Ada (adenosine deaminase) - Rat Genome Database

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Gene: Ada (adenosine deaminase) Rattus norvegicus
Analyze
Symbol: Ada
Name: adenosine deaminase
RGD ID: 2031
Description: Enables adenosine deaminase activity and purine nucleoside binding activity. Involved in several processes, including adenosine catabolic process; negative regulation of circadian sleep/wake cycle, non-REM sleep; and response to vitamin E. Located in dendrite cytoplasm; extracellular space; and neuronal cell body. Used to study hypertension; peritonitis; and pulmonary edema. Biomarker of several diseases, including glucose metabolism disease (multiple); leptospirosis; peritonitis; sporotrichosis; and trypanosomiasis. Human ortholog(s) of this gene implicated in asthma; colon cancer; pleural tuberculosis; severe combined immunodeficiency (multiple); and uterine fibroid. Orthologous to human ADA (adenosine deaminase); PARTICIPATES IN adenine phoshoribosyltransferase deficiency pathway; adenosine monophosphate deaminase deficiency pathway; adenylosuccinate lyase deficiency pathway; INTERACTS WITH (R)-lipoic acid; (R)-noradrenaline; (S)-nicotine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: adenosine aminohydrolase; MGC108610
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: AdaTn(sb-T2/Bart3)2.237Mcwi  
Genetic Models: F344-AdaTn(sb-T2/Bart3)2.237Mcwi
Candidate Gene For: Eau4
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83172,818,174 - 172,842,283 (-)NCBIGRCr8
mRatBN7.23152,398,745 - 152,422,854 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3152,398,747 - 152,447,088 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3156,206,205 - 156,230,314 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03164,705,138 - 164,729,255 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03162,449,261 - 162,473,358 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03160,115,840 - 160,139,947 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3160,115,842 - 160,139,947 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03166,306,001 - 166,330,108 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43154,636,530 - 154,660,637 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.13154,542,567 - 154,566,673 (-)NCBI
Celera3151,051,040 - 151,075,153 (-)NCBICelera
Cytogenetic Map3q42NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
adenosine deaminase deficiency  (ISO,ISS)
asthma  (ISO)
autism spectrum disorder  (ISO)
autistic disorder  (ISO)
Brain Hypoxia-Ischemia  (IEP)
Cadmium Poisoning  (IEP)
Chemical and Drug Induced Liver Injury  (IEP)
colon cancer  (ISO)
colorectal cancer  (ISO)
Coronary Disease  (ISO)
diabetes mellitus  (IEP)
Experimental Diabetes Mellitus  (IEP,ISO)
Experimental Liver Cirrhosis  (ISO)
familial hyperlipidemia  (IEP)
focal epilepsy  (ISO)
gastric ulcer  (ISO)
genetic disease  (ISO)
Hyperemia  (ISO)
hyperglycemia  (IEP)
hypertension  (IDA)
Hypertriglyceridemia  (IEP)
laryngeal squamous cell carcinoma  (ISO)
Legionnaires' disease  (ISO)
leptospirosis  (IEP)
lung disease  (IEP)
Lung Neoplasms  (ISO)
lung non-small cell carcinoma  (ISO)
lymphopenia  (ISO)
malignant mesothelioma  (ISO)
Malignant Pleural Effusions  (ISO)
Mycoplasma pneumoniae pneumonia  (ISO)
Myocardial Reperfusion Injury  (IDA)
obesity  (ISO)
oral cavity cancer  (ISO)
oral squamous cell carcinoma  (ISO)
peritonitis  (IDA,IEP)
Pleural Effusion  (ISO)
pleural tuberculosis  (ISO)
pleurisy  (ISO)
primary immunodeficiency disease  (ISO)
pulmonary edema  (IMP)
pulmonary sarcoidosis  (ISO)
pulmonary tuberculosis  (ISO)
Q fever  (ISO)
severe combined immunodeficiency  (ISO)
severe combined immunodeficiency, autosomal recessive, T cell-negative, B cell-negative, NK cell-positive  (ISO)
spinal cord disease  (ISO)
sporotrichosis  (IEP)
stomach cancer  (ISO)
T-Cell Immunodeficiency, Recurrent Infections, and Autoimmunity with or without Cardiac Malformations  (ISO)
tongue squamous cell carcinoma  (ISO)
trypanosomiasis  (IEP)
type 2 diabetes mellitus  (ISO)
uterine fibroid  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(R)-lipoic acid  (EXP)
(R)-noradrenaline  (EXP,ISO)
(S)-nicotine  (EXP)
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrobenzenesulfonic acid  (EXP)
2,4-dinitrotoluene  (EXP)
2-hydroxypropanoic acid  (ISO)
2-methylcholine  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-\{[(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)carbonyl]amino\}benzoic acid  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
6-propyl-2-thiouracil  (EXP)
8-Epidiosbulbin E acetate  (ISO)
acetamide  (EXP)
acrylamide  (ISO)
adenosine  (ISO)
afimoxifene  (ISO)
all-trans-retinoic acid  (ISO)
alpha-Zearalanol  (EXP)
amitrole  (EXP)
ammonium acetate  (EXP)
ammonium chloride  (EXP)
atrazine  (ISO)
belinostat  (ISO)
benzalkonium chloride  (ISO)
benzene  (EXP)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
beta-lapachone  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (EXP)
calciol  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chloroprene  (EXP)
chrysene  (ISO)
cisplatin  (ISO)
cobalt dichloride  (EXP,ISO)
copper atom  (EXP)
copper(0)  (EXP)
copper(II) chloride  (ISO)
corticotropin  (ISO)
Cuprizon  (EXP)
cyclosporin A  (ISO)
DDE  (ISO)
dexamethasone  (ISO)
dextran sulfate  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (EXP,ISO)
dioxygen  (ISO)
diuron  (ISO)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
doxycycline  (ISO)
endosulfan  (EXP)
entinostat  (ISO)
erdosteine  (EXP)
ethyl methanesulfonate  (ISO)
fipronil  (EXP)
flutamide  (EXP)
folic acid  (ISO)
fructose  (EXP)
fulvestrant  (ISO)
genistein  (ISO)
glycerol  (ISO)
haloperidol  (EXP)
hydrogen sulfide  (ISO)
indole-3-butyric acid  (EXP)
indometacin  (ISO)
inosine  (ISO)
irinotecan  (EXP)
isoprenaline  (ISO)
L-glutamine  (EXP)
lipoic acid  (EXP)
lipopolysaccharide  (ISO)
methimazole  (EXP)
methotrexate  (EXP)
N(gamma)-nitro-L-arginine methyl ester  (EXP)
N-formyl-L-methionyl-L-leucyl-L-phenylalanine  (ISO)
N-nitrosodimethylamine  (EXP)
naphthalene  (ISO)
naringin  (EXP)
neomycin  (ISO)
nickel sulfate  (ISO)
nicotine  (EXP)
oxaliplatin  (EXP,ISO)
panobinostat  (ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP,ISO)
phenethyl caffeate  (EXP)
phenobarbital  (ISO)
phenylmercury acetate  (ISO)
pirinixic acid  (ISO)
potassium bromate  (EXP)
potassium chromate  (ISO)
progesterone  (ISO)
propiconazole  (EXP)
propranolol  (EXP)
quercetin  (EXP,ISO)
rac-lactic acid  (ISO)
resveratrol  (ISO)
rotenone  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 431542  (ISO)
sodium acetate trihydrate  (EXP)
sodium arsenite  (ISO)
streptozocin  (EXP)
sulfadimethoxine  (EXP)
sulforaphane  (ISO)
sunitinib  (ISO)
superoxide  (ISO)
tamibarotene  (ISO)
tamoxifen  (ISO)
temozolomide  (ISO)
tetrachloromethane  (EXP,ISO)
thioacetamide  (EXP)
thymoquinone  (ISO)
titanium dioxide  (ISO)
topotecan  (EXP)
tributylstannane  (ISO)
trichostatin A  (ISO)
trimellitic anhydride  (ISO)
Triptolide  (EXP)
tris(2-butoxyethyl) phosphate  (ISO)
valproic acid  (EXP,ISO)
vorinostat  (ISO)
zidovudine  (ISO)
zinc atom  (EXP)
zinc sulfate  (EXP)
zinc(0)  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adenosine catabolic process  (IBA,IEA,IMP,ISO,ISS)
adenosine metabolic process  (IDA,ISO,TAS)
allantoin metabolic process  (IEA,ISO)
alpha-beta T cell differentiation  (IEA,ISO)
amide catabolic process  (IEA,ISO)
AMP catabolic process  (IEA,ISO)
AMP salvage  (IEA,ISO)
apoptotic process  (ISO)
B cell proliferation  (IEA,ISO)
calcium-mediated signaling  (IEA,ISO)
cell adhesion  (IEA)
dAMP catabolic process  (IEA,ISO)
dATP catabolic process  (IEA,ISO)
deoxyadenosine catabolic process  (IEA,ISO)
embryonic digestive tract development  (IEA,ISO)
germinal center B cell differentiation  (IEA,ISO)
germinal center formation  (IEA,ISO)
GMP salvage  (IEA,ISO)
histamine secretion  (IMP)
hypoxanthine biosynthetic process  (IEA,ISO)
hypoxanthine salvage  (IBA)
in utero embryonic development  (ISO)
inosine biosynthetic process  (IBA,IEA,ISO,ISS)
leukocyte migration  (IEA,ISO)
liver development  (IEA,ISO)
lung alveolus development  (IEA,ISO)
lung development  (ISO)
mature B cell apoptotic process  (IEA,ISO)
mucus secretion  (IEA,ISO)
negative regulation of adenosine receptor signaling pathway  (IBA,IEA,ISO)
negative regulation of apoptotic process  (ISO)
negative regulation of circadian sleep/wake cycle, non-REM sleep  (IMP)
negative regulation of inflammatory response  (IEA,ISO)
negative regulation of leukocyte migration  (IEA,ISO)
negative regulation of mature B cell apoptotic process  (IEA,ISO)
negative regulation of mucus secretion  (IEA,ISO)
negative regulation of penile erection  (IEA,ISO)
negative regulation of thymocyte apoptotic process  (IEA,ISO)
penile erection  (IEA,ISO)
Peyer's patch development  (IEA,ISO)
placenta development  (IEA,ISO)
positive regulation of alpha-beta T cell differentiation  (IEA,ISO)
positive regulation of B cell proliferation  (IEA,ISO)
positive regulation of calcium-mediated signaling  (IEA,ISO)
positive regulation of germinal center formation  (IEA,ISO)
positive regulation of heart rate  (IEA,ISO)
positive regulation of smooth muscle contraction  (IEA,ISO)
positive regulation of T cell activation  (ISO)
positive regulation of T cell differentiation  (ISO)
positive regulation of T cell differentiation in thymus  (IEA,ISO)
positive regulation of T cell receptor signaling pathway  (IEA,ISO)
purine nucleotide salvage  (ISO)
purine ribonucleoside monophosphate biosynthetic process  (IEA)
regulation of cell-cell adhesion mediated by integrin  (IEA,ISO)
regulation of circadian sleep/wake cycle, sleep  (IEP)
regulation of T cell differentiation  (ISO)
regulation of T cell differentiation in thymus  (IMP)
response to cadmium ion  (IEP)
response to hydrogen peroxide  (IEP)
response to hypoxia  (IEA,IMP,ISO)
response to L-arginine  (IEP)
response to purine-containing compound  (IEA,ISO)
response to vitamin E  (IDA)
response to xenobiotic stimulus  (IEP)
smooth muscle contraction  (IEA,ISO)
T cell activation  (IBA,ISO)
T cell differentiation  (ISO)
T cell differentiation in thymus  (IEA,ISO)
T cell receptor signaling pathway  (IEA,ISO)
thymocyte apoptotic process  (IEA,ISO)
trophectodermal cell differentiation  (IEA,ISO)
xanthine biosynthetic process  (IEA,ISO)

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Curcumin improves episodic memory in cadmium induced memory impairment through inhibition of acetylcholinesterase and adenosine deaminase activities in a rat model. Akinyemi AJ, etal., Metab Brain Dis. 2017 Feb;32(1):87-95. doi: 10.1007/s11011-016-9887-x. Epub 2016 Aug 5.
2. Anti-inflammatory and antimicrobial effect of lectin from Lonchocarpus sericeus seeds in an experimental rat model of infectious peritonitis. Alencar NM, etal., J Pharm Pharmacol. 2005 Jul;57(7):919-22.
3. Serum and pleural adenosine deaminase. Correlation with lymphocytic populations. Baganha MF, etal., Chest. 1990 Mar;97(3):605-10. doi: 10.1378/chest.97.3.605.
4. Serum adenosine deaminase in pulmonary tuberculosis, malignancy and non-tubercular respiratory diseases. Bansal SK, etal., Indian J Chest Dis Allied Sci. 1991 Oct-Dec;33(4):189-93.
5. The distribution of adenosine deaminase among lymphocyte populations in the rat. Barton R, etal., J Immunol. 1979 Jan;122(1):216-20.
6. The effects of an induced adenosine deaminase deficiency on T-cell differentiation in the rat. Barton RW, Cell Immunol. 1985 Oct 15;95(2):297-310. doi: 10.1016/0008-8749(85)90317-x.
7. The ecto-enzymes CD73 and adenosine deaminase modulate 5'-AMP-derived adenosine in myofibroblasts of the rat small intestine. Bin A, etal., Purinergic Signal. 2018 Dec;14(4):409-421. doi: 10.1007/s11302-018-9623-6. Epub 2018 Sep 29.
8. Syzygium cumini seed extract ameliorates adenosine deaminase activity and biochemical parameters but does not alter insulin sensitivity and pancreas architecture in a short-term model of diabetes. Bitencourt PE, etal., J Complement Integr Med. 2015 Sep;12(3):187-93. doi: 10.1515/jcim-2015-0008.
9. Adenosine deaminase-deficient mice generated using a two-stage genetic engineering strategy exhibit a combined immunodeficiency. Blackburn MR, etal., J Biol Chem 1998 Feb 27;273(9):5093-100.
10. Adenosine deaminase activity in serum and lymphocytes of rats infected with Sporothrix schenckii. Castro VS, etal., Mycopathologia. 2012 Jul;174(1):31-9. doi: 10.1007/s11046-011-9511-x. Epub 2011 Dec 15.
11. Study of leukocytic hydrolytic enzymes in patients with acute stage of coronary heart disease. Chavan V, etal., Indian J Med Sci. 2007 Feb;61(2):73-82.
12. Macrophages are a source of extracellular adenosine deaminase-2 during inflammatory responses. Conlon BA and Law WR, Clin Exp Immunol. 2004 Oct;138(1):14-20. doi: 10.1111/j.1365-2249.2004.02591.x.
13. Fine-tuning modulation of myenteric motoneurons by endogenous adenosine: on the role of secreted adenosine deaminase. Correia-de-Sa P, etal., Auton Neurosci. 2006 Jun 30;126-127:211-24. Epub 2006 Mar 6.
14. Activity of the enzyme adenosine deaminase in serum, erythrocytes and lymphocytes of rats infected with Trypanosoma evansi. da Silva AS, etal., Parasitology. 2011 Feb;138(2):201-8.
15. Enhanced oral bioavailability of 2'- beta-fluoro-2',3'-dideoxyadenosine (F-ddA) through local inhibition of intestinal adenosine deaminase. DeGraw RT and Anderson BD, Pharm Res 2001 Sep;18(9):1270-6.
16. Adenosine deaminase activity and its isoenzymes in the sputum of patients with pulmonary tuberculosis. Dimakou K, etal., Int J Tuberc Lung Dis. 2009 Jun;13(6):744-8.
17. Adenosine deaminase, 5'-nucleotidase, guanase and cytidine deaminase activities in gastric tissues from patients with gastric cancer. Durak I, etal., Cancer Lett. 1994 Sep 15;84(2):199-202. doi: 10.1016/0304-3835(94)90376-x.
18. Adenosine deaminase, 5' nucleotidase, xanthine oxidase, superoxide dismutase, and catalase activities in cancerous and noncancerous human laryngeal tissues. Durak I, etal., Free Radic Biol Med. 1993 Dec;15(6):681-4. doi: 10.1016/0891-5849(93)90174-s.
19. Effects of black grape extract on activities of DNA turn-over enzymes in cancerous and non cancerous human colon tissues. Durak I, etal., Life Sci. 2005 May 6;76(25):2995-3000. doi: 10.1016/j.lfs.2004.11.018. Epub 2005 Jan 28.
20. Activities of adenosine deaminase and 5'-nucleotidase in cancerous and noncancerous human colorectal tissues. Eroglu A, etal., Med Oncol. 2000 Nov;17(4):319-24. doi: 10.1007/BF02782198.
21. Expression of adenosine deaminase and 5'-nucleotidase in artificially induced deciduoma in rat and hamster. Farheen S, etal., Indian J Exp Biol 2002 Aug;40(8):889-93.
22. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
23. Distribution of adenosine deaminase activity in rat brain and spinal cord. Geiger JD and Nagy JI, J Neurosci. 1986 Sep;6(9):2707-14.
24. Genetic variability within Adenosine Deaminase gene and uterine leiomyomas. Gloria-Bottini F, etal., Eur J Obstet Gynecol Reprod Biol. 2016 Apr;199:108-9. doi: 10.1016/j.ejogrb.2016.02.002. Epub 2016 Feb 17.
25. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
26. The effects of ginkgo biloba extract on tissue adenosine deaminase, xanthine oxidase, myeloperoxidase, malondialdehyde, and nitric oxide in cisplatin-induced nephrotoxicity. Gulec M, etal., Toxicol Ind Health. 2006 Apr;22(3):125-30.
27. Developmental expression of adenosine deaminase during decidualization in the rat uterus. Hong L, etal., Biol Reprod. 1991 Jan;44(1):83-93. doi: 10.1095/biolreprod44.1.83.
28. Adenosine deaminase from deoxycoformycin-sensitive and -resistant rat hepatoma cells. Purification and characterization. Hunt SW 3rd and Hoffee PA, J Biol Chem. 1982 Dec 10;257(23):14239-44.
29. The effect of caffeic acid phenethyl ester on short-term acute myocardial ischemia. Ince H, etal., Med Sci Monit. 2006 May;12(5):BR187-93.
30. AMP deaminase and adenosine deaminase activities in liver and brain regions in acute ammonia intoxication and subacute toxic hepatitis. Kaminsky Y and Kosenko E, Brain Res. 2010 Jan 22;1311:175-81. doi: 10.1016/j.brainres.2009.10.073. Epub 2009 Nov 10.
31. Adenosine deaminase activity in bronchoalveolar lavage in Turkish patients with smear negative pulmonary tuberculosis. Kayacan O, etal., Respir Med. 2002 Jul;96(7):536-41.
32. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
33. Adenosine Deaminase - a Novel Diagnostic and Prognostic Biomarker for Oral Squamous Cell Carcinoma. Kelgandre DC, etal., Asian Pac J Cancer Prev. 2016;17(4):1865-8. doi: 10.7314/apjcp.2016.17.4.1865.
34. Antioxidants modulate adenosine metabolism in rat mesangial cells cultured under high glucose conditions. Kocic G, etal., Ren Fail. 2002 Nov;24(6):691-701.
35. L-arginine intake effect on adenine nucleotide metabolism in rat parenchymal and reproductive tissues. Kocic G, etal., ScientificWorldJournal. 2012;2012:208239. doi: 10.1100/2012/208239. Epub 2012 Apr 24.
36. Alteration of adenosine deaminase levels in peripheral blood lymphocytes of patients with gastric cancer. Kojima O, etal., Jpn J Surg. 1985 Mar;15(2):130-3. doi: 10.1007/BF02469742.
37. Activation of AMP deaminase and adenosine deaminase in the liver during ammonia poisoning and hepatitis. Kosenko EA and Kaminsky YG, Bull Exp Biol Med. 2010 Jul;150(1):36-8.
38. [Adenosine deaminase activity in bronchoalveolar lavage fluid of sarcoidosis patients]. Kubota M, etal., Nihon Kokyuki Gakkai Zasshi. 1999 May;37(5):374-9.
39. Adenosine deaminase activity in the serum of type 2 diabetic patients. Kurtul N, etal., Acta Medica (Hradec Kralove). 2004;47(1):33-5.
40. The relationship between serum total sialic acid levels and adenosine deaminase activity in obesity. Kurtul N, etal., Saudi Med J. 2006 Feb;27(2):170-3.
41. ADA polymorphisms and asthma: a study in the Chinese Han population. Liu Y, etal., J Asthma. 2006 Apr;43(3):203-6.
42. Adenosine protected against pulmonary edema through transporter- and receptor A2-mediated endothelial barrier enhancement. Lu Q, etal., Am J Physiol Lung Cell Mol Physiol. 2010 Jun;298(6):L755-67. Epub 2010 Mar 12.
43. Activity of adenosine deaminase in the sleep regulatory areas of the rat CNS. Mackiewicz M, etal., Brain Res Mol Brain Res 2000 Sep 15;80(2):252-5.
44. Enzymes of adenosine metabolism in the brain: diurnal rhythm and the effect of sleep deprivation. Mackiewicz M, etal., J Neurochem. 2003 Apr;85(2):348-57.
45. Rutin and curcumin reduce inflammation, triglyceride levels and ADA activity in serum and immune cells in a model of hyperlipidemia. Manzoni AG, etal., Blood Cells Mol Dis. 2019 May;76:13-21. doi: 10.1016/j.bcmd.2018.12.005. Epub 2018 Dec 28.
46. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
47. Age-dependent variations of cell response to oxidative stress: proteomic approach to protein expression and phosphorylation. Miura Y, etal., Electrophoresis. 2005 Jul;26(14):2786-96.
48. Adenosine deaminase activity in the aetiological diagnosis of community-acquired pneumonia. Molinos L, etal., Scand J Infect Dis. 1997;29(3):287-90.
49. Adenosine deaminase inhibitor EHNA exhibits a potent anticancer effect against malignant pleural mesothelioma. Nakajima Y, etal., Cell Physiol Biochem. 2015;35(1):51-60. doi: 10.1159/000369674. Epub 2015 Jan 2.
50. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
51. Opioid-induced decreases in rat brain adenosine levels are reversed by inhibiting adenosine deaminase. Nelson AM, etal., Anesthesiology. 2009 Dec;111(6):1327-33.
52. Maximal activities of enzymes involved in adenosine metabolism in muscle and adipose tissue of rats under conditions of variations in insulin sensitivity. Newsholme EA, etal., FEBS Lett. 1985 Feb 11;181(1):189-92.
53. Is adenosine deaminase in pleural fluid a useful marker for differentiating tuberculosis from lung cancer or mesothelioma in Japan, a country with intermediate incidence of tuberculosis? Ogata Y, etal., Acta Med Okayama. 2011 Aug;65(4):259-63. doi: 10.18926/AMO/46851.
54. Adenosine in the tuberomammillary nucleus inhibits the histaminergic system via A1 receptors and promotes non-rapid eye movement sleep. Oishi Y, etal., Proc Natl Acad Sci U S A. 2008 Dec 16;105(50):19992-7. Epub 2008 Dec 9.
55. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
56. Sodium acetate improves disrupted glucoregulation and hepatic triglyceride content in insulin-resistant female rats: involvement of adenosine deaminase and dipeptidyl peptidase-4 activities. Omolekulo TE, etal., Naunyn Schmiedebergs Arch Pharmacol. 2019 Jan;392(1):103-116. doi: 10.1007/s00210-018-1569-2. Epub 2018 Oct 2.
57. Localization of S-adenosylhomocysteine hydrolase and adenosine deaminase immunoreactivities in rat brain. Patel BT and Tudball N, Brain Res. 1986 Apr 9;370(2):250-64.
58. Antiinflammatory effects of Tacrolimus in a mouse model of pleurisy. Pereira R, etal., Transpl Immunol. 2006 Aug;16(2):105-11. Epub 2006 May 30.
59. Neuroinflammation after neonatal hypoxia-ischemia is associated with alterations in the purinergic system: adenosine deaminase 1 isoenzyme is the most predominant after insult. Pimentel VC, etal., Mol Cell Biochem. 2015 May;403(1-2):169-77. doi: 10.1007/s11010-015-2347-9. Epub 2015 Feb 27.
60. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
61. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
62. RefSeq and LocusLink: NCBI gene-centered resources Pruitt KD and Maglott DR, Nucleic Acids Res. 2001 Jan 1;29(1):137-40.
63. Rat cerebral-cortex adenosine deaminase activity and its subcellular distribution. Pull I and McIlwain H, Biochem J. 1974 Oct;144(1):37-41.
64. The association of adenosine deaminase activity with T-lymphocytes and subsets in pulmonary tuberculosis and bronchogenic carcinoma. Pushpakom R, etal., J Med Assoc Thai. 1990 May;73(5):244-8.
65. Adenosine deaminase in saliva as a diagnostic marker of squamous cell carcinoma of tongue. Rai B, etal., Clin Oral Investig. 2011 Jun;15(3):347-9. doi: 10.1007/s00784-010-0404-z. Epub 2010 Apr 9.
66. GOA pipeline RGD automated data pipeline
67. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
68. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
69. Novel splicing, missense, and deletion mutations in seven adenosine deaminase-deficient patients with late/delayed onset of combined immunodeficiency disease. Contribution of genotype to phenotype. Santisteban I, etal., J Clin Invest 1993 Nov;92(5):2291-302.
70. Adenosine deaminase and 5'-nucleotidase activities in saliva from patients with oral and laryngeal cancer. Saracoglu U, etal., Oral Dis. 2005 Sep;11(5):323-5. doi: 10.1111/j.1601-0825.2005.01131.x.
71. Effects of resveratrol on nucleotide degrading enzymes in streptozotocin-induced diabetic rats. Schmatz R, etal., Life Sci. 2009 Mar 13;84(11-12):345-50. Epub 2009 Jan 8.
72. Alloxan diabetes regulates adenosine deaminase activity in mice: tissue- and age-specific correlation. Singh LS and Sharma R, Biochem Mol Biol Int. 1998 Sep;46(1):55-61.
73. A study of three polymorphic sites of ADA gene in colon cancer. Spina C, etal., Cancer Invest. 2010 Dec;28(10):989-92. doi: 10.3109/07357907.2010.483501. Epub 2010 Jun 30.
74. Adenosine and inosine release during hypoxia in the isolated spinal cord of neonatal rats. Takahashi T, etal., Br J Pharmacol. 2010 Dec;161(8):1806-16. doi: 10.1111/j.1476-5381.2010.01002.x.
75. Pleural Fluid Adenosine Deaminase (ADA) Predicts Survival in Patients with Malignant Pleural Effusion. Terra RM, etal., Lung. 2016 Aug;194(4):681-6. doi: 10.1007/s00408-016-9891-2. Epub 2016 Jun 14.
76. Effects of adenosine deaminase inhibition on blood pressure in old spontaneously hypertensive rats. Tofovic SP, etal., Clin Exp Hypertens. 1998 Apr;20(3):329-44.
77. Adenosine deaminase activity in serum, erythrocytes and lymphocytes of rats infected with Leptospira icterohaemorrhagiae. Tonin AA, etal., Res Vet Sci. 2011 Feb 12.
78. Zinc aspartate alleviates lung injury induced by intestinal ischemia-reperfusion in rats. Turut H, etal., J Surg Res. 2009 Jan;151(1):62-7. Epub 2008 Feb 7.
79. Increased adenosine deaminase (ADA) activity and a shift from ADA-dependent to ADA-independent phases during T-cell activation: a paradox. Veit BC, etal., J Natl Cancer Inst. 1984 May;72(5):1151-9.
80. Caspase-4 activation in association with decreased adenosine deaminase activity may be a factor for gastric ulcer. Yaguchi T, etal., Digestion. 2010;81(1):62-7. doi: 10.1159/000252771. Epub 2009 Dec 22.
81. Ultrastructural immunolocalization of adenosine deaminase in histaminergic neurons of the tuberomammillary nucleus of rat. Yamamoto T, etal., Brain Res. 1990 Sep 17;527(2):335-41.
82. Increased pleural fluid adenosine deaminase levels in patients with malignant pleural effusions: a potential predictor of talc pleurodesis outcome. Yildirim H, etal., Lung. 2007 Dec;185(6):349-54. doi: 10.1007/s00408-007-9042-x. Epub 2007 Oct 19.
83. ADA activity is decreased in lymphocytes from patients with advanced stage of lung cancer. Zanini D, etal., Med Oncol. 2019 Aug 2;36(9):78. doi: 10.1007/s12032-019-1301-1.
84. Differential diagnosis of tuberculous and malignant pleural effusions: what is the role of adenosine deaminase? Zarić B, etal., Lung. 2008 Jul-Aug;186(4):233-240. doi: 10.1007/s00408-008-9085-7. Epub 2008 Mar 21.
Additional References at PubMed
PMID:1618849   PMID:1914521   PMID:2015347   PMID:2387582   PMID:3182793   PMID:7592575   PMID:7594462   PMID:7599635   PMID:7670465   PMID:7691243   PMID:7731963   PMID:7759315  
PMID:8171392   PMID:8452534   PMID:8492116   PMID:8663040   PMID:8672487   PMID:8894685   PMID:9272950   PMID:9361033   PMID:10720488   PMID:10845921   PMID:10899903   PMID:11067867  
PMID:11435465   PMID:11591798   PMID:11772392   PMID:11940672   PMID:11999881   PMID:12163459   PMID:12477932   PMID:14607964   PMID:15240734   PMID:15489334   PMID:15630442   PMID:16626672  
PMID:16670267   PMID:16670300   PMID:16841096   PMID:17601796   PMID:17942570   PMID:18340377   PMID:19559780   PMID:24286264   PMID:25278365   PMID:27694000   PMID:27832996  


Genomics

Comparative Map Data
Ada
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83172,818,174 - 172,842,283 (-)NCBIGRCr8
mRatBN7.23152,398,745 - 152,422,854 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3152,398,747 - 152,447,088 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3156,206,205 - 156,230,314 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03164,705,138 - 164,729,255 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03162,449,261 - 162,473,358 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03160,115,840 - 160,139,947 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3160,115,842 - 160,139,947 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03166,306,001 - 166,330,108 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43154,636,530 - 154,660,637 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.13154,542,567 - 154,566,673 (-)NCBI
Celera3151,051,040 - 151,075,153 (-)NCBICelera
Cytogenetic Map3q42NCBI
ADA
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382044,619,522 - 44,651,699 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2044,584,896 - 44,652,252 (-)EnsemblGRCh38hg38GRCh38
GRCh372043,248,163 - 43,280,340 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362042,681,577 - 42,713,790 (-)NCBINCBI36Build 36hg18NCBI36
Build 342042,681,577 - 42,713,790NCBI
Celera2039,956,805 - 39,989,017 (-)NCBICelera
Cytogenetic Map20q13.12NCBI
HuRef2039,989,704 - 40,021,872 (-)NCBIHuRef
CHM1_12043,151,279 - 43,183,492 (-)NCBICHM1_1
T2T-CHM13v2.02046,355,294 - 46,387,474 (-)NCBIT2T-CHM13v2.0
Ada
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392163,565,703 - 163,592,154 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2163,568,504 - 163,592,159 (-)EnsemblGRCm39 Ensembl
GRCm382163,726,571 - 163,750,239 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2163,726,584 - 163,750,239 (-)EnsemblGRCm38mm10GRCm38
MGSCv372163,552,320 - 163,575,913 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362163,418,025 - 163,441,618 (-)NCBIMGSCv36mm8
Celera2169,670,309 - 169,693,933 (-)NCBICelera
Cytogenetic Map2H3NCBI
cM Map284.44NCBI
Ada
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544512,696,096 - 12,717,488 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495544512,696,096 - 12,717,488 (+)NCBIChiLan1.0ChiLan1.0
ADA
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22150,352,747 - 50,384,972 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12050,345,850 - 50,378,060 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02040,950,238 - 40,982,481 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12042,044,613 - 42,076,868 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2042,044,613 - 42,076,868 (-)Ensemblpanpan1.1panPan2
ADA
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12432,083,786 - 32,119,810 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2432,083,931 - 32,111,160 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2431,725,150 - 31,756,275 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02432,790,716 - 32,821,895 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2432,790,730 - 32,818,187 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12432,052,411 - 32,083,510 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02432,167,117 - 32,198,181 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02432,708,375 - 32,739,510 (-)NCBIUU_Cfam_GSD_1.0
Ada
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640181,082,150 - 181,103,907 (-)NCBIHiC_Itri_2
SpeTri2.0NW_0049365302,217,713 - 2,224,070 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ADA
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1747,044,497 - 47,072,245 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11747,044,492 - 47,072,232 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21752,502,115 - 52,544,469 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ADA
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1219,167,209 - 19,200,233 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366605067,836,179 - 67,868,616 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ada
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247909,809,492 - 9,829,883 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247909,809,550 - 9,829,199 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Ada
66 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:52
Count of miRNA genes:47
Interacting mature miRNAs:52
Transcripts:ENSRNOT00000014151
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2301411Bp320Blood pressure QTL 3200.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)3145925360166177555Rat
12879876Bw182Body weight QTL 1820.003body mass (VT:0001259)body weight (CMO:0000012)3145925360166177555Rat
2312673Scl63Serum cholesterol level QTL 630.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)398535255168026850Rat
1300113Bp176Blood pressure QTL 1763.9arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)3145956084157309487Rat
12879872Cm97Cardiac mass QTL 970.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)3145925360166177555Rat
1578653Vnigr3Vascular neointimal growth QTL 33.1artery morphology trait (VT:0002191)artery neointimal hyperplastic lesion area (CMO:0001414)3130656562169034231Rat
1598877Bp285Blood pressure QTL 2851.50.03arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3120538241165538241Rat
12879873Cm96Cardiac mass QTL 960.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)3145925360166177555Rat
2302373Gluco39Glucose level QTL 395.01blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)398535386161695835Rat
12879874Cm98Cardiac mass QTL 980.005heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)3145925360166177555Rat
1298068Bp167Blood pressure QTL 1670.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3141074471169034231Rat
12879875Kidm64Kidney mass QTL 640.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)3145925360166177555Rat
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)331172320163586636Rat
2298477Eau4Experimental allergic uveoretinitis QTL 40.0011uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)3137398739169034231Rat
8552791Vie2Viral induced encephalitis QTL 24.1brain integrity trait (VT:0010579)encephalitis incidence/prevalence measurement (CMO:0002361)3145956084169034231Rat
61335Bp20Blood pressure QTL 203arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3141339236155617360Rat
2317883Alcrsp26Alcohol response QTL 261.80.63response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)3145526770169034231Rat
1581568Rf53Renal function QTL 53urine total protein amount (VT:0000032)urine protein excretion rate to body weight ratio (CMO:0001099)356395968161299569Rat
1331726Bp208Blood pressure QTL 2083.129arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)3141339013162184794Rat
1578754Stresp16Stress response QTL 1640.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)3112681431157681431Rat
1598854Memor10Memory QTL 102exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)3145956084161299569Rat
9589106Insul23Insulin level QTL 2313.860.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)3131635904169034231Rat
10755461Coatc16Coat color QTL 16coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)3122438700167438700Rat
8662816Vetf4Vascular elastic tissue fragility QTL 44renal artery integrity trait (VT:0010642)number of ruptures of the internal elastic lamina of the renal arteries (CMO:0002563)359242096157323038Rat
1559282Emca5Estrogen-induced mammary cancer QTL 53.9mammary gland integrity trait (VT:0010552)percentage of study population developing mammary tumors during a period of time (CMO:0000948)343827364169034231Rat
2303620Vencon4Ventilatory control QTL 43.9respiration trait (VT:0001943)tidal volume (CMO:0000222)3127162703168026850Rat
631841Niddm39Non-insulin dependent diabetes mellitus QTL 393.36blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)394856903159898684Rat
1576306Schws3Schwannoma susceptibility QTL 30.001nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)3118839124163839124Rat
619618Rf3Renal disease susceptibility QTL 36.50.001urine albumin amount (VT:0002871)urine albumin excretion rate to body weight ratio (CMO:0001270)3107693393152693393Rat
1300159Kidm4Kidney mass QTL 43.83kidney mass (VT:0002707)right kidney wet weight to body weight ratio (CMO:0001953)3121056165157309487Rat
631673Iddm13Insulin dependent diabetes mellitus QTL 131.30.663blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)3130193298161695983Rat
2312659Slep7Serum leptin concentration QTL 70.001blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)398535255168026850Rat
2301971Cm71Cardiac mass QTL 714.63heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)341874578155617519Rat
2301970Bw81Body weight QTL 815.19body mass (VT:0001259)body weight (CMO:0000012)341874578155617519Rat
1578666Vnigr1Vascular neointimal growth QTL 14.6artery morphology trait (VT:0002191)artery lumen area (CMO:0001409)3149040888168026850Rat
1578656Vnigr2Vascular neointimal growth QTL 24.2artery morphology trait (VT:0002191)lesioned artery residual lumen area (CMO:0001417)3130656562169034231Rat
8552952Pigfal13Plasma insulin-like growth factor 1 level QTL 13blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)3138799500169034231Rat
12879871Am7Aortic mass QTL 70.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)3145925360166177555Rat
631541Bp81Blood pressure QTL 814arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3124122556169034231Rat
2312670Bw94Body weight QTL 940.01inguinal fat pad mass (VT:0010424)inguinal fat pad weight to body weight ratio (CMO:0001253)398535255168026850Rat


Genetic Models
This gene Ada is modified in the following models/strains:
F344-AdaTn(sb-T2/Bart3)2.237Mcwi    


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000014151   ⟹   ENSRNOP00000014151
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl3152,398,747 - 152,422,907 (-)Ensembl
Rnor_6.0 Ensembl3160,115,842 - 160,139,947 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000095363   ⟹   ENSRNOP00000090926
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl3152,398,747 - 152,447,088 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000104407   ⟹   ENSRNOP00000090682
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl3152,398,747 - 152,407,931 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000114756   ⟹   ENSRNOP00000090362
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl3152,398,747 - 152,408,126 (-)Ensembl
RefSeq Acc Id: NM_130399   ⟹   NP_569083
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83172,818,174 - 172,842,283 (-)NCBI
mRatBN7.23152,398,745 - 152,422,854 (-)NCBI
Rnor_6.03160,115,840 - 160,139,947 (-)NCBI
Rnor_5.03166,306,001 - 166,330,108 (-)NCBI
RGSC_v3.43154,636,530 - 154,660,637 (-)RGD
Celera3151,051,040 - 151,075,153 (-)RGD
Sequence:
RefSeq Acc Id: XM_039104230   ⟹   XP_038960158
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83172,818,174 - 172,827,712 (-)NCBI
mRatBN7.23152,398,745 - 152,408,382 (-)NCBI
RefSeq Acc Id: NP_569083   ⟸   NM_130399
- UniProtKB: Q920P6 (UniProtKB/Swiss-Prot),   A6JX48 (UniProtKB/TrEMBL),   A0A8I6AB50 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000014151   ⟸   ENSRNOT00000014151
RefSeq Acc Id: XP_038960158   ⟸   XM_039104230
- Peptide Label: isoform X1
- UniProtKB: A0A8I6GI51 (UniProtKB/TrEMBL),   A0A8I6ANW5 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000090926   ⟸   ENSRNOT00000095363
Ensembl Acc Id: ENSRNOP00000090362   ⟸   ENSRNOT00000114756
Ensembl Acc Id: ENSRNOP00000090682   ⟸   ENSRNOT00000104407
Protein Domains
Adenosine deaminase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q920P6-F1-model_v2 AlphaFold Q920P6 1-352 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13692641
Promoter ID:EPDNEW_R3164
Type:single initiation site
Name:Ada_1
Description:adenosine deaminase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.03160,139,958 - 160,140,018EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2031 AgrOrtholog
BioCyc Gene G2FUF-46896 BioCyc
BioCyc Pathway PWY-6609 [adenine and adenosine salvage III] BioCyc
  PWY-7179 [purine deoxyribonucleosides degradation I] BioCyc
  PWY-7179-1 [purine deoxyribonucleosides degradation II] BioCyc
  PWY0-1296 [purine ribonucleosides degradation] BioCyc
  SALVADEHYPOX-PWY [adenosine nucleotides degradation II] BioCyc
BioCyc Pathway Image PWY-6609 BioCyc
  PWY-7179 BioCyc
  PWY-7179-1 BioCyc
  PWY0-1296 BioCyc
  SALVADEHYPOX-PWY BioCyc
Ensembl Genes ENSRNOG00000010265 Ensembl, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00055003913 UniProtKB/Swiss-Prot
  ENSRNOG00060001531 UniProtKB/Swiss-Prot
  ENSRNOG00065025525 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000014151.7 UniProtKB/Swiss-Prot
  ENSRNOT00000095363.1 UniProtKB/TrEMBL
  ENSRNOT00000104407.1 UniProtKB/TrEMBL
  ENSRNOT00000114756.1 UniProtKB/TrEMBL
  ENSRNOT00055006244 UniProtKB/Swiss-Prot
  ENSRNOT00060002310 UniProtKB/Swiss-Prot
  ENSRNOT00065044013 UniProtKB/Swiss-Prot
Gene3D-CATH Metal-dependent hydrolases UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7384286 IMAGE-MGC_LOAD
InterPro A/AMP_deam_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  A/AMP_deaminase_dom UniProtKB/Swiss-Prot
  A_deaminase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  A_deaminase_dom UniProtKB/TrEMBL
  Ado/ade_deaminase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Metal_Hydrolase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:24165 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:108610 IMAGE-MGC_LOAD
NCBI Gene 24165 ENTREZGENE
PANTHER ADENOSINE DEAMINASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11409 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam A_deaminase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB ADA RGD
PhenoGen Ada PhenoGen
PROSITE A_DEAMINASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000010265 RatGTEx
  ENSRNOG00055003913 RatGTEx
  ENSRNOG00060001531 RatGTEx
  ENSRNOG00065025525 RatGTEx
Superfamily-SCOP SSF51556 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I6AB50 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6ANW5 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6GI51 ENTREZGENE, UniProtKB/TrEMBL
  A6JX47_RAT UniProtKB/TrEMBL
  A6JX48 ENTREZGENE, UniProtKB/TrEMBL
  ADA_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Ada  Adenosine deaminase      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in many regions of the brain 631747
gene_expression enzyme activity detected in uterine decidua 632211
gene_expression enzyme activity detected in intestine 632212
gene_function catalyzes the conversion of adenosine to inosine in adenosine metabolism 631747
gene_process may be involved in the regulation of the sleep wake cycle 631747
gene_process plays a role in adenosine metabolism 631747