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Gene: Pou4f1 (POU class 4 homeobox 1) Rattus norvegicus

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Symbol:

Pou4f1

Name:

POU class 4 homeobox 1

RGD ID:

620074

Description:

Enables RNA polymerase II-specific DNA-binding transcription factor binding activity. Involved in negative regulation of neuron apoptotic process and spermatogenesis. Predicted to be located in several cellular components, including chromatin; neuron projection; and nucleus. Predicted to be part of RNA polymerase II transcription regulator complex. Orthologous to human POU4F1 (POU class 4 homeobox 1); PARTICIPATES IN p53 signaling pathway; INTERACTS WITH 6-propyl-2-thiouracil; bisphenol A; lead diacetate.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

brain-3A; brain-specific homeobox/POU domain protein 3A; brn-3A; Brn3a; POU domain, class 4, transcription factor 1

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	POU4F1 (POU class 4 homeobox 1)	HGNC	Ensembl, HomoloGene, NCBI, Panther
Mus musculus (house mouse):	Pou4f1 (POU domain, class 4, transcription factor 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Pou4f1 (POU class 4 homeobox 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	POU4F1 (POU class 4 homeobox 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	POU4F1 (POU class 4 homeobox 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Pou4f1 (POU class 4 homeobox 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	POU4F1 (POU class 4 homeobox 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	POU4F1 (POU class 4 homeobox 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Pou4f1 (POU class 4 homeobox 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	POU4F1 (POU class 4 homeobox 1)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Pou4f1 (POU domain, class 4, transcription factor 1)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	pou4f1 (POU class 4 homeobox 1)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	unc-86	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|PANTHER\|SonicParanoid)
Drosophila melanogaster (fruit fly):	acj6	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|OrthoFinder\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	pou4f1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	15	87,668,328 - 87,674,643 (-)	NCBI		GRCr8
mRatBN7.2	15	81,253,714 - 81,260,057 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	15	81,257,781 - 81,259,728 (-)	Ensembl		mRatBN7.2 Ensembl
Rnor_6.0	15	88,618,255 - 88,622,712 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	15	88,620,470 - 88,622,413 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	15	92,114,015 - 92,118,240 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	15	88,535,625 - 88,539,256 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	15	88,553,052 - 88,553,272 (-)	NCBI
Celera	15	80,380,878 - 80,387,018 (-)	NCBI		Celera
Cytogenetic Map	15	q22	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

acute myeloid leukemia (ISO)

ATAXIA, INTENTION TREMOR, AND HYPOTONIA SYNDROME, CHILDHOOD-ONSET (ISO)

cervix uteri carcinoma in situ (ISO)

chromosome 13q14 deletion syndrome (ISO)

genetic disease (ISO)

nonprogressive cerebellar ataxia with mental retardation (ISO)

Uterine Cervical Neoplasms (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2-dimethylhydrazine (ISO)

2,3,7,8-tetrachlorodibenzodioxine (ISO)

2-palmitoylglycerol (ISO)

4,4'-sulfonyldiphenol (ISO)

6-propyl-2-thiouracil (EXP)

aflatoxin B1 (ISO)

aldehydo-D-glucose (ISO)

all-trans-retinoic acid (ISO)

antimycin A (ISO)

antirheumatic drug (ISO)

arsane (ISO)

arsenic atom (ISO)

arsenous acid (ISO)

azoxystrobin (ISO)

benzo[a]pyrene (ISO)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (EXP,ISO)

bisphenol F (ISO)

carbamazepine (ISO)

CGP 52608 (ISO)

cyclosporin A (ISO)

D-glucose (ISO)

deguelin (ISO)

diarsenic trioxide (ISO)

dorsomorphin (ISO)

fructose (ISO)

glucose (ISO)

lead diacetate (EXP)

lead(0) (EXP)

leflunomide (ISO)

mercury dibromide (ISO)

methotrexate (ISO)

methylmercury chloride (ISO)

mono(2-ethylhexyl) phthalate (ISO)

p-chloromercuribenzoic acid (ISO)

paracetamol (ISO)

PCB138 (EXP)

picoxystrobin (ISO)

rotenone (ISO)

SB 431542 (ISO)

silicon dioxide (ISO)

sodium arsenite (ISO)

titanium dioxide (ISO)

trichostatin A (ISO)

triclosan (ISO)

Triptolide (ISO)

triptonide (ISO)

urethane (ISO)

valproic acid (ISO)

vorinostat (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cell migration in hindbrain (IEA,ISO)

cellular response to cytokine stimulus (IEA,ISO,ISS)

cellular response to estradiol stimulus (IEA,ISO,ISS)

central nervous system neuron differentiation (IEA,ISO)

habenula development (IEA,ISO)

heart development (ISO)

innervation (IEA,ISO)

intrinsic apoptotic signaling pathway by p53 class mediator (IEA,ISO,ISS)

mesoderm development (IEA,ISO)

negative regulation of apoptotic process (ISO,TAS)

negative regulation of gene expression (IEA,ISO)

negative regulation of neuron apoptotic process (IEA,IMP,ISO)

negative regulation of programmed cell death (ISO,ISS)

negative regulation of transcription by RNA polymerase II (IEA,ISO)

nervous system development (ISO)

neuron apoptotic process (IEA,ISO)

neuron differentiation (ISO)

neuron fate specification (IEA,ISO)

neuron migration (IEA,ISO)

neuron projection development (IEA,ISO,ISS)

peripheral nervous system neuron development (IEA,ISO)

peripheral nervous system neuron differentiation (ISO)

positive regulation of gene expression (IEA,ISO,ISS)

positive regulation of neuron apoptotic process (IEA,ISO)

positive regulation of osteoclast differentiation (IEA,ISO,ISS)

positive regulation of transcription by RNA polymerase II (IEA,ISO)

proprioception involved in equilibrioception (IEA,ISO)

regulation of cell cycle (IEA,ISO,ISS)

regulation of DNA-binding transcription factor activity (ISO,ISS)

regulation of DNA-templated transcription (ISO)

regulation of neurogenesis (IEA,ISO)

regulation of transcription by RNA polymerase II (IBA)

sensory system development (IEA,ISO)

spermatogenesis (IEP)

suckling behavior (IEA,ISO)

transcription by RNA polymerase II (TAS)

trigeminal nerve development (IEA,ISO)

ventricular compact myocardium morphogenesis (IEA,ISO)

Cellular Component

chromatin (IEA,ISO)

cytoplasm (IEA,ISO,ISS)

neuron projection (IEA,ISO)

nucleus (ISO,ISS)

RNA polymerase II transcription regulator complex (IEA,ISO)

Molecular Function

chromatin binding (IEA,ISO)

DNA binding (ISO,TAS)

DNA-binding transcription activator activity, RNA polymerase II-specific (IEA,ISO,ISS)

DNA-binding transcription factor activity (ISO,TAS)

DNA-binding transcription factor activity, RNA polymerase II-specific (IBA,ISO)

DNA-binding transcription repressor activity, RNA polymerase II-specific (IEA,ISO)

GTPase binding (IEA,ISO)

protein binding (ISO)

RNA polymerase II cis-regulatory region sequence-specific DNA binding (IBA,IEA,ISO)

RNA polymerase II-specific DNA-binding transcription factor binding (IEA,IPI,ISO)

sequence-specific DNA binding (ISO,ISS)

sequence-specific double-stranded DNA binding (ISO)

single-stranded DNA binding (IEA,ISO,ISS)

Molecular Pathway Annotations Click to see Annotation Detail View

p53 signaling pathway (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Transcriptional regulation by p53.	Beckerman R and Prives C, Cold Spring Harb Perspect Biol. 2010 Aug;2(8):a000935. doi: 10.1101/cshperspect.a000935. Epub 2010 Apr 28.
2.	The closely related POU family transcription factors Brn-3a and Brn-3b are expressed in distinct cell types in the testis.	Budhram-Mahadeo V, etal., Int J Biochem Cell Biol. 2001 Oct;33(10):1027-39.
3.	p53 suppresses the activation of the Bcl-2 promoter by the Brn-3a POU family transcription factor.	Budhram-Mahadeo V, etal., J Biol Chem. 1999 May 21;274(21):15237-44. doi: 10.1074/jbc.274.21.15237.
4.	The BRN-3A transcription factor protects sensory but not sympathetic neurons from programmed cell death/apoptosis.	Ensor E, etal., J Biol Chem 2001 Feb 16;276(7):5204-12.
5.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
7.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
8.	Electronic Transfer of LocusLink and RefSeq Data	NCBI rat LocusLink and RefSeq merged data July 26, 2002
9.	GOA pipeline	RGD automated data pipeline
10.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
11.	Comprehensive gene review and curation	RGD comprehensive gene curation
12.	Interaction of Brn3a and HIPK2 mediates transcriptional repression of sensory neuron survival.	Wiggins AK, etal., J Cell Biol 2004 Oct 25;167(2):257-67. Epub 2004 Oct 18.

Additional References at PubMed

PMID:1383937	PMID:2739723	PMID:7623109	PMID:7935408	PMID:8290353	PMID:8621561	PMID:8876243	PMID:8955272	PMID:8972215	PMID:9448000	PMID:12810599	PMID:12934100
PMID:15532030	PMID:15968082	PMID:16040009	PMID:16752387	PMID:17145718	PMID:17196582	PMID:17239249	PMID:17668438	PMID:18303621	PMID:18368538	PMID:18421303	PMID:18839516
PMID:19877281	PMID:19906978	PMID:20096094	PMID:20228055	PMID:21315070	PMID:21734270	PMID:23805044	PMID:26200499	PMID:28594399

Genomics

Comparative Map Data

Pou4f1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	15	87,668,328 - 87,674,643 (-)	NCBI		GRCr8
mRatBN7.2	15	81,253,714 - 81,260,057 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	15	81,257,781 - 81,259,728 (-)	Ensembl		mRatBN7.2 Ensembl
Rnor_6.0	15	88,618,255 - 88,622,712 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	15	88,620,470 - 88,622,413 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	15	92,114,015 - 92,118,240 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	15	88,535,625 - 88,539,256 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	15	88,553,052 - 88,553,272 (-)	NCBI
Celera	15	80,380,878 - 80,387,018 (-)	NCBI		Celera
Cytogenetic Map	15	q22	NCBI

POU4F1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	13	78,598,362 - 78,603,552 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	13	78,598,362 - 78,603,552 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	13	79,172,497 - 79,177,687 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	13	78,071,228 - 78,075,696 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	13	78,071,232 - 78,075,696	NCBI
Celera	13	60,071,661 - 60,076,129 (-)	NCBI		Celera
Cytogenetic Map	13	q31.1	NCBI
HuRef	13	59,873,428 - 59,878,003 (-)	NCBI		HuRef
CHM1_1	13	79,141,107 - 79,145,483 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	13	77,824,085 - 77,829,278 (-)	NCBI		T2T-CHM13v2.0

Pou4f1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	14	104,699,111 - 104,705,554 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	14	104,699,112 - 104,705,435 (-)	Ensembl		GRCm39 Ensembl
GRCm38	14	104,461,675 - 104,468,118 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	14	104,461,676 - 104,467,999 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	14	104,861,537 - 104,867,216 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	14	103,347,999 - 103,353,678 (-)	NCBI		MGSCv36	mm8
Celera	14	103,076,392 - 103,080,281 (-)	NCBI		Celera
Cytogenetic Map	14	E2.3	NCBI
cM Map	14	54.21	NCBI

Pou4f1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0	NW_004955404	28,812,762 - 28,818,024 (+)	NCBI	ChiLan1.0	ChiLan1.0

POU4F1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	14	79,962,702 - 80,181,037 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	13	78,718,089 - 78,769,633 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	13	59,821,614 - 59,829,671 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	13	78,863,468 - 78,863,992 (-)	NCBI	panpan1.1	PanPan1.1	panPan2

POU4F1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	22	31,992,657 - 31,997,066 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
Dog10K_Boxer_Tasha	22	31,792,017 - 31,794,362 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	22	32,315,525 - 32,317,867 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	22	32,315,761 - 32,317,760 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	22	31,977,103 - 31,979,449 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	22	32,014,166 - 32,016,510 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	22	32,086,264 - 32,088,616 (-)	NCBI		UU_Cfam_GSD_1.0

Pou4f1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404945	127,439,842 - 127,446,181 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936511	2,857,331 - 2,859,277 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936511	2,857,017 - 2,859,705 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

POU4F1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	11	50,730,428 - 50,732,539 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	11	50,729,746 - 50,732,626 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	11	55,418,338 - 55,421,499 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

POU4F1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	3	57,667,248 - 57,673,071 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
Vero_WHO_p1.0	NW_023666046	13,898,273 - 13,902,805 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Pou4f1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624751	21,812,850 - 21,814,747 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624751	21,812,567 - 21,817,837 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Pou4f1
14 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	54
Count of miRNA genes:	50
Interacting mature miRNAs:	54
Transcripts:	ENSRNOT00000012828
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
731177	Uae26	Urinary albumin excretion QTL 26	2.4	0.025	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	15	67588667	101769107	Rat
1300144	Rf23	Renal function QTL 23	3.61		renal blood flow trait (VT:2000006)	absolute change in renal vascular resistance (CMO:0001900)	15	40631268	98288169	Rat
1576315	Schws6	Schwannoma susceptibility QTL 6		0.0069	nervous system integrity trait (VT:0010566)	post-insult time of death (CMO:0002005)	15	53806152	98806152	Rat
1549844	Bss7	Bone structure and strength QTL 7	6.4		femur strength trait (VT:0010010)	femur midshaft polar moment of inertia (CMO:0001669)	15	75788062	101769107	Rat
61477	Aia4	Adjuvant induced arthritis QTL 4	3		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	15	55596089	91365858	Rat
2300326	Plaw1	Placental weight QTL 1	15	0.005	placenta mass (VT:0004257)	placenta wet weight (CMO:0002088)	15	68327165	100062518	Rat
70182	BpQTLcluster12	Blood pressure QTL cluster 12	3.53		arterial blood pressure trait (VT:2000000)	absolute change in mean arterial blood pressure (CMO:0000533)	15	73690657	95018120	Rat
152025253	Hrtrt24	Heart rate QTL 24	3.82		heart pumping trait (VT:2000009)		15	27885774	86257085	Rat
70155	Gcs1	Gastric cancer susceptibility QTL1	3.8		stomach morphology trait (VT:0000470)	stomach tumor susceptibility score (CMO:0002043)	15	76306099	101769107	Rat
1582227	Gluco30	Glucose level QTL 30	3.6	0.0003	blood glucose amount (VT:0000188)	absolute change in blood glucose level area under curve (CMO:0002034)	15	28030665	82262678	Rat
1581555	Eae19	Experimental allergic encephalomyelitis QTL 19	4.7		nervous system integrity trait (VT:0010566)	experimental autoimmune encephalomyelitis severity score (CMO:0001419)	15	76306099	90088744	Rat
1582228	Epfw3	Epididymal fat weight QTL 3	4.1	0.0002	epididymal fat pad mass (VT:0010421)	epididymal fat pad weight to body weight ratio (CMO:0000658)	15	28030665	82262678	Rat
1578646	Bmd18	Bone mineral density QTL 18	5.2		femur mineral mass (VT:0010011)	trabecular volumetric bone mineral density (CMO:0001729)	15	22806240	98288169	Rat
631655	Bp126	Blood pressure QTL 126	4		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	15	58156477	101769107	Rat
1578647	Bmd17	Bone mineral density QTL 17	4		femur mineral mass (VT:0010011)	total volumetric bone mineral density (CMO:0001728)	15	22806240	98288169	Rat
631516	Gluco31	Glucose level QTL 31	7		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	15	55596089	95018120	Rat
1331724	Bp223	Blood pressure QTL 223	3.53715		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	15	73690518	95018228	Rat
1641889	Colcr6	Colorectal carcinoma resistance QTL 6	2.9	0.0126	intestine integrity trait (VT:0010554)	benign colorectal tumor surface area measurement (CMO:0001799)	15	73690518	99794247	Rat
1582242	Gluco28	Glucose level QTL 28	3.3	0.0008	blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	15	28030665	82262678	Rat
1578660	Bss19	Bone structure and strength QTL 19	4.3		femur morphology trait (VT:0000559)	bone trabecular cross-sectional area (CMO:0002311)	15	22806240	98288169	Rat
1582244	Bw79	Body weight QTL 79	4	0.0002	epididymal fat pad mass (VT:0010421)	epididymal fat pad weight to body weight ratio (CMO:0000658)	15	28030665	82262678	Rat
2317055	Aia10	Adjuvant induced arthritis QTL 10	3.41		joint integrity trait (VT:0010548)	left rear ankle joint diameter (CMO:0002149)	15	75788062	101769107	Rat
1582214	Stl21	Serum triglyceride level QTL 21	3.1	0.022	blood triglyceride amount (VT:0002644)	serum triglyceride level (CMO:0000360)	15	28030665	82262678	Rat

Markers in Region

PMC125354P1

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	15	81,257,804 - 81,258,078 (+)	MAPPER	mRatBN7.2
Rnor_6.0	15	88,620,494 - 88,620,767	NCBI	Rnor6.0
Rnor_5.0	15	92,116,254 - 92,116,527	UniSTS	Rnor5.0
RGSC_v3.4	15	88,537,237 - 88,537,510	UniSTS	RGSC3.4
Celera	15	80,384,969 - 80,385,242	UniSTS
Cytogenetic Map	15	q22	UniSTS

Pou4f1

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	15	81,257,337 - 81,257,415 (+)	MAPPER	mRatBN7.2
Rnor_6.0	15	88,620,027 - 88,620,104	NCBI	Rnor6.0
Rnor_5.0	15	92,115,787 - 92,115,864	UniSTS	Rnor5.0
RGSC_v3.4	15	88,536,770 - 88,536,847	UniSTS	RGSC3.4
Celera	15	80,384,502 - 80,384,579	UniSTS
Cytogenetic Map	15	q22	UniSTS

UniSTS:465489

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	15	81,257,765 - 81,257,929 (+)	MAPPER	mRatBN7.2
Rnor_6.0	15	88,620,455 - 88,620,618	NCBI	Rnor6.0
Rnor_5.0	15	92,116,215 - 92,116,378	UniSTS	Rnor5.0
RGSC_v3.4	15	88,537,198 - 88,537,361	UniSTS	RGSC3.4
Celera	15	80,384,930 - 80,385,093	UniSTS
Cytogenetic Map	15	q22	UniSTS

UniSTS:470675

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	15	81,257,776 - 81,257,929 (+)	MAPPER	mRatBN7.2
Rnor_6.0	15	88,620,466 - 88,620,618	NCBI	Rnor6.0
Rnor_5.0	15	92,116,226 - 92,116,378	UniSTS	Rnor5.0
RGSC_v3.4	15	88,537,209 - 88,537,361	UniSTS	RGSC3.4
Celera	15	80,384,941 - 80,385,093	UniSTS
Cytogenetic Map	15	q22	UniSTS

UniSTS:276144

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	15	81,258,786 - 81,259,784 (+)	MAPPER	mRatBN7.2
Rnor_6.0	15	88,621,472 - 88,622,469	NCBI	Rnor6.0
Rnor_5.0	15	92,117,134 - 92,118,131	UniSTS	Rnor5.0
RGSC_v3.4	15	88,538,315 - 88,539,312	UniSTS	RGSC3.4
Cytogenetic Map	15	q22	UniSTS

Pou4f1

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	15	81,258,900 - 81,259,735 (+)	MAPPER	mRatBN7.2
Rnor_6.0	15	88,621,586 - 88,622,420	NCBI	Rnor6.0
Rnor_5.0	15	92,117,248 - 92,118,082	UniSTS	Rnor5.0
RGSC_v3.4	15	88,538,429 - 88,539,263	UniSTS	RGSC3.4
Celera	15	80,386,144 - 80,386,978	UniSTS
Cytogenetic Map	15	q22	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	nervous system	renal system	reproductive system	respiratory system
9	8	6	98	69	65	45	18	45	6	133	38	83	34	53	20

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001419538	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006222050	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AF390075	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473951	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000015	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000092174 ⟹ ENSRNOP00000074614

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	15	81,257,781 - 81,259,728 (-)	Ensembl
Rnor_6.0 Ensembl	15	88,620,470 - 88,622,413 (-)	Ensembl

RefSeq Acc Id:

NM_001419538 ⟹ NP_001406467

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	15	87,668,328 - 87,674,643 (-)	NCBI
mRatBN7.2	15	81,253,714 - 81,260,029 (-)	NCBI

Protein Sequences


Protein RefSeqs	NP_001406467	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAK70502	(Get FASTA)	NCBI Sequence Viewer
	EDM02474	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000074614.2
GenBank Protein	P20266	(Get FASTA)	NCBI Sequence Viewer

Ensembl Acc Id:

ENSRNOP00000074614 ⟸ ENSRNOT00000092174

RefSeq Acc Id:

NP_001406467 ⟸ NM_001419538

Protein Domains

Homeobox POU-specific

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:620074	AgrOrtholog
BioCyc Gene	G2FUF-12651	BioCyc
Ensembl Genes	ENSRNOG00000060662	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000092174.2	UniProtKB/TrEMBL
Gene3D-CATH	1.10.260.40	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Homeodomain-like	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro	Homeobox-like_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Homeobox_CS	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Homeobox_dom	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Lambda_DNA-bd_dom_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	POU	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	POU_dom	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	POU_domain_TF	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene	114503	ENTREZGENE
PANTHER	POU DOMAIN	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PTHR11636:SF42	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	Homeodomain	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Pou	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Pou4f1	PhenoGen
PRINTS	POUDOMAIN	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE	HOMEOBOX_1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	HOMEOBOX_2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	POU_1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	POU_2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	POU_3	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000060662	RatGTEx
SMART	HOX	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	POU	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP	SSF46689	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SSF47413	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt	A0A0G2K8H8_RAT	UniProtKB/TrEMBL
	A6HUB1_RAT	UniProtKB/TrEMBL
	P20266	ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary	Q91XM4	UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2008-09-24	Pou4f1	POU class 4 homeobox 1	Pou4f1	POU domain, class 4, transcription factor 1	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2005-01-20	Pou4f1	POU domain, class 4, transcription factor 1			Symbol and Name status set to approved	1299863	APPROVED
2002-08-07	Pou4f1	POU domain, class 4, transcription factor 1			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

RGD Manual Annotations

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

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