Serinc5 (serine incorporator 5) - Rat Genome Database

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Gene: Serinc5 (serine incorporator 5) Rattus norvegicus
Analyze
Symbol: Serinc5
Name: serine incorporator 5
RGD ID: 621571
Description: Predicted to enable protein-macromolecule adaptor activity. Involved in several processes, including phosphatidylserine metabolic process; positive regulation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity; and positive regulation of serine C-palmitoyltransferase activity. Predicted to be located in several cellular components, including Golgi apparatus; centrosome; and myelin sheath. Predicted to be active in membrane. Orthologous to human SERINC5 (serine incorporator 5); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,6-dinitrotoluene; 3H-1,2-dithiole-3-thione.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: developmentally regulated protein TPO1; Tpo1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8225,581,952 - 25,685,403 (+)NCBIGRCr8
mRatBN7.2223,846,899 - 23,950,346 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl223,846,900 - 23,950,346 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx230,876,948 - 30,979,311 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0228,977,299 - 29,079,662 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0223,805,425 - 23,908,207 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0222,195,507 - 22,310,289 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl222,195,600 - 22,310,312 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0241,398,814 - 41,516,426 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4222,871,987 - 22,977,705 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1222,792,355 - 22,898,074 (+)NCBI
Celera219,936,153 - 20,037,869 (+)NCBICelera
Cytogenetic Map2q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-demecolcine  (ISO)
1,2-dimethylhydrazine  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,6-dinitrotoluene  (EXP)
2-hydroxypropanoic acid  (ISO)
3H-1,2-dithiole-3-thione  (EXP)
4-hydroxyphenyl retinamide  (ISO)
6-propyl-2-thiouracil  (EXP)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
benzo[a]pyrene  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
caffeine  (ISO)
carbon nanotube  (ISO)
chlorpyrifos  (ISO)
cisplatin  (ISO)
clobetasol  (ISO)
coumestrol  (ISO)
Cuprizon  (EXP)
cyclosporin A  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (ISO)
diethylstilbestrol  (ISO)
dioxygen  (ISO)
dorsomorphin  (ISO)
endosulfan  (EXP)
Enterolactone  (ISO)
epoxiconazole  (ISO)
ethyl methanesulfonate  (ISO)
flavonoids  (EXP)
flutamide  (EXP)
formaldehyde  (ISO)
fulvestrant  (ISO)
gentamycin  (EXP)
lead(0)  (ISO)
methapyrilene  (EXP)
methoxychlor  (EXP)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
mifepristone  (EXP)
oxaliplatin  (EXP)
paracetamol  (EXP,ISO)
phenobarbital  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
rac-lactic acid  (ISO)
rotenone  (EXP)
SB 431542  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (ISO)
sulforaphane  (ISO)
tamibarotene  (ISO)
tetrachloromethane  (EXP,ISO)
thiram  (ISO)
titanium dioxide  (ISO)
topotecan  (EXP)
trichostatin A  (ISO)
triclosan  (ISO)
triphenyl phosphate  (ISO)
urethane  (ISO)
valproic acid  (EXP,ISO)
vinclozolin  (EXP)
vincristine  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Serinc, an activity-regulated protein family, incorporates serine into membrane lipid synthesis. Inuzuka M, etal., J Biol Chem. 2005 Oct 21;280(42):35776-83. Epub 2005 Aug 24.
3. TPO1, a member of a novel protein family, is developmentally regulated in cultured oligodendrocytes. Krueger WH, etal., J Neurochem 1997 Oct;69(4):1343-55.
4. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:16405874   PMID:19056867   PMID:26416733   PMID:26416734  


Genomics

Comparative Map Data
Serinc5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8225,581,952 - 25,685,403 (+)NCBIGRCr8
mRatBN7.2223,846,899 - 23,950,346 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl223,846,900 - 23,950,346 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx230,876,948 - 30,979,311 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0228,977,299 - 29,079,662 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0223,805,425 - 23,908,207 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0222,195,507 - 22,310,289 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl222,195,600 - 22,310,312 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0241,398,814 - 41,516,426 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4222,871,987 - 22,977,705 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1222,792,355 - 22,898,074 (+)NCBI
Celera219,936,153 - 20,037,869 (+)NCBICelera
Cytogenetic Map2q12NCBI
SERINC5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38580,111,225 - 80,256,048 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl580,111,228 - 80,256,048 (-)EnsemblGRCh38hg38GRCh38
GRCh37579,407,048 - 79,551,867 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36579,443,230 - 79,587,626 (-)NCBINCBI36Build 36hg18NCBI36
Celera575,308,393 - 75,453,225 (-)NCBICelera
Cytogenetic Map5q14.1NCBI
HuRef574,614,526 - 74,759,739 (-)NCBIHuRef
CHM1_1578,840,061 - 78,985,426 (-)NCBICHM1_1
T2T-CHM13v2.0580,595,078 - 80,740,399 (-)NCBIT2T-CHM13v2.0
Serinc5
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391392,747,646 - 92,848,455 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1392,747,599 - 92,848,455 (+)EnsemblGRCm39 Ensembl
GRCm381392,611,138 - 92,711,947 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1392,611,091 - 92,711,947 (+)EnsemblGRCm38mm10GRCm38
MGSCv371393,381,093 - 93,481,902 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361393,711,891 - 93,812,700 (+)NCBIMGSCv36mm8
Celera1396,219,502 - 96,315,704 (+)NCBICelera
Cytogenetic Map13C3NCBI
cM Map1347.75NCBI
Serinc5
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541829,527,307 - 29,565,159 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541829,502,562 - 29,573,966 (+)NCBIChiLan1.0ChiLan1.0
SERINC5
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2435,050,092 - 35,195,849 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1533,203,723 - 33,349,475 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0535,059,291 - 35,204,987 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1535,332,193 - 35,449,905 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl535,332,187 - 35,475,016 (+)Ensemblpanpan1.1panPan2
SERINC5
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1326,788,368 - 26,894,811 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl326,733,673 - 26,891,255 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha328,029,028 - 28,135,470 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0326,707,775 - 26,814,701 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl326,707,833 - 26,814,701 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1326,647,886 - 26,754,545 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0326,620,080 - 26,731,366 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0326,902,941 - 27,005,575 (+)NCBIUU_Cfam_GSD_1.0
Serinc5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213182,879,210 - 182,981,654 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365497,873,608 - 7,979,828 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365497,873,709 - 7,979,767 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SERINC5
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl288,843,011 - 89,046,026 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1288,843,003 - 88,992,077 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2290,636,261 - 90,694,041 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SERINC5
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1474,330,410 - 74,449,069 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl474,335,401 - 74,449,035 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604923,177,767 - 23,297,414 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Serinc5
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247431,242,835 - 1,308,842 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247431,239,698 - 1,308,735 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Serinc5
800 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:403
Count of miRNA genes:243
Interacting mature miRNAs:288
Transcripts:ENSRNOT00000065131
Prediction methods:Miranda
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
10755430Coatc6Coat color QTL 60.02576coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)21159110056591100Rat
1600379Mcs18Mammary carcinoma susceptibility QTL 182.6mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)2788777242804738Rat
7387318Stl32Serum triglyceride level QTL 323.20.0003blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)22238462767384627Rat
631682Bp115Blood pressure QTL 1154.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2137410502Rat
61355Bp36Blood pressure QTL 362.9blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)25873687102844969Rat
2300168Bmd47Bone mineral density QTL 476.60.0001femur mineral mass (VT:0010011)bone mineral density (CMO:0001226)22066244865662448Rat
10755499Bp389Blood pressure QTL 3892.61arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)218960362228801039Rat
1578664Bmd9Bone mineral QTL density 95femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)21185206249003364Rat
738010Lnnr3Liver neoplastic nodule remodeling QTL 32.94liver integrity trait (VT:0010547)liver remodeling tumorous lesion number (CMO:0001461)2141244106Rat
1357990Ael1Aortic elastin QTL 13.10.00091aorta elastin amount (VT:0003905)aortic elastin21907682564076825Rat
731167Glom4Glomerulus QTL 42.40.0082kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)22030467265304672Rat
738012Anxrr3Anxiety related response QTL 33.8exploratory behavior trait (VT:0010471)percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)2902351954023519Rat
731184Mamtr4Mammary tumor resistance QTL 40.0003mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)21649174061491740Rat

Markers in Region
RH137865  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2223,900,635 - 23,900,777 (+)MAPPERmRatBN7.2
Rnor_6.0222,249,232 - 22,249,373NCBIRnor6.0
Rnor_5.0241,452,828 - 41,452,969UniSTSRnor5.0
RGSC_v3.4222,927,015 - 22,927,156UniSTSRGSC3.4
Celera219,989,084 - 19,989,225UniSTS
Cytogenetic Map2q12UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000065131   ⟹   ENSRNOP00000060697
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl223,846,918 - 23,950,346 (+)Ensembl
Rnor_6.0 Ensembl222,195,600 - 22,310,312 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000098981   ⟹   ENSRNOP00000079663
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl223,846,900 - 23,950,346 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000107615   ⟹   ENSRNOP00000080464
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl223,913,240 - 23,950,346 (+)Ensembl
RefSeq Acc Id: NM_133395   ⟹   NP_596886
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8225,581,971 - 25,685,403 (+)NCBI
mRatBN7.2223,846,918 - 23,950,346 (+)NCBI
Rnor_6.0222,195,507 - 22,310,289 (+)NCBI
Rnor_5.0241,398,814 - 41,516,426 (+)NCBI
RGSC_v3.4222,871,987 - 22,977,705 (+)RGD
Celera219,936,153 - 20,037,869 (+)NCBI
Sequence:
RefSeq Acc Id: XM_063281216   ⟹   XP_063137286
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8225,581,952 - 25,685,403 (+)NCBI
Protein Sequences
Protein RefSeqs NP_596886 (Get FASTA)   NCBI Sequence Viewer  
  XP_063137286 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA41097 (Get FASTA)   NCBI Sequence Viewer  
  AAZ80297 (Get FASTA)   NCBI Sequence Viewer  
  EDM10024 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000060697.4
  ENSRNOP00000079663.1
  ENSRNOP00000080464.1
GenBank Protein Q63175 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_596886   ⟸   NM_133395
- UniProtKB: G3V9U9 (UniProtKB/Swiss-Prot),   Q63175 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSRNOP00000060697   ⟸   ENSRNOT00000065131
Ensembl Acc Id: ENSRNOP00000079663   ⟸   ENSRNOT00000098981
Ensembl Acc Id: ENSRNOP00000080464   ⟸   ENSRNOT00000107615
RefSeq Acc Id: XP_063137286   ⟸   XM_063281216
- Peptide Label: isoform X1
- UniProtKB: A0A8I6G3K7 (UniProtKB/TrEMBL)

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q63175-F1-model_v2 AlphaFold Q63175 1-460 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13691062
Promoter ID:EPDNEW_R1586
Type:initiation region
Name:Serinc5_1
Description:serine incorporator 5
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0222,195,536 - 22,195,596EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621571 AgrOrtholog
BioCyc Gene G2FUF-54862 BioCyc
Ensembl Genes ENSRNOG00000024039 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000065131.4 UniProtKB/TrEMBL
  ENSRNOT00000098981.1 UniProtKB/TrEMBL
  ENSRNOT00000107615.1 UniProtKB/TrEMBL
InterPro TDE1/TMS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:170907 UniProtKB/Swiss-Prot
NCBI Gene 170907 ENTREZGENE
PANTHER PTHR10383 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR10383:SF16 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Serinc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Serinc5 PhenoGen
PROSITE PROKAR_LIPOPROTEIN UniProtKB/TrEMBL
RatGTEx ENSRNOG00000024039 RatGTEx
UniProt A0A140TAJ2_RAT UniProtKB/TrEMBL
  A0A8I6G3K7 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6G4K4_RAT UniProtKB/TrEMBL
  G3V9U9 ENTREZGENE
  Q63175 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary G3V9U9 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2010-05-05 Serinc5  serine incorporator 5  Tpo1  developmentally regulated protein TPO1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-07-08 Tpo1  developmentally regulated protein TPO1      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Tpo1  developmentally regulated protein TPO1      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_regulation induced during the differentiation of oligodendrocyte lineage cells and during brain development at the time of myelination 634407