SERINC5 (serine incorporator 5) - Rat Genome Database

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Gene: SERINC5 (serine incorporator 5) Homo sapiens
Analyze
Symbol: SERINC5
Name: serine incorporator 5
RGD ID: 1604715
HGNC Page HGNC
Description: Predicted to enable L-serine transmembrane transporter activity. Involved in defense response to virus; detection of virus; and innate immune response. Located in several cellular components, including centrosome; cytosol; and plasma membrane; INTERACTS WITH (-)-demecolcine; 2,3,7,8-tetrachlorodibenzodioxine; 2-hydroxypropanoic acid.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: C5orf12; TPO1
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl580,111,651 - 80,256,048 (-)EnsemblGRCh38hg38GRCh38
GRCh38580,111,225 - 80,256,048 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37579,407,048 - 79,551,867 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36579,443,230 - 79,587,626 (-)NCBINCBI36hg18NCBI36
Celera575,308,393 - 75,453,225 (-)NCBI
Cytogenetic Map5q14.1NCBI
HuRef574,614,526 - 74,759,739 (-)NCBIHuRef
CHM1_1578,840,061 - 78,985,426 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

References

References - curated
1. RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:8889548   PMID:12477932   PMID:12688535   PMID:15637075   PMID:17672918   PMID:19056867   PMID:20379614   PMID:21873635   PMID:23979607   PMID:26416733   PMID:26416734   PMID:26439863  
PMID:27681140   PMID:28179429   PMID:28275190   PMID:28298427   PMID:28611215   PMID:28659343   PMID:29117863   PMID:29268082   PMID:29507755   PMID:30158294   PMID:31043528   PMID:31186327  
PMID:31597782   PMID:31852789   PMID:31907454   PMID:31935717   PMID:31941773   PMID:32441921   PMID:32493821   PMID:32541384   PMID:32590431   PMID:32788212   PMID:32796070   PMID:32835602  
PMID:32838948   PMID:32873704   PMID:33173092   PMID:33597208   PMID:34209034  


Genomics

Comparative Map Data
SERINC5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl580,111,651 - 80,256,048 (-)EnsemblGRCh38hg38GRCh38
GRCh38580,111,225 - 80,256,048 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37579,407,048 - 79,551,867 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36579,443,230 - 79,587,626 (-)NCBINCBI36hg18NCBI36
Celera575,308,393 - 75,453,225 (-)NCBI
Cytogenetic Map5q14.1NCBI
HuRef574,614,526 - 74,759,739 (-)NCBIHuRef
CHM1_1578,840,061 - 78,985,426 (-)NCBICHM1_1
Serinc5
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391392,747,646 - 92,848,455 (+)NCBIGRCm39mm39
GRCm39 Ensembl1392,747,599 - 92,848,455 (+)Ensembl
GRCm381392,611,138 - 92,711,947 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1392,611,091 - 92,711,947 (+)EnsemblGRCm38mm10GRCm38
MGSCv371393,381,093 - 93,481,902 (+)NCBIGRCm37mm9NCBIm37
MGSCv361393,711,891 - 93,812,700 (+)NCBImm8
Celera1396,219,502 - 96,315,704 (+)NCBICelera
Cytogenetic Map13C3NCBI
Serinc5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2223,846,899 - 23,950,346 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl223,846,900 - 23,950,346 (+)Ensembl
Rnor_6.0222,195,507 - 22,310,289 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl222,195,600 - 22,310,312 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0241,398,814 - 41,516,426 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4222,871,987 - 22,977,705 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1222,792,355 - 22,898,074 (+)NCBI
Celera219,936,153 - 20,037,869 (+)NCBICelera
Cytogenetic Map2q12NCBI
Serinc5
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541829,527,307 - 29,565,159 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541829,502,562 - 29,573,966 (+)NCBIChiLan1.0ChiLan1.0
SERINC5
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1535,332,193 - 35,449,905 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl535,332,187 - 35,475,016 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0535,059,291 - 35,204,987 (+)NCBIMhudiblu_PPA_v0panPan3
SERINC5
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1326,788,368 - 26,894,811 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl326,733,673 - 26,891,255 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha328,029,028 - 28,135,470 (+)NCBI
ROS_Cfam_1.0326,707,775 - 26,814,701 (+)NCBI
UMICH_Zoey_3.1326,647,886 - 26,754,545 (+)NCBI
UNSW_CanFamBas_1.0326,620,080 - 26,731,366 (+)NCBI
UU_Cfam_GSD_1.0326,902,941 - 27,005,575 (+)NCBI
Serinc5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213182,879,210 - 182,981,654 (+)NCBI
SpeTri2.0NW_0049365497,873,709 - 7,979,767 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SERINC5
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl288,843,003 - 89,046,029 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1288,843,003 - 88,992,077 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2290,636,261 - 90,694,041 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SERINC5
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1474,330,410 - 74,449,069 (-)NCBI
ChlSab1.1 Ensembl474,335,401 - 74,449,035 (-)Ensembl
Vero_WHO_p1.0NW_02366604923,177,767 - 23,297,414 (-)NCBI
Serinc5
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247431,239,698 - 1,308,735 (-)NCBI

Position Markers
RH68505  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37579,536,287 - 79,536,417UniSTSGRCh37
Build 36579,572,043 - 79,572,173RGDNCBI36
Celera575,437,619 - 75,437,749RGD
Cytogenetic Map5q14.1UniSTS
HuRef574,743,643 - 74,743,773UniSTS
GeneMap99-GB4 RH Map5380.12UniSTS
NCBI RH Map5415.6UniSTS
D5S2675  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37579,443,151 - 79,443,282UniSTSGRCh37
Build 36579,478,907 - 79,479,038RGDNCBI36
Celera575,344,521 - 75,344,652RGD
Cytogenetic Map5q14.1UniSTS
HuRef574,650,657 - 74,650,788UniSTS
RH68715  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37579,525,210 - 79,525,343UniSTSGRCh37
Build 36579,560,966 - 79,561,099RGDNCBI36
Celera575,426,544 - 75,426,677RGD
Cytogenetic Map5q14.1UniSTS
HuRef574,732,567 - 74,732,700UniSTS
GeneMap99-GB4 RH Map5379.9UniSTS
NCBI RH Map5414.6UniSTS
RH16321  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37579,535,331 - 79,535,497UniSTSGRCh37
Build 36579,571,087 - 79,571,253RGDNCBI36
Celera575,436,663 - 75,436,829RGD
Cytogenetic Map5q14.1UniSTS
HuRef574,742,687 - 74,742,853UniSTS
GeneMap99-GB4 RH Map5378.03UniSTS
NCBI RH Map5377.1UniSTS
L28256  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37579,491,606 - 79,491,848UniSTSGRCh37
Build 36579,527,362 - 79,527,604RGDNCBI36
Celera575,392,964 - 75,393,206RGD
Cytogenetic Map5q14.1UniSTS
HuRef574,699,020 - 74,699,262UniSTS
RH78501  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37579,434,831 - 79,434,997UniSTSGRCh37
Build 36579,470,587 - 79,470,753RGDNCBI36
Celera575,336,187 - 75,336,353RGD
Cytogenetic Map5q14.1UniSTS
HuRef574,642,323 - 74,642,489UniSTS
GeneMap99-GB4 RH Map5379.62UniSTS
NIB1185  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37579,434,831 - 79,434,994UniSTSGRCh37
Build 36579,470,587 - 79,470,750RGDNCBI36
Celera575,336,187 - 75,336,350RGD
Cytogenetic Map5q14.1UniSTS
HuRef574,642,323 - 74,642,486UniSTS
Stanford-G3 RH Map52979.0UniSTS
NCBI RH Map5403.3UniSTS
GeneMap99-G3 RH Map52974.0UniSTS
A006W30  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37579,435,881 - 79,436,089UniSTSGRCh37
GRCh371669,196,343 - 69,196,573UniSTSGRCh37
Build 36579,471,637 - 79,471,845RGDNCBI36
Celera1653,705,670 - 53,705,900UniSTS
Celera575,337,251 - 75,337,459RGD
Cytogenetic Map5q14.1UniSTS
HuRef1655,069,072 - 55,069,302UniSTS
HuRef574,643,387 - 74,643,595UniSTS
HuRef12124,124,319 - 124,124,545UniSTS
GeneMap99-GB4 RH Map5378.41UniSTS
NCBI RH Map5413.5UniSTS
D5S2485  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37579,454,876 - 79,455,078UniSTSGRCh37
Build 36579,490,632 - 79,490,834RGDNCBI36
Celera575,356,248 - 75,356,450RGD
Cytogenetic Map5q14.1UniSTS
HuRef574,662,384 - 74,662,586UniSTS
Whitehead-RH Map5279.1UniSTS
SHGC-35055  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37579,535,303 - 79,535,429UniSTSGRCh37
Build 36579,571,059 - 79,571,185RGDNCBI36
Celera575,436,635 - 75,436,761RGD
Cytogenetic Map5q14.1UniSTS
HuRef574,742,659 - 74,742,785UniSTS
GeneMap99-GB4 RH Map5379.62UniSTS
Whitehead-RH Map5279.9UniSTS
GeneMap99-G3 RH Map52632.0UniSTS
STS-T96036  
Human AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map5q14.1UniSTS
GeneMap99-GB4 RH Map5378.8UniSTS
D10S275  
Human AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map21q21.3UniSTS
Cytogenetic Map17q24.2UniSTS
Cytogenetic Map1q32.1UniSTS
Cytogenetic Map13q12.13UniSTS
Cytogenetic Map5q31.2UniSTS
Cytogenetic Map10q11.22UniSTS
Cytogenetic Map22q13.33UniSTS
Cytogenetic Map2p25.1UniSTS
Cytogenetic Map4q12UniSTS
Cytogenetic Map19p13.12UniSTS
Cytogenetic Map7p13UniSTS
Cytogenetic Map2q11.2UniSTS
Cytogenetic Map17q25.1UniSTS
Cytogenetic Map8q24.13UniSTS
Cytogenetic Map19q13.12UniSTS
Cytogenetic Map16q22.2UniSTS
Cytogenetic Map16q11.2UniSTS
Cytogenetic Map14q24.3UniSTS
Cytogenetic Map6q22UniSTS
Cytogenetic Map2q33.1UniSTS
Cytogenetic Map20q11UniSTS
Cytogenetic Map5q31.1UniSTS
Cytogenetic Map4q32.3UniSTS
Cytogenetic Map3p22.1UniSTS
Cytogenetic Map1p35.2UniSTS
Cytogenetic Map19q13.3UniSTS
Cytogenetic Map14q24UniSTS
Cytogenetic Map14q22-q24UniSTS
Cytogenetic Map1p21.2UniSTS
Cytogenetic Map12q24.31UniSTS
Cytogenetic Map14q11.2UniSTS
Cytogenetic Map20q13.31UniSTS
Cytogenetic Map19p13.3UniSTS
Cytogenetic Map5q35.3UniSTS
Cytogenetic Map1p36.13UniSTS
Cytogenetic Map4q35.1UniSTS
Cytogenetic MapXp11.3UniSTS
Cytogenetic Map16q24UniSTS
Cytogenetic Map16p13.3UniSTS
Cytogenetic Map16q12.1UniSTS
Cytogenetic Map1p36.1UniSTS
Cytogenetic Map22q12.3UniSTS
Cytogenetic Map6p21.33UniSTS
Cytogenetic Map10p11UniSTS
Cytogenetic Map1p13.1UniSTS
Cytogenetic Map7q22.1UniSTS
Cytogenetic Map19q13.32UniSTS
Cytogenetic Map7p22.2UniSTS
Cytogenetic MapXq22.1UniSTS
Cytogenetic Map16q21UniSTS
Cytogenetic Map1p36.31UniSTS
Cytogenetic Map3q12.3UniSTS
Cytogenetic Map6q24UniSTS
Cytogenetic Map3p21.31UniSTS
Cytogenetic Map9q13-q21UniSTS
Cytogenetic Map3p25UniSTS
Cytogenetic Map6p21.3UniSTS
Cytogenetic Map7q22.3UniSTS
Cytogenetic Map9q22UniSTS
Cytogenetic Map12q13.3UniSTS
Cytogenetic Map1q21-q23UniSTS
Cytogenetic Map5q23.3UniSTS
Cytogenetic Map20q13UniSTS
Cytogenetic Map1p35.1UniSTS
Cytogenetic Map1p32.3UniSTS
Cytogenetic Map21q22.13UniSTS
Cytogenetic Map19q13.2UniSTS
Cytogenetic Map19q13.43UniSTS
Cytogenetic Map22q13.2UniSTS
Cytogenetic MapXp22.2-p22.1UniSTS
Cytogenetic Map7q11.23UniSTS
Cytogenetic Map10q26.13UniSTS
Cytogenetic Map2q33.2UniSTS
Cytogenetic Map8q24.3UniSTS
Cytogenetic Map20pter-q11.23UniSTS
Cytogenetic Map4p16.3UniSTS
Cytogenetic Map10p12.1UniSTS
Cytogenetic Map10p12.3UniSTS
Cytogenetic Map12p13.3UniSTS
Cytogenetic Map3q27UniSTS
Cytogenetic Map17p13.2UniSTS
Cytogenetic Map1p34.2UniSTS
Cytogenetic Map21q22.3UniSTS
Cytogenetic Map2q14.3UniSTS
Cytogenetic Map3p14.1UniSTS
Cytogenetic Map3q26.3UniSTS
Cytogenetic Map1q21.3UniSTS
Cytogenetic Map14q32.31UniSTS
Cytogenetic Map17q22UniSTS
Cytogenetic Map2p16.1UniSTS
Cytogenetic Map3q27.1UniSTS
Cytogenetic Map22q13UniSTS
Cytogenetic Map11q22.3UniSTS
Cytogenetic Map9q21.13UniSTS
Cytogenetic Map16p11.2UniSTS
Cytogenetic Map10q24.31UniSTS
Cytogenetic Map9q22.31UniSTS
Cytogenetic Map15q21UniSTS
Cytogenetic Map17p13.1UniSTS
Cytogenetic Map15q25.2UniSTS
Cytogenetic Map12p12UniSTS
Cytogenetic Map3q13.31UniSTS
Cytogenetic Map5q23.2UniSTS
Cytogenetic Map22q11.2UniSTS
Cytogenetic Map1q24-q25.3UniSTS
Cytogenetic Map7p11UniSTS
Cytogenetic Map2q32.1UniSTS
Cytogenetic Map17q23.3UniSTS
Cytogenetic MapXq13-q21UniSTS
Cytogenetic Map6p24.3UniSTS
Cytogenetic Map11p15.4UniSTS
Cytogenetic Map1q21.2-q21.3UniSTS
Cytogenetic Map6q25.2-q27UniSTS
Cytogenetic Map11q23UniSTS
Cytogenetic Map9q34UniSTS
Cytogenetic Map12q24.32UniSTS
Cytogenetic MapXq13.1UniSTS
Cytogenetic Map10q11.21UniSTS
Cytogenetic Map14q32.3UniSTS
Cytogenetic Map13q12-q14UniSTS
Cytogenetic MapXp11.23UniSTS
Cytogenetic Map22q11.21UniSTS
Cytogenetic Map1p36.11UniSTS
Cytogenetic Map2p11.2UniSTS
Cytogenetic Map1q21.2UniSTS
Cytogenetic Map14q23.1UniSTS
Cytogenetic Map20q13.3UniSTS
Cytogenetic Map2q24.1UniSTS
Cytogenetic Map10q25.3UniSTS
Cytogenetic Map14q31UniSTS
Cytogenetic Map15q25.1UniSTS
Cytogenetic Map15q26.1UniSTS
Cytogenetic Map8p21.1UniSTS
Cytogenetic Map2p15UniSTS
Cytogenetic Map17q23.2UniSTS
Cytogenetic Map11p14.3UniSTS
Cytogenetic Map9q33.3UniSTS
Cytogenetic Map1p13.3UniSTS
Cytogenetic Map4q13UniSTS
Cytogenetic MapXq12UniSTS
Cytogenetic Map3p25.3UniSTS
Cytogenetic Map1p34.3UniSTS
Cytogenetic Map19q13.42UniSTS
Cytogenetic Map16q24.3UniSTS
Cytogenetic MapXp11.4UniSTS
Cytogenetic Map7q34UniSTS
Cytogenetic Map2p25.3UniSTS
Cytogenetic Map1q41UniSTS
Cytogenetic Map5q14.1UniSTS
Cytogenetic Map15q15.2UniSTS
Cytogenetic Map12p11.21UniSTS
Cytogenetic Map5p13.1UniSTS
Cytogenetic Map7q31.3UniSTS
Cytogenetic Map2q35UniSTS
Cytogenetic Map16q23.1UniSTS
Cytogenetic Map12q13.13UniSTS
Cytogenetic Map1p21UniSTS
Cytogenetic MapXq24UniSTS
Cytogenetic Map7p14.2UniSTS
Cytogenetic Map6q24.3UniSTS
Cytogenetic Map22q13.31UniSTS
Cytogenetic Map9p24.3UniSTS
Cytogenetic Map6q12-q13UniSTS
Cytogenetic Map19q13UniSTS
Cytogenetic Map9q31-q33UniSTS
Cytogenetic Map9q34.1UniSTS
Cytogenetic Map17p11.2UniSTS
Cytogenetic Map14q32UniSTS
Cytogenetic Map3p14.3UniSTS
Cytogenetic Map8p11.21UniSTS
Cytogenetic Map16p12.3UniSTS
Cytogenetic Map9q31.3UniSTS
Cytogenetic Map9p13.2UniSTS
Cytogenetic Map5q13.2UniSTS
Cytogenetic Map18q23UniSTS
Cytogenetic Map8p22UniSTS
Cytogenetic Map17p13UniSTS
Cytogenetic Map19p12UniSTS
Cytogenetic Map8p21.2UniSTS
Cytogenetic Map12q13.11UniSTS
Cytogenetic Map1q32.3UniSTS
Cytogenetic Map1p33UniSTS
Cytogenetic Map19q13.31UniSTS
Cytogenetic Map6p21UniSTS
Cytogenetic Map17q21.31UniSTS
Cytogenetic Map3p22.2UniSTS
Cytogenetic Map17q12UniSTS
Cytogenetic MapXp21.1UniSTS
Cytogenetic Map12q13UniSTS
Cytogenetic Map11q13.2UniSTS
Cytogenetic Map11p15.1UniSTS
Cytogenetic Map1q43UniSTS
Cytogenetic Map19p13.2UniSTS
Cytogenetic Map15q21.2UniSTS
Cytogenetic Map9q22.2UniSTS
Cytogenetic MapXp22UniSTS
Cytogenetic Map13q14UniSTS
Cytogenetic Map3p21.3UniSTS
Cytogenetic Map7q22UniSTS
Cytogenetic Map2p22UniSTS
Cytogenetic Map11q13.1UniSTS
Cytogenetic Map3p25.2UniSTS
Cytogenetic Map14q22.3UniSTS
Cytogenetic Map2p14UniSTS
SHGC-33799  
Human AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map5q14.1UniSTS
TNG Radiation Hybrid Map48388.0UniSTS
Stanford-G3 RH Map4888.0UniSTS
NCBI RH Map4118.7UniSTS
GeneMap99-G3 RH Map4872.0UniSTS

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1228
Count of miRNA genes:699
Interacting mature miRNAs:787
Transcripts:ENST00000502747, ENST00000507668, ENST00000509193, ENST00000512721, ENST00000512972, ENST00000513907
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component pharyngeal arch
High
Medium 731 129 882 431 349 294 2358 53 1627 81 1184 973 152 1 509 1325 5 2
Low 1708 2845 841 193 1578 171 1988 2131 2107 307 274 633 23 695 1452 1
Below cutoff 17 3 24 11 13 30 2 7 11

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001174071 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001174072 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_178276 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_126060 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_126061 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011543304 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017009323 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017009324 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017009326 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_024446013 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC010260 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC012636 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF498273 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK026295 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK297467 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC101280 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC101281 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC101282 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC101283 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BU681476 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471084 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CR936687 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DC354040 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KF457934 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KF510917 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KF510918 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KF510925 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KF510928 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000502747
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl580,156,994 - 80,167,180 (-)Ensembl
RefSeq Acc Id: ENST00000507668   ⟹   ENSP00000426237
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl580,138,727 - 80,256,048 (-)Ensembl
RefSeq Acc Id: ENST00000509193   ⟹   ENSP00000426134
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl580,111,651 - 80,256,019 (-)Ensembl
RefSeq Acc Id: ENST00000512972   ⟹   ENSP00000421665
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl580,111,651 - 80,256,019 (-)Ensembl
RefSeq Acc Id: ENST00000513907
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl580,177,315 - 80,255,198 (-)Ensembl
RefSeq Acc Id: ENST00000632581   ⟹   ENSP00000488864
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl580,111,651 - 80,256,019 (-)Ensembl
RefSeq Acc Id: NM_001174071   ⟹   NP_001167542
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38580,111,225 - 80,256,048 (-)NCBI
GRCh37579,407,050 - 79,551,898 (-)RGD
Celera575,308,393 - 75,453,225 (-)RGD
HuRef574,614,526 - 74,759,739 (-)RGD
CHM1_1578,840,061 - 78,985,429 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001174072   ⟹   NP_001167543
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38580,138,727 - 80,256,048 (-)NCBI
GRCh37579,407,050 - 79,551,898 (-)RGD
Celera575,308,393 - 75,453,225 (-)RGD
HuRef574,614,526 - 74,759,739 (-)RGD
CHM1_1578,867,549 - 78,985,429 (-)NCBI
Sequence:
RefSeq Acc Id: NM_178276   ⟹   NP_840060
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38580,111,225 - 80,256,048 (-)NCBI
GRCh37579,407,050 - 79,551,898 (-)RGD
Build 36579,443,230 - 79,587,626 (-)NCBI Archive
Celera575,308,393 - 75,453,225 (-)RGD
HuRef574,614,526 - 74,759,739 (-)RGD
CHM1_1578,840,061 - 78,985,429 (-)NCBI
Sequence:
RefSeq Acc Id: NR_126060
RefSeq Status: VALIDATED
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38580,111,225 - 80,256,048 (-)NCBI
CHM1_1578,840,061 - 78,985,429 (-)NCBI
Sequence:
RefSeq Acc Id: NR_126061
RefSeq Status: VALIDATED
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38580,111,225 - 80,256,048 (-)NCBI
CHM1_1578,840,061 - 78,985,429 (-)NCBI
Sequence:
RefSeq Acc Id: XM_011543304   ⟹   XP_011541606
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38580,138,727 - 80,256,047 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017009323   ⟹   XP_016864812
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38580,138,727 - 80,205,358 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017009324   ⟹   XP_016864813
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38580,138,727 - 80,205,358 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017009326   ⟹   XP_016864815
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38580,138,727 - 80,205,355 (-)NCBI
Sequence:
RefSeq Acc Id: XM_024446013   ⟹   XP_024301781
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38580,138,727 - 80,205,360 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_840060   ⟸   NM_178276
- Peptide Label: isoform 2
- UniProtKB: Q86VE9 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001167542   ⟸   NM_001174071
- Peptide Label: isoform 3
- UniProtKB: Q86VE9 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001167543   ⟸   NM_001174072
- Peptide Label: isoform 1
- UniProtKB: Q86VE9 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_011541606   ⟸   XM_011543304
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_016864812   ⟸   XM_017009323
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_016864813   ⟸   XM_017009324
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_016864815   ⟸   XM_017009326
- Peptide Label: isoform X4
- Sequence:
RefSeq Acc Id: XP_024301781   ⟸   XM_024446013
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: ENSP00000426237   ⟸   ENST00000507668
RefSeq Acc Id: ENSP00000426134   ⟸   ENST00000509193
RefSeq Acc Id: ENSP00000421665   ⟸   ENST00000512972
RefSeq Acc Id: ENSP00000488864   ⟸   ENST00000632581

Promoters
RGD ID:6803537
Promoter ID:HG_KWN:50561
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   CD4+TCell_2Hour,   HeLa_S3,   Jurkat,   K562,   Lymphoblastoid,   NB4
Transcripts:NM_001174071,   NM_001174072,   NM_178276,   UC003KGK.2,   UC003KGL.2
Position:
Human AssemblyChrPosition (strand)Source
Build 36579,587,456 - 79,587,956 (-)MPROMDB
RGD ID:6869996
Promoter ID:EPDNEW_H8163
Type:initiation region
Name:SERINC5_1
Description:serine incorporator 5
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh38580,256,046 - 80,256,106EPDNEW

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 5q13.3-22.1(chr5:74163186-110809453)x3 copy number gain See cases [RCV000051839] Chr5:74163186..110809453 [GRCh38]
Chr5:73459011..110145153 [GRCh37]
Chr5:73494767..110173052 [NCBI36]
Chr5:5q13.3-22.1
pathogenic
GRCh38/hg38 5q14.1(chr5:79665668-81197686)x1 copy number loss See cases [RCV000052576] Chr5:79665668..81197686 [GRCh38]
Chr5:78961491..80493505 [GRCh37]
Chr5:78997247..80529261 [NCBI36]
Chr5:5q14.1
uncertain significance
GRCh37/hg19 5p15.1-q35.2(chr5:17628741-176575720)x1 copy number loss See cases [RCV000511978] Chr5:17628741..176575720 [GRCh37]
Chr5:5p15.1-q35.2
pathogenic
GRCh37/hg19 5p15.33-q35.3(chr5:113577-180719789)x3 copy number gain See cases [RCV000512039] Chr5:113577..180719789 [GRCh37]
Chr5:5p15.33-q35.3
pathogenic
GRCh37/hg19 5p15.33-q35.3(chr5:113577-180719789) copy number gain See cases [RCV000510723] Chr5:113577..180719789 [GRCh37]
Chr5:5p15.33-q35.3
pathogenic
GRCh37/hg19 5p15.33-q35.3(chr5:25328-180693344)x3 copy number gain not provided [RCV000744323] Chr5:25328..180693344 [GRCh37]
Chr5:5p15.33-q35.3
pathogenic
GRCh37/hg19 5p15.33-q35.3(chr5:13648-180905029)x3 copy number gain not provided [RCV000744317] Chr5:13648..180905029 [GRCh37]
Chr5:5p15.33-q35.3
pathogenic
GRCh37/hg19 5q14.1(chr5:79388745-79423347)x3 copy number gain not provided [RCV000744887] Chr5:79388745..79423347 [GRCh37]
Chr5:5q14.1
benign
Single allele deletion Neurodevelopmental disorder [RCV000787436] Chr5:14685137..149511942 [GRCh37]
Chr5:5p15.2-q32
uncertain significance
NM_001174072.3(SERINC5):c.375-14dup duplication not provided [RCV000946853] Chr5:80177405..80177406 [GRCh38]
Chr5:79473227..79473228 [GRCh37]
Chr5:5q14.1
benign
GRCh37/hg19 5q13.2-15(chr5:72790061-97478870)x3 copy number gain not provided [RCV001005683] Chr5:72790061..97478870 [GRCh37]
Chr5:5q13.2-15
pathogenic
NM_001174072.3(SERINC5):c.882T>C (p.Asn294=) single nucleotide variant not provided [RCV000879682] Chr5:80158940 [GRCh38]
Chr5:79454763 [GRCh37]
Chr5:5q14.1
benign
NM_001174072.3(SERINC5):c.1221C>T (p.Thr407=) single nucleotide variant not provided [RCV000974202] Chr5:80146107 [GRCh38]
Chr5:79441930 [GRCh37]
Chr5:5q14.1
benign
NM_001174072.3(SERINC5):c.637T>C (p.Leu213=) single nucleotide variant not provided [RCV000964130] Chr5:80169461 [GRCh38]
Chr5:79465284 [GRCh37]
Chr5:5q14.1
benign
GRCh37/hg19 5q14.1(chr5:79528733-80545287)x3 copy number gain not provided [RCV001005691] Chr5:79528733..80545287 [GRCh37]
Chr5:5q14.1
uncertain significance

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:18825 AgrOrtholog
COSMIC SERINC5 COSMIC
Ensembl Genes ENSG00000164300 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSP00000421665 UniProtKB/Swiss-Prot
  ENSP00000426134 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000426237 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000488864 UniProtKB/TrEMBL
Ensembl Transcript ENST00000507668 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000509193 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000512972 UniProtKB/Swiss-Prot
  ENST00000632581 UniProtKB/TrEMBL
GTEx ENSG00000164300 GTEx
HGNC ID HGNC:18825 ENTREZGENE
Human Proteome Map SERINC5 Human Proteome Map
InterPro Serinc5 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TDE1/TMS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:256987 UniProtKB/Swiss-Prot
NCBI Gene 256987 ENTREZGENE
OMIM 614551 OMIM
PANTHER PTHR10383 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR10383:SF16 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Serinc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA38698 PharmGKB
UniProt A0A0J9YYI4_HUMAN UniProtKB/TrEMBL
  Q86VE9 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary B4DMH7 UniProtKB/Swiss-Prot
  Q495A4 UniProtKB/Swiss-Prot
  Q495A6 UniProtKB/Swiss-Prot