POU4F1 (POU class 4 homeobox 1) - Rat Genome Database

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Gene: POU4F1 (POU class 4 homeobox 1) Canis lupus familiaris
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Symbol: POU4F1
Name: POU class 4 homeobox 1
RGD ID: 12164472
Description: ENCODES a protein that exhibits chromatin binding (inferred); DNA binding (inferred); DNA-binding transcription activator activity, RNA polymerase II-specific (inferred); INVOLVED IN cell migration in hindbrain (ortholog); central nervous system neuron differentiation (ortholog); habenula development (ortholog); PARTICIPATES IN p53 signaling pathway; ASSOCIATED WITH acute myeloid leukemia (ortholog); ATAXIA, INTENTION TREMOR, AND HYPOTONIA SYNDROME, CHILDHOOD-ONSET (ortholog); cervix uteri carcinoma in situ (ortholog); FOUND IN chromatin (inferred); cytoplasm (inferred); neuron projection (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: POU domain, class 4, transcription factor 1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12231,992,657 - 31,997,066 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2231,792,017 - 31,794,362 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02232,315,525 - 32,317,867 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2232,315,761 - 32,317,760 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12231,977,103 - 31,979,449 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02232,014,166 - 32,016,510 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02232,086,264 - 32,088,616 (-)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
cell migration in hindbrain  (IEA,ISO)
cellular response to cytokine stimulus  (IEA)
cellular response to estradiol stimulus  (IEA)
central nervous system neuron differentiation  (IEA,ISO)
habenula development  (IEA,ISO)
heart development  (IEA)
innervation  (IEA,ISO)
intrinsic apoptotic signaling pathway by p53 class mediator  (IEA)
mesoderm development  (IEA,ISO)
negative regulation of apoptotic process  (IEA,ISO)
negative regulation of gene expression  (IEA)
negative regulation of neuron apoptotic process  (IEA,ISO)
negative regulation of programmed cell death  (IEA)
negative regulation of transcription by RNA polymerase II  (IEA,ISO)
nervous system development  (IEA,ISO)
neuron apoptotic process  (IEA,ISO)
neuron differentiation  (IEA,ISO)
neuron fate specification  (IEA)
neuron migration  (IEA,ISO)
neuron projection development  (IEA)
peripheral nervous system neuron development  (IEA,ISO)
peripheral nervous system neuron differentiation  (IEA,ISO)
positive regulation of gene expression  (IEA)
positive regulation of neuron apoptotic process  (IEA,ISO)
positive regulation of osteoclast differentiation  (IEA)
positive regulation of transcription by RNA polymerase II  (IEA,ISO)
proprioception involved in equilibrioception  (IEA,ISO)
regulation of cell cycle  (IEA,ISO)
regulation of DNA-templated transcription  (IEA,ISO)
regulation of neurogenesis  (IEA,ISO)
sensory system development  (IEA)
spermatogenesis  (ISO)
suckling behavior  (IEA,ISO)
trigeminal nerve development  (IEA)
ventricular compact myocardium morphogenesis  (IEA)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
POU4F1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12231,992,657 - 31,997,066 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2231,792,017 - 31,794,362 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02232,315,525 - 32,317,867 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2232,315,761 - 32,317,760 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12231,977,103 - 31,979,449 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02232,014,166 - 32,016,510 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02232,086,264 - 32,088,616 (-)NCBIUU_Cfam_GSD_1.0
POU4F1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381378,598,362 - 78,603,552 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1378,598,362 - 78,603,552 (-)EnsemblGRCh38hg38GRCh38
GRCh371379,172,497 - 79,177,687 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361378,071,228 - 78,075,696 (-)NCBINCBI36Build 36hg18NCBI36
Build 341378,071,232 - 78,075,696NCBI
Celera1360,071,661 - 60,076,129 (-)NCBICelera
Cytogenetic Map13q31.1NCBI
HuRef1359,873,428 - 59,878,003 (-)NCBIHuRef
CHM1_11379,141,107 - 79,145,483 (-)NCBICHM1_1
T2T-CHM13v2.01377,824,085 - 77,829,278 (-)NCBIT2T-CHM13v2.0
Pou4f1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3914104,699,111 - 104,705,554 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl14104,699,112 - 104,705,435 (-)EnsemblGRCm39 Ensembl
GRCm3814104,461,675 - 104,468,118 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl14104,461,676 - 104,467,999 (-)EnsemblGRCm38mm10GRCm38
MGSCv3714104,861,537 - 104,867,216 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3614103,347,999 - 103,353,678 (-)NCBIMGSCv36mm8
Celera14103,076,392 - 103,080,281 (-)NCBICelera
Cytogenetic Map14E2.3NCBI
cM Map1454.21NCBI
Pou4f1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81587,668,328 - 87,674,643 (-)NCBIGRCr8
mRatBN7.21581,253,714 - 81,260,057 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1581,257,781 - 81,259,728 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.01588,618,255 - 88,622,712 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1588,620,470 - 88,622,413 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01592,114,015 - 92,118,240 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41588,535,625 - 88,539,256 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11588,553,052 - 88,553,272 (-)NCBI
Celera1580,380,878 - 80,387,018 (-)NCBICelera
Cytogenetic Map15q22NCBI
Pou4f1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495540428,812,762 - 28,818,024 (+)NCBIChiLan1.0ChiLan1.0
Pou4f1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404945127,439,842 - 127,446,181 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365112,857,331 - 2,859,277 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365112,857,017 - 2,859,705 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
POU4F1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1150,730,428 - 50,732,539 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11150,729,746 - 50,732,626 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21155,418,338 - 55,421,499 (-)NCBISscrofa10.2Sscrofa10.2susScr3
POU4F1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1357,667,248 - 57,673,071 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604613,898,273 - 13,902,805 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pou4f1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475121,812,850 - 21,814,747 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475121,812,567 - 21,817,837 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in POU4F1
62 total Variants

Expression


Sequence


RefSeq Acc Id: ENSCAFT00845049124   ⟹   ENSCAFP00845038542
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl2232,315,761 - 32,317,760 (-)Ensembl
RefSeq Acc Id: XM_038430803   ⟹   XP_038286731
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.02232,315,525 - 32,317,867 (-)NCBI
RefSeq Acc Id: XM_038456821   ⟹   XP_038312749
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
Dog10K_Boxer_Tasha2231,792,017 - 31,794,362 (-)NCBI
RefSeq Acc Id: XM_038506961   ⟹   XP_038362889
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.12231,977,103 - 31,979,449 (-)NCBI
RefSeq Acc Id: XM_038569375   ⟹   XP_038425303
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.02232,086,264 - 32,088,616 (-)NCBI
RefSeq Acc Id: XM_038633542   ⟹   XP_038489470
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.02232,014,166 - 32,016,510 (-)NCBI
RefSeq Acc Id: XP_038362889   ⟸   XM_038506961
RefSeq Acc Id: XP_038489470   ⟸   XM_038633542
RefSeq Acc Id: XP_038286731   ⟸   XM_038430803
- UniProtKB: A0A8C0M7A4 (UniProtKB/TrEMBL),   A0A8I3Q3P1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038312749   ⟸   XM_038456821
- UniProtKB: A0A8C0LMF5 (UniProtKB/TrEMBL),   A0A8C0M7A4 (UniProtKB/TrEMBL),   A0A8I3Q3P1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038425303   ⟸   XM_038569375
- UniProtKB: A0A8C0LMF5 (UniProtKB/TrEMBL),   A0A8C0M7A4 (UniProtKB/TrEMBL),   A0A8I3Q3P1 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCAFP00845038542   ⟸   ENSCAFT00845049124
Protein Domains
Homeobox   POU-specific


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000059274 UniProtKB/TrEMBL
  ENSCAFG00030004590 UniProtKB/TrEMBL
  ENSCAFG00845027838 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000102310.1 UniProtKB/TrEMBL
  ENSCAFT00030008431.1 UniProtKB/TrEMBL
  ENSCAFT00845049124.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.260.40 UniProtKB/TrEMBL
  Homeodomain-like UniProtKB/TrEMBL
InterPro Homeobox-like_sf UniProtKB/TrEMBL
  Homeobox_CS UniProtKB/TrEMBL
  Homeobox_dom UniProtKB/TrEMBL
  Lambda_DNA-bd_dom_sf UniProtKB/TrEMBL
  POU UniProtKB/TrEMBL
  POU_dom UniProtKB/TrEMBL
NCBI Gene POU4F1 ENTREZGENE
PANTHER POU DOMAIN UniProtKB/TrEMBL
  PTHR11636:SF42 UniProtKB/TrEMBL
Pfam Homeodomain UniProtKB/TrEMBL
  Pou UniProtKB/TrEMBL
PRINTS POUDOMAIN UniProtKB/TrEMBL
PROSITE HOMEOBOX_1 UniProtKB/TrEMBL
  HOMEOBOX_2 UniProtKB/TrEMBL
  POU_1 UniProtKB/TrEMBL
  POU_2 UniProtKB/TrEMBL
  POU_3 UniProtKB/TrEMBL
SMART HOX UniProtKB/TrEMBL
  POU UniProtKB/TrEMBL
Superfamily-SCOP SSF46689 UniProtKB/TrEMBL
  SSF47413 UniProtKB/TrEMBL
UniProt A0A8C0LMF5 ENTREZGENE
  A0A8C0M7A4 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3Q3P1 ENTREZGENE, UniProtKB/TrEMBL