Sdha (succinate dehydrogenase complex flavoprotein subunit A) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Gene: Sdha (succinate dehydrogenase complex flavoprotein subunit A) Rattus norvegicus
Analyze
Symbol: Sdha
Name: succinate dehydrogenase complex flavoprotein subunit A
RGD ID: 621557
Description: Enables succinate dehydrogenase (quinone) activity. Involved in respiratory electron transport chain and succinate metabolic process. Located in mitochondrial inner membrane. Human ortholog(s) of this gene implicated in Leigh disease; dilated cardiomyopathy 1GG; lung non-small cell carcinoma; mitochondrial complex II deficiency; and paraganglioma. Orthologous to human SDHA (succinate dehydrogenase complex flavoprotein subunit A); PARTICIPATES IN citric acid cycle pathway; electron transport chain pathway; fumaric aciduria pathway; INTERACTS WITH (+)-schisandrin B; 1,2,4-trimethylbenzene; 1,2-dimethylhydrazine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: flavoprotein subunit of complex II; fp; succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial; succinate dehydrogenase complex, subunit A, flavoprotein (Fp)
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8130,764,553 - 30,789,523 (+)NCBIGRCr8
mRatBN7.2128,935,965 - 28,960,936 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl128,940,164 - 28,961,535 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx128,737,137 - 28,762,259 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0134,736,999 - 34,762,123 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0128,937,767 - 28,962,889 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0131,545,631 - 31,570,601 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl131,545,631 - 31,570,601 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0132,971,779 - 32,996,749 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4129,739,359 - 29,764,329 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1129,742,303 - 29,767,274 (+)NCBI
Celera127,587,801 - 27,612,771 (+)NCBICelera
Cytogenetic Map1p11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(R)-pantothenic acid  (ISO)
1,1-dichloroethene  (ISO)
1,2,4-trimethylbenzene  (EXP)
1,2-dimethylhydrazine  (EXP,ISO)
1,3-dinitrobenzene  (EXP)
1-chloro-2,4-dinitrobenzene  (ISO)
2,2,2-tetramine  (EXP)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
3-bromopyruvic acid  (ISO)
3-chloropropane-1,2-diol  (EXP,ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
5-fluorouracil  (ISO)
6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide  (ISO)
acetamide  (EXP)
acrolein  (ISO)
acrylamide  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
alloxan  (EXP)
alpha-pinene  (ISO)
ammonium chloride  (EXP)
apigenin  (EXP)
Aroclor 1254  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
atrazine  (EXP,ISO)
benzo[a]pyrene  (ISO)
benzo[e]pyrene  (ISO)
biotin  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
chlorpyrifos  (ISO)
choline  (ISO)
chromium(6+)  (ISO)
cisplatin  (ISO)
clobetasol  (ISO)
clofibric acid  (EXP)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) sulfate  (ISO)
curcumin  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (ISO)
Diosbulbin B  (ISO)
doxorubicin  (ISO)
enzyme inhibitor  (ISO)
epoxiconazole  (ISO)
ethanol  (ISO)
flavonoids  (EXP)
folic acid  (ISO)
genistein  (ISO)
gentamycin  (EXP)
glyphosate  (ISO)
indometacin  (EXP,ISO)
isoniazide  (ISO)
ivermectin  (ISO)
L-ascorbic acid  (ISO)
L-methionine  (ISO)
lipopolysaccharide  (ISO)
manganese(II) chloride  (EXP)
methapyrilene  (ISO)
methidathion  (ISO)
methyl methanesulfonate  (ISO)
miconazole  (ISO)
morphine  (EXP)
N-methyl-4-phenylpyridinium  (ISO)
N-nitrosomorpholine  (EXP)
naphthalene  (ISO)
obeticholic acid  (ISO)
ochratoxin A  (ISO)
oxybenzone  (EXP)
ozone  (ISO)
paracetamol  (EXP,ISO)
PCB138  (EXP)
perfluorooctanoic acid  (ISO)
phlorizin  (ISO)
propiconazole  (ISO)
Propiverine  (EXP)
Pseudolaric acid B  (ISO)
pyrogallol  (ISO)
pyrroloquinoline quinone  (ISO)
quercetin  (ISO)
quinoxyfen  (ISO)
rac-1,2-dichloropropane  (ISO)
radon atom  (ISO)
radon(0)  (ISO)
resveratrol  (ISO)
rotenone  (EXP,ISO)
sodium arsenate  (ISO)
sodium arsenite  (EXP,ISO)
sodium fluoride  (ISO)
streptozocin  (EXP)
sunitinib  (ISO)
T-2 toxin  (EXP)
taurine  (ISO)
tetrachloromethane  (EXP,ISO)
thapsigargin  (ISO)
thioacetamide  (EXP)
thyroxine  (ISO)
tofacitinib  (ISO)
tolcapone  (EXP)
toluene  (EXP)
trichloroacetic acid  (EXP)
trichloroethene  (EXP)
triclosan  (ISO)
troglitazone  (EXP)
tunicamycin  (ISO)
vorinostat  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Mutation of a nuclear succinate dehydrogenase gene results in mitochondrial respiratory chain deficiency. Bourgeron T, etal., Nat Genet 1995 Oct;11(2):144-9.
2. Succinate dehydrogenase deficiency in human. Briere JJ, etal., Cell Mol Life Sci. 2005 Oct;62(19-20):2317-24.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. Mitochondrial DNA Depletion in Respiratory Chain-Deficient Parkinson Disease Neurons. Grünewald A, etal., Ann Neurol. 2016 Mar;79(3):366-78. doi: 10.1002/ana.24571. Epub 2016 Jan 28.
6. Genetic variants in genes of tricarboxylic acid cycle key enzymes are associated with prognosis of patients with non-small cell lung cancer. Guo X, etal., Lung Cancer. 2015 Feb;87(2):162-8. doi: 10.1016/j.lungcan.2014.12.005. Epub 2014 Dec 18.
7. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
8. Decreased complex II respiration and HNE-modified SDH subunit in diabetic heart. Lashin OM, etal., Free Radic Biol Med. 2006 Mar 1;40(5):886-96. Epub 2005 Nov 2.
9. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
10. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
11. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
12. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
13. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
14. GOA pipeline RGD automated data pipeline
15. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
16. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
17. Comprehensive gene review and curation RGD comprehensive gene curation
18. Information Derived from GenBank Report RGD, Sept. 2003
19. Assembly of mammalian oxidative phosphorylation complexes I-V and supercomplexes. Signes A and Fernandez-Vizarra E, Essays Biochem. 2018 Jul 20;62(3):255-270. doi: 10.1042/EBC20170098. Print 2018 Jul 20.
20. Intraabdominal adhesion formation is associated with differential mRNA expression of metabolic genes PDHb and SDHa. Wallwiener M, etal., Arch Gynecol Obstet. 2012 Sep;286(3):683-6. doi: 10.1007/s00404-012-2364-9. Epub 2012 May 9.
Additional References at PubMed
PMID:12865426   PMID:14651853   PMID:15989954   PMID:16120479   PMID:16361598   PMID:16751257   PMID:16826196   PMID:17480203   PMID:17634366   PMID:18252725   PMID:18614015   PMID:19723079  
PMID:19808025   PMID:19837698   PMID:21700703   PMID:23602810   PMID:24781757   PMID:25483313   PMID:26316108   PMID:31904090   PMID:32357304   PMID:36005845  


Genomics

Comparative Map Data
Sdha
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8130,764,553 - 30,789,523 (+)NCBIGRCr8
mRatBN7.2128,935,965 - 28,960,936 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl128,940,164 - 28,961,535 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx128,737,137 - 28,762,259 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0134,736,999 - 34,762,123 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0128,937,767 - 28,962,889 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0131,545,631 - 31,570,601 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl131,545,631 - 31,570,601 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0132,971,779 - 32,996,749 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4129,739,359 - 29,764,329 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1129,742,303 - 29,767,274 (+)NCBI
Celera127,587,801 - 27,612,771 (+)NCBICelera
Cytogenetic Map1p11NCBI
SDHA
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385218,320 - 268,746 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl5218,303 - 257,082 (+)EnsemblGRCh38hg38GRCh38
GRCh375218,435 - 257,197 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 365271,356 - 309,815 (+)NCBINCBI36Build 36hg18NCBI36
Build 345271,446 - 309,792NCBI
Celera5317,918 - 356,377 (+)NCBICelera
Cytogenetic Map5p15.33NCBI
HuRef5208,246 - 246,713 (+)NCBIHuRef
CHM1_15215,731 - 254,186 (+)NCBICHM1_1
T2T-CHM13v2.05209,363 - 254,841 (+)NCBIT2T-CHM13v2.0
Sdha
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391374,470,374 - 74,498,359 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1374,470,373 - 74,498,399 (-)EnsemblGRCm39 Ensembl
GRCm381374,322,255 - 74,350,240 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1374,322,254 - 74,350,280 (-)EnsemblGRCm38mm10GRCm38
MGSCv371374,459,703 - 74,487,688 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361374,788,257 - 74,816,242 (-)NCBIMGSCv36mm8
Celera1376,651,719 - 76,679,576 (-)NCBICelera
Cytogenetic Map13C1NCBI
cM Map1340.15NCBI
Sdha
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495550436,911 - 70,494 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495550436,939 - 66,507 (+)NCBIChiLan1.0ChiLan1.0
SDHA
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v24434,053 - 476,070 (+)NCBINHGRI_mPanPan1-v2
SDHA
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13411,935,684 - 11,965,094 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3411,935,941 - 11,965,189 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3416,448,897 - 16,478,318 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03411,837,397 - 11,866,790 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3411,835,625 - 11,866,867 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13411,890,237 - 11,900,823 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03411,876,342 - 11,905,771 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03412,078,358 - 12,107,796 (-)NCBIUU_Cfam_GSD_1.0
Sdha
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213244,987,678 - 245,006,149 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049368151,148,963 - 1,167,568 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049368151,148,963 - 1,167,585 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SDHA
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1679,834,044 - 79,862,524 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11679,838,442 - 79,862,956 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
SDHA
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.14163,726 - 190,145 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366605435,952,891 - 35,986,376 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Sdha
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475154,779 - 90,447 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475154,778 - 90,457 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Sdha
114 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:27
Count of miRNA genes:27
Interacting mature miRNAs:27
Transcripts:ENSRNOT00000018336
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2313053Bss51Bone structure and strength QTL 513.80.0001tibia length (VT:0004357)tibia length (CMO:0000450)1132356093Rat
2313070Bss52Bone structure and strength QTL 524.40.0001body length (VT:0001256)body length (CMO:0000013)1132356093Rat
2313090Bmd69Bone mineral density QTL 694.40.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)1132356093Rat
738020Pia8Pristane induced arthritis QTL 84.7joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1165833076Rat
1578650Bmd6Bone mineral density QTL 612.2femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)150910843284926Rat
1578651Bmd7Bone mineral density QTL 714.2femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)150910843284926Rat
1578669Bss9Bone structure and strength QTL 96.3femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)150910843284926Rat
1554320Bmd1Bone mineral density QTL 112.20.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)150910886060548Rat
1600360Mcs16Mammary carcinoma susceptibility QTL 162.4mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1224439043433040Rat
7421626Bp360Blood pressure QTL 3600.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1439328949393289Rat
631688Hcas2Hepatocarcinoma susceptibility QTL 230.0001liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)15925874115540829Rat
631508Sald1Serum aldosterone level QTL 13.7blood aldosterone amount (VT:0005346)serum aldosterone level (CMO:0000487)1985600154856001Rat
2302038Pia31Pristane induced arthritis QTL 315.50.001blood autoantibody amount (VT:0003725)serum immunoglobulin M-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002111)11099206555992065Rat
1300167Hrtrt2Heart rate QTL 24.35heart pumping trait (VT:2000009)heart rate (CMO:0000002)11148131275088344Rat
2313062Bmd73Bone mineral density QTL 733.90.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)11148131282174945Rat
2313065Bss67Bone structure and strength QTL 673.10.0001tibia area (VT:1000281)tibia total energy absorbed before break (CMO:0001736)11148131282174945Rat
2313069Bss68Bone structure and strength QTL 682.90.0001tibia size trait (VT:0100001)tibia total energy absorbed before break (CMO:0001736)11148131282174945Rat
2313075Bss66Bone structure and strength QTL 663.40.0001tibia length (VT:0004357)tibia length (CMO:0000450)11148131282174945Rat
2313077Bss69Bone structure and strength QTL 693.50.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)11148131282174945Rat
2313092Bmd72Bone mineral density QTL 722.50.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)11148131282174945Rat
2313097Bss70Bone structure and strength QTL 703.50.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)11148131282174945Rat
2317755Glom22Glomerulus QTL 223.8urine protein amount (VT:0005160)urine protein level (CMO:0000591)11148148232355910Rat
1578756Iddm22Insulin dependent diabetes mellitus QTL 222.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)11183518156835181Rat
5684998Bss101Bone structure and strength QTL 1013.6tibia strength trait (VT:1000284)tibia ultimate force (CMO:0001734)11543162149361612Rat
5684999Bss102Bone structure and strength QTL 1025.50.00000072tibia strength trait (VT:1000284)tibia stiffness (CMO:0001735)11543162149361612Rat
631494Bp95Blood pressure QTL 95400.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)11620621049268520Rat
634353Rends2Renal damage susceptibility QTL 20.05kidney blood vessel morphology trait (VT:0000530)organ lesion measurement (CMO:0000677)11933357156983283Rat
1558642Prcr2Prostate cancer resistance QTL 24.3prostate integrity trait (VT:0010571)area of ventral prostate occupied by tumorous lesions to total ventral prostate area ratio (CMO:0000899)12076315844095856Rat
724520Bp145Blood pressure QTL 1452.10.0024arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)12078482865784828Rat
1357397Bw41Body weight QTL 414.190.0001body mass (VT:0001259)body weight (CMO:0000012)12234064749361612Rat
1357401Bw43Body weight QTL 433.75body mass (VT:0001259)body weight (CMO:0000012)12234064749361612Rat
1357400Bw62Body weight QTL624.05inguinal fat pad mass (VT:0010424)inguinal fat pad weight to body weight ratio (CMO:0001253)12234064767340647Rat
631495Bp96Blood pressure QTL 964.52arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)122340647102268831Rat
1331785Rf27Renal function QTL 274.643urine sodium amount (VT:0006274)urine sodium level (CMO:0000129)12887978078430678Rat

Markers in Region
RH134400  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2128,961,194 - 28,961,380 (+)MAPPERmRatBN7.2
Rnor_6.0131,570,860 - 31,571,045NCBIRnor6.0
Rnor_5.0132,997,008 - 32,997,193UniSTSRnor5.0
RGSC_v3.4129,764,588 - 29,764,773UniSTSRGSC3.4
Celera127,613,030 - 27,613,215UniSTS
RH 3.4 Map1315.51UniSTS
Cytogenetic Map1p11UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 43 57 41 19 41 8 11 74 35 41 11 8
Low
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000018336   ⟹   ENSRNOP00000018336
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl128,940,164 - 28,961,535 (+)Ensembl
Rnor_6.0 Ensembl131,545,631 - 31,570,601 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000114225   ⟹   ENSRNOP00000078837
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl128,940,698 - 28,961,535 (+)Ensembl
RefSeq Acc Id: NM_130428   ⟹   NP_569112
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8130,764,553 - 30,789,523 (+)NCBI
mRatBN7.2128,935,965 - 28,960,936 (+)NCBI
Rnor_6.0131,545,631 - 31,570,601 (+)NCBI
Rnor_5.0132,971,779 - 32,996,749 (+)NCBI
RGSC_v3.4129,739,359 - 29,764,329 (+)RGD
Celera127,587,801 - 27,612,771 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_569112 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein ABD77309 (Get FASTA)   NCBI Sequence Viewer  
  BAB69818 (Get FASTA)   NCBI Sequence Viewer  
  EDL87684 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000018336
  ENSRNOP00000018336.4
  ENSRNOP00000078837.1
GenBank Protein Q920L2 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: NP_569112   ⟸   NM_130428
- Peptide Label: precursor
- UniProtKB: Q920L2 (UniProtKB/Swiss-Prot),   A6JUU5 (UniProtKB/TrEMBL),   A0A8L2Q9A7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000018336   ⟸   ENSRNOT00000018336
RefSeq Acc Id: ENSRNOP00000078837   ⟸   ENSRNOT00000114225
Protein Domains
FAD-dependent oxidoreductase 2 FAD binding   Fumarate reductase/succinate dehydrogenase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q920L2-F1-model_v2 AlphaFold Q920L2 1-656 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13689554
Promoter ID:EPDNEW_R79
Type:multiple initiation site
Name:Sdha_1
Description:succinate dehydrogenase complex flavoprotein subunit A
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0131,545,640 - 31,545,700EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621557 AgrOrtholog
BioCyc Gene G2FUF-61946 BioCyc
BioCyc Pathway PWY-3781 [aerobic respiration I (cytochrome c)] BioCyc
  PWY-7279 [aerobic respiration II (cytochrome c) (yeast)] BioCyc
BioCyc Pathway Image PWY-3781 BioCyc
  PWY-7279 BioCyc
Ensembl Genes ENSRNOG00000013331 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000018336 ENTREZGENE
  ENSRNOT00000018336.5 UniProtKB/TrEMBL
  ENSRNOT00000114225.1 UniProtKB/TrEMBL
Gene3D-CATH 3.50.50.60 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.90.700.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Fumarate reductase/succinate dehydrogenase flavoprotein-like, C-terminal domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  succinate dehydrogenase protein domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro FAD-binding_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FAD/NAD-bd_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FRD_SDH_FAD_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Fum_R/Succ_DH_flav-like_C_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Fum_Rdtase/Succ_DH_flav-like_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SdhA/FrdA/AprA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Succ_DH/fumarate_Rdtase_cat_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Succ_DH_flav_su_fwd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Succ_Dhase_FrdA_Gneg UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:157074 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 157074 ENTREZGENE
PANTHER PTHR11632 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SUCCINATE DEHYDROGENASE [UBIQUINONE] FLAVOPROTEIN SUBUNIT, MITOCHONDRIAL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam FAD_binding_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Succ_DH_flav_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Sdha PhenoGen
PIRSF SDHA_APRA_LASPO UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE FRD_SDH_FAD_BINDING UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000013331 RatGTEx
Superfamily-SCOP SSF46977 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF51905 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF56425 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I5ZLT7_RAT UniProtKB/TrEMBL
  A0A8L2Q9A7 ENTREZGENE, UniProtKB/TrEMBL
  A6JUU5 ENTREZGENE, UniProtKB/TrEMBL
  Q0QF18_RAT UniProtKB/TrEMBL
  Q920L2 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-03 Sdha  succinate dehydrogenase complex flavoprotein subunit A  Sdha  succinate dehydrogenase complex, subunit A, flavoprotein (Fp)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-02-26 Sdha  succinate dehydrogenase complex, subunit A, flavoprotein (Fp)      Symbol and Name status set to approved 625702 APPROVED
2002-08-07 Sdha  succinate dehydrogenase complex, subunit A, flavoprotein (Fp)      Symbol and Name status set to provisional 70820 PROVISIONAL