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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69061
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Pdk4
Name: pyruvate dehydrogenase kinase 4
Acc ID: CHEBI:32509
Term: pirinixic acid
Definition: An aryl sulfide that has formula C14H14ClN3O2S.
Chemical ID: MESH:C006253
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Pdk4increases expressionEXP 6480464CTDpirinixic acid results in increased expression of PDK4 mRNAPMID:12832660 PMID:19162173 PMID:19360380 PMID:22484513 PMID:27665778 PMID:32741897
Pdk4increases expressionISOPDK4 (Homo sapiens)6480464CTDpirinixic acid results in increased expression of PDK4 mRNAPMID:15824748 PMID:18518955 PMID:23811191 PMID:27551952
Pdk4increases expressionISOPdk4 (Mus musculus)6480464CTDpirinixic acid results in increased expression of PDK4 mRNAPMID:16357043 PMID:17118139 PMID:17426115 PMID:17950772 PMID:18301758 PMID:18445702 PMID:18467677 PMID:20059764 PMID:20813756 PMID:23811191 PMID:25270620 PMID:25689681
Pdk4multiple interactionsISOPDK4 (Homo sapiens)6480464CTD[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of PDK4 mRNAPMID:19710929
Pdk4multiple interactionsISOPdk4 (Mus musculus)6480464CTD[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of PDK4 mRNA; PPARA gene mutant form inhibits the reaction [pirinixic acid results in increased expression of PDK4 mRNA]; PPARA protein promotes the reaction [pirinixic acid results in increased expression of PDK4 mRNA]PMID:17950772 PMID:18467677 PMID:19710929 PMID:20059764 PMID:25689681
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