RGD Reference Report - Serinc, an activity-regulated protein family, incorporates serine into membrane lipid synthesis. - Rat Genome Database

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Serinc, an activity-regulated protein family, incorporates serine into membrane lipid synthesis.

Authors: Inuzuka, M  Hayakawa, M  Ingi, T 
Citation: Inuzuka M, etal., J Biol Chem. 2005 Oct 21;280(42):35776-83. Epub 2005 Aug 24.
RGD ID: 8553290
Pubmed: PMID:16120614   (View Abstract at PubMed)
DOI: DOI:10.1074/jbc.M505712200   (Journal Full-text)

Cell membranes contain various transporter proteins, some of which are responsible for transferring amino acids across membrane. In this study, we report another class of carrier proteins, termed Serinc1-5, that incorporates a polar amino acid serine into membranes and facilitates the synthesis of two serine-derived lipids, phosphatidylserine and sphingolipids. Serinc is a unique protein family that shows no amino acid homology to other proteins but is highly conserved among eukaryotes. The members contain 11 transmembrane domains, and rat Serinc1 protein co-localizes with lipid biosynthetic enzymes in endoplasmic reticulum membranes. A Serinc protein forms an intracellular complex with key enzymes involved in serine and sphingolipid biosyntheses, and both functions, serine synthesis and membrane incorporation, are linked to each other. In the rat brain, expression of Serinc1 and Serinc2 mRNA was rapidly up-regulated by kainate-induced seizures in neuronal cell layers of the hippocampus. In contrast, myelin throughout the brain is enriched with Serinc5, which was down-regulated in the hippocampus by seizures. These results indicate a novel mechanism linking neural activity and lipid biosynthesis.




Biological Process

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Notes
Source
Original Reference(s)
Serinc1Ratmembrane biogenesis involved_inIDA PMID:16120614BHF-UCL 
Serinc1Ratphosphatidylserine metabolic process involved_inIDA PMID:16120614HGNC-UCL 
Serinc2Ratphosphatidylserine metabolic process involved_inIDA PMID:16120614HGNC-UCL 
Serinc5Ratphosphatidylserine metabolic process involved_inIDA PMID:16120614HGNC-UCL 
Serinc1Ratsphingolipid metabolic process involved_inIDA PMID:16120614HGNC-UCL 
Serinc2Ratsphingolipid metabolic process involved_inISSUniProtKB:Q7TNK0PMID:16120614HGNC-UCL 
Serinc5Ratsphingolipid metabolic process involved_inISSUniProtKB:Q7TNK0PMID:16120614HGNC-UCL 

Cellular Component

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Notes
Source
Original Reference(s)
Serinc1Ratendoplasmic reticulum membrane located_inIDA PMID:16120614HGNC-UCL 
Serinc2Ratendoplasmic reticulum membrane located_inISSUniProtKB:Q7TNK0PMID:16120614HGNC-UCL 
Serinc1Ratplasma membrane located_inIDA PMID:16120614HGNC-UCL 
Serinc2Ratplasma membrane located_inISSUniProtKB:Q7TNK0PMID:16120614HGNC-UCL 
Serinc5Ratplasma membrane located_inISSUniProtKB:Q7TNK0PMID:16120614HGNC-UCL 

Molecular Function

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Notes
Source
Original Reference(s)
Serinc1Ratacetyltransferase activator activity enablesIDA PMID:16120614HGNC-UCL 
Serinc2Ratacetyltransferase activator activity enablesIDA PMID:16120614HGNC-UCL 
Serinc5Ratacetyltransferase activator activity enablesIDA PMID:16120614HGNC-UCL 
Serinc1Ratenzyme binding enablesIPIUniProtKB:P40054PMID:16120614BHF-UCL 
Serinc1Ratenzyme binding enablesIPIUniProtKB:P38616PMID:16120614BHF-UCL 
Serinc1Ratprotein-macromolecule adaptor activity enablesIDA PMID:16120614BHF-UCL 


Genes (Rattus norvegicus)
Serinc1  (serine incorporator 1) Serinc2  (serine incorporator 2) Serinc5  (serine incorporator 5)

Gene Serinc3 serine incorporator 3 Rattus norvegicus