Clpb (ClpB family mitochondrial disaggregase)

Gene: Clpb (ClpB family mitochondrial disaggregase) Rattus norvegicus

Analyze

Symbol:

Clpb

Name:

ClpB family mitochondrial disaggregase (Ensembl:caseinolytic mitochondrial matrix peptidase chaperone subunit B)

RGD ID:

621328

Description:

Predicted to enable ATP hydrolysis activity and ATP-dependent protein disaggregase activity. Predicted to be involved in several processes, including RIG-I signaling pathway; antiviral innate immune response; and granulocyte differentiation. Predicted to be located in mitochondrial intermembrane space. Predicted to be active in mitochondrion. Human ortholog(s) of this gene implicated in 3-methylglutaconic aciduria type 7a; 3-methylglutaconic aciduria type 7b; and severe congenital neutropenia. Orthologous to human CLPB (ClpB family mitochondrial disaggregase); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran; 2,4-dinitrotoluene.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

caseinolytic mitochondrial matrix peptidase chaperone subunit B; caseinolytic peptidase B protein homolog; ClpB caseinolytic peptidase B homolog; ClpB caseinolytic peptidase B homolog (E. coli); ClpB homolog, mitochondrial AAA ATPase chaperonin; mitochondrial disaggregase; Skd3; suppressor of K+ transport defect 3; suppressor of potassium transport defect 3

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	CLPB (ClpB family mitochondrial disaggregase)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, Treefam
Mus musculus (house mouse):	Clpb (ClpB caseinolytic peptidase B)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Clpb (ClpB family mitochondrial disaggregase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	CLPB (ClpB family mitochondrial disaggregase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	CLPB (ClpB family mitochondrial disaggregase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Clpb (ClpB family mitochondrial disaggregase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	CLPB (ClpB family mitochondrial disaggregase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	CLPB (ClpB family mitochondrial disaggregase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Clpb (ClpB family mitochondrial disaggregase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	DHRS7B (dehydrogenase/reductase 7B)	HGNC	OMA
Alliance orthologs ³
Homo sapiens (human):	CLPB (ClpB family mitochondrial disaggregase)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Clpb (ClpB caseinolytic peptidase B)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	HSP78	Alliance	DIOPT (Ensembl Compara\|OrthoInspector\|PANTHER\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	HSP104	Alliance	DIOPT (OrthoInspector\|PANTHER\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	clpb	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoFinder\|PANTHER\|PhylomeDB)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	1	165,440,705 - 165,563,514 (+)	NCBI		GRCr8
mRatBN7.2	1	156,028,740 - 156,158,183 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	1	156,028,930 - 156,168,788 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	1	164,019,285 - 164,141,861 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	1	171,199,372 - 171,321,950 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	1	164,077,596 - 164,199,818 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	1	166,739,372 - 166,866,095 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	1	166,739,532 - 166,866,107 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	1	172,929,476 - 173,055,807 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	1	159,126,512 - 159,246,279 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	1	159,205,528 - 159,325,296	NCBI
Celera	1	154,107,674 - 154,230,148 (+)	NCBI		Celera
Cytogenetic Map	1	q32	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

3-methylglutaconic aciduria type 7a (ISO)

3-methylglutaconic aciduria type 7b (ISO)

3-methylglutaconic aciduria with cataracts, neurologic involvement and neutropenia (ISO)

cerebral folate receptor alpha deficiency (ISO)

genetic disease (ISO)

intellectual disability (ISO)

microcytic anemia (ISO)

neutropenia (ISO)

severe congenital neutropenia 2 (ISO)

Severe Congenital Neutropenia 9, Autosomal Dominant (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(-)-epigallocatechin 3-gallate (ISO)

(1->4)-beta-D-glucan (ISO)

1,2-dimethylhydrazine (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,3,7,8-Tetrachlorodibenzofuran (EXP)

2,4-dinitrotoluene (EXP)

2,6-dinitrotoluene (EXP)

3,4-methylenedioxymethamphetamine (ISO)

3-chloropropane-1,2-diol (EXP)

4,4'-sulfonyldiphenol (ISO)

4-hydroxyphenyl retinamide (ISO)

6-propyl-2-thiouracil (EXP)

acrolein (ISO)

aflatoxin B1 (ISO)

alpha-pinene (ISO)

amitrole (EXP)

ammonium chloride (EXP)

benzo[a]pyrene (ISO)

bisphenol A (EXP,ISO)

buspirone (EXP)

cadmium dichloride (EXP)

carbon nanotube (ISO)

chlorpyrifos (ISO)

cobalt dichloride (EXP,ISO)

copper(II) sulfate (ISO)

cyclosporin A (ISO)

dicrotophos (ISO)

dioxygen (ISO)

doxorubicin (ISO)

entinostat (ISO)

ethanol (ISO)

finasteride (EXP)

flavonoids (EXP)

flutamide (EXP)

folic acid (ISO)

gentamycin (EXP)

hydrogen peroxide (ISO)

inulin (ISO)

isoprenaline (ISO)

ivermectin (ISO)

menadione (ISO)

Mesaconitine (EXP)

methimazole (EXP)

methylmercury chloride (ISO)

nickel atom (ISO)

ozone (ISO)

perfluorooctane-1-sulfonic acid (ISO)

pirinixic acid (EXP,ISO)

potassium chromate (ISO)

propiconazole (EXP)

sodium arsenite (ISO)

sodium fluoride (ISO)

sulfadimethoxine (EXP)

thapsigargin (EXP)

theophylline (ISO)

triptonide (ISO)

valproic acid (ISO)

vinclozolin (EXP)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

antiviral innate immune response (IEA,ISO)

biological_process (ND)

cellular response to heat (IBA,IEA,ISO)

granulocyte differentiation (IEA,ISO,ISS)

RIG-I signaling pathway (IEA,ISO)

Cellular Component

cytoplasm (IBA)

mitochondrial intermembrane space (IEA,ISO,ISS)

mitochondrion (IBA)

Molecular Function

ATP binding (IEA)

ATP hydrolysis activity (IBA,IEA,ISO,ISS)

ATP-dependent protein disaggregase activity (IEA,ISO,ISS)

protein binding (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
3.	Electronic Transfer of LocusLink and RefSeq Data	NCBI rat LocusLink and RefSeq merged data July 26, 2002
4.	Expression of a putative ATPase suppresses the growth defect of a yeast potassium transport mutant: identification of a mammalian member of the Clp/HSP104 family.	Perier F, etal., Gene 1995 Jan 23;152(2):157-63.
5.	GOA pipeline	RGD automated data pipeline
6.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
7.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
8.	Comprehensive gene review and curation	RGD comprehensive gene curation
9.	Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.	Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.

Additional References at PubMed

PMID:2745427	PMID:18614015

Genomics

Comparative Map Data

Clpb
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	1	165,440,705 - 165,563,514 (+)	NCBI		GRCr8
mRatBN7.2	1	156,028,740 - 156,158,183 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	1	156,028,930 - 156,168,788 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	1	164,019,285 - 164,141,861 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	1	171,199,372 - 171,321,950 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	1	164,077,596 - 164,199,818 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	1	166,739,372 - 166,866,095 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	1	166,739,532 - 166,866,107 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	1	172,929,476 - 173,055,807 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	1	159,126,512 - 159,246,279 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	1	159,205,528 - 159,325,296	NCBI
Celera	1	154,107,674 - 154,230,148 (+)	NCBI		Celera
Cytogenetic Map	1	q32	NCBI

CLPB
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	11	72,285,495 - 72,434,531 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	11	72,285,495 - 72,434,680 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	11	71,996,539 - 72,145,575 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	11	71,681,117 - 71,823,216 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	11	71,681,119 - 71,823,216	NCBI
Celera	11	69,304,879 - 69,446,914 (-)	NCBI		Celera
Cytogenetic Map	11	q13.4	NCBI
HuRef	11	68,296,594 - 68,438,806 (-)	NCBI		HuRef
CHM1_1	11	71,886,780 - 72,028,986 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	11	72,211,988 - 72,361,006 (-)	NCBI		T2T-CHM13v2.0

Clpb
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	7	101,312,958 - 101,444,667 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	7	101,312,840 - 101,444,713 (+)	Ensembl		GRCm39 Ensembl
GRCm38	7	101,663,596 - 101,795,460 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	7	101,663,633 - 101,795,506 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	7	108,812,282 - 108,938,682 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	7	101,537,589 - 101,663,989 (+)	NCBI		MGSCv36	mm8
Celera	7	102,026,885 - 102,161,012 (+)	NCBI		Celera
Cytogenetic Map	7	E2	NCBI
cM Map	7	54.63	NCBI

Clpb
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955414	18,967,435 - 19,106,241 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955414	18,968,144 - 19,106,241 (+)	NCBI	ChiLan1.0	ChiLan1.0

CLPB
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	9	73,236,078 - 73,383,210 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	11	74,279,479 - 74,426,781 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	11	67,364,012 - 67,514,035 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	11	70,593,691 - 70,736,909 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	11	70,594,633 - 70,736,699 (-)	Ensembl	panpan1.1		panPan2

CLPB
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	21	25,710,634 - 25,855,418 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	21	25,710,723 - 25,852,857 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	21	25,481,034 - 25,625,477 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	21	25,919,797 - 26,064,299 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	21	25,919,849 - 26,065,369 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	21	25,711,431 - 25,855,832 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	21	25,927,511 - 26,071,959 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	21	25,828,735 - 25,973,390 (+)	NCBI		UU_Cfam_GSD_1.0

Clpb
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404947	59,990,063 - 60,131,202 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936498	1,590,655 - 1,730,815 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936498	1,590,655 - 1,730,815 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

CLPB
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	9	6,836,390 - 6,981,892 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	9	6,836,367 - 7,089,896 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	9	7,598,604 - 7,661,474 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

CLPB
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	1	63,520,305 - 63,667,237 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	1	63,515,814 - 63,667,105 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666043	62,216,964 - 62,365,206 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Clpb
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624817	4,593,639 - 4,735,091 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624817	4,593,823 - 4,735,573 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Clpb
682 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	76
Count of miRNA genes:	74
Interacting mature miRNAs:	76
Transcripts:	ENSRNOT00000026665
Prediction methods:	Microtar, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
70209	Niddm23	Non-insulin dependent diabetes mellitus QTL 23	2.82		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	1	94494440	198324465	Rat
70225	Bp58	Blood pressure QTL 58	3.3		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	32356093	162846471	Rat
71118	Thym1	Thymus enlargement QTL 1	10.17	0.001	thymus mass (VT:0004954)	thymus weight to body weight ratio (CMO:0000612)	1	136829932	181829932	Rat
631199	Cm23	Cardiac mass QTL 23	4.6	0.0004	heart left ventricle mass (VT:0007031)	heart left ventricle wet weight (CMO:0000071)	1	115585465	172949803	Rat
631202	Gluco13	Glucose level QTL 13		0.0001	blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	1	131763437	159756369	Rat
631205	Bp196	Blood pressure QTL 196	4	0.0001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	1	118944897	199050459	Rat
631206	Niddm40	Non-insulin dependent diabetes mellitus QTL 40			blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	1	136745990	163747690	Rat
2302378	Insul11	Insulin level QTL 11	3.25		blood insulin amount (VT:0001560)	serum insulin level (CMO:0000358)	1	144267353	251128347	Rat
61442	Strs1	Sensitivity to stroke QTL 1	7.4		cerebrum integrity trait (VT:0010549)	post-insult time to onset of cerebrovascular lesion (CMO:0002343)	1	121767634	166767634	Rat
70160	Bw18	Body weight QTL 18	5.7		body mass (VT:0001259)	body weight (CMO:0000012)	1	144267353	196383668	Rat
724521	Uae1	Urinary albumin excretion QTL 1	3.8	0.0001	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	1	90508614	173018436	Rat
724531	Uae5	Urinary albumin excretion QTL 5	4		urine albumin amount (VT:0002871)	urine albumin level (CMO:0000130)	1	150700142	252085212	Rat
724550	Thym3	Thymus enlargement QTL 3	7.82	0.001	thymus mass (VT:0004954)	thymus weight to body weight ratio (CMO:0000612)	1	136829932	181829932	Rat
1331749	Hrtrt11	Heart rate QTL 11	2.973		heart pumping trait (VT:2000009)	heart rate (CMO:0000002)	1	94494440	198211706	Rat
1331751	Bp199	Blood pressure QTL 199	3.60022		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	1	94494440	181830018	Rat
737828	Hcas3	Hepatocarcinoma susceptibility QTL 3	4.9		liver integrity trait (VT:0010547)	liver tumorous lesion volume to total liver volume ratio (CMO:0001082)	1	144267353	222987745	Rat
631654	Bp107	Blood pressure QTL 107			arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	125611501	170611501	Rat
1331793	Bp200	Blood pressure QTL 200	3.71601		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	94494440	172949803	Rat
1578654	Bss10	Bone structure and strength QTL 10	4		femur morphology trait (VT:0000559)	femoral neck cortical cross-sectional area (CMO:0001702)	1	49393172	159356837	Rat
731168	Bp154	Blood pressure QTL 154	3.4		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	94642644	214537671	Rat
738006	Anxrr14	Anxiety related response QTL 14	4	0.00035	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	1	130636910	175636910	Rat
738028	Anxrr12	Anxiety related response QTL 12	4.9	0.00001	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	1	130636910	175636910	Rat
631519	Pia11	Pristane induced arthritis QTL 11	5.3		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	1	136830018	181830018	Rat
631544	Bp84	Blood pressure QTL 84	5.6		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	123350408	181759564	Rat
631549	Bp89	Blood pressure QTL 89	5.7		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	123350581	201284552	Rat
1641895	Bp298	Blood pressure QTL 298			arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	1	123350408	182418476	Rat
1598850	Bp297	Blood pressure QTL 297	2.1		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	121006655	166006655	Rat
1598853	Memor3	Memory QTL 3	4.5		exploratory behavior trait (VT:0010471)	total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)	1	143506580	212458660	Rat
1598866	Bp287	Blood pressure QTL 287	5.1		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	121006655	166006655	Rat
634314	Niddm44	Non-insulin dependent diabetes mellitus QTL 44			blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	1	49393289	199050459	Rat
634315	Niddm45	Non-insulin dependent diabetes mellitus QTL 45	7.16		blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	1	144267916	172949660	Rat
634348	Bp138	Blood pressure QTL 138			arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	125611501	168883176	Rat
1578759	Uae30	Urinary albumin excretion QTL 30	3.3	0.003	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	1	150700247	252085048	Rat
1578770	Stresp23	Stress response QTL 23			kidney sympathetic nerve activity (VT:0004050)	stimulated renal sympathetic nerve activity to basal renal sympathetic nerve activity ratio (CMO:0001786)	1	123350408	182418476	Rat
1578778	Pur4	Proteinuria QTL 4	3.3	0.003	urine total protein amount (VT:0000032)	urine total protein excretion rate (CMO:0000756)	1	150700247	252085048	Rat
1578780	Cm52	Cardiac mass QTL 52	3.3	0.0001	heart mass (VT:0007028)	heart wet weight (CMO:0000069)	1	81591954	219808434	Rat
1300158	Bp173	Blood pressure QTL 173	3.48		arterial blood pressure trait (VT:2000000)	blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)	1	115540693	185145286	Rat
1354591	Cm36	Cardiac mass QTL 36	4.1		heart left ventricle mass (VT:0007031)	calculated heart weight (CMO:0000073)	1	102813953	201278233	Rat
1354602	Bw35	Body weight QTL 35	12.2		body mass (VT:0001259)	body weight (CMO:0000012)	1	151162512	201278233	Rat
1354606	Bp246	Blood pressure QTL 246	3.6		arterial blood pressure trait (VT:2000000)	pulse pressure (CMO:0000292)	1	102813953	218753816	Rat
1354610	Bw34	Body weight QTL 34	4.1		body mass (VT:0001259)	body weight (CMO:0000012)	1	151162512	256448636	Rat
1354615	Cm32	Cardiac mass QTL 32	5.2		heart left ventricle mass (VT:0007031)	heart left ventricle wet weight (CMO:0000071)	1	102813953	201278233	Rat
1354620	Kidm19	Kidney mass QTL 19	4		kidney mass (VT:0002707)	calculated kidney weight (CMO:0000160)	1	151162512	201278233	Rat
1354634	Kidm12	Kidney mass QTL 12	3.9		kidney mass (VT:0002707)	right kidney wet weight (CMO:0000082)	1	151162512	201278233	Rat
1354636	Lmblg1	Limb length QTL 1	6.4		tibia length (VT:0004357)	tibia length (CMO:0000450)	1	151162512	201278233	Rat
1354646	Kidm18	Kidney mass QTL 18	5.7		kidney mass (VT:0002707)	calculated kidney weight (CMO:0000160)	1	151162512	256448636	Rat
1354661	Bw33	Body weight QTL 33	5.2		body mass (VT:0001259)	body weight (CMO:0000012)	1	151162512	256448636	Rat
1558645	Bw55	Body weight QTL 55	3.2	0.004	body mass (VT:0001259)	body weight (CMO:0000012)	1	133680936	178680936	Rat
1549837	Hcar15	Hepatocarcinoma resistance QTL 15		0.05	liver integrity trait (VT:0010547)	liver tumorous lesion number (CMO:0001068)	1	153136852	260522016	Rat
1358189	Cstrr1	Cold stress response QTL 1		0.0001	catecholamine amount (VT:0010543)	urine norepinephrine level (CMO:0001629)	1	123350408	182418476	Rat
2313060	Bss71	Bone structure and strength QTL 71	2.6	0.0001	long bone metaphysis morphology trait (VT:0000133)	tibia midshaft total cross-sectional area (CMO:0001715)	1	118944747	163944747	Rat
2303622	Vencon6	Ventilatory control QTL 6		0.001	respiration trait (VT:0001943)	respiration rate (CMO:0000289)	1	154561505	199561505	Rat
1358886	Bp260	Blood pressure QTL 260	3.67		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	1	151162766	225824951	Rat
1358902	Bw47	Body weight QTL 47	1.67		body mass (VT:0001259)	body weight (CMO:0000012)	1	90508614	180359386	Rat
1582204	Livw1	Liver weight QTL 1	3.6	0.0003	liver mass (VT:0003402)	liver weight to body weight ratio (CMO:0000633)	1	155422851	172949803	Rat
2293140	Bp313	Blood pressure QTL 313			arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	121833674	166833674	Rat
61343	Bp28	Blood pressure QTL 28			arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	151646613	196646613	Rat
61348	Bp30	Blood pressure QTL 30	2.4		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	144017057	197814409	Rat
61379	Bp44	Blood pressure QTL 44	19.2		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	144267916	174133260	Rat
4889419	Cstrr2	Cold stress response QTL 2		0.05	urine catecholamine amount (VT:0010502)	absolute change in urine norepinephrine level (CMO:0001634)	1	155866514	158592016	Rat
4889428	Stresp24	Stress response QTL 24		0.05	heart pumping trait (VT:2000009)	absolute change in electrocardiographic low frequency R-R spectral component to high frequency R-R spectral component ratio (CMO:0002162)	1	155866514	200866514	Rat
6893347	Bw98	Body weight QTL 98	0.2	0.53	body mass (VT:0001259)	body weight (CMO:0000012)	1	133680936	178680936	Rat
6893361	Bw104	Body weight QTL 104	0.59	0.27	body mass (VT:0001259)	body weight (CMO:0000012)	1	133680936	178680936	Rat
8655649	Arrd1	Age-related retinal degeneration QTL 1	4.89		retinal layer morphology trait (VT:0003727)	percentage of study population developing retinopathy during a period of time (CMO:0002453)	1	100357752	183970443	Rat
7794788	Mcs32	Mammary carcinoma susceptibility QTL 32	2.61		mammary gland integrity trait (VT:0010552)	mammary tumor incidence/prevalence measurement (CMO:0000946)	1	115540693	238914717	Rat
9685799	Bp375	Blood pressure QTL 375			arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	125611501	170611501	Rat
9685802	Bp376	Blood pressure QTL 376			arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	126540680	171540680	Rat
7771612	Cm80	Cardiac mass QTL 80	8.4		heart left ventricle mass (VT:0007031)	heart left ventricle weight (CMO:0000776)	1	149448574	221264292	Rat
7421630	Bp362	Blood pressure QTL 362		0.001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	1	118608292	241799120	Rat
10059597	Bp377	Blood pressure QTL 377	3.42	0.025	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	32737458	199368955	Rat

Markers in Region

STS-Z40910

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	1	156,151,436 - 156,151,493 (+)	MAPPER	mRatBN7.2
Rnor_6.0	1	166,866,022 - 166,866,078	NCBI	Rnor6.0
Rnor_5.0	1	173,055,736 - 173,055,792	UniSTS	Rnor5.0
Rnor_5.0	4	187,866,146 - 187,866,550	UniSTS	Rnor5.0
RGSC_v3.4	1	159,246,208 - 159,246,264	UniSTS	RGSC3.4
Celera	1	154,230,077 - 154,230,133	UniSTS
Cytogenetic Map	4	q34	UniSTS
Cytogenetic Map	1	q32	UniSTS

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High											2
Medium	3	43	57	41	19	41	8	11	74	35	39	11	8
Low
Below cutoff

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_022947	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008759796	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039089860	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039089865	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063272875	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063272881	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_005491697	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_010057345	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AB027570	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AC122631	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC070917	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000001	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSRNOT00000026665 ⟹ ENSRNOP00000026665

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	1	156,028,944 - 156,151,547 (+)	Ensembl
Rnor_6.0 Ensembl	1	166,739,636 - 166,866,093 (+)	Ensembl

RefSeq Acc Id:

ENSRNOT00000079846 ⟹ ENSRNOP00000072796

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	1	156,028,944 - 156,151,547 (+)	Ensembl
Rnor_6.0 Ensembl	1	166,739,532 - 166,866,107 (+)	Ensembl

RefSeq Acc Id:

ENSRNOT00000103087 ⟹ ENSRNOP00000081336

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	1	156,028,930 - 156,168,788 (+)	Ensembl

RefSeq Acc Id:

ENSRNOT00000113358 ⟹ ENSRNOP00000079895

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	1	156,028,930 - 156,157,575 (+)	Ensembl

RefSeq Acc Id:

NM_022947 ⟹ NP_075236

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	1	165,440,968 - 165,563,512 (+)	NCBI
mRatBN7.2	1	156,028,950 - 156,151,508 (+)	NCBI
Rnor_6.0	1	166,739,636 - 166,866,093 (+)	NCBI
Rnor_5.0	1	172,929,476 - 173,055,807 (+)	NCBI
RGSC_v3.4	1	159,126,512 - 159,246,279 (+)	RGD
Celera	1	154,107,674 - 154,230,148 (+)	RGD

Sequence:

show sequence

GGCTAGCACGGGGGCCGGCACCAGCAGGTTTTAGAGGCAGGTGTCATGATGTTGTCCGCGGTGT
TGAGGAGAACCGCGCCAGCGCCTCGGCTCTTCCTAGGGTTAATCAAATCTCCATCTCTTCAAAG
CCGGGGAGGTGCTTACAACCGTAGCGTAATCACCGGAGACCGCGGGGAGCCGCAGCGGCTGAGA
ACTGCCGCCTGGGTGCGCCCTGGAGCATCTTCTGTCTTGTTCCCCGGACGGGGGGCAGCCACCG
GGGGGCGCCGTGGAGAACGCACCGAGATCCCATACCTGACTGCCGCCTCGTCTGGACGCGGTCC
TAGCCCGGAAGAAACACTCCCAGGACAAGACAGCTGGAATGGGGTCCCCAACAAGGCGGGATTG
GGCATGTGGGCCTTGGCCATGGCGCTGGTGGTTCAGTGCTACAACAAGAATCCATCTAACAAGG
ATGCAGCTTTGATGGAAGCTGCCCGAGCCAATAATGTGCAGGAAGTCAGAAGGCTGTTATCAGA
AGGTGCAGATGTCAACGCAAGGCACAAACTTGGCTGGACAGCATTGATGGTGGCAGCCATCAGC
CACAATGAGAGTGTGGTACAGGTTCTCCTTGCTGCTGGAGCTGACCCAAACCTTGGGGACGACT
TCAGCAGTGTCTACAAGACTGCCAATGAACAGGGAGTCCATTCTTTGGAAGTCCTAGTCACTCG
AGAGGATGACTTCAACAACCGACTAAACCACCGTGCAAGTTTCAAAGGCTGCACAGCCCTGCAC
TATGCTGTCCTGGCCGACGACTACAGCATCGTCAAGGAACTACTGGGTGGAGGAGCCAACCCCC
TTCAGAGGAATGAGATGGGACACACACCCCTGGATTATGCCCGGGAAGGGGAGGTTATGAAGCT
TCTGAAAACTTCTGAAACCAAGTACATGGAGAAGCAGAGGAAGCGTGAGGCAGAAGAACGGCGC
CGCTTCCCACTGGAGCAGCGACTGGAGCAGCACATCATTGGCCAGGAGAGTGCCATTGCTACCG
TTGGTGCTGCGATCCGGAGGAAGGAGAATGGCTGGTACGATGAGGAGCACCCTCTAGTCTTCCT
CTTCTTGGGATCATCTGGAATAGGGAAAACTGAGCTGGCCAAGCAGACAGCAAAGTATATGCAC
AAAGATGCCAAAAAGGGCTTCATCCGGCTCGACATGTCTGAGTTCCAGGAGCGACATGAGGTAG
CCAAGTTTATCGGTTCTCCGCCAGGCTACATCGGCCATGAAGAAGGTGGCCAACTGACCAAGAA
ACTGAAACAGTGCCCAAATGCAGTAGTTCTCTTTGACGAGGTGGACAAGGCCCATCCAGATGTG
CTCACCATCATGCTGCAGCTGTTTGATGAGGGCCGCCTGACAGATGGCAAGGGGAAGACCATTG
ACTGCAAGGATGCCATCTTCATCATGACTTCCAATGTAGCCAGTGATGAGATCGCCCAGCATGC
ATTGCAACTGAGACAGGAAGCTTTGGAGATGAGCCGAAATCGAATAGCTGAAAACCTTGGGGAT
GTCCAGATTAGTGACAAGATCACCATCTCAAAGAACTTCAAAGAGAATATGATCCGACCCATCC
TGAAAGCTCACTTCCGGAGAGACGAGTTTCTGGGAAGGATCAATGAGATCGTCTACTTCCTCCC
TTTCTGCCACTCGGAGCTCATCCAGCTGGTCAACAAGGAACTGAACTTCTGGGCCAAGAGAGCC
AAGCAGAGACACAACATCACACTACTGTGGGACCGCGAGGTGGCAGACGTGTTGGTTGATGGCT
ACAACGTCCAGTATGGTGCCCGCTCCATTAAGCATGAGGTAGAGCGCCGTGTGGTAAACCAGCT
GGCGGCAGCCTATGAGCAGGACCTGCTACCAGGGGGCTGCACCCTGCGTATCACTGTGGAGGAC
TCAGACAAGCAGCTCCTCAAGAGCCCTGAGCTGCCCTCGCCCCAGGCTGAAAAGCGTCCGCCTA
CACTGCGACTGGAGATCATTGATAAGGACAGCAAGACCCACAAACTGGACATCCAGGCACCACT
CCACCCCGAGAAGGTGTGCTACACCATCTAGCATCCACCTGCCTGTGCCCTGAACATCTAATAA
AGGCCCCTTGCTGTGGCATGGCAACC

hide sequence

RefSeq Acc Id:

XM_008759796 ⟹ XP_008758018

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	1	165,440,705 - 165,563,514 (+)	NCBI
mRatBN7.2	1	156,028,995 - 156,158,183 (+)	NCBI
Rnor_6.0	1	166,739,372 - 166,866,095 (+)	NCBI

Sequence:

show sequence

AATCTTGAATCTTTATTGCCACTCCCCGCTAGAGTTTTCCTTTTTGCCACGCCCCTCTGCCAGA
ACTGCATTTCCCAACATTCTTCCAACTCCGCTGTCAGCGGTCATTGTGATGTCATCCCACAGCC
CTCAGGGAAATGTAGTTTGTTCATTGTCCAGCTAGAGAAAGATCTGGGGCCGTGGACTACCACT
CCCGTGAGGTAGTGCGCAGTCCCACCCCGTAAGCGGCGTCTTCGAACGCGCCGCGGCAGCCATG
TTGATCGTGGCTAGCACGGGGGCCGGCACCAGCAGGTTTTAGAAGCAGGTGTCATGATGTTGTC
CGCGGTGTTGAGGAGAACCGCGCCAGCGCCTCGGCTCTTCCTAGGGTTAATCAAATCTCCATCT
CTTCAAAGCCGGGGAGGTGCTTACAACCGTAGCGTAATCACCGGAGACCGCGGGGAGCCGCAGC
GGCTGAGAACTGCCGCCTGGGTGCGCCCTGGAGCATCTTCTGTCTTGTTCCCCGGACGGGGGGC
AGCCACCGGGGGGCGCCGTGGAGAACGCACCGAGATCCCATACCTGACTGCCGCCTCGTCTGGA
CGCGGTCCTAGCCCGGAAGAAACACTCCCAGGACAAGACAGCTGGAATGGGGTCCCCAACAAGG
CGGGATTGGGCATGTGGGCCTTGGCCATGGCGCTGGTGGTTCAGTGCTACAACAAGAATCCATC
TAACAAGGATGCAGCTCTGATGGAAGCTGCCCGAGCCAATAATGTGCAGGAAGTCAGAAGGCTG
TTATCAGAAGGTGCAGATGTCAACGCAAGGCACAAACTTGGCTGGACAGCATTGATGGTGGCAG
CCATCAGCCACAATGAGAGTGTGGTACAGGTTCTCCTTGCTGCTGGAGCTGACCCAAACCTTGG
GGACGACTTCAGCAGTGTCTACAAGACTGCCAATGAACAGGGAGTCCATTCTTTGGAAGATGGG
AGACAAGACTGTGCAAGCTGGCGAATCACAAACCAGTGGACAAGTGCCCTGGAGTTCAGGAGAT
GGCTAGGAGTCCCGGTTGGCGTCCTAGTCACTCGAGAGGATGACTTCAACAACCGACTAAACCA
CCGTGCAAGTTTCAAAGGCTGCACAGCCCTGCACTATGCTGTCCTGGCCGACGACTACAGCATC
GTCAAGGAACTACTGGGTGGAGGAGCCAACCCCCTTCAGAGGAATGAGATGGGACACACACCCC
TGGATTATGCCCGGGAAGGGGAGGTTATGAAGCTTCTGAAAACTTCTGAAACCAAGTACATGGA
GAAGCAGAGGAAGCGTGAGGCAGAAGAACGGCGCCGCTTCCCACTGGAGCAGCGACTGAAGGAG
CACATCATTGGCCAGGAGAGTGCCATTGCTACCGTTGGTGCTGCGATCCGGAGGAAGGAGAATG
GCTGGTATGATGAGGAGCACCCTCTAGTCTTCCTCTTCTTGGGATCATCTGGAATAGGGAAAAC
TGAGCTGGCCAAGCAGACAGCCAAGTATATGCACAAAGATGCCAAAAAGGGCTTCATCCGGCTC
GACATGTCTGAGTTCCAGGAGCGACATGAGGTAGCCAAGTTTATCGGTTCTCCGCCAGGCTACA
TCGGCCATGAAGAAGGTGGCCAACTGACCAAGAAACTGAAACAGTGCCCAAATGCAGTAGTTCT
CTTTGACGAGGTGGACAAGGCCCATCCAGATGTGCTCACCATCATGCTGCAGCTGTTTGATGAG
GGCCGCCTGACAGATGGCAAGGGGAAGACCATTGACTGCAAGGATGCCATCTTCATCATGACTT
CCAATGTAGCCAGTGATGAGATCGCCCAGCATGCATTGCAACTGAGACAGGAAGCTTTGGAGAT
GAGCCGAAATCGAATAGCTGAAAACCTTGGGGATGTCCAGATTAGTGACAAGATCACCATCTCA
AAGAACTTCAAAGAGAATGTGATCCGACCCATCCTGAAAGCTCACTTCCGGAGAGACGAGTTTC
TGGGAAGGATCAATGAGATTGTCTACTTCCTCCCTTTCTGCCACTCGGAGCTCATCCAGCTGGT
CAACAAGGAACTGAACTTCTGGGCCAAGAGAGCCAAGCAGAGACACAACATCACACTACTGTGG
GACCGCGAGGTGGCAGACGTGTTGGTTGATGGCTACAACGTCCACTATGGTGCCCGCTCCATTA
AGCATGAGGTAGAGCGCCGTGTGGTAAACCAGCTGGCGGCAGCCTATGAGCAGGACCTGCTACC
AGGGGGCTGCACCCTGCGTATCACTGTGGAGGACTCAGACAAGCAGCTCCTCAAGAGCCCTGAG
CTGCCCTCGCCCCAGGCTGAAAAGCGTCCGCCTACACTGCGACTGGAGATCATTGATAAGGACA
GCAAGACCCACAAACTGGACATCCAGGCACCACTCCACCCCGAGAAGGTGTGCTACACCATCTA
GCATCCACCTGCCTGTCTGTGCCCTGAACATCTAATAAAGGCCCCTTGCTGTGGCATGGCAACC
AA

hide sequence

RefSeq Acc Id:

XM_039089860 ⟹ XP_038945788

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	1	165,487,578 - 165,563,514 (+)	NCBI
mRatBN7.2	1	156,075,561 - 156,158,183 (+)	NCBI

RefSeq Acc Id:

XM_039089865 ⟹ XP_038945793

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	1	165,530,554 - 165,563,514 (+)	NCBI
mRatBN7.2	1	156,118,549 - 156,158,183 (+)	NCBI

RefSeq Acc Id:

XM_063272875 ⟹ XP_063128945

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	1	165,482,603 - 165,563,514 (+)	NCBI

RefSeq Acc Id:

XM_063272881 ⟹ XP_063128951

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	1	165,491,124 - 165,563,514 (+)	NCBI

RefSeq Acc Id:

XR_005491697

Type:

NON-CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	1	165,440,705 - 165,561,292 (+)	NCBI
mRatBN7.2	1	156,028,935 - 156,149,286 (+)	NCBI

RefSeq Acc Id:

XR_010057345

Type:

NON-CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	1	165,440,707 - 165,561,292 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_075236	(Get FASTA)	NCBI Sequence Viewer
	XP_008758018	(Get FASTA)	NCBI Sequence Viewer
	XP_038945788	(Get FASTA)	NCBI Sequence Viewer
	XP_038945793	(Get FASTA)	NCBI Sequence Viewer
	XP_063128945	(Get FASTA)	NCBI Sequence Viewer
	XP_063128951	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH70917	(Get FASTA)	NCBI Sequence Viewer
	BAA78095	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000026665.8
	ENSRNOP00000072796
	ENSRNOP00000072796.1
	ENSRNOP00000079895.1
	ENSRNOP00000081336
	ENSRNOP00000081336.1
GenBank Protein	Q9WTT2	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_075236 ⟸ NM_022947

- UniProtKB:

Q9WTT2 (UniProtKB/Swiss-Prot), F1M955 (UniProtKB/TrEMBL), Q6IRH7 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MMLSAVLRRTAPAPRLFLGLIKSPSLQSRGGAYNRSVITGDRGEPQRLRTAAWVRPGASSVLFP
GRGAATGGRRGERTEIPYLTAASSGRGPSPEETLPGQDSWNGVPNKAGLGMWALAMALVVQCYN
KNPSNKDAALMEAARANNVQEVRRLLSEGADVNARHKLGWTALMVAAISHNESVVQVLLAAGAD
PNLGDDFSSVYKTANEQGVHSLEVLVTREDDFNNRLNHRASFKGCTALHYAVLADDYSIVKELL
GGGANPLQRNEMGHTPLDYAREGEVMKLLKTSETKYMEKQRKREAEERRRFPLEQRLEQHIIGQ
ESAIATVGAAIRRKENGWYDEEHPLVFLFLGSSGIGKTELAKQTAKYMHKDAKKGFIRLDMSEF
QERHEVAKFIGSPPGYIGHEEGGQLTKKLKQCPNAVVLFDEVDKAHPDVLTIMLQLFDEGRLTD
GKGKTIDCKDAIFIMTSNVASDEIAQHALQLRQEALEMSRNRIAENLGDVQISDKITISKNFKE
NMIRPILKAHFRRDEFLGRINEIVYFLPFCHSELIQLVNKELNFWAKRAKQRHNITLLWDREVA
DVLVDGYNVQYGARSIKHEVERRVVNQLAAAYEQDLLPGGCTLRITVEDSDKQLLKSPELPSPQ
AEKRPPTLRLEIIDKDSKTHKLDIQAPLHPEKVCYTI

hide sequence

RefSeq Acc Id:	XP_008758018 ⟸ XM_008759796
- Peptide Label:	isoform X1
- UniProtKB:	A0A0G2K3V9 (UniProtKB/TrEMBL), A0A8J8YEH1 (UniProtKB/TrEMBL)
- Sequence:	show sequence MMLSAVLRRTAPAPRLFLGLIKSPSLQSRGGAYNRSVITGDRGEPQRLRTAAWVRPGASSVLFP GRGAATGGRRGERTEIPYLTAASSGRGPSPEETLPGQDSWNGVPNKAGLGMWALAMALVVQCYN KNPSNKDAALMEAARANNVQEVRRLLSEGADVNARHKLGWTALMVAAISHNESVVQVLLAAGAD PNLGDDFSSVYKTANEQGVHSLEDGRQDCASWRITNQWTSALEFRRWLGVPVGVLVTREDDFNN RLNHRASFKGCTALHYAVLADDYSIVKELLGGGANPLQRNEMGHTPLDYAREGEVMKLLKTSET KYMEKQRKREAEERRRFPLEQRLKEHIIGQESAIATVGAAIRRKENGWYDEEHPLVFLFLGSSG IGKTELAKQTAKYMHKDAKKGFIRLDMSEFQERHEVAKFIGSPPGYIGHEEGGQLTKKLKQCPN AVVLFDEVDKAHPDVLTIMLQLFDEGRLTDGKGKTIDCKDAIFIMTSNVASDEIAQHALQLRQE ALEMSRNRIAENLGDVQISDKITISKNFKENVIRPILKAHFRRDEFLGRINEIVYFLPFCHSEL IQLVNKELNFWAKRAKQRHNITLLWDREVADVLVDGYNVHYGARSIKHEVERRVVNQLAAAYEQ DLLPGGCTLRITVEDSDKQLLKSPELPSPQAEKRPPTLRLEIIDKDSKTHKLDIQAPLHPEKVC YTI hide sequence

RefSeq Acc Id:

ENSRNOP00000072796 ⟸ ENSRNOT00000079846

RefSeq Acc Id:

ENSRNOP00000026665 ⟸ ENSRNOT00000026665

RefSeq Acc Id:	XP_038945788 ⟸ XM_039089860
- Peptide Label:	isoform X2

RefSeq Acc Id:	XP_038945793 ⟸ XM_039089865
- Peptide Label:	isoform X3

RefSeq Acc Id:

ENSRNOP00000081336 ⟸ ENSRNOT00000103087

RefSeq Acc Id:

ENSRNOP00000079895 ⟸ ENSRNOT00000113358

RefSeq Acc Id:	XP_063128945 ⟸ XM_063272875
- Peptide Label:	isoform X2

RefSeq Acc Id:	XP_063128951 ⟸ XM_063272881
- Peptide Label:	isoform X2

Protein Domains

AAA+ ATPase Clp ATPase C-terminal

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q9WTT2-F1-model_v2	AlphaFold	Q9WTT2	1-677	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13690260

Promoter ID:

EPDNEW_R783

Type:

multiple initiation site

Name:

Clpb_1

Description:

ClpB homolog, mitochondrial AAA ATPase chaperonin

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	1	166,739,630 - 166,739,690	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:621328	AgrOrtholog
BioCyc Gene	G2FUF-58280	BioCyc
Ensembl Genes	ENSRNOG00000019693	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000026665.8	UniProtKB/TrEMBL
	ENSRNOT00000079846.2	UniProtKB/TrEMBL
	ENSRNOT00000103087	ENTREZGENE
	ENSRNOT00000103087.1	UniProtKB/TrEMBL
	ENSRNOT00000113358.1	UniProtKB/TrEMBL
Gene3D-CATH	1.10.8.60	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	1.25.40.20	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	3.40.50.300	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:7105142	IMAGE-MGC_LOAD
InterPro	AAA+_ATPase	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Ankyrin_rpt	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Ankyrin_rpt-contain_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	ATPase_AAA_core	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Clp_ATPase_C	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	ClpA/B	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	P-loop_NTPase	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	rno:65041	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE	MGC:91674	IMAGE-MGC_LOAD
NCBI Gene	65041	ENTREZGENE
PANTHER	ATP-DEPENDENT CLP PROTEASE	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	CASEINOLYTIC PEPTIDASE B PROTEIN HOMOLOG	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	AAA_2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Ank_2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	ClpB_D2-small	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Clpb	PhenoGen
PRINTS	CLPPROTEASEA	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE	ANK_REP_REGION	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	ANK_REPEAT	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000019693	RatGTEx
SMART	AAA	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	ANK	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	ClpB_D2-small	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP	SSF48403	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SSF52540	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt	A0A0G2K3V9	ENTREZGENE, UniProtKB/TrEMBL
	A0A8I5ZSR8_RAT	UniProtKB/TrEMBL
	A0A8I6G3V6_RAT	UniProtKB/TrEMBL
	A0A8J8YEH1	ENTREZGENE, UniProtKB/TrEMBL
	CLPB_RAT	UniProtKB/Swiss-Prot
	F1M955	ENTREZGENE
	Q6IRH7	ENTREZGENE, UniProtKB/TrEMBL
	Q9WTT2	ENTREZGENE
UniProt Secondary	F1M955	UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2023-04-17	Clpb	ClpB family mitochondrial disaggregase	Clpb	caseinolytic mitochondrial matrix peptidase chaperone subunit B	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2019-11-11	Clpb	caseinolytic mitochondrial matrix peptidase chaperone subunit B	Clpb	ClpB homolog, mitochondrial AAA ATPase chaperonin	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2015-03-26	Clpb	ClpB homolog, mitochondrial AAA ATPase chaperonin	Clpb	ClpB caseinolytic peptidase B homolog (E. coli)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2006-03-30	Clpb	ClpB caseinolytic peptidase B homolog (E. coli)	Skd3	suppressor of K+ transport defect 3	Symbol and Name updated	1299863	APPROVED
2004-02-26	Skd3	suppressor of K+ transport defect 3			Symbol and Name status set to approved	625702	APPROVED
2002-08-07	Skd3	suppressor of K+ transport defect 3			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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