GHRH (growth hormone releasing hormone) - Rat Genome Database

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Gene: GHRH (growth hormone releasing hormone) Homo sapiens
Analyze
Symbol: GHRH
Name: growth hormone releasing hormone
RGD ID: 737566
HGNC Page HGNC:4265
Description: Enables growth hormone-releasing hormone activity and growth hormone-releasing hormone receptor binding activity. Involved in positive regulation of cell population proliferation. Acts upstream of or within several processes, including adenylate cyclase-activating G protein-coupled receptor signaling pathway; growth hormone secretion; and positive regulation of growth hormone secretion. Predicted to be located in extracellular region. Predicted to be active in extracellular space; perikaryon; and terminal bouton. Implicated in autoimmune polyendocrine syndrome type 1; endometrial cancer; ovarian cancer; and renal cell carcinoma. Biomarker of breast cancer; endometriosis (multiple); obstructive sleep apnea; and reproductive organ cancer (multiple).
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: GHRF; GRF; growth hormone releasing factor; growth hormone-releasing factor; growth hormone-releasing hormone; INN; MGC119781; sermorelin; somatocrinin; somatoliberin; somatorelin
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382037,251,086 - 37,261,814 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2037,251,086 - 37,261,819 (-)EnsemblGRCh38hg38GRCh38
GRCh372035,879,489 - 35,890,217 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362035,312,903 - 35,318,706 (-)NCBINCBI36Build 36hg18NCBI36
Build 342035,312,902 - 35,318,706NCBI
Celera2032,586,769 - 32,592,579 (-)NCBICelera
Cytogenetic Map20q11.23NCBI
HuRef2032,615,081 - 32,620,891 (-)NCBIHuRef
CHM1_12035,782,445 - 35,788,255 (-)NCBICHM1_1
T2T-CHM13v2.02038,975,156 - 38,985,884 (-)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
axon terminus  (ISO)
extracellular region  (IEA,NAS,TAS)
extracellular space  (IBA,IEA,ISO,ISS)
perikaryon  (IBA,ISO)
terminal bouton  (IBA,IEA,ISS)

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Human Phenotype
References

References - curated
# Reference Title Reference Citation
1. Pituitary adenomas in mice transgenic for growth hormone-releasing hormone. Asa SL, etal., Endocrinology. 1992 Nov;131(5):2083-9.
2. Synthesis of new potent agonistic analogs of growth hormone-releasing hormone (GHRH) and evaluation of their endocrine and cardiac activities. Cai R, etal., Peptides. 2014 Feb;52:104-12. doi: 10.1016/j.peptides.2013.12.010. Epub 2013 Dec 25.
3. Inhibition of growth and reduction in tumorigenicity of UCI-107 ovarian cancer by antagonists of growth hormone-releasing hormone and vasoactive intestinal peptide. Chatzistamou I, etal., J Cancer Res Clin Oncol. 2001 Nov;127(11):645-52.
4. Corticotropin-releasing hormone, luteinizing hormone-releasing hormone, growth hormone-releasing hormone, and somatostatin-like immunoreactivities in biopsies from breast cancer patients. Ciocca DR, etal., Breast Cancer Res Treat. 1990 May;15(3):175-84.
5. Novel neuronal and endocrine autoantibody targets in Autoimmune Polyendocrine Syndrome type 1. Cocco C, etal., Autoimmunity. 2012 Sep;45(6):485-94. doi: 10.3109/08916934.2012.680632. Epub 2012 May 18.
6. Inhibition of growth of experimental human endometrial cancer by an antagonist of growth hormone-releasing hormone. Engel JB, etal., J Clin Endocrinol Metab. 2005 Jun;90(6):3614-21. Epub 2005 Mar 22.
7. [Regulation of hypothalamus-pituitary-adrenal axis and growth hormone axis in obstructive sleep apnea-hypopnea syndrome patients]. Feng XW, etal., Zhonghua Jie He He Hu Xi Za Zhi. 2006 Apr;29(4):230-2.
8. Growth hormone-releasing hormone effects on brain gamma-aminobutyric acid levels in mild cognitive impairment and healthy aging. Friedman SD, etal., JAMA Neurol. 2013 Jul;70(7):883-90. doi: 10.1001/jamaneurol.2013.1425.
9. GOAs Human GO annotations GOA_HUMAN data from the GO Consortium
10. Expression of growth hormone-releasing hormone and its receptor splice variants in human prostate cancer. Halmos G, etal., J Clin Endocrinol Metab. 2002 Oct;87(10):4707-14.
11. Human renal cell carcinoma expresses distinct binding sites for growth hormone-releasing hormone. Halmos G, etal., Proc Natl Acad Sci U S A. 2000 Sep 12;97(19):10555-60.
12. Beneficial effects of novel antagonists of GHRH in different models of Alzheimer's disease. Jaszberenyi M, etal., Aging (Albany NY). 2012 Nov;4(11):755-67.
13. Expression of growth hormone-releasing hormone (GHRH) messenger ribonucleic acid and the presence of biologically active GHRH in human breast, endometrial, and ovarian cancers. Kahan Z, etal., J Clin Endocrinol Metab. 1999 Feb;84(2):582-9.
14. Human uterine and ovarian expression of growth hormone-releasing hormone messenger RNA in benign and malignant gynecologic conditions. Khorram O, etal., Fertil Steril. 2001 Jan;75(1):174-9.
15. Improvement of islet function in a bioartificial pancreas by enhanced oxygen supply and growth hormone releasing hormone agonist. Ludwig B, etal., Proc Natl Acad Sci U S A. 2012 Mar 27;109(13):5022-7. doi: 10.1073/pnas.1201868109. Epub 2012 Mar 5.
16. A germ line mutation that delays prostate cancer progression and prolongs survival in a murine prostate cancer model. Majeed N, etal., Oncogene. 2005 Jul 7;24(29):4736-40.
17. Growth hormone releasing hormone (GHRH) signaling modulates intermittent hypoxia-induced oxidative stress and cognitive deficits in mouse. Nair D, etal., J Neurochem. 2013 Nov;127(4):531-40. doi: 10.1111/jnc.12360. Epub 2013 Jul 19.
18. Sleep in spontaneous dwarf rats. Peterfi Z, etal., Brain Res. 2006 Sep 7;1108(1):133-46. Epub 2006 Jul 21.
19. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
20. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
21. Combining growth hormone-releasing hormone antagonist with luteinizing hormone-releasing hormone antagonist greatly augments benign prostatic hyperplasia shrinkage. Rick FG, etal., J Urol. 2012 Apr;187(4):1498-504. doi: 10.1016/j.juro.2011.11.081. Epub 2012 Feb 17.
22. Antagonists of growth hormone-releasing hormone (GHRH) reduce prostate size in experimental benign prostatic hyperplasia. Rick FG, etal., Proc Natl Acad Sci U S A. 2011 Mar 1;108(9):3755-60. doi: 10.1073/pnas.1018086108. Epub 2011 Feb 14.
23. GH, but not GHRH, plays a role in the development of experimental autoimmune encephalomyelitis. Shohreh R, etal., Endocrinology. 2011 Oct;152(10):3803-10. Epub 2011 Aug 16.
24. Role of growth hormone-releasing hormone in sleep and growth impairments induced by upper airway obstruction in rats. Tarasiuk A, etal., Eur Respir J. 2011 Oct;38(4):870-7. Epub 2011 Mar 15.
Additional References at PubMed
PMID:1333056   PMID:2854259   PMID:2857452   PMID:2992358   PMID:3002494   PMID:3008329   PMID:3029387   PMID:3918305   PMID:6192430   PMID:6415488   PMID:6812220   PMID:7680413  
PMID:8020943   PMID:8421089   PMID:8670892   PMID:10537133   PMID:11773624   PMID:11780052   PMID:12036966   PMID:12126741   PMID:12186980   PMID:12213676   PMID:12424433   PMID:12477932  
PMID:12511850   PMID:12867592   PMID:15362970   PMID:15489334   PMID:15538933   PMID:16214911   PMID:16606630   PMID:17372203   PMID:17546465   PMID:18240029   PMID:18329818   PMID:18684444  
PMID:18996102   PMID:19086053   PMID:19088192   PMID:19453261   PMID:19487270   PMID:19524226   PMID:19622623   PMID:20150954   PMID:20169434   PMID:20372804   PMID:20453000   PMID:20518847  
PMID:20602615   PMID:20633588   PMID:20634197   PMID:20673733   PMID:20734064   PMID:20810604   PMID:20843274   PMID:20869425   PMID:21196925   PMID:21274339   PMID:21478211   PMID:21715545  
PMID:21873635   PMID:22423511   PMID:23542451   PMID:26671997   PMID:26917260   PMID:27816751   PMID:28130121   PMID:28438614   PMID:28626214   PMID:29273763   PMID:29426577   PMID:29571594  
PMID:30344124   PMID:32065979   PMID:33060564   PMID:33961781   PMID:35566020   PMID:36724073  


Genomics

Comparative Map Data
GHRH
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382037,251,086 - 37,261,814 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2037,251,086 - 37,261,819 (-)EnsemblGRCh38hg38GRCh38
GRCh372035,879,489 - 35,890,217 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362035,312,903 - 35,318,706 (-)NCBINCBI36Build 36hg18NCBI36
Build 342035,312,902 - 35,318,706NCBI
Celera2032,586,769 - 32,592,579 (-)NCBICelera
Cytogenetic Map20q11.23NCBI
HuRef2032,615,081 - 32,620,891 (-)NCBIHuRef
CHM1_12035,782,445 - 35,788,255 (-)NCBICHM1_1
T2T-CHM13v2.02038,975,156 - 38,985,884 (-)NCBIT2T-CHM13v2.0
Ghrh
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392157,171,416 - 157,190,645 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2157,171,417 - 157,189,426 (-)EnsemblGRCm39 Ensembl
GRCm382157,329,496 - 157,348,725 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2157,329,497 - 157,347,506 (-)EnsemblGRCm38mm10GRCm38
MGSCv372157,155,232 - 157,172,391 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362157,020,942 - 157,038,038 (-)NCBIMGSCv36mm8
Celera2163,265,842 - 163,283,112 (-)NCBICelera
Cytogenetic Map2H1NCBI
cM Map278.25NCBI
Ghrh
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83166,412,763 - 166,432,519 (-)NCBIGRCr8
mRatBN7.23145,992,762 - 146,012,528 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3145,992,763 - 146,011,889 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3149,818,121 - 149,837,238 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03158,319,491 - 158,338,548 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03156,060,811 - 156,079,879 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03153,449,124 - 153,468,794 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3153,449,125 - 153,468,794 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03158,251,824 - 158,270,812 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43148,027,235 - 148,046,352 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.13147,933,144 - 147,952,261 (-)NCBI
Celera3144,698,178 - 144,717,216 (-)NCBICelera
Cytogenetic Map3q42NCBI
Ghrh
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495542224,481,246 - 24,490,529 (+)NCBIChiLan1.0ChiLan1.0
GHRH
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22142,978,526 - 42,985,770 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12042,971,567 - 42,978,804 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02033,573,001 - 33,583,699 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12034,687,587 - 34,693,258 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2034,687,587 - 34,693,240 (-)Ensemblpanpan1.1panPan2
GHRH
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12425,893,224 - 25,902,095 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2425,893,225 - 25,897,712 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2425,542,127 - 25,546,302 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02426,590,708 - 26,594,898 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2426,590,708 - 26,594,883 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12425,867,994 - 25,872,168 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02425,973,219 - 25,977,394 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02426,462,493 - 26,466,667 (-)NCBIUU_Cfam_GSD_1.0
Ghrh
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640174,794,985 - 174,803,395 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365613,950,340 - 3,952,405 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365613,946,256 - 3,954,472 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GHRH
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1740,387,344 - 40,397,857 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11740,386,725 - 40,398,312 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21745,876,581 - 45,887,302 (-)NCBISscrofa10.2Sscrofa10.2susScr3
GHRH
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1226,482,734 - 26,493,761 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl226,487,973 - 26,493,499 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605075,362,464 - 75,373,119 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ghrh
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046251466,381 - 13,318 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046251465,484 - 8,763 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in GHRH
6 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 20q11.22-12(chr20:34541747-39663219)x1 copy number loss Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052766]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052766]|See cases [RCV000052766] Chr20:34541747..39663219 [GRCh38]
Chr20:33129551..38291861 [GRCh37]
Chr20:32593212..37725275 [NCBI36]
Chr20:20q11.22-12		 pathogenic
GRCh38/hg38 20q11.22-13.11(chr20:34249453-43359749)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053002]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053002]|See cases [RCV000053002] Chr20:34249453..43359749 [GRCh38]
Chr20:32837259..41988389 [GRCh37]
Chr20:32300920..41421803 [NCBI36]
Chr20:20q11.22-13.11		 pathogenic
GRCh38/hg38 20p12.2-q12(chr20:9811433-39316956)x3 copy number gain See cases [RCV000052999] Chr20:9811433..39316956 [GRCh38]
Chr20:9792081..37945599 [GRCh37]
Chr20:9740081..37379013 [NCBI36]
Chr20:20p12.2-q12		 pathogenic
NM_001184731.1(GHRH):c.209G>A (p.Gly70Glu) single nucleotide variant Malignant melanoma [RCV000072621] Chr20:37254309 [GRCh38]
Chr20:35882712 [GRCh37]
Chr20:35316126 [NCBI36]
Chr20:20q11.23		 not provided
GRCh38/hg38 20p13-q13.33(chr20:99557-64277321)x3 copy number gain See cases [RCV000135859] Chr20:99557..64277321 [GRCh38]
Chr20:80198..62908674 [GRCh37]
Chr20:28198..62379118 [NCBI36]
Chr20:20p13-q13.33		 pathogenic
GRCh38/hg38 20q11.22-13.12(chr20:35237946-47631818)x1 copy number loss See cases [RCV000140816] Chr20:35237946..47631818 [GRCh38]
Chr20:33825749..46260562 [GRCh37]
Chr20:33289165..45693969 [NCBI36]
Chr20:20q11.22-13.12		 pathogenic
GRCh37/hg19 20p13-q13.33(chr20:61569-62915555)x3 copy number gain See cases [RCV000510832] Chr20:61569..62915555 [GRCh37]
Chr20:20p13-q13.33		 pathogenic
GRCh37/hg19 20p13-q13.33(chr20:61569-62915555) copy number gain See cases [RCV000512450] Chr20:61569..62915555 [GRCh37]
Chr20:20p13-q13.33		 pathogenic
Single allele deletion Focal-onset seizure [RCV001004039] Chr20:34980430..46806549 [GRCh37]
Chr20:20q11.23-13.13		 likely pathogenic
GRCh37/hg19 20p13-q13.33(chr20:63244-62948788)x3 copy number gain not provided [RCV000741058] Chr20:63244..62948788 [GRCh37]
Chr20:20p13-q13.33		 pathogenic
GRCh37/hg19 20p13-q13.33(chr20:63244-62961294)x3 copy number gain not provided [RCV000741059] Chr20:63244..62961294 [GRCh37]
Chr20:20p13-q13.33		 pathogenic
GRCh37/hg19 20p13-q13.33(chr20:63244-62912463)x3 copy number gain not provided [RCV000741057] Chr20:63244..62912463 [GRCh37]
Chr20:20p13-q13.33		 pathogenic
NM_021081.6(GHRH):c.147C>T (p.Ser49=) single nucleotide variant not provided [RCV000887187] Chr20:37256435 [GRCh38]
Chr20:35884838 [GRCh37]
Chr20:20q11.23		 benign
NC_000020.10:g.(?_35569422)_(36500415_?)dup duplication Aicardi-Goutieres syndrome 5 [RCV003119602]|Congenital disorder of glycosylation [RCV004579604] Chr20:35569422..36500415 [GRCh37]
Chr20:20q11.23		 uncertain significance
NM_021081.6(GHRH):c.106A>C (p.Ile36Leu) single nucleotide variant not specified [RCV004235576] Chr20:37256476 [GRCh38]
Chr20:35884879 [GRCh37]
Chr20:20q11.23		 uncertain significance
NM_021081.6(GHRH):c.226G>C (p.Gly76Arg) single nucleotide variant not specified [RCV004353440] Chr20:37254292 [GRCh38]
Chr20:35882695 [GRCh37]
Chr20:20q11.23		 uncertain significance
NM_021081.6(GHRH):c.179G>A (p.Arg60Lys) single nucleotide variant not specified [RCV004362974] Chr20:37256403 [GRCh38]
Chr20:35884806 [GRCh37]
Chr20:20q11.23		 uncertain significance
NM_021081.6(GHRH):c.70C>A (p.Pro24Thr) single nucleotide variant not specified [RCV004335190] Chr20:37256820 [GRCh38]
Chr20:35885223 [GRCh37]
Chr20:20q11.23		 uncertain significance
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:594
Count of miRNA genes:300
Interacting mature miRNAs:321
Transcripts:ENST00000237527, ENST00000373611, ENST00000373614
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCh38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300007BP29_HBlood pressure QTL 29 (human)Blood pressurehypertension susceptibility203653600562536005Human

Markers in Region
G66937  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh372035,885,121 - 35,885,422UniSTSGRCh37
Build 362035,318,535 - 35,318,836RGDNCBI36
Celera2032,592,401 - 32,592,702RGD
Cytogenetic Map20q11.2UniSTS
HuRef2032,620,713 - 32,621,014UniSTS
G66938  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh372035,884,625 - 35,885,036UniSTSGRCh37
Build 362035,318,039 - 35,318,450RGDNCBI36
Celera2032,591,905 - 32,592,316RGD
Cytogenetic Map20q11.2UniSTS
HuRef2032,620,217 - 32,620,628UniSTS
G66939  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh372035,882,441 - 35,882,789UniSTSGRCh37
Build 362035,315,855 - 35,316,203RGDNCBI36
Celera2032,589,721 - 32,590,069RGD
Cytogenetic Map20q11.2UniSTS
HuRef2032,618,033 - 32,618,381UniSTS
G66940  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh372035,879,261 - 35,879,764UniSTSGRCh37
Build 362035,312,675 - 35,313,178RGDNCBI36
Celera2032,586,541 - 32,587,044RGD
Cytogenetic Map20q11.2UniSTS
HuRef2032,614,853 - 32,615,356UniSTS
RH71427  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh372035,879,493 - 35,879,615UniSTSGRCh37
Build 362035,312,907 - 35,313,029RGDNCBI36
Celera2032,586,773 - 32,586,895RGD
Cytogenetic Map20q11.2UniSTS
HuRef2032,615,085 - 32,615,207UniSTS
GeneMap99-GB4 RH Map20209.07UniSTS
NCBI RH Map20309.5UniSTS
RH71010  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh372035,879,509 - 35,879,625UniSTSGRCh37
Build 362035,312,923 - 35,313,039RGDNCBI36
Celera2032,586,789 - 32,586,905RGD
Cytogenetic Map20q11.2UniSTS
HuRef2032,615,101 - 32,615,217UniSTS
GeneMap99-GB4 RH Map20208.81UniSTS
NCBI RH Map20309.6UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system adipose tissue appendage
High 2 3
Medium 1 107 1 56 1 23
Low 33 298 35 2 56 2 67 8 229 6 87 35 1 2
Below cutoff 583 536 336 89 257 68 695 445 1046 43 435 260 24 130 414

Sequence


Ensembl Acc Id: ENST00000237527   ⟹   ENSP00000237527
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl2037,251,086 - 37,261,819 (-)Ensembl
Ensembl Acc Id: ENST00000373611   ⟹   ENSP00000362713
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl2037,251,160 - 37,256,889 (-)Ensembl
Ensembl Acc Id: ENST00000373614   ⟹   ENSP00000362716
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl2037,251,086 - 37,261,814 (-)Ensembl
RefSeq Acc Id: NM_001184731   ⟹   NP_001171660
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh382037,251,086 - 37,261,814 (-)NCBI
GRCh372035,879,489 - 35,887,534 (-)NCBI
HuRef2032,615,081 - 32,620,891 (-)ENTREZGENE
CHM1_12035,782,445 - 35,788,267 (-)NCBI
T2T-CHM13v2.02038,975,156 - 38,985,884 (-)NCBI
Sequence:
RefSeq Acc Id: NM_021081   ⟹   NP_066567
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh382037,251,086 - 37,261,814 (-)NCBI
GRCh372035,879,489 - 35,887,534 (-)NCBI
Build 362035,312,903 - 35,318,706 (-)NCBI Archive
HuRef2032,615,081 - 32,620,891 (-)ENTREZGENE
CHM1_12035,782,445 - 35,788,267 (-)NCBI
T2T-CHM13v2.02038,975,156 - 38,985,884 (-)NCBI
Sequence:
RefSeq Acc Id: NP_001171660   ⟸   NM_001184731
- Peptide Label: isoform 2 preproprotein
- UniProtKB: P01286 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_066567   ⟸   NM_021081
- Peptide Label: isoform 1 preproprotein
- UniProtKB: Q4KN10 (UniProtKB/Swiss-Prot),   Q5JYR1 (UniProtKB/Swiss-Prot),   P01286 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSP00000362713   ⟸   ENST00000373611
Ensembl Acc Id: ENSP00000362716   ⟸   ENST00000373614
Ensembl Acc Id: ENSP00000237527   ⟸   ENST00000237527

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P01286-F1-model_v2 AlphaFold P01286 1-108 view protein structure

Promoters
RGD ID:6849968
Promoter ID:EP24001
Type:single initiation site
Name:HS_GHRH
Description:Growth hormone-releasing factor, GHRH or GHRF gene.
SO ACC ID:SO:0000170
Source:EPD (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Tissues & Cell Lines:hypothalamus
Experiment Methods:Nuclease protection with homologous sequence ladder; Primer extension
Position:
Human AssemblyChrPosition (strand)Source
Build 362035,323,631 - 35,323,691EPD
RGD ID:13206877
Promoter ID:EPDNEW_H27019
Type:initiation region
Name:GHRH_1
Description:growth hormone releasing hormone
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh382037,261,814 - 37,261,874EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:4265 AgrOrtholog
COSMIC GHRH COSMIC
Ensembl Genes ENSG00000118702 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
  ENSG00000291972 UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000237527 ENTREZGENE
  ENST00000237527.8 UniProtKB/Swiss-Prot
  ENST00000373614 ENTREZGENE
  ENST00000373614.7 UniProtKB/Swiss-Prot
  ENST00000709405.1 UniProtKB/Swiss-Prot
  ENST00000709406.1 UniProtKB/Swiss-Prot
GTEx ENSG00000118702 GTEx
  ENSG00000291972 GTEx
HGNC ID HGNC:4265 ENTREZGENE
Human Proteome Map GHRH Human Proteome Map
InterPro Glucagon_GIP_secretin_VIP UniProtKB/Swiss-Prot
  VIP/GHRH-like UniProtKB/Swiss-Prot
KEGG Report hsa:2691 UniProtKB/Swiss-Prot
NCBI Gene 2691 ENTREZGENE
OMIM 139190 OMIM
PANTHER PTHR11213 UniProtKB/Swiss-Prot
  SOMATOLIBERIN UniProtKB/Swiss-Prot
Pfam Hormone_2 UniProtKB/Swiss-Prot
PharmGKB PA28675 PharmGKB
PROSITE GLUCAGON UniProtKB/Swiss-Prot
SMART GLUCA UniProtKB/Swiss-Prot
UniProt P01286 ENTREZGENE
  Q4KN10 ENTREZGENE
  Q5JYR1 ENTREZGENE
  SLIB_HUMAN UniProtKB/Swiss-Prot
UniProt Secondary Q4KN10 UniProtKB/Swiss-Prot
  Q5JYR1 UniProtKB/Swiss-Prot