Prkab2 (protein kinase AMP-activated non-catalytic subunit beta 2) - Rat Genome Database

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Pathways
Gene: Prkab2 (protein kinase AMP-activated non-catalytic subunit beta 2) Rattus norvegicus
Analyze
Symbol: Prkab2
Name: protein kinase AMP-activated non-catalytic subunit beta 2
RGD ID: 620905
Description: Enables protein kinase binding activity. Predicted to be involved in cellular response to nutrient levels; positive regulation of cold-induced thermogenesis; and signal transduction. Located in apical plasma membrane and cytoplasm. Part of cAMP-dependent protein kinase complex and nucleotide-activated protein kinase complex. Orthologous to human PRKAB2 (protein kinase AMP-activated non-catalytic subunit beta 2); PARTICIPATES IN adenosine monophosphate-activated protein kinase (AMPK) signaling pathway; hypertrophic cardiomyopathy pathway; insulin signaling pathway; INTERACTS WITH 2,2',4,4'-Tetrabromodiphenyl ether; 6-propyl-2-thiouracil; alpha-Zearalanol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: 5'-AMP-activated protein kinase subunit beta-2; AMP-activated protein kinase beta-2 regulatory subunit; AMPK beta-2 chain; AMPK subunit beta-2; MGC93432; protein kinase, AMP-activated, beta 2 non-catalytic subunit
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Is Marker For: QTLs:   Bp365  
Candidate Gene For: Bp365
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82187,946,008 - 187,961,615 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl2187,945,982 - 187,961,608 (+)EnsemblGRCr8
mRatBN7.22185,257,218 - 185,272,846 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2185,257,213 - 185,269,872 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx2192,905,393 - 192,917,612 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02190,713,236 - 190,725,438 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02185,538,007 - 185,550,226 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.02199,831,990 - 199,847,623 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2199,831,990 - 199,847,629 (+)Ensemblrn6Rnor6.0
Rnor_5.02219,309,807 - 219,325,389 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.42192,498,430 - 192,510,624 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera2177,749,772 - 177,761,966 (+)NCBICelera
RGSC_v3.12192,461,183 - 192,473,369 (+)NCBI
Cytogenetic Map2q34NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3-methylcholanthrene  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-vinylcyclohexene dioxide  (ISO)
6-propyl-2-thiouracil  (EXP)
actinomycin D  (ISO)
adefovir pivoxil  (ISO)
aflatoxin B1  (ISO)
alpha-Zearalanol  (EXP)
amitrole  (EXP)
ammonium chloride  (EXP)
antirheumatic drug  (ISO)
atrazine  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bisphenol A  (EXP,ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
cantharidin  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
chloroacetaldehyde  (ISO)
chlorpyrifos  (EXP)
choline  (ISO)
cidofovir anhydrous  (ISO)
cisplatin  (ISO)
clodronic acid  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
coumarin  (ISO)
cyclosporin A  (ISO)
decabromodiphenyl ether  (EXP)
diazinon  (EXP)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (EXP,ISO)
dioxygen  (ISO)
doxorubicin  (ISO)
ethanol  (ISO)
ethyl methanesulfonate  (ISO)
fenofibrate  (ISO)
flutamide  (EXP)
folic acid  (ISO)
formaldehyde  (ISO)
FR900359  (ISO)
graphite  (EXP)
hydrogen peroxide  (ISO)
ibuprofen  (ISO)
ifosfamide  (ISO)
L-methionine  (ISO)
lead(0)  (ISO)
leflunomide  (ISO)
lycopene  (ISO)
manganese(II) chloride  (EXP)
menadione  (ISO)
metformin  (EXP)
methimazole  (EXP)
methotrexate  (ISO)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
N-methyl-4-phenylpyridinium  (EXP)
nickel atom  (ISO)
nickel sulfate  (ISO)
nitrates  (ISO)
Nutlin-3  (ISO)
okadaic acid  (ISO)
ozone  (ISO)
paracetamol  (EXP,ISO)
perfluorooctanoic acid  (EXP)
phenethyl isothiocyanate  (ISO)
quercetin  (ISO)
sodium arsenite  (ISO)
sunitinib  (ISO)
testosterone enanthate  (ISO)
tetrachloromethane  (EXP,ISO)
tetracycline  (ISO)
thimerosal  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
triphenyl phosphate  (ISO)
Triptolide  (EXP)
valproic acid  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Control of glycogen synthase through ADIPOR1-AMPK pathway in renal distal tubules of normal and diabetic rats. Cammisotto PG, etal., Am J Physiol Renal Physiol. 2008 Apr;294(4):F881-9. doi: 10.1152/ajprenal.00373.2007. Epub 2008 Feb 6.
2. Expression of the AMP-activated protein kinase beta1 and beta2 subunits in skeletal muscle. Chen Z, etal., FEBS Lett 1999 Oct 29;460(2):343-8.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. The AMP-activated protein kinase pathway--new players upstream and downstream. Hardie DG J Cell Sci. 2004 Nov 1;117(Pt 23):5479-87.
6. Management of cellular energy by the AMP-activated protein kinase system. Hardie DG, etal., FEBS Lett. 2003 Jul 3;546(1):113-20.
7. AMP-activated protein kinase beta subunit tethers alpha and gamma subunits via its C-terminal sequence (186-270). Iseli TJ, etal., J Biol Chem. 2005 Apr 8;280(14):13395-400. Epub 2005 Jan 28.
8. Glutathione S-transferases interact with AMP-activated protein kinase: evidence for S-glutathionylation and activation in vitro. Klaus A, etal., PLoS One. 2013 May 31;8(5):e62497. doi: 10.1371/journal.pone.0062497. Print 2013.
9. Activation of AMPK alpha- and gamma-isoform complexes in the intact ischemic rat heart. Li J, etal., Am J Physiol Heart Circ Physiol. 2006 Oct;291(4):H1927-34. Epub 2006 Apr 28.
10. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
11. Lack of Adipocyte AMPK Exacerbates Insulin Resistance and Hepatic Steatosis through Brown and Beige Adipose Tissue Function. Mottillo EP, etal., Cell Metab. 2016 Jul 12;24(1):118-29. doi: 10.1016/j.cmet.2016.06.006.
12. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
13. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
14. GOA pipeline RGD automated data pipeline
15. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
16. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
17. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
Additional References at PubMed
PMID:11724780   PMID:14614828   PMID:17709097   PMID:17851531   PMID:20562859   PMID:21399626   PMID:21988832   PMID:27099349   PMID:31189568  


Genomics

Comparative Map Data
Prkab2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82187,946,008 - 187,961,615 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl2187,945,982 - 187,961,608 (+)EnsemblGRCr8
mRatBN7.22185,257,218 - 185,272,846 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2185,257,213 - 185,269,872 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx2192,905,393 - 192,917,612 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02190,713,236 - 190,725,438 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02185,538,007 - 185,550,226 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.02199,831,990 - 199,847,623 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2199,831,990 - 199,847,629 (+)Ensemblrn6Rnor6.0
Rnor_5.02219,309,807 - 219,325,389 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.42192,498,430 - 192,510,624 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera2177,749,772 - 177,761,966 (+)NCBICelera
RGSC_v3.12192,461,183 - 192,473,369 (+)NCBI
Cytogenetic Map2q34NCBI
PRKAB2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381147,155,106 - 147,172,470 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1147,155,106 - 147,173,716 (-)Ensemblhg38GRCh38
GRCh371146,626,685 - 146,644,049 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361145,093,309 - 145,110,753 (-)NCBIBuild 36Build 36hg18NCBI36
Build 341143,851,502 - 143,868,945NCBI
Celera1122,340,718 - 122,358,162 (+)NCBICelera
Cytogenetic Map1q21.1NCBI
HuRef1120,039,190 - 120,056,673 (-)NCBIHuRef
CHM1_11148,523,232 - 148,540,715 (-)NCBICHM1_1
T2T-CHM13v2.01147,635,939 - 147,653,299 (+)NCBIT2T-CHM13v2.0
Prkab2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39397,565,527 - 97,581,128 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl397,565,509 - 97,581,128 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38397,658,211 - 97,673,812 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl397,658,193 - 97,673,812 (+)Ensemblmm10GRCm38
MGSCv37397,462,135 - 97,477,006 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36397,743,617 - 97,758,488 (+)NCBIMGSCv36mm8
Celera399,057,874 - 99,072,745 (+)NCBICelera
Cytogenetic Map3F2.2NCBI
cM Map342.25NCBI
Prkab2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555681,252,736 - 1,279,761 (+)Ensembl
ChiLan1.0NW_0049555681,253,331 - 1,279,761 (+)NCBIChiLan1.0ChiLan1.0
PRKAB2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21102,556,601 - 102,574,428 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11102,144,935 - 102,162,775 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01122,577,308 - 122,595,083 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11112,934,877 - 112,952,364 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1112,934,877 - 112,952,364 (+)EnsemblpanPan2panpan1.1
PRKAB2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11757,614,499 - 57,630,041 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1757,616,451 - 57,630,041 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1757,138,994 - 57,154,977 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01758,608,987 - 58,624,968 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1758,547,205 - 58,625,036 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11757,507,665 - 57,523,856 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01757,555,486 - 57,571,458 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01758,281,440 - 58,297,432 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
LOC101973983
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244050583,224,028 - 3,239,362 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493695377,688 - 93,374 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493695377,671 - 93,383 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PRKAB2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl4100,378,071 - 100,394,338 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.14100,378,047 - 100,394,346 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.24110,207,633 - 110,223,926 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PRKAB2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Vero_WHO_p1.0NW_02366603815,067,417 - 15,083,027 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Prkab2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462477216,110,294 - 16,127,119 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462477216,110,805 - 16,127,221 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Prkab2
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1359,635,638 - 59,651,072 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Prkab2
84 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:137
Count of miRNA genes:89
Interacting mature miRNAs:106
Transcripts:ENSRNOT00000063783
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1358356Srcrt1Stress Responsive Cort QTL13.66blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)2163997722225110681Rat
1578648Bss11Bone structure and strength QTL 114.7femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)2169358774214358774Rat
1331734Bp204Blood pressure QTL 2043.61192arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2170656145239614549Rat
631566Bp90Blood pressure QTL 900.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2149957381221199885Rat
1298074Bp164Blood pressure QTL 1640.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)244537979205135428Rat
1354648Bp239Blood pressure QTL 2390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)267845370229470703Rat
1354649Kidm17Kidney mass QTL 172.9kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)283465462229820014Rat
10755499Bp389Blood pressure QTL 3892.61arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)220695736231474293Rat
1298076Bp166Blood pressure QTL 1660.0009arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2138595962205135428Rat
1581576Pur7Proteinuria QTL 70.0001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)280396178220931218Rat
152025245Scl81Serum cholesterol level QTL 813.49blood cholesterol amount (VT:0000180)2124537199209621565Rat
1581578Cm49Cardiac mass QTL 494.90.01heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)2145807215220931416Rat
631198Cm22Cardiac mass QTL 224.30.0008heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)278269809208420281Rat
1554319Bmd2Bone mineral density QTL 213.40.0001lumbar vertebra area (VT:0010570)lumbar vertebra cross-sectional area (CMO:0001689)2122597372215234002Rat
12879836Kidm61Kidney mass QTL 610.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)2154723085199723085Rat
1581569Uae32Urinary albumin excretion QTL 320.0001urine protein amount (VT:0005160)urine albumin excretion rate (CMO:0000757)280396178220931218Rat
10043136Iddm54Insulin dependent diabetes mellitus QTL 543.40.0001blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)2145807215190807215Rat
12879837Am2Aortic mass QTL 20.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)2154723085199723085Rat
10043139Iddm55Insulin dependent diabetes mellitus QTL 553.10.0001blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)2150313808195313808Rat
12879838Cm86Cardiac mass QTL 860.002heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)2154723085199723085Rat
1302793Bw16Body weight QTL 1650.0001body mass (VT:0001259)body weight (CMO:0000012)2159440891205135267Rat
12879839Cm85Cardiac mass QTL 850.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)2154723085199723085Rat
1549833Bp257Blood pressure QTL 2570.003arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2170652929215652929Rat
1358900Bw48Body weight QTL 484.88body mass (VT:0001259)body weight (CMO:0000012)2159440891220931218Rat
4889834Pur24Proteinuria QTL 245.80.014urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)2171994826205135428Rat
1359030Bp277Blood pressure QTL 277arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2143565208188565208Rat
1331760Bp206Blood pressure QTL 2063.62454arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)24265106205135428Rat
12879840Bw179Body weight QTL 1790.005body mass (VT:0001259)body weight (CMO:0000012)2154723085199723085Rat
1581502Esta3Estrogen-induced thymic atrophy QTL 3thymus mass (VT:0004954)thymus wet weight (CMO:0000855)2139067258192287892Rat
9589044Scfw1Subcutaneous fat weight QTL 15.80.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)2184856304229856304Rat
8694435Bw166Body weight QTL 16614.080.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)2184856304229856304Rat
1359032Hrtrt18Heart rate QTL 18heart pumping trait (VT:2000009)heart rate (CMO:0000002)2159440760195313808Rat
2301966Bp322Blood pressure QTL 3223.58arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2144882354205135428Rat
1298080Bp163Blood pressure QTL 1630.02arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)267845182205135428Rat
1357991Ael2Aortic elastin QTL 24.20.000071aorta elastin amount (VT:0003905)aortic elastin2169227906214227906Rat
8662832Vetf7Vascular elastic tissue fragility QTL 73.5aorta elastin amount (VT:0003905)aorta wall extracellular elastin dry weight to aorta wall dry weight ratio (CMO:0002002)283400752223709938Rat
1298085Bp165Blood pressure QTL 1650.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)244537979205135428Rat
8694194Abfw1Abdominal fat weight QTL 111.70.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)2184856304229856304Rat
1578671Bmd10Bone mineral density QTL 105.4femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)2175931416220931416Rat
1641891Alcrsp17Alcohol response QTL 17response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2151869660251712708Rat
724534Uae6Urinary albumin excretion QTL 610urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)280396034220931416Rat
61374Edpm2Estrogen-dependent pituitary mass QTL 24.420.86pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)278269809205135428Rat
2300189Bmd48Bone mineral density QTL 485.80.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)2182024327227024327Rat
8662843Vetf9Vascular elastic tissue fragility QTL 92.05thoracic aorta molecular composition trait (VT:0010568)aorta wall extracellular elastin dry weight to aorta wall extracellular collagen weight ratio (CMO:0002003)2159440760228950743Rat
2301408Kidm36Kidney mass QTL 360.002kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)2184482291229482291Rat
1331794Bp202Blood pressure QTL 2023.66819arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2143344967251712708Rat
71113Cari2Carrageenan-induced inflammation QTL 22.70.009hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)2143746578205135428Rat
1331805Cm29Cardiac mass QTL 293.50746heart mass (VT:0007028)heart wet weight (CMO:0000069)2143344967251712708Rat
634308Sach6Saccharin preference QTL 64.9taste sensitivity trait (VT:0001986)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)2114384617215381366Rat
1598805Memor8Memory QTL 83exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)2150096616195096616Rat
1358917Cm42Cardiac mass QTL 422.82heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328206613235Rat
724568Uae13Urinary albumin excretion QTL 134.4urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)2145306936212705578Rat
7488929Bp366Blood pressure QTL 3660.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2187663373195783351Rat
1358913Cm41Cardiac mass QTL 412.73heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328206613235Rat
1300165Rf9Renal function QTL 93.28kidney glomerulus integrity trait (VT:0010546)index of glomerular damage (CMO:0001135)2113746222205135428Rat
738013Alc15Alcohol consumption QTL 154.10.00022consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)2186850607231850607Rat
61401Niddm2Non-insulin dependent diabetes mellitus QTL 24.54blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2147287892192287892Rat
631507Bp105Blood pressure QTL 1050.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2114384617215381366Rat
1641925Alcrsp2Alcohol response QTL 2response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2151869660223841096Rat
1354609Niddm62Non-insulin dependent diabetes mellitus QTL 624.720.000006insulin secretion trait (VT:0003564)plasma insulin level (CMO:0000342)2117415288205135428Rat
1598833Bp295Blood pressure QTL 2953.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2150096616195096616Rat
61417Cia10Collagen induced arthritis QTL 103.4joint integrity trait (VT:0010548)experimental arthritis severity measurement (CMO:0001459)2182635347227635347Rat
1354622Kidm16Kidney mass QTL 163kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)283465462225110681Rat
631266Bp132Blood pressure QTL 1320.0005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)247856345205135428Rat
631522Bp74Blood pressure QTL 740.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2175008837220008837Rat
8694383Bw158Body weight QTL 1587.690.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)2184856304229856304Rat
7488927Bp365Blood pressure QTL 3650.008arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2165453811210453811Rat
7488925Bp364Blood pressure QTL 3640.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2163253030208253030Rat
2306901Bp337Blood pressure QTL 3370.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2166372086229820014Rat
1354605Rf48Renal function QTL 482.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)276328396209350714Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 162 91 90 59 92 59 6 356 192 11 141 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000063783   ⟹   ENSRNOP00000062137
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2187,945,982 - 187,958,641 (+)Ensembl
mRatBN7.2 Ensembl2185,257,213 - 185,269,872 (+)Ensembl
Rnor_6.0 Ensembl2199,831,990 - 199,844,649 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000086588   ⟹   ENSRNOP00000069519
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl2199,832,023 - 199,847,629 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000099010   ⟹   ENSRNOP00000086904
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2185,257,632 - 185,269,817 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000102819   ⟹   ENSRNOP00000090150
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2185,257,354 - 185,264,831 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000108265   ⟹   ENSRNOP00000078691
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2185,257,287 - 185,269,817 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000113165   ⟹   ENSRNOP00000093894
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2185,257,213 - 185,264,329 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000124604   ⟹   ENSRNOP00000111047
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2187,946,372 - 187,961,608 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000128124   ⟹   ENSRNOP00000102840
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2187,946,043 - 187,961,608 (+)Ensembl
RefSeq Acc Id: NM_022627   ⟹   NP_072149
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82187,946,401 - 187,958,595 (+)NCBI
mRatBN7.22185,257,632 - 185,269,826 (+)NCBI
Rnor_6.02199,832,409 - 199,844,603 (+)NCBI
Rnor_5.02219,309,807 - 219,325,389 (+)NCBI
RGSC_v3.42192,498,430 - 192,510,624 (+)RGD
Celera2177,749,772 - 177,761,966 (+)RGD
Sequence:
RefSeq Acc Id: XM_006233011   ⟹   XP_006233073
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82187,946,009 - 187,961,615 (+)NCBI
mRatBN7.22185,257,235 - 185,272,846 (+)NCBI
Rnor_6.02199,831,990 - 199,847,623 (+)NCBI
Rnor_5.02219,309,807 - 219,325,389 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006233012   ⟹   XP_006233074
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82187,946,151 - 187,961,615 (+)NCBI
mRatBN7.22185,257,382 - 185,272,846 (+)NCBI
Rnor_6.02199,832,180 - 199,847,623 (+)NCBI
Rnor_5.02219,309,807 - 219,325,389 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039103078   ⟹   XP_038959006
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82187,946,424 - 187,961,615 (+)NCBI
mRatBN7.22185,257,654 - 185,272,846 (+)NCBI
RefSeq Acc Id: XM_039103079   ⟹   XP_038959007
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82187,946,008 - 187,961,615 (+)NCBI
mRatBN7.22185,257,235 - 185,272,846 (+)NCBI
RefSeq Acc Id: XM_039103080   ⟹   XP_038959008
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82187,946,157 - 187,961,615 (+)NCBI
mRatBN7.22185,257,388 - 185,272,846 (+)NCBI
RefSeq Acc Id: XR_005500366
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82187,946,008 - 187,957,642 (+)NCBI
mRatBN7.22185,257,218 - 185,272,846 (+)NCBI
RefSeq Acc Id: NP_072149   ⟸   NM_022627
- UniProtKB: Q9QZH4 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006233073   ⟸   XM_006233011
- Peptide Label: isoform X1
- UniProtKB: A0A0G2JVK3 (UniProtKB/TrEMBL),   A6K3B7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006233074   ⟸   XM_006233012
- Peptide Label: isoform X1
- UniProtKB: A0A0G2JVK3 (UniProtKB/TrEMBL),   A6K3B7 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000062137   ⟸   ENSRNOT00000063783
Ensembl Acc Id: ENSRNOP00000069519   ⟸   ENSRNOT00000086588
RefSeq Acc Id: XP_038959007   ⟸   XM_039103079
- Peptide Label: isoform X3
- UniProtKB: A0A8I5ZLG3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038959008   ⟸   XM_039103080
- Peptide Label: isoform X3
- UniProtKB: A0A8I5ZLG3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038959006   ⟸   XM_039103078
- Peptide Label: isoform X2
Ensembl Acc Id: ENSRNOP00000086904   ⟸   ENSRNOT00000099010
Ensembl Acc Id: ENSRNOP00000078691   ⟸   ENSRNOT00000108265
Ensembl Acc Id: ENSRNOP00000090150   ⟸   ENSRNOT00000102819
Ensembl Acc Id: ENSRNOP00000093894   ⟸   ENSRNOT00000113165
Ensembl Acc Id: ENSRNOP00000102840   ⟸   ENSRNOT00000128124
Ensembl Acc Id: ENSRNOP00000111047   ⟸   ENSRNOT00000124604
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9QZH4-F1-model_v2 AlphaFold Q9QZH4 1-271 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13691597
Promoter ID:EPDNEW_R2122
Type:single initiation site
Name:Prkab2_1
Description:protein kinase AMP-activated non-catalytic subunit beta 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R2123  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.02199,832,116 - 199,832,176EPDNEW
RGD ID:13691598
Promoter ID:EPDNEW_R2123
Type:multiple initiation site
Name:Prkab2_2
Description:protein kinase AMP-activated non-catalytic subunit beta 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R2122  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.02199,832,401 - 199,832,461EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620905 AgrOrtholog
BioCyc Gene G2FUF-51935 BioCyc
Ensembl Genes ENSRNOG00000018166 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000124604 ENTREZGENE
  ENSRNOT00000128124 ENTREZGENE
Gene3D-CATH 2.60.40.10 UniProtKB/Swiss-Prot
  6.20.250.60 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7135534 IMAGE-MGC_LOAD
InterPro AMPK1_CBM UniProtKB/Swiss-Prot
  ASC_dom UniProtKB/Swiss-Prot
  ASC_dom_sf UniProtKB/Swiss-Prot
  CRP1_MDG1_kinase UniProtKB/Swiss-Prot
  Ig-like_fold UniProtKB/Swiss-Prot
  Ig_E-set UniProtKB/Swiss-Prot
KEGG Report rno:64562 UniProtKB/Swiss-Prot
MGC_CLONE MGC:93432 IMAGE-MGC_LOAD
NCBI Gene 64562 ENTREZGENE
PANTHER 5'-AMP-ACTIVATED PROTEIN KINASE , BETA SUBUNIT UniProtKB/Swiss-Prot
  5'-AMP-ACTIVATED PROTEIN KINASE SUBUNIT BETA-2 UniProtKB/Swiss-Prot
Pfam AMPK1_CBM UniProtKB/Swiss-Prot
  AMPKBI UniProtKB/Swiss-Prot
PhenoGen Prkab2 PhenoGen
RatGTEx ENSRNOG00000018166 RatGTEx
SMART AMPKBI UniProtKB/Swiss-Prot
Superfamily-SCOP SSF160219 UniProtKB/Swiss-Prot
  SSF81296 UniProtKB/Swiss-Prot
UniProt A0A0G2JVK3 ENTREZGENE
  A0A8I5ZLG3 ENTREZGENE
  A0ABK0LN81_RAT UniProtKB/TrEMBL
  A0ABK0LZA4_RAT UniProtKB/TrEMBL
  A6K3B7 ENTREZGENE, UniProtKB/TrEMBL
  A6K3B8_RAT UniProtKB/TrEMBL
  AAKB2_RAT UniProtKB/Swiss-Prot
  G3V9X3_RAT UniProtKB/TrEMBL
  Q9QZH4 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-03 Prkab2  protein kinase AMP-activated non-catalytic subunit beta 2  Prkab2  protein kinase, AMP-activated, beta 2 non-catalytic subunit  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Prkab2  protein kinase, AMP-activated, beta 2 non-catalytic subunit    AMP-activated protein kinase beta-2 regulatory subunit  Name updated 1299863 APPROVED
2002-08-07 Prkab2  AMP-activated protein kinase beta-2 regulatory subunit      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in skeletal muscle 631899
gene_product member of the AMP-activated protein kinase (AMPK) isoenzyme family  
gene_regulation Ser-182 is only partially phosphorylated in skeletal muscle