
diclofenac  (ISO)
dieldrin  (EXP)
diethyl phthalate  (ISO)
diisobutyl phthalate  (ISO)
Diisodecyl phthalate  (ISO)
diisononyl phthalate  (ISO)
dimethylarsinic acid  (EXP)
dioxygen  (ISO)
diquat  (ISO)
diuron  (ISO)
doxorubicin  (EXP,ISO)
enilconazole  (ISO)
entinostat  (ISO)
epoxiconazole  (ISO)
erythromycin estolate  (EXP)
ethanol  (EXP,ISO)
ethylbenzene  (ISO)
etoposide  (ISO)
fenofibrate  (EXP,ISO)
flutamide  (ISO)
folic acid  (ISO)
fructose  (ISO)
furan  (EXP)
gemfibrozil  (EXP)
gentamycin  (EXP)
glucose  (ISO)
glyphosate  (ISO)
graphene oxide  (ISO)
graphite  (ISO)
GW 4064  (ISO)
GW 501516  (ISO)
GW 7647  (ISO)
heptachlor  (EXP)
hexachlorophene  (ISO)
hexadecanoic acid  (ISO)
ibuprofen  (EXP,ISO)
imidacloprid  (ISO)
Indeno[1,2,3-cd]pyrene  (ISO)
indole-3-methanol  (EXP)
indometacin  (ISO)
iron atom  (EXP)
iron(0)  (EXP)
L-methionine  (ISO)
lead diacetate  (EXP,ISO)
linoleic acid  (EXP)
lipopolysaccharide  (ISO)
manganese(II) chloride  (ISO)
metformin  (EXP)
methamphetamine  (EXP,ISO)
methotrexate  (ISO)
methylisothiazolinone  (ISO)
methylmercury chloride  (ISO)
mevalonic acid  (EXP)
mono(2-ethylhexyl) phthalate  (ISO)
monosodium L-glutamate  (ISO)
Muraglitazar  (EXP)
myo-inositol hexakisphosphate  (ISO)
N(gamma)-nitro-L-arginine methyl ester  (ISO)
N-acetyl-L-cysteine  (EXP)
N-methyl-4-phenylpyridinium  (ISO)
N-nitrosodiethylamine  (EXP)
nefazodone  (EXP)
neohesperidin  (ISO)
nevirapine  (EXP)
nickel atom  (ISO)
nicotinamide  (EXP)
nicotinic acid  (EXP)
octadecanoic acid  (ISO)
okadaic acid  (ISO)
oleic acid  (ISO)
orphenadrine  (EXP)
oxaliplatin  (EXP)
ozone  (EXP,ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP,ISO)
parthenolide  (EXP)
perflubutane  (ISO)
perfluorobutanesulfonic acid  (ISO)
perfluorobutyric acid  (ISO)
perfluorodecanoic acid  (ISO)
perfluorododecanoic acid  (ISO)
perfluoroheptanoic acid  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorohexanoic acid  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (EXP,ISO)
perfluoroundecanoic acid  (ISO)
phenformin  (EXP)
phenobarbital  (EXP,ISO)
phenylarsine oxide  (ISO)
phenylephrine  (EXP)
phosgene  (ISO)
picoxystrobin  (ISO)
pioglitazone  (ISO)
pirinixic acid  (EXP,ISO)
pravastatin  (EXP,ISO)
pregnenolone 16alpha-carbonitrile  (EXP,ISO)
Primycin  (ISO)
probenecid  (EXP)
pterostilbene  (ISO)
pyruvic acid  (ISO)
quercetin  (ISO)
resveratrol  (EXP,ISO)
rotenone  (EXP,ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SCH 23390  (EXP)
sevoflurane  (EXP)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
simvastatin  (EXP,ISO)
sirtinol  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (ISO)
sunitinib  (ISO)
tamoxifen  (ISO)
Terfenadine  (ISO)
Tesaglitazar  (EXP)
testosterone enanthate  (ISO)
Tetrachlorobisphenol A  (ISO)
tetrachloroethene  (ISO)
tetrachloromethane  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
topiramate  (EXP)
topotecan  (EXP)
torcetrapib  (ISO)
tributylstannane  (ISO)
trichloroethene  (ISO)
trichostatin A  (ISO)
triphenyl phosphate  (EXP)
Triptolide  (ISO)
troglitazone  (EXP,ISO)
tunicamycin  (ISO)
valproic acid  (ISO)
vancomycin  (ISO)
vinclozolin  (EXP)
zaragozic acid A  (EXP,ISO)
zinc atom  (EXP)
zinc sulfate  (EXP)
zinc(0)  (EXP)
ziram  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Downregulation of the skeletal muscle pyruvate dehydrogenase complex in the Otsuka Long-Evans Tokushima Fatty rat both before and after the onset of diabetes mellitus. Bajotto G, etal., Life Sci. 2004 Sep 10;75(17):2117-30.
2. Evidence for existence of tissue-specific regulation of the mammalian pyruvate dehydrogenase complex. Bowker-Kinley MM, etal., Biochem J 1998 Jan 1;329 ( Pt 1):191-6.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. Evaluation of the role of peroxisome-proliferator-activated receptor alpha in the regulation of cardiac pyruvate dehydrogenase kinase 4 protein expression in response to starvation, high-fat feeding and hyperthyroidism. Holness MJ, etal., Biochem J 2002 Jun 15;364(Pt 3):687-94.
6. Up-regulation of pyruvate dehydrogenase kinase isoform 4 (PDK4) protein expression in oxidative skeletal muscle does not require the obligatory participation of peroxisome-proliferator-activated receptor alpha (PPARalpha). Holness MJ, etal., Biochem J 2002 Sep 15;366(Pt 3):839-46.
7. Investigation of potential mechanisms regulating protein expression of hepatic pyruvate dehydrogenase kinase isoforms 2 and 4 by fatty acids and thyroid hormone. Holness MJ, etal., Biochem J 2003 Feb 1;369(Pt 3):687-95.
8. Site specificity of four pyruvate dehydrogenase kinase isoenzymes toward the three phosphorylation sites of human pyruvate dehydrogenase. Korotchkina LG and Patel MS, J Biol Chem. 2001 Oct 5;276(40):37223-9. Epub 2001 Aug 2.
9. High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
10. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
11. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
12. Regulation of mammalian pyruvate dehydrogenase complex by phosphorylation: complexity of multiple phosphorylation sites and kinases. Patel MS and Korotchkina LG, Exp Mol Med. 2001 Dec 31;33(4):191-7.
13. GOA pipeline RGD automated data pipeline
14. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
15. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
16. Pyruvate dehydrogenase kinase regulatory mechanisms and inhibition in treating diabetes, heart ischemia, and cancer. Roche TE and Hiromasa Y, Cell Mol Life Sci. 2007 Apr;64(7-8):830-49.
17. Fibre-type specific modification of the activity and regulation of skeletal muscle pyruvate dehydrogenase kinase (PDK) by prolonged starvation and refeeding is associated with targeted regulation of PDK isoenzyme 4 expression. Sugden MC, etal., Biochem J. 2000 Mar 15;346 Pt 3:651-7.
18. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
Additional References at PubMed
PMID:11485553   PMID:12865426   PMID:14651853   PMID:14966024   PMID:15026305   PMID:15721319   PMID:15967803   PMID:16483874   PMID:16606348   PMID:16873695   PMID:17516843   PMID:17957038  
PMID:18083902   PMID:18519799   PMID:18614015   PMID:18658136   PMID:19224132   PMID:19627255   PMID:19703515   PMID:19948729   PMID:20715114   PMID:20739620   PMID:21076970   PMID:21084676  
PMID:21586575   PMID:21803180   PMID:21852536   PMID:22360721   PMID:23247844   PMID:26769971   PMID:27981737   PMID:30213959   PMID:31376939   PMID:33203874   PMID:34517782   PMID:34800366  
PMID:36281857   PMID:38401019  


Genomics

Comparative Map Data
Pdk4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8434,558,327 - 34,568,329 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl434,556,330 - 34,568,381 (-)EnsemblGRCr8
mRatBN7.2433,591,796 - 33,601,798 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl433,589,799 - 33,601,850 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx438,550,814 - 38,560,816 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0434,476,968 - 34,486,970 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0432,886,756 - 32,896,758 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0430,546,772 - 30,556,774 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl430,546,664 - 30,556,814 (-)Ensemblrn6Rnor6.0
Rnor_5.0430,453,698 - 30,463,700 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4430,235,296 - 30,245,298 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera429,118,393 - 29,128,395 (-)NCBICelera
RGSC_v3.1430,279,190 - 30,289,193 (-)NCBI
RH 3.4 Map4811.93RGD
Cytogenetic Map4q21NCBI
PDK4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38795,583,499 - 95,596,516 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl795,583,497 - 95,597,638 (-)Ensemblhg38GRCh38
GRCh37795,212,811 - 95,225,828 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36795,050,745 - 95,063,861 (-)NCBIBuild 36Build 36hg18NCBI36
Build 34794,857,461 - 94,870,454NCBI
Celera789,911,513 - 89,924,633 (-)NCBICelera
Cytogenetic Map7q21.3NCBI
HuRef789,819,915 - 89,833,034 (-)NCBIHuRef
CHM1_1795,142,829 - 95,155,944 (-)NCBICHM1_1
T2T-CHM13v2.0796,819,655 - 96,832,673 (-)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v2794,541,818 - 94,554,938 (-)NCBI
Pdk4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3965,483,351 - 5,496,278 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl65,483,351 - 5,496,309 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm3865,483,351 - 5,496,278 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl65,483,351 - 5,496,309 (-)Ensemblmm10GRCm38
MGSCv3765,433,351 - 5,446,278 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv3665,433,351 - 5,446,278 (-)NCBIMGSCv36mm8
Celera65,632,922 - 5,645,841 (-)NCBICelera
Cytogenetic Map6A1NCBI
cM Map62.06NCBI
Pdk4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543212,169,435 - 12,182,409 (-)Ensembl
ChiLan1.0NW_00495543212,169,548 - 12,182,064 (-)NCBIChiLan1.0ChiLan1.0
PDK4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v26113,425,312 - 113,438,178 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan17161,689,949 - 161,703,070 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0787,540,600 - 87,553,673 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.17101,128,054 - 101,141,157 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl7101,128,060 - 101,141,157 (-)EnsemblpanPan2panpan1.1
PDK4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11420,825,861 - 20,839,290 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1420,827,831 - 20,839,256 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1420,384,777 - 20,398,210 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01420,648,173 - 20,661,596 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1420,648,177 - 20,661,596 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11420,792,835 - 20,806,252 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01420,527,757 - 20,541,169 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01420,785,483 - 20,798,897 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Pdk4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440511834,149,865 - 34,162,274 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365854,700,418 - 4,714,450 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365854,701,012 - 4,713,421 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PDK4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl975,246,002 - 75,260,134 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1975,246,956 - 75,260,134 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2982,625,083 - 82,638,263 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PDK4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12153,445,607 - 53,458,729 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2153,445,457 - 53,460,776 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604250,888,557 - 50,901,587 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pdk4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248132,258,279 - 2,270,824 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248132,258,279 - 2,270,540 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Pdk4
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v16133,130,842 - 133,142,939 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Pdk4
42 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:434
Count of miRNA genes:253
Interacting mature miRNAs:314
Transcripts:ENSRNOT00000012760
Prediction methods:Microtar, Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2302371Stl22Serum triglyceride level QTL 225.15blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)41308014658080146Rat
2303585Bw86Body weight QTL 864body mass (VT:0001259)body weight (CMO:0000012)41564430960644309Rat
8552906Pigfal3Plasma insulin-like growth factor 1 level QTL 3blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)41103870656038706Rat
10755501Bp390Blood pressure QTL 3902.5arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)427730518170099664Rat
8552782Vie1Viral induced encephalitis QTL 126.4brain integrity trait (VT:0010579)encephalitis incidence/prevalence measurement (CMO:0002361)4135396961Rat
6478766Anxrr47Anxiety related response QTL 470.09637locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)41103870656038706Rat
70222Eae2Experimental allergic encephalomyelitis QTL 24.3nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)42228845340471598Rat
61330Eau1Experimental allergic uveoretinitis QTL 10.0003uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)426234499134199155Rat
631642Stl2Serum triglyceride level QTL 23.3blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)4589457557613242Rat
6478769Anxrr48Anxiety related response QTL 480.02514locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)41103870656038706Rat
631261Tcas3Tongue tumor susceptibility QTL 36.88tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)41170660492690519Rat
2313401Anxrr27Anxiety related response QTL 27aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)41890069763900697Rat
631209Bw2Body weight QTL24.2retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)4145429897Rat
8552803Bw144Body weight QTL 14416body mass (VT:0001259)change in body weight to body weight ratio (CMO:0002216)4135396961Rat
6909128Pancm4Pancreatic morphology QTL 411.35pancreas mass (VT:0010144)pancreas wet weight (CMO:0000626)427862204126119996Rat
8694374Bw155Body weight QTL 1553.390.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)41103870656038706Rat
8552801Bw143Body weight QTL 1437.3body mass (VT:0001259)change in body weight to body weight ratio (CMO:0002216)4135396961Rat
2303168Bp330Blood pressure QTL 3304.250.017arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)45889999148002343Rat
61412Pia2Pristane induced arthritis QTL 23.9joint integrity trait (VT:0010548)post-insult time to onset of experimental arthritis (CMO:0001450)42228845363245191Rat
8552807Vie4Viral induced encephalitis QTL 47.3brain integrity trait (VT:0010579)encephalitis incidence/prevalence measurement (CMO:0002361)41890069763900697Rat
6478724Anxrr35Anxiety related response QTL 350.00449defecation behavior trait (VT:0010462)defecation measurement (CMO:0000997)41103870656038706Rat
8655906Rf60Renal function QTL 603.8blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)43044896182336920Rat
61415Eae11Experimental allergic encephalomyelitis QTL 112.9nervous system integrity trait (VT:0010566)post-insult time to onset of experimental autoimmune encephalomyelitis (CMO:0001422)4140471598Rat
619616Bp79Blood pressure QTL 790.0292arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)4588999950889999Rat
8552809Vie5Viral induced encephalitis QTL 525.3brain integrity trait (VT:0010579)encephalitis incidence/prevalence measurement (CMO:0002361)4135396961Rat
7387227Uae40Urinary albumin excretion QTL 402.90.0052urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)41891315163913151Rat
6909122Insul22Insulin level QTL 224.63blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)42786220462997402Rat
1358203Stl19Serum triglyceride level QTL 192.80.002blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)42192515166925151Rat
70192BpQTLcluster5Blood pressure QTL cluster 54.183arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)4163900697Rat
9590304Scort17Serum corticosterone level QTL 174.960.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)41103870656038706Rat
12798520Anxrr55Anxiety related response QTL 554.450.01locomotor behavior trait (VT:0001392)number of rearing movements with lid-pushing in an experimental apparatus (CMO:0002715)433538597116185060Rat
11530004Niddm71Non-insulin dependent diabetes mellitus QTL 710.001blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)43353881653719714Rat
2316958Gluco58Glucose level QTL 5810blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)412212457182430611Rat
1354665Stl10Serum triglyceride level QTL 103.57blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)42228845345429897Rat
1300141Bp178Blood pressure QTL 178arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)41075870140490708Rat

Markers in Region
RH129461  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2433,589,988 - 33,590,168 (+)MAPPERmRatBN7.2
Rnor_6.0430,544,965 - 30,545,144NCBIRnor6.0
Rnor_5.0430,451,891 - 30,452,070UniSTSRnor5.0
RGSC_v3.4430,233,489 - 30,233,668UniSTSRGSC3.4
Celera429,116,586 - 29,116,765UniSTS
RH 3.4 Map13552.3UniSTS
Cytogenetic Map4q13UniSTS
RH142384  
Rat AssemblyChrPosition (strand)SourceJBrowse
RH 3.4 Map4811.93UniSTS
Cytogenetic Map4q13UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 11 67 154 91 90 59 29 59 6 291 128 9 133 80 92 31 11 11

Sequence


Ensembl Acc Id: ENSRNOT00000012760   ⟹   ENSRNOP00000012759
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl434,556,330 - 34,568,381 (-)Ensembl
mRatBN7.2 Ensembl433,589,799 - 33,601,850 (-)Ensembl
Rnor_6.0 Ensembl430,546,664 - 30,556,814 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000120230   ⟹   ENSRNOP00000095804
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl434,556,330 - 34,568,381 (-)Ensembl
mRatBN7.2 Ensembl433,589,799 - 33,601,850 (-)Ensembl
RefSeq Acc Id: NM_053551   ⟹   NP_446003
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8434,558,327 - 34,568,329 (-)NCBI
mRatBN7.2433,591,796 - 33,601,798 (-)NCBI
Rnor_6.0430,546,772 - 30,556,774 (-)NCBI
Rnor_5.0430,453,698 - 30,463,700 (-)NCBI
RGSC_v3.4430,235,296 - 30,245,298 (-)RGD
Celera429,118,393 - 29,128,395 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_446003 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAC00177 (Get FASTA)   NCBI Sequence Viewer  
  EDM15025 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000012759
GenBank Protein O54937 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_446003   ⟸   NM_053551
- UniProtKB: O54937 (UniProtKB/Swiss-Prot),   G3V778 (UniProtKB/TrEMBL),   A6IDT8 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000012759   ⟸   ENSRNOT00000012760
Ensembl Acc Id: ENSRNOP00000095804   ⟸   ENSRNOT00000120230
Protein Domains
Branched-chain alpha-ketoacid dehydrogenase   Histidine kinase   Histidine kinase/HSP90-like ATPase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O54937-F1-model_v2 AlphaFold O54937 1-412 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13692860
Promoter ID:EPDNEW_R3385
Type:single initiation site
Name:Pdk4_1
Description:pyruvate dehydrogenase kinase 4
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0430,556,822 - 30,556,882EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:69061 AgrOrtholog
BioCyc Gene G2FUF-45704 BioCyc
Ensembl Genes ENSRNOG00000009565 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000012760 ENTREZGENE
Gene3D-CATH 1.20.140.20 UniProtKB/Swiss-Prot
  3.30.565.10 UniProtKB/Swiss-Prot
InterPro AK/P_DHK_N_sf UniProtKB/Swiss-Prot
  BCDHK/PDK_N UniProtKB/Swiss-Prot
  BCKD/PDK UniProtKB/Swiss-Prot
  HATPase_C_sf UniProtKB/Swiss-Prot
  His_kinase_dom UniProtKB/Swiss-Prot
KEGG Report rno:89813 UniProtKB/Swiss-Prot
NCBI Gene 89813 ENTREZGENE
PANTHER [PYRUVATE DEHYDROGENASE (ACETYL-TRANSFERRING)] KINASE ISOZYME 4, MITOCHONDRIAL UniProtKB/Swiss-Prot
  PTHR11947 UniProtKB/Swiss-Prot
Pfam BCDHK_Adom3 UniProtKB/Swiss-Prot
  HATPase_c UniProtKB/Swiss-Prot
PhenoGen Pdk4 PhenoGen
PROSITE HIS_KIN UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000009565 RatGTEx
SMART HATPase_c UniProtKB/Swiss-Prot
Superfamily-SCOP SSF55874 UniProtKB/Swiss-Prot
  SSF69012 UniProtKB/Swiss-Prot
TIGR TC234545
UniProt A0A8I6GLB7_RAT UniProtKB/TrEMBL
  A6IDT8 ENTREZGENE, UniProtKB/TrEMBL
  G3V778 ENTREZGENE, UniProtKB/TrEMBL
  O54937 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-01-13 Pdk4  pyruvate dehydrogenase kinase 4  Pdk4  pyruvate dehydrogenase kinase, isozyme 4  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-10-10 Pdk4  pyruvate dehydrogenase kinase, isozyme 4  Pdk4  pyruvate dehydrogenase kinase, isoenzyme 4  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Pdk4  pyruvate dehydrogenase kinase, isoenzyme 4    pyruvate dehydrogenate kinase 4  Name updated 1299863 APPROVED
2002-06-10 Pdk4  pyruvate dehydrogenate kinase 4      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expression increases several fold during starvation 68199
gene_expression expression in muscle decreases on treatment of ZDF rats with GW1929 68199
gene_regulation activated by acetyl-CoA and NADH 729541