Ghrh (growth hormone releasing hormone) - Rat Genome Database

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Gene: Ghrh (growth hormone releasing hormone) Rattus norvegicus
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Symbol: Ghrh
Name: growth hormone releasing hormone
RGD ID: 61883
Description: Enables growth hormone-releasing hormone activity. Involved in several processes, including negative regulation of cardiac muscle cell apoptotic process; positive regulation of cell communication; and positive regulation of circadian sleep/wake cycle, non-REM sleep. Located in axon terminus; extracellular space; and perikaryon. Used to study myocardial infarction and prostatic hypertrophy. Biomarker of sleep disorder. Human ortholog(s) of this gene implicated in autoimmune polyendocrine syndrome type 1; endometrial cancer; ovarian cancer; and renal cell carcinoma. Orthologous to human GHRH (growth hormone releasing hormone); INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: GHRF; GRF; growth hormone-releasing factor; growth hormone-releasing hormone; somatoliberin
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Candidate Gene For: Slep7 Bw94 Scl63
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83166,412,763 - 166,432,519 (-)NCBIGRCr8
mRatBN7.23145,992,762 - 146,012,528 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3145,992,763 - 146,011,889 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3149,818,121 - 149,837,238 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03158,319,491 - 158,338,548 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03156,060,811 - 156,079,879 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03153,449,124 - 153,468,794 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3153,449,125 - 153,468,794 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03158,251,824 - 158,270,812 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43148,027,235 - 148,046,352 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.13147,933,144 - 147,952,261 (-)NCBI
Celera3144,698,178 - 144,717,216 (-)NCBICelera
Cytogenetic Map3q42NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Gene expression in arcuate nucleus-median eminence of rats treated with leptin or ciliary neurotrophic factor. Ambati S, etal., Biofactors. 2007;31(2):133-44.
2. Pituitary adenomas in mice transgenic for growth hormone-releasing hormone. Asa SL, etal., Endocrinology. 1992 Nov;131(5):2083-9.
3. Expression of the growth hormone-releasing hormone gene and its peptide product in the rat ovary. Bagnato A, etal., Endocrinology. 1992 Mar;130(3):1097-102.
4. Characterization of a growth hormone-releasing hormone binding site in the rat renal medulla. Boulanger L, etal., Peptides 2002 Jan;23(1):43-50.
5. Growth hormone releasing factor, somatocrinin, releases pituitary growth hormone in vitro. Brazeau P, etal., Proc Natl Acad Sci U S A. 1982 Dec;79(24):7909-13.
6. Synthesis of new potent agonistic analogs of growth hormone-releasing hormone (GHRH) and evaluation of their endocrine and cardiac activities. Cai R, etal., Peptides. 2014 Feb;52:104-12. doi: 10.1016/j.peptides.2013.12.010. Epub 2013 Dec 25.
7. Prenatal dexamethasone exposure potentiates diet-induced hepatosteatosis and decreases plasma IGF-I in a sex-specific fashion. Carbone DL, etal., Endocrinology. 2012 Jan;153(1):295-306. doi: 10.1210/en.2011-1601. Epub 2011 Nov 8.
8. Inhibition of growth and reduction in tumorigenicity of UCI-107 ovarian cancer by antagonists of growth hormone-releasing hormone and vasoactive intestinal peptide. Chatzistamou I, etal., J Cancer Res Clin Oncol. 2001 Nov;127(11):645-52.
9. Corticotropin-releasing hormone, luteinizing hormone-releasing hormone, growth hormone-releasing hormone, and somatostatin-like immunoreactivities in biopsies from breast cancer patients. Ciocca DR, etal., Breast Cancer Res Treat. 1990 May;15(3):175-84.
10. Novel neuronal and endocrine autoantibody targets in Autoimmune Polyendocrine Syndrome type 1. Cocco C, etal., Autoimmunity. 2012 Sep;45(6):485-94. doi: 10.3109/08916934.2012.680632. Epub 2012 May 18.
11. Ghrelin and growth hormone (GH) secretagogues potentiate GH-releasing hormone (GHRH)-induced cyclic adenosine 3',5'-monophosphate production in cells expressing transfected GHRH and GH secretagogue receptors. Cunha SR and Mayo KE, Endocrinology 2002 Dec;143(12):4570-82.
12. GHRH and IL1beta increase cytoplasmic Ca(2+) levels in cultured hypothalamic GABAergic neurons. De A, etal., Brain Res. 2002 Sep 13;949(1-2):209-12.
13. Inhibition of growth of experimental human endometrial cancer by an antagonist of growth hormone-releasing hormone. Engel JB, etal., J Clin Endocrinol Metab. 2005 Jun;90(6):3614-21. Epub 2005 Mar 22.
14. [The effect of chronic intermittent hypoxia to hypothalamus-pituitary-adrenal axis and growth hormone level in rats during sleep]. Feng XW, etal., Zhongguo Ying Yong Sheng Li Xue Za Zhi. 2005 Nov;21(4):414-7.
15. [Regulation of hypothalamus-pituitary-adrenal axis and growth hormone axis in obstructive sleep apnea-hypopnea syndrome patients]. Feng XW, etal., Zhonghua Jie He He Hu Xi Za Zhi. 2006 Apr;29(4):230-2.
16. Growth hormone-releasing hormone effects on brain gamma-aminobutyric acid levels in mild cognitive impairment and healthy aging. Friedman SD, etal., JAMA Neurol. 2013 Jul;70(7):883-90. doi: 10.1001/jamaneurol.2013.1425.
17. Growth hormone-releasing hormone and pituitary somatotrope proliferation. Frohman LA and Kineman RD, Minerva Endocrinol. 2002 Dec;27(4):277-85.
18. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
19. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
20. Expression of the rat growth hormone-releasing hormone gene in placenta is directed by an alternative promoter. Gonzalez-Crespo S and Boronat A, Proc Natl Acad Sci U S A 1991 Oct 1;88(19):8749-53.
21. Growth hormone-releasing hormone promotes survival of cardiac myocytes in vitro and protects against ischaemia-reperfusion injury in rat heart. Granata R, etal., Cardiovasc Res. 2009 Jul 15;83(2):303-12. Epub 2009 Mar 17.
22. Expression of growth hormone-releasing hormone and its receptor splice variants in human prostate cancer. Halmos G, etal., J Clin Endocrinol Metab. 2002 Oct;87(10):4707-14.
23. Human renal cell carcinoma expresses distinct binding sites for growth hormone-releasing hormone. Halmos G, etal., Proc Natl Acad Sci U S A. 2000 Sep 12;97(19):10555-60.
24. Beneficial effects of novel antagonists of GHRH in different models of Alzheimer's disease. Jaszberenyi M, etal., Aging (Albany NY). 2012 Nov;4(11):755-67.
25. Expression of growth hormone-releasing hormone (GHRH) messenger ribonucleic acid and the presence of biologically active GHRH in human breast, endometrial, and ovarian cancers. Kahan Z, etal., J Clin Endocrinol Metab. 1999 Feb;84(2):582-9.
26. Cardioprotective effects of growth hormone-releasing hormone agonist after myocardial infarction. Kanashiro-Takeuchi RM, etal., Proc Natl Acad Sci U S A. 2010 Feb 9;107(6):2604-9. Epub 2010 Jan 21.
27. Human uterine and ovarian expression of growth hormone-releasing hormone messenger RNA in benign and malignant gynecologic conditions. Khorram O, etal., Fertil Steril. 2001 Jan;75(1):174-9.
28. Expression profiling and Ingenuity biological function analyses of interleukin-6- versus nerve growth factor-stimulated PC12 cells. Kunz D, etal., BMC Genomics. 2009 Feb 24;10:90.
29. GHRH receptor-targeted botulinum neurotoxin selectively inhibits pulsatile GH secretion in male rats. Leggett J, etal., Endocrinology. 2013 Sep;154(9):3305-18. doi: 10.1210/en.2012-2175. Epub 2013 Jul 3.
30. Localized suppression of cortical growth hormone-releasing hormone receptors state-specifically attenuates electroencephalographic delta waves. Liao F, etal., J Neurosci. 2010 Mar 17;30(11):4151-9. doi: 10.1523/JNEUROSCI.6047-09.2010.
31. Improvement of islet function in a bioartificial pancreas by enhanced oxygen supply and growth hormone releasing hormone agonist. Ludwig B, etal., Proc Natl Acad Sci U S A. 2012 Mar 27;109(13):5022-7. doi: 10.1073/pnas.1201868109. Epub 2012 Mar 5.
32. Muscle reinnervation and IGF-I synthesis are affected by exposure to heparin: an effect partially antagonized by anti-growth hormone-releasing hormone. Madaschi L, etal., Neurochem Res. 2003 Jan;28(1):163-8.
33. A germ line mutation that delays prostate cancer progression and prolongs survival in a murine prostate cancer model. Majeed N, etal., Oncogene. 2005 Jul 7;24(29):4736-40.
34. Characterization of cDNA and genomic clones encoding the precursor to rat hypothalamic growth hormone-releasing factor. Mayo KE, etal., Nature. 1985 Apr 4-10;314(6010):464-7.
35. Immunocytochemical localization of growth hormone-releasing factor in the rat hypothalamus. Merchenthaler I, etal., Endocrinology. 1984 Apr;114(4):1082-5.
36. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
37. The effects of GH-releasing hormone/somatostatin on the 5'-promoter activity of the GH gene in vitro. Morishita M, etal., J Mol Endocrinol. 2003 Dec;31(3):441-8.
38. Growth hormone releasing hormone (GHRH) signaling modulates intermittent hypoxia-induced oxidative stress and cognitive deficits in mouse. Nair D, etal., J Neurochem. 2013 Nov;127(4):531-40. doi: 10.1111/jnc.12360. Epub 2013 Jul 19.
39. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
40. Ceramide enhances growth hormone (GH)-releasing hormone-stimulated cyclic adenosine 3',5'-monophosphate accumulation but inhibits GH release in rat anterior pituitary cells. Negishi T, etal., Endocrinology. 1999 Dec;140(12):5691-7.
41. Growth hormone-releasing hormone and glucocorticoids determine the balance between luteinising hormone (LH) beta- and LH beta/follicle-stimulating hormone beta-positive gonadotrophs and somatotrophs in the 14-day-old rat pituitary tissue in aggregate cell culture. Pals K, etal., J Neuroendocrinol. 2008 May;20(5):535-48. Epub 2008 Mar 15.
42. Differential splicing of the growth hormone-releasing hormone gene in rat placenta generates a novel pre-proGHRH mRNA that encodes a different C-terminal flanking peptide. Perez-Riba M, etal., FEBS Lett. 1997 Feb 3;402(2-3):273-6.
43. Growth hormone-releasing hormone activates sleep regulatory neurons of the rat preoptic hypothalamus. Peterfi Z, etal., Am J Physiol Regul Integr Comp Physiol. 2010 Jan;298(1):R147-56. Epub 2009 Nov 4.
44. Sleep in spontaneous dwarf rats. Peterfi Z, etal., Brain Res. 2006 Sep 7;1108(1):133-46. Epub 2006 Jul 21.
45. GOA pipeline RGD automated data pipeline
46. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
47. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
48. Comprehensive gene review and curation RGD comprehensive gene curation
49. Combining growth hormone-releasing hormone antagonist with luteinizing hormone-releasing hormone antagonist greatly augments benign prostatic hyperplasia shrinkage. Rick FG, etal., J Urol. 2012 Apr;187(4):1498-504. doi: 10.1016/j.juro.2011.11.081. Epub 2012 Feb 17.
50. Antagonists of growth hormone-releasing hormone (GHRH) reduce prostate size in experimental benign prostatic hyperplasia. Rick FG, etal., Proc Natl Acad Sci U S A. 2011 Mar 1;108(9):3755-60. doi: 10.1073/pnas.1018086108. Epub 2011 Feb 14.
51. GH, but not GHRH, plays a role in the development of experimental autoimmune encephalomyelitis. Shohreh R, etal., Endocrinology. 2011 Oct;152(10):3803-10. Epub 2011 Aug 16.
52. Presence of a spermatogenic-specific promoter in the rat growth hormone-releasing hormone gene. Srivastava CH, etal., Endocrinology. 1995 Apr;136(4):1502-8.
53. Growth hormone-releasing hormone: cerebral cortical sleep-related EEG actions and expression. Szentirmai E, etal., Am J Physiol Regul Integr Comp Physiol. 2007 Aug;293(2):R922-30. Epub 2007 May 30.
54. Role of growth hormone-releasing hormone in sleep and growth impairments induced by upper airway obstruction in rats. Tarasiuk A, etal., Eur Respir J. 2011 Oct;38(4):870-7. Epub 2011 Mar 15.
55. The hypothalamic mechanisms of the hypophysiotropic action of ghrelin. Wren AM, etal., Neuroendocrinology 2002 Nov;76(5):316-24.
Additional References at PubMed
PMID:1333056   PMID:1334535   PMID:2857452   PMID:3008329   PMID:6406907   PMID:7680413   PMID:7694848   PMID:7867561   PMID:7912976   PMID:7980597   PMID:8391647   PMID:8395283  
PMID:8421089   PMID:9348175   PMID:10537133   PMID:11773624   PMID:12867592   PMID:12876464   PMID:15070777   PMID:15146101   PMID:15538933   PMID:15985453   PMID:16246898   PMID:16513828  
PMID:16728494   PMID:18329818   PMID:18628614   PMID:19553459   PMID:20814072   PMID:23417421   PMID:26831066   PMID:27480202   PMID:37572878  


Genomics

Comparative Map Data
Ghrh
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83166,412,763 - 166,432,519 (-)NCBIGRCr8
mRatBN7.23145,992,762 - 146,012,528 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3145,992,763 - 146,011,889 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3149,818,121 - 149,837,238 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03158,319,491 - 158,338,548 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03156,060,811 - 156,079,879 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03153,449,124 - 153,468,794 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3153,449,125 - 153,468,794 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03158,251,824 - 158,270,812 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43148,027,235 - 148,046,352 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.13147,933,144 - 147,952,261 (-)NCBI
Celera3144,698,178 - 144,717,216 (-)NCBICelera
Cytogenetic Map3q42NCBI
GHRH
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382037,251,086 - 37,261,814 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2037,251,086 - 37,261,819 (-)EnsemblGRCh38hg38GRCh38
GRCh372035,879,489 - 35,890,217 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362035,312,903 - 35,318,706 (-)NCBINCBI36Build 36hg18NCBI36
Build 342035,312,902 - 35,318,706NCBI
Celera2032,586,769 - 32,592,579 (-)NCBICelera
Cytogenetic Map20q11.23NCBI
HuRef2032,615,081 - 32,620,891 (-)NCBIHuRef
CHM1_12035,782,445 - 35,788,255 (-)NCBICHM1_1
T2T-CHM13v2.02038,975,156 - 38,985,884 (-)NCBIT2T-CHM13v2.0
Ghrh
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392157,171,416 - 157,190,645 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2157,171,417 - 157,189,426 (-)EnsemblGRCm39 Ensembl
GRCm382157,329,496 - 157,348,725 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2157,329,497 - 157,347,506 (-)EnsemblGRCm38mm10GRCm38
MGSCv372157,155,232 - 157,172,391 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362157,020,942 - 157,038,038 (-)NCBIMGSCv36mm8
Celera2163,265,842 - 163,283,112 (-)NCBICelera
Cytogenetic Map2H1NCBI
cM Map278.25NCBI
Ghrh
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495542224,481,246 - 24,490,529 (+)NCBIChiLan1.0ChiLan1.0
GHRH
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22142,978,526 - 42,985,770 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12042,971,567 - 42,978,804 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02033,573,001 - 33,583,699 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12034,687,587 - 34,693,258 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2034,687,587 - 34,693,240 (-)Ensemblpanpan1.1panPan2
GHRH
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12425,893,224 - 25,902,095 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2425,893,225 - 25,897,712 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2425,542,127 - 25,546,302 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02426,590,708 - 26,594,898 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2426,590,708 - 26,594,883 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12425,867,994 - 25,872,168 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02425,973,219 - 25,977,394 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02426,462,493 - 26,466,667 (-)NCBIUU_Cfam_GSD_1.0
Ghrh
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640174,794,985 - 174,803,395 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365613,950,340 - 3,952,405 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365613,946,256 - 3,954,472 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GHRH
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1740,387,344 - 40,397,857 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11740,386,725 - 40,398,312 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21745,876,581 - 45,887,302 (-)NCBISscrofa10.2Sscrofa10.2susScr3
GHRH
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1226,482,734 - 26,493,761 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl226,487,973 - 26,493,499 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605075,362,464 - 75,373,119 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ghrh
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046251466,381 - 13,318 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046251465,484 - 8,763 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Ghrh
104 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:48
Count of miRNA genes:41
Interacting mature miRNAs:44
Transcripts:ENSRNOT00000010298, ENSRNOT00000010443
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
12879876Bw182Body weight QTL 1820.003body mass (VT:0001259)body weight (CMO:0000012)3145925360166177555Rat
2301411Bp320Blood pressure QTL 3200.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)3145925360166177555Rat
2312673Scl63Serum cholesterol level QTL 630.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)398535255168026850Rat
1300113Bp176Blood pressure QTL 1763.9arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)3145956084157309487Rat
12879872Cm97Cardiac mass QTL 970.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)3145925360166177555Rat
1598877Bp285Blood pressure QTL 2851.50.03arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3120538241165538241Rat
1578653Vnigr3Vascular neointimal growth QTL 33.1artery morphology trait (VT:0002191)artery neointimal hyperplastic lesion area (CMO:0001414)3130656562169034231Rat
12879873Cm96Cardiac mass QTL 960.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)3145925360166177555Rat
2302373Gluco39Glucose level QTL 395.01blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)398535386161695835Rat
12879874Cm98Cardiac mass QTL 980.005heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)3145925360166177555Rat
1298068Bp167Blood pressure QTL 1670.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3141074471169034231Rat
12879875Kidm64Kidney mass QTL 640.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)3145925360166177555Rat
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)331172320163586636Rat
2292591Esta4Estrogen-induced thymic atrophy QTL 4thymus mass (VT:0004954)thymus wet weight (CMO:0000855)347233211147415807Rat
2298477Eau4Experimental allergic uveoretinitis QTL 40.0011uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)3137398739169034231Rat
8552791Vie2Viral induced encephalitis QTL 24.1brain integrity trait (VT:0010579)encephalitis incidence/prevalence measurement (CMO:0002361)3145956084169034231Rat
61335Bp20Blood pressure QTL 203arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3141339236155617360Rat
1581568Rf53Renal function QTL 53urine total protein amount (VT:0000032)urine protein excretion rate to body weight ratio (CMO:0001099)356395968161299569Rat
2317883Alcrsp26Alcohol response QTL 261.80.63response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)3145526770169034231Rat
1578754Stresp16Stress response QTL 1640.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)3112681431157681431Rat
1331726Bp208Blood pressure QTL 2083.129arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)3141339013162184794Rat
1598854Memor10Memory QTL 102exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)3145956084161299569Rat
9589106Insul23Insulin level QTL 2313.860.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)3131635904169034231Rat
10755461Coatc16Coat color QTL 16coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)3122438700167438700Rat
8662816Vetf4Vascular elastic tissue fragility QTL 44renal artery integrity trait (VT:0010642)number of ruptures of the internal elastic lamina of the renal arteries (CMO:0002563)359242096157323038Rat
1559282Emca5Estrogen-induced mammary cancer QTL 53.9mammary gland integrity trait (VT:0010552)percentage of study population developing mammary tumors during a period of time (CMO:0000948)343827364169034231Rat
2303620Vencon4Ventilatory control QTL 43.9respiration trait (VT:0001943)tidal volume (CMO:0000222)3127162703168026850Rat
631841Niddm39Non-insulin dependent diabetes mellitus QTL 393.36blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)394856903159898684Rat
1576306Schws3Schwannoma susceptibility QTL 30.001nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)3118839124163839124Rat
619618Rf3Renal disease susceptibility QTL 36.50.001urine albumin amount (VT:0002871)urine albumin excretion rate to body weight ratio (CMO:0001270)3107693393152693393Rat
1300159Kidm4Kidney mass QTL 43.83kidney mass (VT:0002707)right kidney wet weight to body weight ratio (CMO:0001953)3121056165157309487Rat
5686842Rf59Renal function QTL 59urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)3140069424146976080Rat
2301971Cm71Cardiac mass QTL 714.63heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)341874578155617519Rat
2312659Slep7Serum leptin concentration QTL 70.001blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)398535255168026850Rat
631673Iddm13Insulin dependent diabetes mellitus QTL 131.30.663blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)3130193298161695983Rat
2301970Bw81Body weight QTL 815.19body mass (VT:0001259)body weight (CMO:0000012)341874578155617519Rat
1581546Pur13Proteinuria QTL 132.930.0335urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)378196190146592722Rat
1578656Vnigr2Vascular neointimal growth QTL 24.2artery morphology trait (VT:0002191)lesioned artery residual lumen area (CMO:0001417)3130656562169034231Rat
8552952Pigfal13Plasma insulin-like growth factor 1 level QTL 13blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)3138799500169034231Rat
12879871Am7Aortic mass QTL 70.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)3145925360166177555Rat
631541Bp81Blood pressure QTL 814arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3124122556169034231Rat
2293087Iddm27Insulin dependent diabetes mellitus QTL 272.68blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)397551417147415807Rat
2312670Bw94Body weight QTL 940.01inguinal fat pad mass (VT:0010424)inguinal fat pad weight to body weight ratio (CMO:0001253)398535255168026850Rat

Markers in Region
D3Got116  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23146,013,606 - 146,013,771 (+)MAPPERmRatBN7.2
Rnor_6.03153,469,939 - 153,470,103NCBIRnor6.0
Rnor_5.03158,249,942 - 158,250,106UniSTSRnor5.0
RGSC_v3.43148,048,069 - 148,048,234RGDRGSC3.4
RGSC_v3.43148,048,070 - 148,048,234UniSTSRGSC3.4
RGSC_v3.13147,953,978 - 147,954,143RGD
Celera3144,718,934 - 144,719,098UniSTS
RH 3.4 Map31351.2UniSTS
RH 3.4 Map31351.2RGD
RH 2.0 Map3910.9RGD
Cytogenetic Map3q42UniSTS
D3Got118  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23146,013,606 - 146,013,749 (+)MAPPERmRatBN7.2
Rnor_6.03153,469,939 - 153,470,081NCBIRnor6.0
Rnor_5.03158,249,964 - 158,250,106UniSTSRnor5.0
RGSC_v3.43148,048,069 - 148,048,212RGDRGSC3.4
RGSC_v3.43148,048,070 - 148,048,212UniSTSRGSC3.4
RGSC_v3.13147,953,979 - 147,954,121RGD
Celera3144,718,934 - 144,719,076UniSTS
RH 3.4 Map31355.2UniSTS
RH 3.4 Map31355.2RGD
RH 2.0 Map3917.7RGD
Cytogenetic Map3q42UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 8 30 107 67 68 38 25 38 6 158 72 88 31 53 30

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_031577 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008762304 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063283212 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063283213 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC095852 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH474005 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000003 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M73486 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M73487 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U10154 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U10155 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U10156 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U41183 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X02319 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X02320 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X02321 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X02322 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X02335 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  Z34003 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  Z34004 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  Z34092 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000010298   ⟹   ENSRNOP00000010298
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl3145,993,724 - 146,011,889 (-)Ensembl
Rnor_6.0 Ensembl3153,450,086 - 153,454,160 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000010443   ⟹   ENSRNOP00000010444
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl3145,992,763 - 146,011,889 (-)Ensembl
Rnor_6.0 Ensembl3153,449,125 - 153,468,221 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000082145   ⟹   ENSRNOP00000072891
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl3153,449,125 - 153,468,794 (-)Ensembl
RefSeq Acc Id: NM_031577   ⟹   NP_113765
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83166,412,763 - 166,431,880 (-)NCBI
mRatBN7.23145,992,762 - 146,011,889 (-)NCBI
Rnor_6.03153,449,124 - 153,468,221 (-)NCBI
Rnor_5.03158,251,824 - 158,270,812 (+)NCBI
RGSC_v3.43148,027,235 - 148,046,352 (-)RGD
Celera3144,698,178 - 144,717,216 (-)RGD
Sequence:
RefSeq Acc Id: XM_008762304   ⟹   XP_008760526
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83166,412,763 - 166,432,519 (-)NCBI
mRatBN7.23145,992,762 - 146,012,528 (-)NCBI
Rnor_6.03153,449,124 - 153,468,794 (-)NCBI
Sequence:
RefSeq Acc Id: XM_063283212   ⟹   XP_063139282
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83166,412,763 - 166,432,519 (-)NCBI
RefSeq Acc Id: XM_063283213   ⟹   XP_063139283
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83166,412,763 - 166,421,171 (-)NCBI
RefSeq Acc Id: NP_113765   ⟸   NM_031577
- Peptide Label: precursor
- UniProtKB: P09916 (UniProtKB/Swiss-Prot),   A6JWS0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008760526   ⟸   XM_008762304
- Peptide Label: isoform X1
- UniProtKB: P09916 (UniProtKB/Swiss-Prot),   A6JWS0 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000072891   ⟸   ENSRNOT00000082145
Ensembl Acc Id: ENSRNOP00000010444   ⟸   ENSRNOT00000010443
Ensembl Acc Id: ENSRNOP00000010298   ⟸   ENSRNOT00000010298
RefSeq Acc Id: XP_063139282   ⟸   XM_063283212
- Peptide Label: isoform X1
- UniProtKB: P09916 (UniProtKB/Swiss-Prot),   A6JWS0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063139283   ⟸   XM_063283213
- Peptide Label: isoform X1
- UniProtKB: P09916 (UniProtKB/Swiss-Prot),   A6JWS0 (UniProtKB/TrEMBL)
Protein Domains
Glucagon / GIP / secretin / VIP family

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P09916-F1-model_v2 AlphaFold P09916 1-104 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:61883 AgrOrtholog
BioCyc Gene G2FUF-47058 BioCyc
Ensembl Genes ENSRNOG00000007782 Ensembl, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00055026810 UniProtKB/Swiss-Prot
  ENSRNOG00060023424 UniProtKB/Swiss-Prot
  ENSRNOG00065027216 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000010298.7 UniProtKB/TrEMBL
  ENSRNOT00000010443.7 UniProtKB/Swiss-Prot
  ENSRNOT00055046303 UniProtKB/Swiss-Prot
  ENSRNOT00060040595 UniProtKB/Swiss-Prot
  ENSRNOT00065046945 UniProtKB/Swiss-Prot
InterPro Glucagon_GIP_secretin_VIP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  VIP/GHRH-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:29446 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 29446 ENTREZGENE
PANTHER PTHR11213 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SOMATOLIBERIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Hormone_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Ghrh PhenoGen
PROSITE GLUCAGON UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000007782 RatGTEx
  ENSRNOG00055026810 RatGTEx
  ENSRNOG00060023424 RatGTEx
  ENSRNOG00065027216 RatGTEx
SMART GLUCA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A6JWS0 ENTREZGENE, UniProtKB/TrEMBL
  A6JWS2_RAT UniProtKB/TrEMBL
  A6JWS3_RAT UniProtKB/TrEMBL
  A6JWS4_RAT UniProtKB/TrEMBL
  P09916 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary P97567 UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Ghrh  growth hormone releasing hormone      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference